Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit B, brain isoform

Gene

Atp6v1b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit B, brain isoform
Short name:
V-ATPase subunit B 2
Alternative name(s):
Endomembrane proton pump 58 kDa subunit
Vacuolar proton pump subunit B 2
Gene namesi
Name:Atp6v1b2
Synonyms:Atp6b2, Vat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:109618 Atp6v1b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown in the whole cochlea, especially in hair cells and spiral ganglion neurons causes a dose-dependent hearing loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446271 – 511V-type proton ATPase subunit B, brain isoformAdd BLAST511

Proteomic databases

EPDiP62814
MaxQBiP62814
PaxDbiP62814
PeptideAtlasiP62814
PRIDEiP62814

2D gel databases

REPRODUCTION-2DPAGEiP62814
UCD-2DPAGEiP62814

PTM databases

iPTMnetiP62814
PhosphoSitePlusiP62814
SwissPalmiP62814

Expressioni

Tissue specificityi

Mainly expressed in the organ of Corti and spiral ganglion neurons, in both the early postnatal cochlea (P2) and the adult cochlea (P30).1 Publication

Gene expression databases

BgeeiENSMUSG00000006273 Expressed in 309 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_ATP6V1B2
GenevisibleiP62814 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

BioGridi198262, 1 interactor
IntActiP62814, 7 interactors
MINTiP62814
STRINGi10090.ENSMUSP00000006435

Structurei

3D structure databases

ProteinModelPortaliP62814
SMRiP62814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
GeneTreeiENSGT00550000074724
HOVERGENiHBG002176
InParanoidiP62814
KOiK02147
OMAiFTPLCAG
OrthoDBiEOG091G04TR
PhylomeDBiP62814
TreeFamiTF300313

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P62814-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRAMRGIV NGAAPELPVP TGGPMAGARE QALAVSRNYL SQPRLTYKTV
60 70 80 90 100
SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE
110 120 130 140 150
GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF
160 170 180 190 200
LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN
210 220 230 240 250
EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEE
260 270 280 290 300
NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM
310 320 330 340 350
SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ
360 370 380 390 400
IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR
410 420 430 440 450
LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL
460 470 480 490 500
YLEFLQKFEK NFITQGPYEN RTVYETLDIG WQLLRIFPKE MLKRIPQSTL
510
SEFYPRDSAK H
Length:511
Mass (Da):56,551
Last modified:August 16, 2004 - v1
Checksum:iE116BF9A36EEF36B
GO

Sequence cautioni

The sequence BAE30303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE30526 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE31441 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 23GG → RP in AAC52411 (PubMed:8741845).Curated2
Sequence conflicti36S → G in AAC52411 (PubMed:8741845).Curated1
Sequence conflicti80T → A in BAE35206 (PubMed:16141072).Curated1
Sequence conflicti85 – 86QV → AS in AAC52411 (PubMed:8741845).Curated2
Sequence conflicti262 – 264NLA → ILP in AAC52411 (PubMed:8741845).Curated3
Sequence conflicti270E → K in BAE35536 (PubMed:16141072).Curated1
Sequence conflicti270E → K in BAE35612 (PubMed:16141072).Curated1
Sequence conflicti276R → C in AAC52411 (PubMed:8741845).Curated1
Sequence conflicti300M → T in AAC52411 (PubMed:8741845).Curated1
Sequence conflicti304A → P in AAC52411 (PubMed:8741845).Curated1
Sequence conflicti318P → H in BAE35536 (PubMed:16141072).Curated1
Sequence conflicti318P → H in BAE35612 (PubMed:16141072).Curated1
Sequence conflicti365I → M in BAE40674 (PubMed:16141072).Curated1
Sequence conflicti371Y → C in BAE35206 (PubMed:16141072).Curated1
Sequence conflicti373T → I in BAE30303 (PubMed:16141072).Curated1
Sequence conflicti373T → I in BAE30526 (PubMed:16141072).Curated1
Sequence conflicti405A → P in AAC52411 (PubMed:8741845).Curated1
Sequence conflicti437A → V in BAE30197 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13838 Genomic DNA Translation: AAC52411.1
Y12634 mRNA Translation: CAA73182.1
AK146499 mRNA Translation: BAE27215.1
AK151200 mRNA Translation: BAE30197.1
AK151322 mRNA Translation: BAE30303.1 Different initiation.
AK151586 mRNA Translation: BAE30526.1 Different initiation.
AK152718 mRNA Translation: BAE31441.1 Different initiation.
AK152766 mRNA Translation: BAE31479.1
AK159133 mRNA Translation: BAE34845.1
AK159153 mRNA Translation: BAE34860.1
AK159586 mRNA Translation: BAE35206.1
AK159701 mRNA Translation: BAE35300.1
AK159986 mRNA Translation: BAE35536.1
AK160080 mRNA Translation: BAE35612.1
AK160854 mRNA Translation: BAE36047.1
AK166669 mRNA Translation: BAE38930.1
AK168852 mRNA Translation: BAE40674.1
AK169155 mRNA Translation: BAE40934.1
AK169270 mRNA Translation: BAE41031.1
BC012497 mRNA Translation: AAH12497.1
BC046302 mRNA Translation: AAH46302.1
BC085300 mRNA Translation: AAH85300.1
CCDSiCCDS40358.1
RefSeqiNP_031535.2, NM_007509.3
UniGeneiMm.249096

Genome annotation databases

EnsembliENSMUST00000006435; ENSMUSP00000006435; ENSMUSG00000006273
GeneIDi11966
KEGGimmu:11966
UCSCiuc009lww.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13838 Genomic DNA Translation: AAC52411.1
Y12634 mRNA Translation: CAA73182.1
AK146499 mRNA Translation: BAE27215.1
AK151200 mRNA Translation: BAE30197.1
AK151322 mRNA Translation: BAE30303.1 Different initiation.
AK151586 mRNA Translation: BAE30526.1 Different initiation.
AK152718 mRNA Translation: BAE31441.1 Different initiation.
AK152766 mRNA Translation: BAE31479.1
AK159133 mRNA Translation: BAE34845.1
AK159153 mRNA Translation: BAE34860.1
AK159586 mRNA Translation: BAE35206.1
AK159701 mRNA Translation: BAE35300.1
AK159986 mRNA Translation: BAE35536.1
AK160080 mRNA Translation: BAE35612.1
AK160854 mRNA Translation: BAE36047.1
AK166669 mRNA Translation: BAE38930.1
AK168852 mRNA Translation: BAE40674.1
AK169155 mRNA Translation: BAE40934.1
AK169270 mRNA Translation: BAE41031.1
BC012497 mRNA Translation: AAH12497.1
BC046302 mRNA Translation: AAH46302.1
BC085300 mRNA Translation: AAH85300.1
CCDSiCCDS40358.1
RefSeqiNP_031535.2, NM_007509.3
UniGeneiMm.249096

3D structure databases

ProteinModelPortaliP62814
SMRiP62814
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198262, 1 interactor
IntActiP62814, 7 interactors
MINTiP62814
STRINGi10090.ENSMUSP00000006435

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiP62814
PhosphoSitePlusiP62814
SwissPalmiP62814

2D gel databases

REPRODUCTION-2DPAGEiP62814
UCD-2DPAGEiP62814

Proteomic databases

EPDiP62814
MaxQBiP62814
PaxDbiP62814
PeptideAtlasiP62814
PRIDEiP62814

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006435; ENSMUSP00000006435; ENSMUSG00000006273
GeneIDi11966
KEGGimmu:11966
UCSCiuc009lww.2 mouse

Organism-specific databases

CTDi526
MGIiMGI:109618 Atp6v1b2

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
GeneTreeiENSGT00550000074724
HOVERGENiHBG002176
InParanoidiP62814
KOiK02147
OMAiFTPLCAG
OrthoDBiEOG091G04TR
PhylomeDBiP62814
TreeFamiTF300313

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Miscellaneous databases

ChiTaRSiAtp6v1b2 mouse
PROiPR:P62814
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006273 Expressed in 309 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_ATP6V1B2
GenevisibleiP62814 MM

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATB2_MOUSE
AccessioniPrimary (citable) accession number: P62814
Secondary accession number(s): O09045
, P50517, Q3TG74, Q3TL62, Q3TVK6, Q3TWR0, Q3U791, Q3U7C8, Q3U9Z0, Q3UAW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again