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Protein

Histone H4

Gene

HIST1H4A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi17 – 215

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
  • protein domain specific binding Source: UniProtKB
  • protein heterodimerization activity Source: InterPro
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1221632 Meiotic synapsis
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-912446 Meiotic recombination
R-HSA-977225 Amyloid fiber formation

SIGNOR Signaling Network Open Resource

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SIGNORi
P62805

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIST1H4A
Synonyms:H4/A, H4FA
AND
Name:HIST1H4B
Synonyms:H4/I, H4FI
AND
Name:HIST1H4C
Synonyms:H4/G, H4FG
AND
Name:HIST1H4D
Synonyms:H4/B, H4FB
AND
Name:HIST1H4E
Synonyms:H4/J, H4FJ
AND
Name:HIST1H4F
Synonyms:H4/C, H4FC
AND
Name:HIST1H4H
Synonyms:H4/H, H4FH
AND
Name:HIST1H4I
Synonyms:H4/M, H4FM
AND
Name:HIST1H4J
Synonyms:H4/E, H4FE
AND
Name:HIST1H4K
Synonyms:H4/D, H4FD
AND
Name:HIST1H4L
Synonyms:H4/K, H4FK
AND
Name:HIST2H4A
Synonyms:H4/N, H4F2, H4FN, HIST2H4
AND
Name:HIST2H4B
Synonyms:H4/O, H4FO
AND
Name:HIST4H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Chromosome 12, Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000158406.4
HostDB:ENSG00000197061.4
HostDB:ENSG00000197238.4
HostDB:ENSG00000197837.3
HostDB:ENSG00000270276.2
HostDB:ENSG00000270882.2
HostDB:ENSG00000273542.1
HostDB:ENSG00000274618.1
HostDB:ENSG00000275126.1
HostDB:ENSG00000276180.1
HostDB:ENSG00000276966.2
HostDB:ENSG00000277157.1
HostDB:ENSG00000278637.1
HostDB:ENSG00000278705.1

Human Gene Nomenclature Database

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HGNCi
HGNC:4781 HIST1H4A
HGNC:4789 HIST1H4B
HGNC:4787 HIST1H4C
HGNC:4782 HIST1H4D
HGNC:4790 HIST1H4E
HGNC:4783 HIST1H4F
HGNC:4788 HIST1H4H
HGNC:4793 HIST1H4I
HGNC:4785 HIST1H4J
HGNC:4784 HIST1H4K
HGNC:4791 HIST1H4L
HGNC:4794 HIST2H4A
HGNC:29607 HIST2H4B
HGNC:20510 HIST4H4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
142750 gene
602822 gene
602823 gene
602824 gene
602825 gene
602826 gene
602827 gene
602828 gene
602829 gene
602830 gene
602831 gene
602833 gene
615069 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P62805

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
121504
554313
8294
8359
8360
8361
8362
8363
8364
8365
8366
8367
8368
8370

Open Targets

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OpenTargetsi
ENSG00000158406
ENSG00000197061
ENSG00000197238
ENSG00000197837
ENSG00000270276
ENSG00000270882
ENSG00000273542
ENSG00000274618
ENSG00000275126
ENSG00000276180
ENSG00000276966
ENSG00000277157
ENSG00000278637
ENSG00000278705

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29169

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5876

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HIST1H4A

Domain mapping of disease mutations (DMDM)

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DMDMi
51317339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001583202 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine1 Publication1
Modified residuei4Asymmetric dimethylarginine; by PRMT1; alternate3 Publications1
Modified residuei4Citrulline; alternate2 Publications1
Modified residuei4Omega-N-methylarginine; by PRMT1; alternate3 Publications1
Modified residuei4Symmetric dimethylarginine; by PRMT5 and PRMT7; alternateBy similarity1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei6N6-acetyllysine; alternateCombined sources2 Publications1
Modified residuei6N6-butyryllysine; alternate1 Publication1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Modified residuei9N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei9N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei9N6-acetyllysine; alternateCombined sources2 Publications1
Modified residuei9N6-butyryllysine; alternate2 Publications1
Modified residuei9N6-crotonyllysine; alternate1 Publication1
Modified residuei9N6-propionyllysine; alternate1 Publication1
Modified residuei13N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei13N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternateCombined sources3 Publications1
Modified residuei13N6-butyryllysine; alternate1 Publication1
Modified residuei13N6-crotonyllysine; alternate1 Publication1
Modified residuei13N6-succinyllysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei17N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei17N6-acetyllysine; alternateCombined sources3 Publications1
Modified residuei17N6-butyryllysine; alternate2 Publications1
Modified residuei17N6-crotonyllysine; alternateBy similarity1
Modified residuei17N6-propionyllysine; alternate1 Publication1
Modified residuei21N6,N6,N6-trimethyllysine; alternate3 Publications1
Modified residuei21N6,N6-dimethyllysine; alternate3 Publications1
Modified residuei21N6-methyllysine; alternate3 Publications1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei32N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei32N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei32N6-acetyllysine; alternateCombined sources1
Modified residuei32N6-butyryllysine; alternate1 Publication1
Modified residuei32N6-propionyllysine; alternate1 Publication1
Modified residuei32N6-succinyllysine; alternate1 Publication1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei45N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei45N6-butyryllysine; alternate1 Publication1
Modified residuei45N6-propionyllysine; alternate1 Publication1
Modified residuei48Phosphoserine; by PAK2Combined sources1 Publication1
Modified residuei52PhosphotyrosineCombined sources1
Modified residuei60N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei78N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei78N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei78N6-butyryllysine; alternate1 Publication1
Modified residuei78N6-propionyllysine; alternate1 Publication1
Modified residuei78N6-succinyllysine; alternate1 Publication1
Modified residuei80N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei80N6-butyryllysine; alternate1 Publication1
Modified residuei80N6-propionyllysine; alternate1 Publication1
Modified residuei80N6-succinyllysine; alternateBy similarity1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei81PhosphothreonineBy similarity1
Modified residuei89PhosphotyrosineCombined sources1
Modified residuei92N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei92N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei92N6-acetyllysine; alternate1 Publication1
Modified residuei92N6-butyryllysine; alternate1 Publication1
Modified residuei92N6-propionyllysine; alternate1 Publication1
Modified residuei92N6-succinyllysine; alternate1 Publication1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.3 Publications
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.4 Publications
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.3 Publications
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.3 Publications
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.2 Publications
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).5 Publications
Sumoylated, which is associated with transcriptional repression.1 Publication
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Butyrylation of histones marks active promoters and competes with histone acetylation.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62805

MaxQB - The MaxQuant DataBase

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MaxQBi
P62805

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62805

PeptideAtlas

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PeptideAtlasi
P62805

PRoteomics IDEntifications database

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PRIDEi
P62805

ProteomicsDB human proteome resource

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ProteomicsDBi
57424

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62805

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P62805

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62805

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62805

SwissPalm database of S-palmitoylation events

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SwissPalmi
P62805

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000158406 Expressed in 163 organ(s), highest expression level in stomach

CleanEx database of gene expression profiles

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CleanExi
HS_HIST1H4A
HS_HIST1H4B
HS_HIST1H4C
HS_HIST1H4D
HS_HIST1H4E
HS_HIST1H4F
HS_HIST1H4H
HS_HIST1H4I
HS_HIST1H4L
HS_HIST2H4A
HS_HIST2H4B
HS_HIST4H4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62805 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62805 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB011503
CAB021887
CAB037279
HPA042201

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113899, 25 interactors
113955, 188 interactors
113956, 18 interactors
113957, 31 interactors
113958, 17 interactors
113959, 21 interactors
113960, 17 interactors
113961, 22 interactors
113962, 17 interactors
113963, 22 interactors
113964, 19 interactors
113966, 50 interactors
125732, 89 interactors
299853, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62805

Database of interacting proteins

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DIPi
DIP-33079N

Protein interaction database and analysis system

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IntActi
P62805, 136 interactors

Molecular INTeraction database

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MINTi
P62805

STRING: functional protein association networks

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STRINGi
9606.ENSP00000367034

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P62805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P62805

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62805

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P62805

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3467 Eukaryota
COG2036 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153448
ENSGT00940000153449
ENSGT00940000153453
ENSGT00940000153502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234654

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051878

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62805

KEGG Orthology (KO)

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KOi
K11254

Identification of Orthologs from Complete Genome Data

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OMAi
QKEHING

Database of Orthologous Groups

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OrthoDBi
EOG09370I2I

Database for complete collections of gene phylogenies

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PhylomeDBi
P62805

Family and domain databases

Conserved Domains Database

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CDDi
cd00076 H4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd

Pfam protein domain database

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Pfami
View protein in Pfam
PF15511 CENP-T_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00623 HISTONEH4

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00047 HISTONE_H4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P62805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E5DFD3F8B97598
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI28106 differs from that shown. Reason: Frameshift at position 3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71V → A in AAH67496 (PubMed:15489334).Curated1
Sequence conflicti77A → P in CAG46986 (Ref. 11) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03620664E → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs747622981Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X00038 Genomic DNA Translation: CAA24918.1 Sequence problems.
M16707 Genomic DNA Translation: AAA52652.1
M60749 Genomic DNA Translation: AAA63188.1
X60481 Genomic DNA Translation: CAA43011.1
X60482 Genomic DNA Translation: CAA43012.1
X60483 Genomic DNA Translation: CAA43013.1
X60484 Genomic DNA Translation: CAA43014.1
X60486 Genomic DNA Translation: CAA43016.1
X60487 Genomic DNA Translation: CAA43017.1
X67081 Genomic DNA Translation: CAA47464.1
Z80787 Genomic DNA Translation: CAB02549.1
X83548 Genomic DNA Translation: CAA58538.1
AF525682 Genomic DNA Translation: AAM83108.1
AY128653 Genomic DNA Translation: AAN01438.1
AY128654 Genomic DNA Translation: AAN01439.1
AY128655 Genomic DNA Translation: AAN01440.1
AY128656 Genomic DNA Translation: AAN01441.1
AY128657 Genomic DNA Translation: AAN01442.1
AY128658 Genomic DNA Translation: AAN01443.1
AY128659 Genomic DNA Translation: AAN01444.1
AY128661 Genomic DNA Translation: AAN01446.1
AY128662 Genomic DNA Translation: AAN01447.1
AY128663 Genomic DNA Translation: AAN01448.1
AY128664 Genomic DNA Translation: AAN01449.1
AY128665 Genomic DNA Translation: AAN01450.1
AB000905 Genomic DNA Translation: BAA19208.1
AY648850 Genomic DNA Translation: AAT68253.1
CR542169 mRNA Translation: CAG46966.1
CR542172 mRNA Translation: CAG46969.1
CR542180 mRNA Translation: CAG46977.1
CR542187 mRNA Translation: CAG46984.1
CR542189 mRNA Translation: CAG46986.1
AL021807 Genomic DNA No translation available.
AL021917 Genomic DNA No translation available.
AL031777 Genomic DNA No translation available.
AL049822 Genomic DNA No translation available.
AL353759 Genomic DNA No translation available.
Z98744 Genomic DNA No translation available.
AL591493 Genomic DNA Translation: CAI12560.1
AL591493 Genomic DNA Translation: CAI12567.1
CH471087 Genomic DNA Translation: EAW55509.1
CH471087 Genomic DNA Translation: EAW55510.1
CH471087 Genomic DNA Translation: EAW55538.1
CH471087 Genomic DNA Translation: EAW55549.1
CH471087 Genomic DNA Translation: EAW55555.1
CH471094 Genomic DNA Translation: EAW96325.1
CH471081 Genomic DNA Translation: EAX03086.1
CH471081 Genomic DNA Translation: EAX03111.1
CH471081 Genomic DNA Translation: EAX03112.1
CH471081 Genomic DNA Translation: EAX03121.1
BC017361 mRNA Translation: AAH17361.1
BC054014 mRNA Translation: AAH54014.1
BC066248 mRNA Translation: AAH66248.1
BC066249 mRNA Translation: AAH66249.1
BC066250 mRNA Translation: AAH66250.1
BC067495 mRNA Translation: AAH67495.1
BC067496 mRNA Translation: AAH67496.1
BC067497 mRNA Translation: AAH67497.1
BC069288 mRNA Translation: AAH69288.1
BC069392 mRNA Translation: AAH69392.1
BC069467 mRNA Translation: AAH69467.1
BC069654 mRNA Translation: AAH69654.1
BC093763 mRNA Translation: AAH93763.1
BC093765 mRNA Translation: AAH93765.1
BC093969 mRNA Translation: AAH93969.1
BC111093 mRNA Translation: AAI11094.1
BC111434 mRNA Translation: AAI11435.1
BC112193 mRNA Translation: AAI12194.1
BC120939 mRNA Translation: AAI20940.1
BC128104 mRNA Translation: AAI28105.1
BC128105 mRNA Translation: AAI28106.1 Frameshift.
BC130558 mRNA Translation: AAI30559.1
BC130560 mRNA Translation: AAI30561.1
BC143045 mRNA Translation: AAI43046.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30847.1
CCDS30851.1
CCDS4571.1
CCDS4572.1
CCDS4583.1
CCDS4589.1
CCDS4593.1
CCDS4598.1
CCDS4604.1
CCDS4620.1
CCDS4630.1
CCDS4631.1
CCDS4637.1
CCDS8665.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D40335 HSHU4

NCBI Reference Sequences

More...
RefSeqi
NP_001029249.1, NM_001034077.4
NP_003486.1, NM_003495.2
NP_003529.1, NM_003538.3
NP_003530.1, NM_003539.3
NP_003531.1, NM_003540.3
NP_003532.1, NM_003541.2
NP_003533.1, NM_003542.3
NP_003534.1, NM_003543.3
NP_003535.1, NM_003544.2
NP_003536.1, NM_003545.3
NP_003537.1, NM_003546.2
NP_003539.1, NM_003548.2
NP_068803.1, NM_021968.3
NP_778224.1, NM_175054.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.143080
Hs.247816
Hs.248172
Hs.248178
Hs.248179
Hs.278483
Hs.46423
Hs.528055
Hs.533295
Hs.55468
Hs.591790
Hs.655235
Hs.662174
Hs.706635
Hs.745457

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000244537; ENSP00000244537; ENSG00000274618
ENST00000355057; ENSP00000347168; ENSG00000197238
ENST00000358064; ENSP00000350767; ENSG00000197837
ENST00000377727; ENSP00000366956; ENSG00000158406
ENST00000377745; ENSP00000366974; ENSG00000278705
ENST00000377803; ENSP00000367034; ENSG00000197061
ENST00000539745; ENSP00000443017; ENSG00000197837
ENST00000578186; ENSP00000462667; ENSG00000270882
ENST00000579512; ENSP00000462355; ENSG00000270276
ENST00000611927; ENSP00000479794; ENSG00000273542
ENST00000612061; ENSP00000482412; ENSG00000270276
ENST00000613412; ENSP00000481343; ENSG00000270882
ENST00000614247; ENSP00000479461; ENSG00000277157
ENST00000614272; ENSP00000478519; ENSG00000270882
ENST00000615164; ENSP00000484789; ENSG00000276966
ENST00000615353; ENSP00000481486; ENSG00000276180
ENST00000617569; ENSP00000479106; ENSG00000278637
ENST00000618193; ENSP00000478786; ENSG00000270882
ENST00000618305; ENSP00000480960; ENSG00000275126
ENST00000621520; ENSP00000481507; ENSG00000270276
ENST00000634560; ENSP00000489319; ENSG00000158406
ENST00000634956; ENSP00000489567; ENSG00000158406
ENST00000635491; ENSP00000489236; ENSG00000158406

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
121504
554313
8294
8359
8360
8361
8362
8363
8364
8365
8366
8367
8368
8370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:121504
hsa:554313
hsa:8294
hsa:8359
hsa:8360
hsa:8361
hsa:8362
hsa:8363
hsa:8364
hsa:8365
hsa:8366
hsa:8367
hsa:8368
hsa:8370

UCSC genome browser

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UCSCi
uc001ess.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00038 Genomic DNA Translation: CAA24918.1 Sequence problems.
M16707 Genomic DNA Translation: AAA52652.1
M60749 Genomic DNA Translation: AAA63188.1
X60481 Genomic DNA Translation: CAA43011.1
X60482 Genomic DNA Translation: CAA43012.1
X60483 Genomic DNA Translation: CAA43013.1
X60484 Genomic DNA Translation: CAA43014.1
X60486 Genomic DNA Translation: CAA43016.1
X60487 Genomic DNA Translation: CAA43017.1
X67081 Genomic DNA Translation: CAA47464.1
Z80787 Genomic DNA Translation: CAB02549.1
X83548 Genomic DNA Translation: CAA58538.1
AF525682 Genomic DNA Translation: AAM83108.1
AY128653 Genomic DNA Translation: AAN01438.1
AY128654 Genomic DNA Translation: AAN01439.1
AY128655 Genomic DNA Translation: AAN01440.1
AY128656 Genomic DNA Translation: AAN01441.1
AY128657 Genomic DNA Translation: AAN01442.1
AY128658 Genomic DNA Translation: AAN01443.1
AY128659 Genomic DNA Translation: AAN01444.1
AY128661 Genomic DNA Translation: AAN01446.1
AY128662 Genomic DNA Translation: AAN01447.1
AY128663 Genomic DNA Translation: AAN01448.1
AY128664 Genomic DNA Translation: AAN01449.1
AY128665 Genomic DNA Translation: AAN01450.1
AB000905 Genomic DNA Translation: BAA19208.1
AY648850 Genomic DNA Translation: AAT68253.1
CR542169 mRNA Translation: CAG46966.1
CR542172 mRNA Translation: CAG46969.1
CR542180 mRNA Translation: CAG46977.1
CR542187 mRNA Translation: CAG46984.1
CR542189 mRNA Translation: CAG46986.1
AL021807 Genomic DNA No translation available.
AL021917 Genomic DNA No translation available.
AL031777 Genomic DNA No translation available.
AL049822 Genomic DNA No translation available.
AL353759 Genomic DNA No translation available.
Z98744 Genomic DNA No translation available.
AL591493 Genomic DNA Translation: CAI12560.1
AL591493 Genomic DNA Translation: CAI12567.1
CH471087 Genomic DNA Translation: EAW55509.1
CH471087 Genomic DNA Translation: EAW55510.1
CH471087 Genomic DNA Translation: EAW55538.1
CH471087 Genomic DNA Translation: EAW55549.1
CH471087 Genomic DNA Translation: EAW55555.1
CH471094 Genomic DNA Translation: EAW96325.1
CH471081 Genomic DNA Translation: EAX03086.1
CH471081 Genomic DNA Translation: EAX03111.1
CH471081 Genomic DNA Translation: EAX03112.1
CH471081 Genomic DNA Translation: EAX03121.1
BC017361 mRNA Translation: AAH17361.1
BC054014 mRNA Translation: AAH54014.1
BC066248 mRNA Translation: AAH66248.1
BC066249 mRNA Translation: AAH66249.1
BC066250 mRNA Translation: AAH66250.1
BC067495 mRNA Translation: AAH67495.1
BC067496 mRNA Translation: AAH67496.1
BC067497 mRNA Translation: AAH67497.1
BC069288 mRNA Translation: AAH69288.1
BC069392 mRNA Translation: AAH69392.1
BC069467 mRNA Translation: AAH69467.1
BC069654 mRNA Translation: AAH69654.1
BC093763 mRNA Translation: AAH93763.1
BC093765 mRNA Translation: AAH93765.1
BC093969 mRNA Translation: AAH93969.1
BC111093 mRNA Translation: AAI11094.1
BC111434 mRNA Translation: AAI11435.1
BC112193 mRNA Translation: AAI12194.1
BC120939 mRNA Translation: AAI20940.1
BC128104 mRNA Translation: AAI28105.1
BC128105 mRNA Translation: AAI28106.1 Frameshift.
BC130558 mRNA Translation: AAI30559.1
BC130560 mRNA Translation: AAI30561.1
BC143045 mRNA Translation: AAI43046.1
CCDSiCCDS30847.1
CCDS30851.1
CCDS4571.1
CCDS4572.1
CCDS4583.1
CCDS4589.1
CCDS4593.1
CCDS4598.1
CCDS4604.1
CCDS4620.1
CCDS4630.1
CCDS4631.1
CCDS4637.1
CCDS8665.1
PIRiD40335 HSHU4
RefSeqiNP_001029249.1, NM_001034077.4
NP_003486.1, NM_003495.2
NP_003529.1, NM_003538.3
NP_003530.1, NM_003539.3
NP_003531.1, NM_003540.3
NP_003532.1, NM_003541.2
NP_003533.1, NM_003542.3
NP_003534.1, NM_003543.3
NP_003535.1, NM_003544.2
NP_003536.1, NM_003545.3
NP_003537.1, NM_003546.2
NP_003539.1, NM_003548.2
NP_068803.1, NM_021968.3
NP_778224.1, NM_175054.2
UniGeneiHs.143080
Hs.247816
Hs.248172
Hs.248178
Hs.248179
Hs.278483
Hs.46423
Hs.528055
Hs.533295
Hs.55468
Hs.591790
Hs.655235
Hs.662174
Hs.706635
Hs.745457

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZKKX-ray1.45E/F/G/H16-25[»]
2BQZX-ray1.50B/F18-26[»]
2CV5X-ray2.50B/F1-103[»]
2IG0X-ray1.70B17-26[»]
2KWNNMR-B10-24[»]
2KWONMR-B2-21[»]
2LVMNMR-B15-28[»]
2QQSX-ray2.82C/D17-26[»]
2RJEX-ray1.86P/Q16-26[»]
2RNYNMR-B14-28[»]
2RS9NMR-A2-11[»]
3A6NX-ray2.70B/F1-103[»]
3AFAX-ray2.50B/F1-103[»]
3AN2X-ray3.60B/F1-103[»]
3AV1X-ray2.50B/F1-103[»]
3AV2X-ray2.80B/F1-103[»]
3AYWX-ray2.90B/F1-103[»]
3AZEX-ray3.00B/F1-103[»]
3AZFX-ray2.70B/F1-103[»]
3AZGX-ray2.40B/F1-103[»]
3AZHX-ray3.49B/F1-103[»]
3AZIX-ray2.70B/F1-103[»]
3AZJX-ray2.89B/F1-103[»]
3AZKX-ray3.20B/F1-103[»]
3AZLX-ray2.70B/F1-103[»]
3AZMX-ray2.89B/F1-103[»]
3AZNX-ray3.00B/F1-103[»]
3CFSX-ray2.40E28-42[»]
3CFVX-ray2.60E/F25-42[»]
3F9WX-ray1.60E/F/G/H16-25[»]
3F9XX-ray1.25E/F/G/H16-25[»]
3F9YX-ray1.50E/F16-25[»]
3F9ZX-ray1.60E/F/G/H16-25[»]
3IJ1X-ray2.10B16-26[»]
3JPXX-ray2.05B14-28[»]
3NQJX-ray2.10B21-103[»]
3NQUX-ray2.50B1-103[»]
3O36X-ray1.70D/E15-20[»]
3QBYX-ray1.95H16-26[»]
3QZSX-ray1.80C/D13-22[»]
3QZTX-ray1.50B13-22[»]
3QZVX-ray2.00C8-18[»]
3R45X-ray2.60B1-103[»]
3UVWX-ray1.37B2-12[»]
3UVXX-ray1.91B12-22[»]
3UVYX-ray2.02B16-26[»]
3UW9X-ray2.30E/F8-18[»]
3W96X-ray3.00B/F1-103[»]
3W97X-ray3.20B/F1-103[»]
3W98X-ray3.42B/F1-103[»]
3W99X-ray3.00B/F17-103[»]
3WA9X-ray3.07B/F1-103[»]
3WAAX-ray3.20B/F1-103[»]
3WKJX-ray2.80B/F1-103[»]
3WTPX-ray2.67B/F1-103[»]
3X1SX-ray2.81B/F2-103[»]
3X1TX-ray2.81B/F2-103[»]
3X1UX-ray3.25B/F2-103[»]
3X1VX-ray2.92B/F2-103[»]
4GQBX-ray2.06C2-22[»]
4H9NX-ray1.95B2-103[»]
4H9OX-ray2.05B2-103[»]
4H9PX-ray2.20B2-103[»]
4H9QX-ray1.95B2-103[»]
4H9RX-ray2.20B2-103[»]
4H9SX-ray2.60C/D21-103[»]
4HGAX-ray2.80C1-103[»]
4M38X-ray2.20E/F2-22[»]
4N3WX-ray1.90C14-28[»]
4N4FX-ray1.83C6-26[»]
4QUTX-ray1.70B10-16[»]
4QUUX-ray1.80B4-16[»]
4QYDX-ray1.94B5-18[»]
4U9WX-ray2.49E/F/G/H2-6[»]
4YM5X-ray4.00B/F1-103[»]
4YM6X-ray3.51B/F1-103[»]
4YY6X-ray1.45Z2-12[»]
4YYDX-ray1.52Z2-12[»]
4YYGX-ray2.10B2-12[»]
4YYHX-ray1.74Y/Z2-12[»]
4YYIX-ray1.50C/F2-12[»]
4YYJX-ray1.85C/F2-12[»]
4YYKX-ray1.79C/F2-12[»]
4YYMX-ray1.50Z2-12[»]
4YYNX-ray1.85Z2-12[»]
4Z2MX-ray2.98H/J1-103[»]
4Z5TX-ray2.80B/F1-103[»]
5AV5X-ray2.40B/F1-103[»]
5AV6X-ray2.20B/F1-103[»]
5AV8X-ray2.20B/F1-103[»]
5AV9X-ray2.20B/F1-103[»]
5AVBX-ray2.40B/F1-103[»]
5AVCX-ray2.40B/F1-103[»]
5AY8X-ray2.80B/F1-103[»]
5B0YX-ray2.56B/F1-103[»]
5B0ZX-ray1.99B/F1-103[»]
5B24X-ray3.60B/F1-103[»]
5B2IX-ray3.00B/F1-103[»]
5B2JX-ray2.60B/F1-103[»]
5B31X-ray2.20B/F1-103[»]
5B32X-ray2.35B/F1-103[»]
5B33X-ray2.92B/F1-103[»]
5B40X-ray3.33B/F1-103[»]
5BNVX-ray2.79B/E2-103[»]
5BNXX-ray2.31B2-103[»]
5BO0X-ray2.91B2-103[»]
5C3IX-ray3.50C/G/K/O/S/W1-103[»]
5CPIX-ray2.90B/F1-103[»]
5CPJX-ray3.15B/F1-103[»]
5CPKX-ray2.63B/F1-103[»]
5FA5X-ray2.34C2-21[»]
5FFWX-ray1.50C2-11[»]
5FWEX-ray2.05C/D2-16[»]
5GSEX-ray3.14B/F/L/P1-103[»]
5GSUX-ray3.10B/F2-103[»]
5GT0X-ray2.82B/F2-103[»]
5GT3X-ray2.91B/F2-103[»]
5GTCX-ray2.70B/F1-103[»]
5GXQX-ray2.85B/F1-103[»]
5JA4X-ray2.42B2-103[»]
5JRGX-ray2.50B/F1-103[»]
5KDMX-ray3.50B2-103[»]
5TEGX-ray1.30D/E17-24[»]
5X7XX-ray2.18B/F1-103[»]
5XF3X-ray2.60B/F1-103[»]
5XF4X-ray2.87B/F1-103[»]
5XF5X-ray2.82B/F1-103[»]
5Y0CX-ray2.09B/F1-103[»]
5Y0DX-ray1.99B/F1-103[»]
5Z30X-ray2.45B/F1-103[»]
6A5Lelectron microscopy5.60b/f1-103[»]
6A5Oelectron microscopy9.90b/f1-103[»]
6A5Pelectron microscopy7.00b/f1-103[»]
6A5Relectron microscopy8.70b/f1-103[»]
6A5Telectron microscopy6.70b/f1-103[»]
6A5Uelectron microscopy7.60b/f1-103[»]
6A5Velectron microscopy6.90b/f1-103[»]
6BUZelectron microscopy3.92B/F1-103[»]
6C0Welectron microscopy4.00B/F1-102[»]
6ETXelectron microscopy4.80J/N1-103[»]
6FMLelectron microscopy4.34N/R2-103[»]
6MLCX-ray1.80E/F2-21[»]
ProteinModelPortaliP62805
SMRiP62805
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113899, 25 interactors
113955, 188 interactors
113956, 18 interactors
113957, 31 interactors
113958, 17 interactors
113959, 21 interactors
113960, 17 interactors
113961, 22 interactors
113962, 17 interactors
113963, 22 interactors
113964, 19 interactors
113966, 50 interactors
125732, 89 interactors
299853, 19 interactors
CORUMiP62805
DIPiDIP-33079N
IntActiP62805, 136 interactors
MINTiP62805
STRINGi9606.ENSP00000367034

Chemistry databases

BindingDBiP62805
ChEMBLiCHEMBL5876

PTM databases

iPTMnetiP62805
PhosphoSitePlusiP62805
SwissPalmiP62805

Polymorphism and mutation databases

BioMutaiHIST1H4A
DMDMi51317339

2D gel databases

SWISS-2DPAGEiP62805

Proteomic databases

EPDiP62805
MaxQBiP62805
PaxDbiP62805
PeptideAtlasiP62805
PRIDEiP62805
ProteomicsDBi57424
TopDownProteomicsiP62805

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8294
8360
8362
8363
8364
8365
8366
8367
8368
8370
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244537; ENSP00000244537; ENSG00000274618
ENST00000355057; ENSP00000347168; ENSG00000197238
ENST00000358064; ENSP00000350767; ENSG00000197837
ENST00000377727; ENSP00000366956; ENSG00000158406
ENST00000377745; ENSP00000366974; ENSG00000278705
ENST00000377803; ENSP00000367034; ENSG00000197061
ENST00000539745; ENSP00000443017; ENSG00000197837
ENST00000578186; ENSP00000462667; ENSG00000270882
ENST00000579512; ENSP00000462355; ENSG00000270276
ENST00000611927; ENSP00000479794; ENSG00000273542
ENST00000612061; ENSP00000482412; ENSG00000270276
ENST00000613412; ENSP00000481343; ENSG00000270882
ENST00000614247; ENSP00000479461; ENSG00000277157
ENST00000614272; ENSP00000478519; ENSG00000270882
ENST00000615164; ENSP00000484789; ENSG00000276966
ENST00000615353; ENSP00000481486; ENSG00000276180
ENST00000617569; ENSP00000479106; ENSG00000278637
ENST00000618193; ENSP00000478786; ENSG00000270882
ENST00000618305; ENSP00000480960; ENSG00000275126
ENST00000621520; ENSP00000481507; ENSG00000270276
ENST00000634560; ENSP00000489319; ENSG00000158406
ENST00000634956; ENSP00000489567; ENSG00000158406
ENST00000635491; ENSP00000489236; ENSG00000158406
GeneIDi121504
554313
8294
8359
8360
8361
8362
8363
8364
8365
8366
8367
8368
8370
KEGGihsa:121504
hsa:554313
hsa:8294
hsa:8359
hsa:8360
hsa:8361
hsa:8362
hsa:8363
hsa:8364
hsa:8365
hsa:8366
hsa:8367
hsa:8368
hsa:8370
UCSCiuc001ess.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
121504
554313
8294
8359
8360
8361
8362
8363
8364
8365
8366
8367
8368
8370
DisGeNETi121504
554313
8294
8359
8360
8361
8362
8363
8364
8365
8366
8367
8368
8370
EuPathDBiHostDB:ENSG00000158406.4
HostDB:ENSG00000197061.4
HostDB:ENSG00000197238.4
HostDB:ENSG00000197837.3
HostDB:ENSG00000270276.2
HostDB:ENSG00000270882.2
HostDB:ENSG00000273542.1
HostDB:ENSG00000274618.1
HostDB:ENSG00000275126.1
HostDB:ENSG00000276180.1
HostDB:ENSG00000276966.2
HostDB:ENSG00000277157.1
HostDB:ENSG00000278637.1
HostDB:ENSG00000278705.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HGNCiHGNC:4781 HIST1H4A
HGNC:4789 HIST1H4B
HGNC:4787 HIST1H4C
HGNC:4782 HIST1H4D
HGNC:4790 HIST1H4E
HGNC:4783 HIST1H4F
HGNC:4788 HIST1H4H
HGNC:4793 HIST1H4I
HGNC:4785 HIST1H4J
HGNC:4784 HIST1H4K
HGNC:4791 HIST1H4L
HGNC:4794 HIST2H4A
HGNC:29607 HIST2H4B
HGNC:20510 HIST4H4
HPAiCAB011503
CAB021887
CAB037279
HPA042201
MIMi142750 gene
602822 gene
602823 gene
602824 gene
602825 gene
602826 gene
602827 gene
602828 gene
602829 gene
602830 gene
602831 gene
602833 gene
615069 gene
neXtProtiNX_P62805
OpenTargetsiENSG00000158406
ENSG00000197061
ENSG00000197238
ENSG00000197837
ENSG00000270276
ENSG00000270882
ENSG00000273542
ENSG00000274618
ENSG00000275126
ENSG00000276180
ENSG00000276966
ENSG00000277157
ENSG00000278637
ENSG00000278705
PharmGKBiPA29169

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00940000153448
ENSGT00940000153449
ENSGT00940000153453
ENSGT00940000153502
HOGENOMiHOG000234654
HOVERGENiHBG051878
InParanoidiP62805
KOiK11254
OMAiQKEHING
OrthoDBiEOG09370I2I
PhylomeDBiP62805

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-912446 Meiotic recombination
R-HSA-977225 Amyloid fiber formation
SIGNORiP62805

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HIST1H4A human
HIST1H4E human
HIST1H4F human
HIST2H4A human
EvolutionaryTraceiP62805

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST4H4

Protein Ontology

More...
PROi
PR:P62805

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158406 Expressed in 163 organ(s), highest expression level in stomach
CleanExiHS_HIST1H4A
HS_HIST1H4B
HS_HIST1H4C
HS_HIST1H4D
HS_HIST1H4E
HS_HIST1H4F
HS_HIST1H4H
HS_HIST1H4I
HS_HIST1H4L
HS_HIST2H4A
HS_HIST2H4B
HS_HIST4H4
ExpressionAtlasiP62805 baseline and differential
GenevisibleiP62805 HS

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62805
Secondary accession number(s): A2VCL0
, P02304, P02305, Q6DRA9, Q6FGB8, Q6NWP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  8. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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