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Protein

Protein S100-A3

Gene

S100a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi93ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinitySequence analysisAdd BLAST14
Calcium bindingi63 – 742; high affinitySequence analysisAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338849 S100a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439731 – 101Protein S100-A3Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 68By similarity
Modified residuei51Citrulline; by PAD3By similarity1

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization (By similarity).By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP62818
PeptideAtlasiP62818
PRIDEiP62818

Expressioni

Tissue specificityi

Skin specific, specifically expressed in cuticle of pelage follicle.1 Publication

Gene expression databases

BgeeiENSMUSG00000001021 Expressed in 49 organ(s), highest expression level in skin of back
CleanExiMM_S100A3
ExpressionAtlasiP62818 baseline and differential
GenevisibleiP62818 MM

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001047

Structurei

3D structure databases

ProteinModelPortaliP62818
SMRiP62818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1Add BLAST36
Domaini50 – 85EF-hand 2Add BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3DW Eukaryota
ENOG411196G LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP62818
OMAiMTRPLEQ
OrthoDBiEOG091G10JX
PhylomeDBiP62818
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028488 S100A3
PANTHERiPTHR11639:SF12 PTHR11639:SF12, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P62818-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRPLEQAVA AIVCTFQEYA GRCGDKYKIC QSELKELLQK ELPTWTPSEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFGEYVRSLA SLCLYCHEYF KECPPEPPCP

Q
Length:101
Mass (Da):11,747
Last modified:August 16, 2004 - v1
Checksum:iEE46EABF16646CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA Translation: AAC64107.1
AF004941 mRNA Translation: AAC78730.1
CCDSiCCDS17537.1
RefSeqiNP_035440.1, NM_011310.2
XP_006501234.1, XM_006501171.3
XP_006501236.1, XM_006501173.3
XP_006501237.1, XM_006501174.1
XP_006501238.1, XM_006501175.2
XP_006501239.1, XM_006501176.2
XP_011238349.1, XM_011240047.1
XP_017174998.1, XM_017319509.1
UniGeneiMm.440044
Mm.464895

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021
ENSMUST00000200290; ENSMUSP00000142334; ENSMUSG00000001021
ENSMUST00000200508; ENSMUSP00000142747; ENSMUSG00000001021
GeneIDi20197
KEGGimmu:20197
UCSCiuc008qcy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087470 mRNA Translation: AAC64107.1
AF004941 mRNA Translation: AAC78730.1
CCDSiCCDS17537.1
RefSeqiNP_035440.1, NM_011310.2
XP_006501234.1, XM_006501171.3
XP_006501236.1, XM_006501173.3
XP_006501237.1, XM_006501174.1
XP_006501238.1, XM_006501175.2
XP_006501239.1, XM_006501176.2
XP_011238349.1, XM_011240047.1
XP_017174998.1, XM_017319509.1
UniGeneiMm.440044
Mm.464895

3D structure databases

ProteinModelPortaliP62818
SMRiP62818
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001047

Proteomic databases

PaxDbiP62818
PeptideAtlasiP62818
PRIDEiP62818

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001047; ENSMUSP00000001047; ENSMUSG00000001021
ENSMUST00000200290; ENSMUSP00000142334; ENSMUSG00000001021
ENSMUST00000200508; ENSMUSP00000142747; ENSMUSG00000001021
GeneIDi20197
KEGGimmu:20197
UCSCiuc008qcy.1 mouse

Organism-specific databases

CTDi6274
MGIiMGI:1338849 S100a3

Phylogenomic databases

eggNOGiENOG410J3DW Eukaryota
ENOG411196G LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP62818
OMAiMTRPLEQ
OrthoDBiEOG091G10JX
PhylomeDBiP62818
TreeFamiTF332727

Miscellaneous databases

PROiPR:P62818
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001021 Expressed in 49 organ(s), highest expression level in skin of back
CleanExiMM_S100A3
ExpressionAtlasiP62818 baseline and differential
GenevisibleiP62818 MM

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028488 S100A3
PANTHERiPTHR11639:SF12 PTHR11639:SF12, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A3_MOUSE
AccessioniPrimary (citable) accession number: P62818
Secondary accession number(s): P56566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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