UniProtKB - P62807 (H2B1C_HUMAN)
Functioni
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
GO - Molecular functioni
- DNA binding Source: GO_Central
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- antibacterial humoral response Source: UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- innate immune response in mucosa Source: UniProtKB
- nucleosome assembly Source: GO_Central
Keywordsi
Molecular function | Antibiotic, Antimicrobial, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P62807 |
Reactomei | R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329, Cleavage of the damaged pyrimidine R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-1221632, Meiotic synapsis R-HSA-171306, Packaging Of Telomere Ends R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2299718, Condensation of Prophase Chromosomes R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214847, HATs acetylate histones R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5334118, DNA methylation R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5689880, Ub-specific processing proteases R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68616, Assembly of the ORC complex at the origin of replication R-HSA-69473, G2/M DNA damage checkpoint R-HSA-73728, RNA Polymerase I Promoter Opening R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519, Estrogen-dependent gene expression R-HSA-912446, Meiotic recombination R-HSA-9609690, HCMV Early Events R-HSA-9610379, HCMV Late Events R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9670095, Inhibition of DNA recombination at telomere R-HSA-9710421, Defective pyroptosis R-HSA-977225, Amyloid fiber formation |
SignaLinki | P62807 |
SIGNORi | P62807 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H2B type 1-C/E/F/G/IAlternative name(s): Histone H2B.1 A Histone H2B.a Short name: H2B/a Histone H2B.g Short name: H2B/g Histone H2B.h Short name: H2B/h Histone H2B.k Short name: H2B/k Histone H2B.l Short name: H2B/l |
Gene namesi | AND AND AND AND |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4756, H2BC10 HGNC:4757, H2BC4 HGNC:4753, H2BC6 HGNC:4752, H2BC7 HGNC:4746, H2BC8 |
MIMi | 602798, gene 602804, gene 602805, gene 602807, gene 602847, gene |
neXtProti | NX_P62807 |
VEuPathDBi | HostDB:ENSG00000180596 HostDB:ENSG00000273802 HostDB:ENSG00000274290 HostDB:ENSG00000277224 HostDB:ENSG00000278588 |
Subcellular locationi
Nucleus
Other locations
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- nucleosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Nucleosome core, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3017 8339 8343 8344 8346 8347 |
OpenTargetsi | ENSG00000180596 ENSG00000273802 ENSG00000274290 ENSG00000277224 ENSG00000278588 |
PharmGKBi | PA29132 |
Miscellaneous databases
Pharosi | P62807, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Genetic variation databases
BioMutai | HIST1H2BG |
DMDMi | 290457686 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity5 Publications | |||
ChainiPRO_0000071826 | 2 – 126 | Histone H2B type 1-C/E/F/G/IAdd BLAST | 125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylprolineBy similarity | 1 | |
Modified residuei | 6 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-acetyllysine; alternate2 Publications | 1 | |
Modified residuei | 6 | N6-butyryllysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-lactoyllysine; alternate1 Publication | 1 | |
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 12 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 12 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 12 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 12 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 13 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 13 | N6-acetyllysine; alternate2 Publications | 1 | |
Modified residuei | 13 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 15 | Phosphoserine; by STK4/MST11 Publication | 1 | |
Modified residuei | 16 | N6-acetyllysine; alternate2 Publications | 1 | |
Modified residuei | 16 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 16 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-acetyllysine; alternate2 Publications | 1 | |
Modified residuei | 21 | N6-butyryllysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-lactoyllysine; alternate1 Publication | 1 | |
Cross-linki | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 24 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 24 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 24 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 25 | N6-(2-hydroxyisobutyryl)lysine1 Publication | 1 | |
Modified residuei | 35 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-succinyllysine; alternate1 Publication | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication | ||
Modified residuei | 37 | Phosphoserine; by AMPKBy similarity | 1 | |
Modified residuei | 44 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 44 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 44 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 47 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 47 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 47 | N6-methyllysine; alternate1 Publication | 1 | |
Modified residuei | 58 | N6,N6-dimethyllysine; alternate1 Publication | 1 | |
Modified residuei | 58 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 80 | Dimethylated arginineBy similarity | 1 | |
Modified residuei | 86 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 86 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 86 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 86 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 86 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 87 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 93 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 109 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 109 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 109 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 109 | N6-methyllysine; alternate1 Publication | 1 | |
Glycosylationi | 113 | O-linked (GlcNAc) serine1 Publication | 1 | |
Modified residuei | 116 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 117 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 117 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 117 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 117 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 117 | N6-malonyllysine; alternate1 Publication | 1 | |
Modified residuei | 117 | N6-methylated lysine; alternateBy similarity | 1 | |
Modified residuei | 117 | N6-succinyllysine; alternate1 Publication | 1 | |
Modified residuei | 121 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 121 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 121 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 121 | N6-lactoyllysine; alternate1 Publication | 1 | |
Modified residuei | 121 | N6-succinyllysine; alternate1 Publication | 1 | |
Cross-linki | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate4 Publications |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P62807 |
jPOSTi | P62807 |
MassIVEi | P62807 |
MaxQBi | P62807 |
PaxDbi | P62807 |
PeptideAtlasi | P62807 |
PRIDEi | P62807 |
TopDownProteomicsi | P62807 |
PTM databases
GlyGeni | P62807, 1 site |
iPTMneti | P62807 |
PhosphoSitePlusi | P62807 |
SwissPalmi | P62807 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180596, Expressed in stomach and 157 other tissues |
ExpressionAtlasi | P62807, baseline and differential |
Genevisiblei | P62807, HS |
Organism-specific databases
HPAi | ENSG00000180596, Low tissue specificity ENSG00000273802, Tissue enhanced (prostate) ENSG00000274290, Low tissue specificity ENSG00000277224, Tissue enhanced (prostate) ENSG00000278588, Group enriched (bone marrow, brain, choroid plexus, lymphoid tissue) |
Interactioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Binary interactionsi
P62807
With | #Exp. | IntAct |
---|---|---|
AP2M1 [Q96CW1] | 5 | EBI-354552,EBI-297683 |
itself | 2 | EBI-354552,EBI-354552 |
TP53BP1 [Q12888] | 6 | EBI-354552,EBI-396540 |
TP53BP2 - isoform 3 [Q13625-3] | 3 | EBI-354552,EBI-10175039 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 109270, 141 interactors 113935, 560 interactors 113939, 250 interactors 113940, 83 interactors 113942, 133 interactors 113943, 50 interactors |
DIPi | DIP-32890N |
IntActi | P62807, 255 interactors |
MINTi | P62807 |
STRINGi | 9606.ENSP00000321744 |
Miscellaneous databases
RNActi | P62807, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P62807 |
SMRi | P62807 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 35 | Basic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1744, Eukaryota |
GeneTreei | ENSGT01030000234651 |
HOGENOMi | CLU_075666_2_1_1 |
InParanoidi | P62807 |
OMAi | AREWIVL |
OrthoDBi | 1536672at2759 |
PhylomeDBi | P62807 |
TreeFami | TF300212 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000558, Histone_H2B |
PANTHERi | PTHR23428, PTHR23428, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00621, HISTONEH2B |
SMARTi | View protein in SMART SM00427, H2B, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00357, HISTONE_H2B, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | A → S in CAB02545 (PubMed:9119399).Curated | 1 | |
Sequence conflicti | 33 | S → T in CAB02545 (PubMed:9119399).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055887 | 27 | G → S1 PublicationCorresponds to variant dbSNP:rs7766641Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60750 Genomic DNA Translation: AAA63189.1 Z80782 Genomic DNA Translation: CAB02544.1 Z80779 Genomic DNA Translation: CAB02541.1 Z80780 Genomic DNA Translation: CAB02542.1 Z80783 Genomic DNA Translation: CAB02545.1 AF531286 Genomic DNA Translation: AAN06686.1 AF531288 Genomic DNA Translation: AAN06688.1 AF531289 Genomic DNA Translation: AAN06689.1 AF531290 Genomic DNA Translation: AAN06690.1 AF531292 Genomic DNA Translation: AAN06692.1 AL031777 Genomic DNA No translation available. AL353759 Genomic DNA No translation available. BC001131 mRNA No translation available. BC009612 mRNA No translation available. BC096120 mRNA Translation: AAH96120.1 BC096122 mRNA Translation: AAH96122.1 BC096123 mRNA Translation: AAH96123.1 BC101653 mRNA Translation: AAI01654.1 BC101655 mRNA Translation: AAI01656.1 BC101748 mRNA Translation: AAI01749.1 BC101750 mRNA Translation: AAI01751.1 BC106899 mRNA Translation: AAI06900.1 |
CCDSi | CCDS4584.1 CCDS4588.1 CCDS4592.1 CCDS4594.1 CCDS4603.1 |
PIRi | E40335, HSHUB2 S65409 |
RefSeqi | NP_003509.1, NM_003518.3 NP_003513.1, NM_003522.3 NP_003514.2, NM_003523.2 NP_003516.1, NM_003525.2 NP_003517.2, NM_003526.2 NP_066407.1, NM_021063.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60750 Genomic DNA Translation: AAA63189.1 Z80782 Genomic DNA Translation: CAB02544.1 Z80779 Genomic DNA Translation: CAB02541.1 Z80780 Genomic DNA Translation: CAB02542.1 Z80783 Genomic DNA Translation: CAB02545.1 AF531286 Genomic DNA Translation: AAN06686.1 AF531288 Genomic DNA Translation: AAN06688.1 AF531289 Genomic DNA Translation: AAN06689.1 AF531290 Genomic DNA Translation: AAN06690.1 AF531292 Genomic DNA Translation: AAN06692.1 AL031777 Genomic DNA No translation available. AL353759 Genomic DNA No translation available. BC001131 mRNA No translation available. BC009612 mRNA No translation available. BC096120 mRNA Translation: AAH96120.1 BC096122 mRNA Translation: AAH96122.1 BC096123 mRNA Translation: AAH96123.1 BC101653 mRNA Translation: AAI01654.1 BC101655 mRNA Translation: AAI01656.1 BC101748 mRNA Translation: AAI01749.1 BC101750 mRNA Translation: AAI01751.1 BC106899 mRNA Translation: AAI06900.1 |
CCDSi | CCDS4584.1 CCDS4588.1 CCDS4592.1 CCDS4594.1 CCDS4603.1 |
PIRi | E40335, HSHUB2 S65409 |
RefSeqi | NP_003509.1, NM_003518.3 NP_003513.1, NM_003522.3 NP_003514.2, NM_003523.2 NP_003516.1, NM_003525.2 NP_003517.2, NM_003526.2 NP_066407.1, NM_021063.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GT0 | X-ray | 2.82 | D/H | 2-126 | [»] | |
5KGF | electron microscopy | 4.54 | D/H | 1-126 | [»] | |
6ACO | X-ray | 1.71 | B | 118-124 | [»] | |
6C0W | electron microscopy | 4.00 | D/H | 1-126 | [»] | |
6FML | electron microscopy | 4.34 | P/T | 2-126 | [»] | |
6R0C | electron microscopy | 4.20 | D/H | 1-126 | [»] | |
6RNY | electron microscopy | 3.90 | D/H | 1-126 | [»] | |
6SE0 | electron microscopy | 3.80 | D/H | 1-126 | [»] | |
6SE6 | electron microscopy | 3.50 | D/H | 1-126 | [»] | |
6SEE | electron microscopy | 4.20 | D/H | 1-126 | [»] | |
6SEF | electron microscopy | 3.70 | D/H | 1-126 | [»] | |
6SEG | electron microscopy | 3.10 | D/H | 1-126 | [»] | |
6UPK | electron microscopy | 4.90 | D | 1-126 | [»] | |
6UPL | electron microscopy | 7.40 | D/L | 1-126 | [»] | |
6X59 | electron microscopy | 2.98 | D/H | 3-126 | [»] | |
6X5A | electron microscopy | 4.36 | D/H | 3-126 | [»] | |
6XJD | electron microscopy | 6.80 | D/H | 3-126 | [»] | |
7A08 | electron microscopy | 3.11 | c/g | 2-126 | [»] | |
7JO9 | electron microscopy | 3.30 | D/H | 2-126 | [»] | |
7JOA | electron microscopy | 3.30 | D/H | 2-126 | [»] | |
AlphaFoldDBi | P62807 | |||||
SMRi | P62807 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109270, 141 interactors 113935, 560 interactors 113939, 250 interactors 113940, 83 interactors 113942, 133 interactors 113943, 50 interactors |
DIPi | DIP-32890N |
IntActi | P62807, 255 interactors |
MINTi | P62807 |
STRINGi | 9606.ENSP00000321744 |
Chemistry databases
DrugBanki | DB09130, Copper |
PTM databases
GlyGeni | P62807, 1 site |
iPTMneti | P62807 |
PhosphoSitePlusi | P62807 |
SwissPalmi | P62807 |
Genetic variation databases
BioMutai | HIST1H2BG |
DMDMi | 290457686 |
Proteomic databases
EPDi | P62807 |
jPOSTi | P62807 |
MassIVEi | P62807 |
MaxQBi | P62807 |
PaxDbi | P62807 |
PeptideAtlasi | P62807 |
PRIDEi | P62807 |
TopDownProteomicsi | P62807 |
Protocols and materials databases
ABCDi | P62807, 1 sequenced antibody |
Antibodypediai | 10912, 319 antibodies from 24 providers 72347, 43 antibodies from 4 providers 76967, 1 antibodies from 1 providers 77815, 2 antibodies from 1 providers 77855, 1 antibodies from 1 providers |
DNASUi | 8339 |
Genome annotation databases
Organism-specific databases
CTDi | 3017 8339 8343 8344 8346 8347 |
DisGeNETi | 3017 8339 8343 8344 8346 8347 |
GeneCardsi | H2BC10 H2BC4 H2BC6 H2BC7 H2BC8 |
HGNCi | HGNC:4756, H2BC10 HGNC:4757, H2BC4 HGNC:4753, H2BC6 HGNC:4752, H2BC7 HGNC:4746, H2BC8 |
HPAi | ENSG00000180596, Low tissue specificity ENSG00000273802, Tissue enhanced (prostate) ENSG00000274290, Low tissue specificity ENSG00000277224, Tissue enhanced (prostate) ENSG00000278588, Group enriched (bone marrow, brain, choroid plexus, lymphoid tissue) |
MIMi | 602798, gene 602804, gene 602805, gene 602807, gene 602847, gene |
neXtProti | NX_P62807 |
OpenTargetsi | ENSG00000180596 ENSG00000273802 ENSG00000274290 ENSG00000277224 ENSG00000278588 |
PharmGKBi | PA29132 |
VEuPathDBi | HostDB:ENSG00000180596 HostDB:ENSG00000273802 HostDB:ENSG00000274290 HostDB:ENSG00000277224 HostDB:ENSG00000278588 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1744, Eukaryota |
GeneTreei | ENSGT01030000234651 |
HOGENOMi | CLU_075666_2_1_1 |
InParanoidi | P62807 |
OMAi | AREWIVL |
OrthoDBi | 1536672at2759 |
PhylomeDBi | P62807 |
TreeFami | TF300212 |
Enzyme and pathway databases
PathwayCommonsi | P62807 |
Reactomei | R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329, Cleavage of the damaged pyrimidine R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-1221632, Meiotic synapsis R-HSA-171306, Packaging Of Telomere Ends R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2299718, Condensation of Prophase Chromosomes R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214847, HATs acetylate histones R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5334118, DNA methylation R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5689880, Ub-specific processing proteases R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68616, Assembly of the ORC complex at the origin of replication R-HSA-69473, G2/M DNA damage checkpoint R-HSA-73728, RNA Polymerase I Promoter Opening R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519, Estrogen-dependent gene expression R-HSA-912446, Meiotic recombination R-HSA-9609690, HCMV Early Events R-HSA-9610379, HCMV Late Events R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9670095, Inhibition of DNA recombination at telomere R-HSA-9710421, Defective pyroptosis R-HSA-977225, Amyloid fiber formation |
SignaLinki | P62807 |
SIGNORi | P62807 |
Miscellaneous databases
BioGRID-ORCSi | 3017, 139 hits in 1018 CRISPR screens 8339, 253 hits in 988 CRISPR screens 8343, 390 hits in 1001 CRISPR screens 8344, 579 hits in 1002 CRISPR screens 8346, 79 hits in 989 CRISPR screens 8347, 710 hits in 1021 CRISPR screens |
ChiTaRSi | HIST1H2BC, human HIST1H2BE, human HIST1H2BG, human |
GeneWikii | HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI Histone_H2B_type_1-C |
Pharosi | P62807, Tbio |
PROi | PR:P62807 |
RNActi | P62807, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180596, Expressed in stomach and 157 other tissues |
ExpressionAtlasi | P62807, baseline and differential |
Genevisiblei | P62807, HS |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000558, Histone_H2B |
PANTHERi | PTHR23428, PTHR23428, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00621, HISTONEH2B |
SMARTi | View protein in SMART SM00427, H2B, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00357, HISTONE_H2B, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H2B1C_HUMAN | |
Accessioni | P62807Primary (citable) accession number: P62807 Secondary accession number(s): P02278 Q93080 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | March 2, 2010 | |
Last modified: | May 25, 2022 | |
This is version 188 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families