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Protein

V-type proton ATPase subunit B, brain isoform

Gene

Atp6v1b2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556 ROS, RNS production in phagocytes
R-RNO-77387 Insulin receptor recycling
R-RNO-917977 Transferrin endocytosis and recycling
R-RNO-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit B, brain isoform
Short name:
V-ATPase subunit B 2
Alternative name(s):
Endomembrane proton pump 58 kDa subunit
Vacuolar proton pump subunit B 2
Gene namesi
Name:Atp6v1b2
Synonyms:Atp6b2, Vat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi620284 Atp6v1b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446291 – 511V-type proton ATPase subunit B, brain isoformAdd BLAST511

Proteomic databases

PaxDbiP62815
PRIDEiP62815

2D gel databases

World-2DPAGEi0004:P62815

PTM databases

iPTMnetiP62815
PhosphoSitePlusiP62815

Expressioni

Gene expression databases

BgeeiENSRNOG00000011891 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP62815 RN

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

BioGridi250775, 2 interactors
IntActiP62815, 2 interactors
STRINGi10116.ENSRNOP00000015931

Structurei

3D structure databases

ProteinModelPortaliP62815
SMRiP62815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
GeneTreeiENSGT00550000074724
HOGENOMiHOG000165320
HOVERGENiHBG002176
InParanoidiP62815
KOiK02147
OMAiFTPLCAG
OrthoDBiEOG091G04TR
PhylomeDBiP62815
TreeFamiTF300313

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P62815-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRAMRGIV NGAAPELPVP TGGPMAGARE QALAVSRNYL SQPRLTYKTV
60 70 80 90 100
SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE
110 120 130 140 150
GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF
160 170 180 190 200
LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN
210 220 230 240 250
EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEE
260 270 280 290 300
NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM
310 320 330 340 350
SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ
360 370 380 390 400
IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR
410 420 430 440 450
LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL
460 470 480 490 500
YLEFLQKFEK NFITQGPYEN RTVYETLDIG WQLLRIFPKE MLKRIPQSTL
510
SEFYPRDSAK H
Length:511
Mass (Da):56,551
Last modified:August 16, 2004 - v1
Checksum:iE116BF9A36EEF36B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12635 mRNA Translation: CAA73183.1
BC085714 mRNA Translation: AAH85714.1
RefSeqiNP_476561.1, NM_057213.2
UniGeneiRn.8109

Genome annotation databases

EnsembliENSRNOT00000015931; ENSRNOP00000015931; ENSRNOG00000011891
GeneIDi117596
KEGGirno:117596
UCSCiRGD:620284 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12635 mRNA Translation: CAA73183.1
BC085714 mRNA Translation: AAH85714.1
RefSeqiNP_476561.1, NM_057213.2
UniGeneiRn.8109

3D structure databases

ProteinModelPortaliP62815
SMRiP62815
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250775, 2 interactors
IntActiP62815, 2 interactors
STRINGi10116.ENSRNOP00000015931

PTM databases

iPTMnetiP62815
PhosphoSitePlusiP62815

2D gel databases

World-2DPAGEi0004:P62815

Proteomic databases

PaxDbiP62815
PRIDEiP62815

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015931; ENSRNOP00000015931; ENSRNOG00000011891
GeneIDi117596
KEGGirno:117596
UCSCiRGD:620284 rat

Organism-specific databases

CTDi526
RGDi620284 Atp6v1b2

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
GeneTreeiENSGT00550000074724
HOGENOMiHOG000165320
HOVERGENiHBG002176
InParanoidiP62815
KOiK02147
OMAiFTPLCAG
OrthoDBiEOG091G04TR
PhylomeDBiP62815
TreeFamiTF300313

Enzyme and pathway databases

ReactomeiR-RNO-1222556 ROS, RNS production in phagocytes
R-RNO-77387 Insulin receptor recycling
R-RNO-917977 Transferrin endocytosis and recycling
R-RNO-983712 Ion channel transport

Miscellaneous databases

PROiPR:P62815

Gene expression databases

BgeeiENSRNOG00000011891 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP62815 RN

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATB2_RAT
AccessioniPrimary (citable) accession number: P62815
Secondary accession number(s): O09045, P50517
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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