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Entry version 158 (12 Aug 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H4

Gene

H4c2

more
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Stimulates osteogenesis and hematopoiesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi17 – 215

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Osteogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-RNO-110331, Cleavage of the damaged purine
R-RNO-171306, Packaging Of Telomere Ends
R-RNO-201722, Formation of the beta-catenin:TCF transactivating complex
R-RNO-212300, PRC2 methylates histones and DNA
R-RNO-2299718, Condensation of Prophase Chromosomes
R-RNO-2559580, Oxidative Stress Induced Senescence
R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-RNO-2559586, DNA Damage/Telomere Stress Induced Senescence
R-RNO-3214841, PKMTs methylate histone lysines
R-RNO-3214842, HDMs demethylate histones
R-RNO-3214847, HATs acetylate histones
R-RNO-3214858, RMTs methylate histone arginines
R-RNO-427359, SIRT1 negatively regulates rRNA expression
R-RNO-427413, NoRC negatively regulates rRNA expression
R-RNO-4551638, SUMOylation of chromatin organization proteins
R-RNO-5250924, B-WICH complex positively regulates rRNA expression
R-RNO-5578749, Transcriptional regulation by small RNAs
R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-RNO-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-RNO-5693571, Nonhomologous End-Joining (NHEJ)
R-RNO-5693607, Processing of DNA double-strand break ends
R-RNO-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-RNO-69473, G2/M DNA damage checkpoint
R-RNO-73728, RNA Polymerase I Promoter Opening
R-RNO-73772, RNA Polymerase I Promoter Escape
R-RNO-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-RNO-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H4
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H4c2
Synonyms:Hist1h4b, Hist4
AND
Name:Hist1h4m
AND
Name:H4f16
Synonyms:H4ft, Hist4h4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 17, Chromosome 2, Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
620814, Hist1h4b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001583552 – 103Histone H4Add BLAST102
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000022559190 – 103Osteogenic growth peptideAdd BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei4Asymmetric dimethylarginine; by PRMT1; alternateBy similarity1
Modified residuei4Citrulline; alternateBy similarity1
Modified residuei4Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei4Symmetric dimethylarginine; by PRMT5 and PRMT7; alternateBy similarity1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei6N6-acetyllysine; alternateBy similarity1
Modified residuei6N6-butyryllysine; alternateBy similarity1
Modified residuei6N6-crotonyllysine; alternateBy similarity1
Modified residuei6N6-glutaryllysine; alternateBy similarity1
Modified residuei9N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei9N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei9N6-acetyllysine; alternateBy similarity1
Modified residuei9N6-butyryllysine; alternateBy similarity1
Modified residuei9N6-crotonyllysine; alternateBy similarity1
Modified residuei9N6-propionyllysine; alternateBy similarity1
Modified residuei13N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei13N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei13N6-acetyllysine; alternateBy similarity1
Modified residuei13N6-butyryllysine; alternateBy similarity1
Modified residuei13N6-crotonyllysine; alternateBy similarity1
Modified residuei13N6-glutaryllysine; alternateBy similarity1
Modified residuei13N6-methyllysine; alternateBy similarity1
Modified residuei13N6-succinyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei17N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei17N6-acetyllysine; alternate1 Publication1
Modified residuei17N6-butyryllysine; alternateBy similarity1
Modified residuei17N6-crotonyllysine; alternateBy similarity1
Modified residuei17N6-propionyllysine; alternateBy similarity1
Modified residuei21N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei21N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei21N6-methyllysine; alternate1 Publication1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei32N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei32N6-acetyllysine; alternateBy similarity1
Modified residuei32N6-butyryllysine; alternateBy similarity1
Modified residuei32N6-glutaryllysine; alternateBy similarity1
Modified residuei32N6-propionyllysine; alternateBy similarity1
Modified residuei32N6-succinyllysine; alternateBy similarity1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternateBy similarity
Modified residuei45N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei45N6-butyryllysine; alternateBy similarity1
Modified residuei45N6-propionyllysine; alternateBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei52PhosphotyrosineBy similarity1
Modified residuei60N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei60N6-glutaryllysine; alternateBy similarity1
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei78N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei78N6-butyryllysine; alternateBy similarity1
Modified residuei78N6-glutaryllysine; alternateBy similarity1
Modified residuei78N6-propionyllysine; alternateBy similarity1
Modified residuei78N6-succinyllysine; alternateBy similarity1
Modified residuei80N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei80N6-butyryllysine; alternateBy similarity1
Modified residuei80N6-glutaryllysine; alternateBy similarity1
Modified residuei80N6-propionyllysine; alternateBy similarity1
Modified residuei80N6-succinyllysine; alternateBy similarity1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei81PhosphothreonineCombined sources1
Modified residuei89PhosphotyrosineCombined sources1
Modified residuei92N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity1
Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei92N6-butyryllysine; alternateBy similarity1
Modified residuei92N6-glutaryllysine; alternateBy similarity1
Modified residuei92N6-propionyllysine; alternateBy similarity1
Modified residuei92N6-succinyllysine; alternateBy similarity1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.By similarity
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.By similarity
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).By similarity
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.By similarity
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).By similarity
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).By similarity
Sumoylated, which is associated with transcriptional repression.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).By similarity
Butyrylation of histones marks active promoters and competes with histone acetylation.By similarity
Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.By similarity
Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62804

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62804

PRoteomics IDEntifications database

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PRIDEi
P62804

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62804

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62804

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62804

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

OGP is found in serum. A potentially OGP-specific transcript is highly expressed in spleen with lower levels in lung, liver, thymus, spinal chord, pituitary gland, adrenal gland, bone marrow and lymph nodes as well as very low levels in kidney, heart and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000032224, Expressed in liver and 19 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62804, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
1200084, 1 interactor
249165, 5 interactors
254947, 2 interactors
595036, 2 interactors

Protein interaction database and analysis system

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IntActi
P62804, 2 interactors

STRING: functional protein association networks

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STRINGi
10116.ENSRNOP00000067813

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62804

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3467, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00980000198564
ENSGT00990000203597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_109117_2_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62804

KEGG Orthology (KO)

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KOi
K11254

Identification of Orthologs from Complete Genome Data

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OMAi
QKEHING

Database of Orthologous Groups

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OrthoDBi
1564596at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62804

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00076, H4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035425, CENP-T/H4_C
IPR009072, Histone-fold
IPR001951, Histone_H4
IPR019809, Histone_H4_CS
IPR004823, TAF_TATA-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15511, CENP-T_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00623, HISTONEH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00417, H4, 1 hit
SM00803, TAF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113, SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00047, HISTONE_H4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform Histone H4 (identifier: P62804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E5DFD3F8B97598
GO
Isoform OGP precursor (identifier: P62804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:19
Mass (Da):2,131
Checksum:iDA46847BA27B7A8B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188041 – 84Missing in isoform OGP precursor. CuratedAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M27433 Genomic DNA Translation: AAA60735.1
X13554 Genomic DNA Translation: CAA31906.1
M28409 Genomic DNA Translation: AAA41306.1
AY936209 mRNA Translation: AAX28930.1
BC100619 mRNA Translation: AAI00620.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A91265, HSRT4
S53749

NCBI Reference Sequences

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RefSeqi
NP_001116941.1, NM_001123469.1 [P62804-1]
NP_001258150.1, NM_001271221.1 [P62804-1]
NP_073177.1, NM_022686.2 [P62804-1]
XP_003749904.3, XM_003749856.4 [P62804-1]
XP_008761668.1, XM_008763446.1 [P62804-1]
XP_008761670.1, XM_008763448.2 [P62804-1]
XP_008769992.1, XM_008771770.2 [P62804-1]
XP_008772221.1, XM_008773999.1 [P62804-1]
XP_578415.4, XM_578415.6 [P62804-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000040210; ENSRNOP00000039602; ENSRNOG00000032224 [P62804-1]
ENSRNOT00000071512; ENSRNOP00000065233; ENSRNOG00000045840 [P62804-1]
ENSRNOT00000072147; ENSRNOP00000066653; ENSRNOG00000048735 [P62804-1]
ENSRNOT00000072286; ENSRNOP00000067502; ENSRNOG00000050933 [P62804-1]
ENSRNOT00000074109; ENSRNOP00000066622; ENSRNOG00000046636 [P62804-1]
ENSRNOT00000074198; ENSRNOP00000066695; ENSRNOG00000048642 [P62804-1]
ENSRNOT00000074526; ENSRNOP00000067813; ENSRNOG00000045978 [P62804-1]
ENSRNOT00000075065; ENSRNOP00000067176; ENSRNOG00000048215 [P62804-1]
ENSRNOT00000080490; ENSRNOP00000071163; ENSRNOG00000054017 [P62804-1]
ENSRNOT00000085381; ENSRNOP00000069989; ENSRNOG00000058444 [P62804-1]
ENSRNOT00000088408; ENSRNOP00000074659; ENSRNOG00000051891 [P62804-1]
ENSRNOT00000091201; ENSRNOP00000074796; ENSRNOG00000057690 [P62804-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100912489
100912564
291152
295277
364723
500351
502913
64627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:100912489
rno:100912564
rno:291152
rno:295277
rno:364723
rno:500351
rno:502913
rno:64627

UCSC genome browser

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UCSCi
RGD:620814, rat [P62804-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27433 Genomic DNA Translation: AAA60735.1
X13554 Genomic DNA Translation: CAA31906.1
M28409 Genomic DNA Translation: AAA41306.1
AY936209 mRNA Translation: AAX28930.1
BC100619 mRNA Translation: AAI00620.1
PIRiA91265, HSRT4
S53749
RefSeqiNP_001116941.1, NM_001123469.1 [P62804-1]
NP_001258150.1, NM_001271221.1 [P62804-1]
NP_073177.1, NM_022686.2 [P62804-1]
XP_003749904.3, XM_003749856.4 [P62804-1]
XP_008761668.1, XM_008763446.1 [P62804-1]
XP_008761670.1, XM_008763448.2 [P62804-1]
XP_008769992.1, XM_008771770.2 [P62804-1]
XP_008772221.1, XM_008773999.1 [P62804-1]
XP_578415.4, XM_578415.6 [P62804-1]

3D structure databases

SMRiP62804
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1200084, 1 interactor
249165, 5 interactors
254947, 2 interactors
595036, 2 interactors
IntActiP62804, 2 interactors
STRINGi10116.ENSRNOP00000067813

PTM databases

iPTMnetiP62804
PhosphoSitePlusiP62804
SwissPalmiP62804

Proteomic databases

jPOSTiP62804
PaxDbiP62804
PRIDEiP62804

Genome annotation databases

EnsembliENSRNOT00000040210; ENSRNOP00000039602; ENSRNOG00000032224 [P62804-1]
ENSRNOT00000071512; ENSRNOP00000065233; ENSRNOG00000045840 [P62804-1]
ENSRNOT00000072147; ENSRNOP00000066653; ENSRNOG00000048735 [P62804-1]
ENSRNOT00000072286; ENSRNOP00000067502; ENSRNOG00000050933 [P62804-1]
ENSRNOT00000074109; ENSRNOP00000066622; ENSRNOG00000046636 [P62804-1]
ENSRNOT00000074198; ENSRNOP00000066695; ENSRNOG00000048642 [P62804-1]
ENSRNOT00000074526; ENSRNOP00000067813; ENSRNOG00000045978 [P62804-1]
ENSRNOT00000075065; ENSRNOP00000067176; ENSRNOG00000048215 [P62804-1]
ENSRNOT00000080490; ENSRNOP00000071163; ENSRNOG00000054017 [P62804-1]
ENSRNOT00000085381; ENSRNOP00000069989; ENSRNOG00000058444 [P62804-1]
ENSRNOT00000088408; ENSRNOP00000074659; ENSRNOG00000051891 [P62804-1]
ENSRNOT00000091201; ENSRNOP00000074796; ENSRNOG00000057690 [P62804-1]
GeneIDi100912489
100912564
291152
295277
364723
500351
502913
64627
KEGGirno:100912489
rno:100912564
rno:291152
rno:295277
rno:364723
rno:500351
rno:502913
rno:64627
UCSCiRGD:620814, rat [P62804-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
291152
295277
364723
500351
502913
64627
RGDi620814, Hist1h4b

Phylogenomic databases

eggNOGiKOG3467, Eukaryota
GeneTreeiENSGT00980000198564
ENSGT00990000203597
HOGENOMiCLU_109117_2_3_1
InParanoidiP62804
KOiK11254
OMAiQKEHING
OrthoDBi1564596at2759
PhylomeDBiP62804

Enzyme and pathway databases

ReactomeiR-RNO-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-RNO-110331, Cleavage of the damaged purine
R-RNO-171306, Packaging Of Telomere Ends
R-RNO-201722, Formation of the beta-catenin:TCF transactivating complex
R-RNO-212300, PRC2 methylates histones and DNA
R-RNO-2299718, Condensation of Prophase Chromosomes
R-RNO-2559580, Oxidative Stress Induced Senescence
R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-RNO-2559586, DNA Damage/Telomere Stress Induced Senescence
R-RNO-3214841, PKMTs methylate histone lysines
R-RNO-3214842, HDMs demethylate histones
R-RNO-3214847, HATs acetylate histones
R-RNO-3214858, RMTs methylate histone arginines
R-RNO-427359, SIRT1 negatively regulates rRNA expression
R-RNO-427413, NoRC negatively regulates rRNA expression
R-RNO-4551638, SUMOylation of chromatin organization proteins
R-RNO-5250924, B-WICH complex positively regulates rRNA expression
R-RNO-5578749, Transcriptional regulation by small RNAs
R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-RNO-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-RNO-5693571, Nonhomologous End-Joining (NHEJ)
R-RNO-5693607, Processing of DNA double-strand break ends
R-RNO-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-RNO-69473, G2/M DNA damage checkpoint
R-RNO-73728, RNA Polymerase I Promoter Opening
R-RNO-73772, RNA Polymerase I Promoter Escape
R-RNO-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-RNO-9018519, Estrogen-dependent gene expression

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P62804

Gene expression databases

BgeeiENSRNOG00000032224, Expressed in liver and 19 other tissues
GenevisibleiP62804, RN

Family and domain databases

CDDicd00076, H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425, CENP-T/H4_C
IPR009072, Histone-fold
IPR001951, Histone_H4
IPR019809, Histone_H4_CS
IPR004823, TAF_TATA-bd
PfamiView protein in Pfam
PF15511, CENP-T_C, 1 hit
PRINTSiPR00623, HISTONEH4
SMARTiView protein in SMART
SM00417, H4, 1 hit
SM00803, TAF, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047, HISTONE_H4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62804
Secondary accession number(s): P02304
, P02305, Q5BM23, Q7M0E8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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