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Protein

Histone H4

Gene

his-1

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-3214841 PKMTs methylate histone lysines
R-CEL-3214842 HDMs demethylate histones
R-CEL-3214847 HATs acetylate histones
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-4551638 SUMOylation of chromatin organization proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:his-1
ORF Names:T10C6.14
AND
Name:his-5
ORF Names:F45F2.3
AND
Name:his-10
ORF Names:ZK131.4
AND
Name:his-14
ORF Names:ZK131.8
AND
Name:his-18
ORF Names:K06C4.10
AND
Name:his-26
ORF Names:ZK131.1
AND
Name:his-28
ORF Names:K06C4.2
AND
Name:his-31
ORF Names:F17E9.12
AND
Name:his-37
ORF Names:C50F4.7
AND
Name:his-38
ORF Names:K03A1.6
AND
Name:his-46
ORF Names:B0035.9
AND
Name:his-50
ORF Names:F07B7.9
AND
Name:his-56
ORF Names:F54E12.3
AND
Name:his-60
ORF Names:F55G1.11
AND
Name:his-64
ORF Names:F22B3.1
AND
Name:his-67
ORF Names:T23D8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V, Chromosome X

Organism-specific databases

WormBaseiB0035.9 ; CE03252 ; WBGene00001920 ; his-46
C50F4.7 ; CE03252 ; WBGene00001911 ; his-37
F07B7.9 ; CE03252 ; WBGene00001924 ; his-50
F17E9.12 ; CE03252 ; WBGene00001905 ; his-31
F22B3.1 ; CE03252 ; WBGene00001938 ; his-64
F45F2.3 ; CE03252 ; WBGene00001879 ; his-5
F54E12.3 ; CE03252 ; WBGene00001930 ; his-56
F55G1.11 ; CE03252 ; WBGene00001934 ; his-60
K03A1.6 ; CE03252 ; WBGene00001912 ; his-38
K06C4.10 ; CE03252 ; WBGene00001892 ; his-18
K06C4.2 ; CE03252 ; WBGene00001902 ; his-28
T10C6.14 ; CE03252 ; WBGene00001875 ; his-1
T23D8.5 ; CE03252 ; WBGene00001941 ; his-67
ZK131.1 ; CE03252 ; WBGene00001900 ; his-26
ZK131.4 ; CE03252 ; WBGene00001884 ; his-10
ZK131.8 ; CE03252 ; WBGene00001888 ; his-14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001582902 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei21N6-methyllysine1 Publication1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP62784
PaxDbiP62784
PeptideAtlasiP62784
PRIDEiP62784

PTM databases

iPTMnetiP62784

Expressioni

Gene expression databases

BgeeiWBGene00001875 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi43149, 1 interactor
44273, 1 interactor
44379, 2 interactors
53446, 1 interactor
56168, 1 interactor
56177, 1 interactor
IntActiP62784, 2 interactors
STRINGi6239.ZK131.8

Structurei

3D structure databases

ProteinModelPortaliP62784
SMRiP62784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000119019
HOGENOMiHOG000234654
InParanoidiP62784
KOiK11254
OMAiHINGITK
OrthoDBiEOG091G0XGD
PhylomeDBiP62784

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYCEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,369
Last modified:January 23, 2007 - v2
Checksum:iA9E5DFD3F8AF04FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3G → E AA sequence (PubMed:3665432).Curated1
Sequence conflicti29Missing AA sequence (PubMed:3665432).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA Translation: CAA33643.1
FO081018 Genomic DNA Translation: CCD68533.1
FO081059 Genomic DNA Translation: CCD68871.1
FO081135 Genomic DNA Translation: CCD69398.1
FO081223 Genomic DNA Translation: CCD70020.1
FO081551 Genomic DNA Translation: CCD72360.1
FO081551 Genomic DNA Translation: CCD72370.1
FO081579 Genomic DNA Translation: CCD72542.1
Z68336 Genomic DNA Translation: CAA92734.1
Z70750 Genomic DNA Translation: CAA94742.1
Z73102 Genomic DNA Translation: CAA97407.1
Z81128 Genomic DNA Translation: CAB03396.1
Z82271 Genomic DNA Translation: CAB05210.1
Z83245 Genomic DNA Translation: CAB05835.4
Z83245 Genomic DNA Translation: CAB05837.1
Z83245 Genomic DNA Translation: CAB05839.1
Z93388 Genomic DNA Translation: CAB07657.1
PIRiJS0314
S04240
T27741
T29230
RefSeqiNP_492641.1, NM_060240.4
NP_496889.1, NM_064488.1
NP_496893.1, NM_064492.1
NP_496896.1, NM_064495.1
NP_501203.2, NM_068802.5
NP_501406.1, NM_069005.1
NP_502133.1, NM_069732.1
NP_502139.1, NM_069738.1
NP_502154.1, NM_069753.3
NP_505200.1, NM_072799.3
NP_505275.1, NM_072874.1
NP_505291.1, NM_072890.1
NP_505298.1, NM_072897.4
NP_505466.1, NM_073065.6
NP_507034.1, NM_074633.1
NP_509231.1, NM_076830.1
UniGeneiCel.12858
Cel.12870
Cel.17998
Cel.21434
Cel.24406
Cel.24432
Cel.25563
Cel.28726
Cel.28998
Cel.29185
Cel.29404
Cel.32620
Cel.32860
Cel.33123
Cel.770

Genome annotation databases

EnsemblMetazoaiB0035.9; B0035.9; WBGene00001920
C50F4.7; C50F4.7; WBGene00001911
F07B7.9; F07B7.9; WBGene00001924
F17E9.12; F17E9.12; WBGene00001905
F22B3.1; F22B3.1; WBGene00001938
F45F2.3; F45F2.3; WBGene00001879
F54E12.3; F54E12.3; WBGene00001930
F55G1.11; F55G1.11; WBGene00001934
K03A1.6; K03A1.6; WBGene00001912
K06C4.10; K06C4.10; WBGene00001892
K06C4.2; K06C4.2; WBGene00001902
T10C6.14; T10C6.14; WBGene00001875
T23D8.5; T23D8.5; WBGene00001941
ZK131.1; ZK131.1; WBGene00001900
ZK131.4; ZK131.4; WBGene00001884
ZK131.8; ZK131.8; WBGene00001888
GeneIDi175027
175032
177522
178050
178055
178066
179233
179260
179264
179267
179341
188792
191667
191671
191677
191680
KEGGicel:CELE_B0035.9
cel:CELE_C50F4.7
cel:CELE_F07B7.9
cel:CELE_F17E9.12
cel:CELE_F22B3.1
cel:CELE_F45F2.3
cel:CELE_F54E12.3
cel:CELE_F55G1.11
cel:CELE_K03A1.6
cel:CELE_K06C4.10
cel:CELE_K06C4.2
cel:CELE_T10C6.14
cel:CELE_T23D8.5
cel:CELE_ZK131.1
cel:CELE_ZK131.4
cel:CELE_ZK131.8
UCSCiT23D8.5 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA Translation: CAA33643.1
FO081018 Genomic DNA Translation: CCD68533.1
FO081059 Genomic DNA Translation: CCD68871.1
FO081135 Genomic DNA Translation: CCD69398.1
FO081223 Genomic DNA Translation: CCD70020.1
FO081551 Genomic DNA Translation: CCD72360.1
FO081551 Genomic DNA Translation: CCD72370.1
FO081579 Genomic DNA Translation: CCD72542.1
Z68336 Genomic DNA Translation: CAA92734.1
Z70750 Genomic DNA Translation: CAA94742.1
Z73102 Genomic DNA Translation: CAA97407.1
Z81128 Genomic DNA Translation: CAB03396.1
Z82271 Genomic DNA Translation: CAB05210.1
Z83245 Genomic DNA Translation: CAB05835.4
Z83245 Genomic DNA Translation: CAB05837.1
Z83245 Genomic DNA Translation: CAB05839.1
Z93388 Genomic DNA Translation: CAB07657.1
PIRiJS0314
S04240
T27741
T29230
RefSeqiNP_492641.1, NM_060240.4
NP_496889.1, NM_064488.1
NP_496893.1, NM_064492.1
NP_496896.1, NM_064495.1
NP_501203.2, NM_068802.5
NP_501406.1, NM_069005.1
NP_502133.1, NM_069732.1
NP_502139.1, NM_069738.1
NP_502154.1, NM_069753.3
NP_505200.1, NM_072799.3
NP_505275.1, NM_072874.1
NP_505291.1, NM_072890.1
NP_505298.1, NM_072897.4
NP_505466.1, NM_073065.6
NP_507034.1, NM_074633.1
NP_509231.1, NM_076830.1
UniGeneiCel.12858
Cel.12870
Cel.17998
Cel.21434
Cel.24406
Cel.24432
Cel.25563
Cel.28726
Cel.28998
Cel.29185
Cel.29404
Cel.32620
Cel.32860
Cel.33123
Cel.770

3D structure databases

ProteinModelPortaliP62784
SMRiP62784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43149, 1 interactor
44273, 1 interactor
44379, 2 interactors
53446, 1 interactor
56168, 1 interactor
56177, 1 interactor
IntActiP62784, 2 interactors
STRINGi6239.ZK131.8

PTM databases

iPTMnetiP62784

Proteomic databases

EPDiP62784
PaxDbiP62784
PeptideAtlasiP62784
PRIDEiP62784

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.9; B0035.9; WBGene00001920
C50F4.7; C50F4.7; WBGene00001911
F07B7.9; F07B7.9; WBGene00001924
F17E9.12; F17E9.12; WBGene00001905
F22B3.1; F22B3.1; WBGene00001938
F45F2.3; F45F2.3; WBGene00001879
F54E12.3; F54E12.3; WBGene00001930
F55G1.11; F55G1.11; WBGene00001934
K03A1.6; K03A1.6; WBGene00001912
K06C4.10; K06C4.10; WBGene00001892
K06C4.2; K06C4.2; WBGene00001902
T10C6.14; T10C6.14; WBGene00001875
T23D8.5; T23D8.5; WBGene00001941
ZK131.1; ZK131.1; WBGene00001900
ZK131.4; ZK131.4; WBGene00001884
ZK131.8; ZK131.8; WBGene00001888
GeneIDi175027
175032
177522
178050
178055
178066
179233
179260
179264
179267
179341
188792
191667
191671
191677
191680
KEGGicel:CELE_B0035.9
cel:CELE_C50F4.7
cel:CELE_F07B7.9
cel:CELE_F17E9.12
cel:CELE_F22B3.1
cel:CELE_F45F2.3
cel:CELE_F54E12.3
cel:CELE_F55G1.11
cel:CELE_K03A1.6
cel:CELE_K06C4.10
cel:CELE_K06C4.2
cel:CELE_T10C6.14
cel:CELE_T23D8.5
cel:CELE_ZK131.1
cel:CELE_ZK131.4
cel:CELE_ZK131.8
UCSCiT23D8.5 c. elegans

Organism-specific databases

CTDi175027
175032
177522
178050
178055
178066
179233
179260
179264
179267
179341
188792
191667
191671
191677
191680
WormBaseiB0035.9 ; CE03252 ; WBGene00001920 ; his-46
C50F4.7 ; CE03252 ; WBGene00001911 ; his-37
F07B7.9 ; CE03252 ; WBGene00001924 ; his-50
F17E9.12 ; CE03252 ; WBGene00001905 ; his-31
F22B3.1 ; CE03252 ; WBGene00001938 ; his-64
F45F2.3 ; CE03252 ; WBGene00001879 ; his-5
F54E12.3 ; CE03252 ; WBGene00001930 ; his-56
F55G1.11 ; CE03252 ; WBGene00001934 ; his-60
K03A1.6 ; CE03252 ; WBGene00001912 ; his-38
K06C4.10 ; CE03252 ; WBGene00001892 ; his-18
K06C4.2 ; CE03252 ; WBGene00001902 ; his-28
T10C6.14 ; CE03252 ; WBGene00001875 ; his-1
T23D8.5 ; CE03252 ; WBGene00001941 ; his-67
ZK131.1 ; CE03252 ; WBGene00001900 ; his-26
ZK131.4 ; CE03252 ; WBGene00001884 ; his-10
ZK131.8 ; CE03252 ; WBGene00001888 ; his-14

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000119019
HOGENOMiHOG000234654
InParanoidiP62784
KOiK11254
OMAiHINGITK
OrthoDBiEOG091G0XGD
PhylomeDBiP62784

Enzyme and pathway databases

ReactomeiR-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-3214841 PKMTs methylate histone lysines
R-CEL-3214842 HDMs demethylate histones
R-CEL-3214847 HATs acetylate histones
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-4551638 SUMOylation of chromatin organization proteins

Miscellaneous databases

PROiPR:P62784

Gene expression databases

BgeeiWBGene00001875 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH4_CAEEL
AccessioniPrimary (citable) accession number: P62784
Secondary accession number(s): O02619
, P02306, P18678, Q7JNV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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