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Protein

Histone H4

Gene

Hist1h4a

more
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214815 HDACs deacetylate histones
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3214842 HDMs demethylate histones
R-MMU-3214847 HATs acetylate histones
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
AND
Name:Hist1h4b
Synonyms:H4-53
AND
Name:Hist1h4c
Synonyms:H4-12
AND
AND
AND
AND
AND
AND
AND
AND
Name:Hist2h4a
Synonyms:Hist2h4
AND
Name:Hist4h4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 13, Chromosome 3, Chromosome 6

Organism-specific databases

MGIiMGI:2448419 Hist1h4a
MGI:2448420 Hist1h4b
MGI:2448421 Hist1h4c
MGI:2448423 Hist1h4d
MGI:2448425 Hist1h4f
MGI:2448427 Hist1h4h
MGI:2448432 Hist1h4i
MGI:2448436 Hist1h4j
MGI:2448439 Hist1h4k
MGI:2448441 Hist1h4m
MGI:2140113 Hist2h4
MGI:2448443 Hist4h4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001583292 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine1 Publication1
Modified residuei4Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei4Citrulline; alternateBy similarity1
Modified residuei4Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei4Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate1 Publication1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei6N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei6N6-acetyllysine; alternateCombined sources1
Modified residuei6N6-butyryllysine; alternate1 Publication1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Modified residuei9N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei9N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei9N6-acetyllysine; alternateCombined sources1
Modified residuei9N6-butyryllysine; alternate1 Publication1
Modified residuei9N6-crotonyllysine; alternate1 Publication1
Modified residuei9N6-propionyllysine; alternateBy similarity1
Modified residuei13N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei13N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternateCombined sources1
Modified residuei13N6-butyryllysine; alternate1 Publication1
Modified residuei13N6-crotonyllysine; alternateBy similarity1
Modified residuei13N6-succinyllysine; alternateBy similarity1
Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei17N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei17N6-acetyllysine; alternateCombined sources1
Modified residuei17N6-butyryllysine; alternateBy similarity1
Modified residuei17N6-crotonyllysine; alternate1 Publication1
Modified residuei17N6-propionyllysine; alternateBy similarity1
Modified residuei21N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei21N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei21N6-methyllysine; alternateBy similarity1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei32N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei32N6-acetyllysine; alternateCombined sources1
Modified residuei32N6-butyryllysine; alternateBy similarity1
Modified residuei32N6-propionyllysine; alternateBy similarity1
Modified residuei32N6-succinyllysine; alternate1 Publication1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei45N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei45N6-butyryllysine; alternateBy similarity1
Modified residuei45N6-propionyllysine; alternateBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei52PhosphotyrosineCombined sources1
Modified residuei60N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei78N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei78N6-butyryllysine; alternateBy similarity1
Modified residuei78N6-propionyllysine; alternateBy similarity1
Modified residuei78N6-succinyllysine; alternate1 Publication1
Modified residuei80N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei80N6-butyryllysine; alternateBy similarity1
Modified residuei80N6-propionyllysine; alternateBy similarity1
Modified residuei80N6-succinyllysine; alternate1 Publication1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei81PhosphothreonineCombined sources1
Modified residuei89PhosphotyrosineCombined sources1
Modified residuei92N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei92N6-butyryllysine; alternateBy similarity1
Modified residuei92N6-propionyllysine; alternateBy similarity1
Modified residuei92N6-succinyllysine; alternateCombined sources1 Publication1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Post-translational modificationi

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.By similarity
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.2 Publications
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).By similarity
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing (By similarity).By similarity
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).By similarity
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).By similarity
Sumoylated, which is associated with transcriptional repression.By similarity
Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.1 Publication
Hydroxybutyrylation of histones is induced by starvation.1 Publication
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62806
MaxQBiP62806
PaxDbiP62806
PRIDEiP62806
TopDownProteomicsiP62806

PTM databases

iPTMnetiP62806
PhosphoSitePlusiP62806

Expressioni

Gene expression databases

BgeeiENSMUSG00000060093 Expressed in 42 organ(s), highest expression level in testis
CleanExiMM_HIST1H4A
MM_HIST1H4B
MM_HIST1H4C
MM_HIST1H4D
MM_HIST1H4F
MM_HIST1H4H
MM_HIST1H4I
MM_HIST1H4J
MM_HIST1H4K
MM_HIST1H4M
MM_HIST2H4
MM_HIST4H4
ExpressionAtlasiP62806 baseline and differential
GenevisibleiP62806 MM

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213404, 1 interactor
220610, 4 interactors
235074, 1 interactor
235075, 2 interactors
235079, 1 interactor
235942, 10 interactors
236472, 5 interactors
236473, 1 interactor
CORUMiP62806
DIPiDIP-45837N
IntActiP62806, 17 interactors
MINTiP62806
STRINGi10090.ENSMUSP00000136357

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62806
SMRiP62806
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62806

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000119019
HOVERGENiHBG051878
InParanoidiP62806
KOiK11254
OMAiQKEHING
OrthoDBiEOG091G0XGD
PhylomeDBiP62806

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:January 23, 2007 - v2
Checksum:iA9E5DFD3F8B97598
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → V in BAB26692 (PubMed:16141072).Curated1
Sequence conflicti80K → E in BAB27698 (PubMed:16141072).Curated1
Sequence conflicti90A → R in CAA31622 (PubMed:2915930).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00753 Genomic DNA Translation: CAA24130.1
X13235 Genomic DNA Translation: CAA31621.1
X13236 Genomic DNA Translation: CAA31622.1
U62672 Genomic DNA Translation: AAB04766.1
Y12290 Genomic DNA Translation: CAA72967.1
AY158956 Genomic DNA Translation: AAO06266.1
AY158957 Genomic DNA Translation: AAO06267.1
AY158958 Genomic DNA Translation: AAO06268.1
AY158959 Genomic DNA Translation: AAO06269.1
AY158960 Genomic DNA Translation: AAO06270.1
AY158961 Genomic DNA Translation: AAO06271.1
AY158962 Genomic DNA Translation: AAO06272.1
AY158963 Genomic DNA Translation: AAO06273.1
AY158964 Genomic DNA Translation: AAO06274.1
AY158965 Genomic DNA Translation: AAO06275.1
AY158966 Genomic DNA Translation: AAO06276.1
AY158967 Genomic DNA Translation: AAO06277.1
AK007642 mRNA Translation: BAB25157.1
AK010085 mRNA Translation: BAB26692.1
AK011560 mRNA Translation: BAB27698.1
AK139521 mRNA Translation: BAE24047.1
AL589651 Genomic DNA Translation: CAI24108.1
AL589651 Genomic DNA Translation: CAI24109.1
AL590388 Genomic DNA Translation: CAI25838.1
AL590388 Genomic DNA Translation: CAI25839.1
AL590614 Genomic DNA Translation: CAI26128.1
BC028550 mRNA Translation: AAH28550.3
BC052219 mRNA No translation available.
BC057955 mRNA Translation: AAH57955.1
BC058529 mRNA Translation: AAH58529.2
BC087952 mRNA Translation: AAH87952.1
BC092144 mRNA Translation: AAH92144.1
BC115446 mRNA Translation: AAI15447.1
BC115447 mRNA Translation: AAI15448.1
BC115451 mRNA Translation: AAI15452.1
BC115448 mRNA Translation: AAI15449.1
BC115449 mRNA Translation: AAI15450.1
BC115450 mRNA Translation: AAI15451.1
BC117010 mRNA Translation: AAI17011.1
BC117012 mRNA Translation: AAI17013.1
BC111813 mRNA Translation: AAI11814.1
BC119241 mRNA Translation: AAI19242.1
BC119243 mRNA Translation: AAI19244.1
BC119611 mRNA Translation: AAI19612.1
BC119612 mRNA Translation: AAI19613.1
BC125598 mRNA Translation: AAI25599.1
BC125600 mRNA Translation: AAI25601.1
BC132186 mRNA Translation: AAI32187.1
BC132212 mRNA Translation: AAI32213.1
BC139809 mRNA Translation: AAI39810.1
BC152397 mRNA Translation: AAI52398.1
CCDSiCCDS26291.1
CCDS26292.1
CCDS26300.1
CCDS26306.1
CCDS26340.1
CCDS26345.1
CCDS26353.1
CCDS26359.1
CCDS26366.1
CCDS26367.1
CCDS39684.1
CCDS51002.1
CCDS56872.1
PIRiS03426
S03427
RefSeqiNP_001182350.1, NM_001195421.1
NP_291074.1, NM_033596.3
NP_694813.1, NM_153173.4
NP_783583.1, NM_175652.3
NP_783585.1, NM_175654.2
NP_783586.1, NM_175655.2
NP_783587.1, NM_175656.3
NP_783588.1, NM_175657.2
NP_835499.1, NM_178192.2
NP_835500.1, NM_178193.2
NP_835515.1, NM_178208.2
NP_835582.1, NM_178210.2
NP_835583.1, NM_178211.2
UniGeneiMm.14775
Mm.158272
Mm.227295
Mm.228709
Mm.246720
Mm.255646
Mm.260530
Mm.261642
Mm.261662
Mm.261664
Mm.442307
Mm.486099

Genome annotation databases

EnsembliENSMUST00000087714; ENSMUSP00000085006; ENSMUSG00000067455
ENSMUST00000102964; ENSMUSP00000100029; ENSMUSG00000060093
ENSMUST00000102965; ENSMUSP00000100030; ENSMUSG00000069266
ENSMUST00000102967; ENSMUSP00000100032; ENSMUSG00000060678
ENSMUST00000102968; ENSMUSP00000100033; ENSMUSG00000061482
ENSMUST00000102971; ENSMUSP00000100036; ENSMUSG00000069274
ENSMUST00000102972; ENSMUSP00000100037; ENSMUSG00000060981
ENSMUST00000102977; ENSMUSP00000100042; ENSMUSG00000060639
ENSMUST00000102979; ENSMUSP00000100044; ENSMUSG00000069305
ENSMUST00000102983; ENSMUSP00000100048; ENSMUSG00000064288
ENSMUST00000104941; ENSMUSP00000100546; ENSMUSG00000069306
ENSMUST00000171473; ENSMUSP00000129930; ENSMUSG00000091405
ENSMUST00000179285; ENSMUSP00000136357; ENSMUSG00000096010
GeneIDi100041230
319155
319156
319157
319158
319159
319160
319161
320332
326619
326620
69386
97122
KEGGimmu:100041230
mmu:319155
mmu:319156
mmu:319157
mmu:319158
mmu:319159
mmu:319160
mmu:319161
mmu:320332
mmu:326619
mmu:326620
mmu:69386
mmu:97122
UCSCiuc007pre.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00753 Genomic DNA Translation: CAA24130.1
X13235 Genomic DNA Translation: CAA31621.1
X13236 Genomic DNA Translation: CAA31622.1
U62672 Genomic DNA Translation: AAB04766.1
Y12290 Genomic DNA Translation: CAA72967.1
AY158956 Genomic DNA Translation: AAO06266.1
AY158957 Genomic DNA Translation: AAO06267.1
AY158958 Genomic DNA Translation: AAO06268.1
AY158959 Genomic DNA Translation: AAO06269.1
AY158960 Genomic DNA Translation: AAO06270.1
AY158961 Genomic DNA Translation: AAO06271.1
AY158962 Genomic DNA Translation: AAO06272.1
AY158963 Genomic DNA Translation: AAO06273.1
AY158964 Genomic DNA Translation: AAO06274.1
AY158965 Genomic DNA Translation: AAO06275.1
AY158966 Genomic DNA Translation: AAO06276.1
AY158967 Genomic DNA Translation: AAO06277.1
AK007642 mRNA Translation: BAB25157.1
AK010085 mRNA Translation: BAB26692.1
AK011560 mRNA Translation: BAB27698.1
AK139521 mRNA Translation: BAE24047.1
AL589651 Genomic DNA Translation: CAI24108.1
AL589651 Genomic DNA Translation: CAI24109.1
AL590388 Genomic DNA Translation: CAI25838.1
AL590388 Genomic DNA Translation: CAI25839.1
AL590614 Genomic DNA Translation: CAI26128.1
BC028550 mRNA Translation: AAH28550.3
BC052219 mRNA No translation available.
BC057955 mRNA Translation: AAH57955.1
BC058529 mRNA Translation: AAH58529.2
BC087952 mRNA Translation: AAH87952.1
BC092144 mRNA Translation: AAH92144.1
BC115446 mRNA Translation: AAI15447.1
BC115447 mRNA Translation: AAI15448.1
BC115451 mRNA Translation: AAI15452.1
BC115448 mRNA Translation: AAI15449.1
BC115449 mRNA Translation: AAI15450.1
BC115450 mRNA Translation: AAI15451.1
BC117010 mRNA Translation: AAI17011.1
BC117012 mRNA Translation: AAI17013.1
BC111813 mRNA Translation: AAI11814.1
BC119241 mRNA Translation: AAI19242.1
BC119243 mRNA Translation: AAI19244.1
BC119611 mRNA Translation: AAI19612.1
BC119612 mRNA Translation: AAI19613.1
BC125598 mRNA Translation: AAI25599.1
BC125600 mRNA Translation: AAI25601.1
BC132186 mRNA Translation: AAI32187.1
BC132212 mRNA Translation: AAI32213.1
BC139809 mRNA Translation: AAI39810.1
BC152397 mRNA Translation: AAI52398.1
CCDSiCCDS26291.1
CCDS26292.1
CCDS26300.1
CCDS26306.1
CCDS26340.1
CCDS26345.1
CCDS26353.1
CCDS26359.1
CCDS26366.1
CCDS26367.1
CCDS39684.1
CCDS51002.1
CCDS56872.1
PIRiS03426
S03427
RefSeqiNP_001182350.1, NM_001195421.1
NP_291074.1, NM_033596.3
NP_694813.1, NM_153173.4
NP_783583.1, NM_175652.3
NP_783585.1, NM_175654.2
NP_783586.1, NM_175655.2
NP_783587.1, NM_175656.3
NP_783588.1, NM_175657.2
NP_835499.1, NM_178192.2
NP_835500.1, NM_178193.2
NP_835515.1, NM_178208.2
NP_835582.1, NM_178210.2
NP_835583.1, NM_178211.2
UniGeneiMm.14775
Mm.158272
Mm.227295
Mm.228709
Mm.246720
Mm.255646
Mm.260530
Mm.261642
Mm.261662
Mm.261664
Mm.442307
Mm.486099

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F66X-ray2.60B/F1-103[»]
1U35X-ray3.00B/F1-103[»]
2WP2X-ray2.37P/Q2-21[»]
4AU7X-ray2.07C18-25[»]
4DOWX-ray1.95C/D15-26[»]
5B1LX-ray2.35B/F1-103[»]
5B1MX-ray2.34B/F1-103[»]
5XM0X-ray2.87B/F1-103[»]
5XM1X-ray3.45B/F1-103[»]
ProteinModelPortaliP62806
SMRiP62806
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213404, 1 interactor
220610, 4 interactors
235074, 1 interactor
235075, 2 interactors
235079, 1 interactor
235942, 10 interactors
236472, 5 interactors
236473, 1 interactor
CORUMiP62806
DIPiDIP-45837N
IntActiP62806, 17 interactors
MINTiP62806
STRINGi10090.ENSMUSP00000136357

PTM databases

iPTMnetiP62806
PhosphoSitePlusiP62806

Proteomic databases

EPDiP62806
MaxQBiP62806
PaxDbiP62806
PRIDEiP62806
TopDownProteomicsiP62806

Protocols and materials databases

DNASUi319156
319157
319159
320332
326620
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087714; ENSMUSP00000085006; ENSMUSG00000067455
ENSMUST00000102964; ENSMUSP00000100029; ENSMUSG00000060093
ENSMUST00000102965; ENSMUSP00000100030; ENSMUSG00000069266
ENSMUST00000102967; ENSMUSP00000100032; ENSMUSG00000060678
ENSMUST00000102968; ENSMUSP00000100033; ENSMUSG00000061482
ENSMUST00000102971; ENSMUSP00000100036; ENSMUSG00000069274
ENSMUST00000102972; ENSMUSP00000100037; ENSMUSG00000060981
ENSMUST00000102977; ENSMUSP00000100042; ENSMUSG00000060639
ENSMUST00000102979; ENSMUSP00000100044; ENSMUSG00000069305
ENSMUST00000102983; ENSMUSP00000100048; ENSMUSG00000064288
ENSMUST00000104941; ENSMUSP00000100546; ENSMUSG00000069306
ENSMUST00000171473; ENSMUSP00000129930; ENSMUSG00000091405
ENSMUST00000179285; ENSMUSP00000136357; ENSMUSG00000096010
GeneIDi100041230
319155
319156
319157
319158
319159
319160
319161
320332
326619
326620
69386
97122
KEGGimmu:100041230
mmu:319155
mmu:319156
mmu:319157
mmu:319158
mmu:319159
mmu:319160
mmu:319161
mmu:320332
mmu:326619
mmu:326620
mmu:69386
mmu:97122
UCSCiuc007pre.1 mouse

Organism-specific databases

CTDi100041230
121504
319161
8294
8359
8360
8361
8362
8363
8364
8365
8366
97122
MGIiMGI:2448419 Hist1h4a
MGI:2448420 Hist1h4b
MGI:2448421 Hist1h4c
MGI:2448423 Hist1h4d
MGI:2448425 Hist1h4f
MGI:2448427 Hist1h4h
MGI:2448432 Hist1h4i
MGI:2448436 Hist1h4j
MGI:2448439 Hist1h4k
MGI:2448441 Hist1h4m
MGI:2140113 Hist2h4
MGI:2448443 Hist4h4

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000119019
HOVERGENiHBG051878
InParanoidiP62806
KOiK11254
OMAiQKEHING
OrthoDBiEOG091G0XGD
PhylomeDBiP62806

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214815 HDACs deacetylate histones
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3214842 HDMs demethylate histones
R-MMU-3214847 HATs acetylate histones
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

EvolutionaryTraceiP62806
PROiPR:P62806
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060093 Expressed in 42 organ(s), highest expression level in testis
CleanExiMM_HIST1H4A
MM_HIST1H4B
MM_HIST1H4C
MM_HIST1H4D
MM_HIST1H4F
MM_HIST1H4H
MM_HIST1H4I
MM_HIST1H4J
MM_HIST1H4K
MM_HIST1H4M
MM_HIST2H4
MM_HIST4H4
ExpressionAtlasiP62806 baseline and differential
GenevisibleiP62806 MM

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH4_MOUSE
AccessioniPrimary (citable) accession number: P62806
Secondary accession number(s): A0AUM5
, A4FUP8, A4QMY0, P02304, P02305, Q0VDL9, Q2M2Q5, Q5T006, Q6PDS7, Q811M0, Q9D0C9, Q9D6Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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