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Entry version 185 (02 Jun 2021)
Sequence version 4 (02 Mar 2010)
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Protein

Histone H2B type 1-C/E/F/G/I

Gene

H2BC4

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, DNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P62807

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329, Cleavage of the damaged pyrimidine
R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331, Cleavage of the damaged purine
R-HSA-1221632, Meiotic synapsis
R-HSA-171306, Packaging Of Telomere Ends
R-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300, PRC2 methylates histones and DNA
R-HSA-2299718, Condensation of Prophase Chromosomes
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214815, HDACs deacetylate histones
R-HSA-3214847, HATs acetylate histones
R-HSA-427359, SIRT1 negatively regulates rRNA expression
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-5334118, DNA methylation
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5689880, Ub-specific processing proteases
R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571, Nonhomologous End-Joining (NHEJ)
R-HSA-5693607, Processing of DNA double-strand break ends
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-69473, G2/M DNA damage checkpoint
R-HSA-73728, RNA Polymerase I Promoter Opening
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-912446, Meiotic recombination
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9616222, Transcriptional regulation of granulopoiesis
R-HSA-9670095, Inhibition of DNA recombination at telomere
R-HSA-977225, Amyloid fiber formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H2B type 1-C/E/F/G/I
Alternative name(s):
Histone H2B.1 A
Histone H2B.a
Short name:
H2B/a
Histone H2B.g
Short name:
H2B/g
Histone H2B.h
Short name:
H2B/h
Histone H2B.k
Short name:
H2B/k
Histone H2B.l
Short name:
H2B/l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H2BC4Imported
Synonyms:H2BFL, HIST1H2BC
AND
Name:H2BC6Imported
Synonyms:H2BFH, HIST1H2BE
AND
Name:H2BC7Imported
Synonyms:H2BFG, HIST1H2BF
AND
Name:H2BC8Imported
Synonyms:H2BFA, HIST1H2BG
AND
Name:H2BC10Imported
Synonyms:H2BFK, HIST1H2BI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:4756, H2BC10
HGNC:4757, H2BC4
HGNC:4753, H2BC6
HGNC:4752, H2BC7
HGNC:4746, H2BC8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602798, gene
602804, gene
602805, gene
602807, gene
602847, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P62807

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000180596.7
HostDB:ENSG00000273802.2
HostDB:ENSG00000274290.2
HostDB:ENSG00000277224.2
HostDB:ENSG00000278588.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
3017
8339
8343
8344
8346
8347

Open Targets

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OpenTargetsi
ENSG00000180596
ENSG00000273802
ENSG00000274290
ENSG00000277224
ENSG00000278588

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P62807, Tbio

Chemistry databases

Drug and drug target database

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DrugBanki
DB09130, Copper

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HIST1H2BG

Domain mapping of disease mutations (DMDM)

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DMDMi
290457686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity5 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000718262 – 126Histone H2B type 1-C/E/F/G/IAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylprolineBy similarity1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei6N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei6N6-acetyllysine; alternate2 Publications1
Modified residuei6N6-butyryllysine; alternate1 Publication1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Modified residuei6N6-lactoyllysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei12N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei12N6-acetyllysine; alternate1 Publication1
Modified residuei12N6-crotonyllysine; alternate1 Publication1
Modified residuei12N6-lactoyllysine; alternate1 Publication1
Modified residuei13N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternate2 Publications1
Modified residuei13N6-crotonyllysine; alternate1 Publication1
Modified residuei15Phosphoserine; by STK4/MST11 Publication1
Modified residuei16N6-acetyllysine; alternate2 Publications1
Modified residuei16N6-crotonyllysine; alternate1 Publication1
Modified residuei16N6-lactoyllysine; alternate1 Publication1
Modified residuei17N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei17N6-acetyllysine; alternate1 Publication1
Modified residuei17N6-crotonyllysine; alternate1 Publication1
Modified residuei17N6-glutaryllysine; alternate1 Publication1
Modified residuei17N6-lactoyllysine; alternate1 Publication1
Modified residuei21N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei21N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei21N6-acetyllysine; alternate2 Publications1
Modified residuei21N6-butyryllysine; alternate1 Publication1
Modified residuei21N6-crotonyllysine; alternate1 Publication1
Modified residuei21N6-lactoyllysine; alternate1 Publication1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei24N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei24N6-acetyllysine; alternateBy similarity1
Modified residuei24N6-crotonyllysine; alternate1 Publication1
Modified residuei24N6-lactoyllysine; alternate1 Publication1
Modified residuei25N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei35N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei35N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei35N6-crotonyllysine; alternate1 Publication1
Modified residuei35N6-glutaryllysine; alternate1 Publication1
Modified residuei35N6-succinyllysine; alternate1 Publication1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei37Phosphoserine; by AMPKBy similarity1
Modified residuei44N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei44N6-glutaryllysine; alternate1 Publication1
Modified residuei44N6-lactoyllysine; alternate1 Publication1
Modified residuei47N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei47N6-glutaryllysine; alternate1 Publication1
Modified residuei47N6-methyllysine; alternate1 Publication1
Modified residuei58N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei58N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei80Dimethylated arginineBy similarity1
Modified residuei86N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei86N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei86N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei86N6-acetyllysine; alternateBy similarity1
Modified residuei86N6-lactoyllysine; alternate1 Publication1
Modified residuei87Omega-N-methylarginineBy similarity1
Modified residuei93Omega-N-methylarginineBy similarity1
Modified residuei109N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei109N6-glutaryllysine; alternate1 Publication1
Modified residuei109N6-lactoyllysine; alternate1 Publication1
Modified residuei109N6-methyllysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi113O-linked (GlcNAc) serine1 Publication1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei117N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei117N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei117N6-glutaryllysine; alternate1 Publication1
Modified residuei117N6-lactoyllysine; alternate1 Publication1
Modified residuei117N6-malonyllysine; alternate1 Publication1
Modified residuei117N6-methylated lysine; alternateBy similarity1
Modified residuei117N6-succinyllysine; alternate1 Publication1
Modified residuei121N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei121N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei121N6-glutaryllysine; alternate1 Publication1
Modified residuei121N6-lactoyllysine; alternate1 Publication1
Modified residuei121N6-succinyllysine; alternate1 Publication1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.1 Publication
Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.By similarity1 Publication
GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.1 Publication
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62807

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62807

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P62807

MaxQB - The MaxQuant DataBase

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MaxQBi
P62807

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62807

PeptideAtlas

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PeptideAtlasi
P62807

PRoteomics IDEntifications database

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PRIDEi
P62807

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57425

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62807

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P62807, 1 site

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62807

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62807

SwissPalm database of S-palmitoylation events

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SwissPalmi
P62807

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000180596, Expressed in stomach and 157 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62807, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62807, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000180596, Group enriched (blood, lymphoid tissue)
ENSG00000273802, Tissue enhanced (lymphoid)
ENSG00000274290, Tissue enriched (lymphoid)
ENSG00000277224, Tissue enriched (lymphoid)
ENSG00000278588, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109270, 96 interactors
113935, 226 interactors
113939, 11 interactors
113940, 13 interactors
113942, 10 interactors
113943, 47 interactors

Database of interacting proteins

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DIPi
DIP-32890N

Protein interaction database and analysis system

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IntActi
P62807, 253 interactors

Molecular INTeraction database

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MINTi
P62807

STRING: functional protein association networks

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STRINGi
9606.ENSP00000483237

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P62807, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62807

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 35Basic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1744, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01030000234651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_075666_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62807

Identification of Orthologs from Complete Genome Data

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OMAi
DIFDRMA

Database of Orthologous Groups

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OrthoDBi
1536672at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62807

TreeFam database of animal gene trees

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TreeFami
TF300212

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR000558, Histone_H2B

The PANTHER Classification System

More...
PANTHERi
PTHR23428, PTHR23428, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00125, Histone, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00621, HISTONEH2B

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00427, H2B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113, SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00357, HISTONE_H2B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P62807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:March 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAE1479F44BE703D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → S in CAB02545 (PubMed:9119399).Curated1
Sequence conflicti33S → T in CAB02545 (PubMed:9119399).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05588727G → S1 PublicationCorresponds to variant dbSNP:rs7766641Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60750 Genomic DNA Translation: AAA63189.1
Z80782 Genomic DNA Translation: CAB02544.1
Z80779 Genomic DNA Translation: CAB02541.1
Z80780 Genomic DNA Translation: CAB02542.1
Z80783 Genomic DNA Translation: CAB02545.1
AF531286 Genomic DNA Translation: AAN06686.1
AF531288 Genomic DNA Translation: AAN06688.1
AF531289 Genomic DNA Translation: AAN06689.1
AF531290 Genomic DNA Translation: AAN06690.1
AF531292 Genomic DNA Translation: AAN06692.1
AL031777 Genomic DNA No translation available.
AL353759 Genomic DNA No translation available.
BC001131 mRNA No translation available.
BC009612 mRNA No translation available.
BC096120 mRNA Translation: AAH96120.1
BC096122 mRNA Translation: AAH96122.1
BC096123 mRNA Translation: AAH96123.1
BC101653 mRNA Translation: AAI01654.1
BC101655 mRNA Translation: AAI01656.1
BC101748 mRNA Translation: AAI01749.1
BC101750 mRNA Translation: AAI01751.1
BC106899 mRNA Translation: AAI06900.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4584.1
CCDS4588.1
CCDS4592.1
CCDS4594.1
CCDS4603.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E40335, HSHUB2
S65409

NCBI Reference Sequences

More...
RefSeqi
NP_003509.1, NM_003518.3
NP_003513.1, NM_003522.3
NP_003514.2, NM_003523.2
NP_003516.1, NM_003525.2
NP_003517.2, NM_003526.2
NP_066407.1, NM_021063.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314332; ENSP00000321744; ENSG00000180596
ENST00000356530; ENSP00000348924; ENSG00000277224
ENST00000377733; ENSP00000366962; ENSG00000278588
ENST00000396984; ENSP00000380180; ENSG00000180596
ENST00000541790; ENSP00000445633; ENSG00000273802
ENST00000614097; ENSP00000483237; ENSG00000274290
ENST00000634910; ENSP00000489317; ENSG00000274290

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3017
8339
8343
8344
8346
8347

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3017
hsa:8339
hsa:8343
hsa:8344
hsa:8346
hsa:8347

UCSC genome browser

More...
UCSCi
uc003ngk.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60750 Genomic DNA Translation: AAA63189.1
Z80782 Genomic DNA Translation: CAB02544.1
Z80779 Genomic DNA Translation: CAB02541.1
Z80780 Genomic DNA Translation: CAB02542.1
Z80783 Genomic DNA Translation: CAB02545.1
AF531286 Genomic DNA Translation: AAN06686.1
AF531288 Genomic DNA Translation: AAN06688.1
AF531289 Genomic DNA Translation: AAN06689.1
AF531290 Genomic DNA Translation: AAN06690.1
AF531292 Genomic DNA Translation: AAN06692.1
AL031777 Genomic DNA No translation available.
AL353759 Genomic DNA No translation available.
BC001131 mRNA No translation available.
BC009612 mRNA No translation available.
BC096120 mRNA Translation: AAH96120.1
BC096122 mRNA Translation: AAH96122.1
BC096123 mRNA Translation: AAH96123.1
BC101653 mRNA Translation: AAI01654.1
BC101655 mRNA Translation: AAI01656.1
BC101748 mRNA Translation: AAI01749.1
BC101750 mRNA Translation: AAI01751.1
BC106899 mRNA Translation: AAI06900.1
CCDSiCCDS4584.1
CCDS4588.1
CCDS4592.1
CCDS4594.1
CCDS4603.1
PIRiE40335, HSHUB2
S65409
RefSeqiNP_003509.1, NM_003518.3
NP_003513.1, NM_003522.3
NP_003514.2, NM_003523.2
NP_003516.1, NM_003525.2
NP_003517.2, NM_003526.2
NP_066407.1, NM_021063.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GT0X-ray2.82D/H2-126[»]
5KGFelectron microscopy4.54D/H1-126[»]
6ACOX-ray1.71B118-124[»]
6C0Welectron microscopy4.00D/H1-126[»]
6FMLelectron microscopy4.34P/T2-126[»]
6R0Celectron microscopy4.20D/H1-126[»]
6RNYelectron microscopy3.90D/H1-126[»]
6SE0electron microscopy3.80D/H1-126[»]
6SE6electron microscopy3.50D/H1-126[»]
6SEEelectron microscopy4.20D/H1-126[»]
6SEFelectron microscopy3.70D/H1-126[»]
6SEGelectron microscopy3.10D/H1-126[»]
6UPKelectron microscopy4.90D1-126[»]
6UPLelectron microscopy7.40D/L1-126[»]
6X59electron microscopy2.98D/H3-126[»]
6X5Aelectron microscopy4.36D/H3-126[»]
6XJDelectron microscopy6.80D/H3-126[»]
7A08electron microscopy3.11c/g2-126[»]
7JO9electron microscopy3.30D/H2-126[»]
7JOAelectron microscopy3.30D/H2-126[»]
SMRiP62807
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109270, 96 interactors
113935, 226 interactors
113939, 11 interactors
113940, 13 interactors
113942, 10 interactors
113943, 47 interactors
DIPiDIP-32890N
IntActiP62807, 253 interactors
MINTiP62807
STRINGi9606.ENSP00000483237

Chemistry databases

DrugBankiDB09130, Copper

PTM databases

GlyGeniP62807, 1 site
iPTMnetiP62807
PhosphoSitePlusiP62807
SwissPalmiP62807

Genetic variation databases

BioMutaiHIST1H2BG
DMDMi290457686

Proteomic databases

EPDiP62807
jPOSTiP62807
MassIVEiP62807
MaxQBiP62807
PaxDbiP62807
PeptideAtlasiP62807
PRIDEiP62807
ProteomicsDBi57425
TopDownProteomicsiP62807

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P62807, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10912, 211 antibodies
72347, 43 antibodies
76967, 1 antibodies
77815, 2 antibodies
77855, 1 antibodies

The DNASU plasmid repository

More...
DNASUi
8339

Genome annotation databases

EnsembliENST00000314332; ENSP00000321744; ENSG00000180596
ENST00000356530; ENSP00000348924; ENSG00000277224
ENST00000377733; ENSP00000366962; ENSG00000278588
ENST00000396984; ENSP00000380180; ENSG00000180596
ENST00000541790; ENSP00000445633; ENSG00000273802
ENST00000614097; ENSP00000483237; ENSG00000274290
ENST00000634910; ENSP00000489317; ENSG00000274290
GeneIDi3017
8339
8343
8344
8346
8347
KEGGihsa:3017
hsa:8339
hsa:8343
hsa:8344
hsa:8346
hsa:8347
UCSCiuc003ngk.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3017
8339
8343
8344
8346
8347
DisGeNETi3017
8339
8343
8344
8346
8347

GeneCards: human genes, protein and diseases

More...
GeneCardsi
H2BC10
H2BC4
H2BC6
H2BC7
H2BC8
HGNCiHGNC:4756, H2BC10
HGNC:4757, H2BC4
HGNC:4753, H2BC6
HGNC:4752, H2BC7
HGNC:4746, H2BC8
HPAiENSG00000180596, Group enriched (blood, lymphoid tissue)
ENSG00000273802, Tissue enhanced (lymphoid)
ENSG00000274290, Tissue enriched (lymphoid)
ENSG00000277224, Tissue enriched (lymphoid)
ENSG00000278588, Tissue enriched (lymphoid)
MIMi602798, gene
602804, gene
602805, gene
602807, gene
602847, gene
neXtProtiNX_P62807
OpenTargetsiENSG00000180596
ENSG00000273802
ENSG00000274290
ENSG00000277224
ENSG00000278588
PharmGKBiPA29132
VEuPathDBiHostDB:ENSG00000180596.7
HostDB:ENSG00000273802.2
HostDB:ENSG00000274290.2
HostDB:ENSG00000277224.2
HostDB:ENSG00000278588.1

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1744, Eukaryota
GeneTreeiENSGT01030000234651
HOGENOMiCLU_075666_2_1_1
InParanoidiP62807
OMAiDIFDRMA
OrthoDBi1536672at2759
PhylomeDBiP62807
TreeFamiTF300212

Enzyme and pathway databases

PathwayCommonsiP62807
ReactomeiR-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329, Cleavage of the damaged pyrimidine
R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331, Cleavage of the damaged purine
R-HSA-1221632, Meiotic synapsis
R-HSA-171306, Packaging Of Telomere Ends
R-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300, PRC2 methylates histones and DNA
R-HSA-2299718, Condensation of Prophase Chromosomes
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214815, HDACs deacetylate histones
R-HSA-3214847, HATs acetylate histones
R-HSA-427359, SIRT1 negatively regulates rRNA expression
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-5334118, DNA methylation
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5689880, Ub-specific processing proteases
R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571, Nonhomologous End-Joining (NHEJ)
R-HSA-5693607, Processing of DNA double-strand break ends
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-69473, G2/M DNA damage checkpoint
R-HSA-73728, RNA Polymerase I Promoter Opening
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-912446, Meiotic recombination
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9616222, Transcriptional regulation of granulopoiesis
R-HSA-9670095, Inhibition of DNA recombination at telomere
R-HSA-977225, Amyloid fiber formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3017, 134 hits in 937 CRISPR screens
8339, 246 hits in 913 CRISPR screens
8343, 385 hits in 922 CRISPR screens
8344, 574 hits in 923 CRISPR screens
8346, 78 hits in 913 CRISPR screens
8347, 702 hits in 942 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HIST1H2BC, human
HIST1H2BE, human
HIST1H2BG, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HIST1H2BE
HIST1H2BF
HIST1H2BG
HIST1H2BI
Histone_H2B_type_1-C
PharosiP62807, Tbio

Protein Ontology

More...
PROi
PR:P62807
RNActiP62807, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180596, Expressed in stomach and 157 other tissues
ExpressionAtlasiP62807, baseline and differential
GenevisibleiP62807, HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR000558, Histone_H2B
PANTHERiPTHR23428, PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PRINTSiPR00621, HISTONEH2B
SMARTiView protein in SMART
SM00427, H2B, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357, HISTONE_H2B, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2B1C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62807
Secondary accession number(s): P02278
, Q3B872, Q4VB69, Q93078, Q93080
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 2, 2010
Last modified: June 2, 2021
This is version 185 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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