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Entry version 131 (11 Dec 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H4

Gene

his-1

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi17 – 215

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-212300 PRC2 methylates histones and DNA
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3214815 HDACs deacetylate histones
R-CEL-3214841 PKMTs methylate histone lysines
R-CEL-3214842 HDMs demethylate histones
R-CEL-3214847 HATs acetylate histones
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-427359 SIRT1 negatively regulates rRNA expression
R-CEL-427413 NoRC negatively regulates rRNA expression
R-CEL-4551638 SUMOylation of chromatin organization proteins
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-73772 RNA Polymerase I Promoter Escape
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:his-1
ORF Names:T10C6.14
AND
Name:his-5
ORF Names:F45F2.3
AND
Name:his-10
ORF Names:ZK131.4
AND
Name:his-14
ORF Names:ZK131.8
AND
Name:his-18
ORF Names:K06C4.10
AND
Name:his-26
ORF Names:ZK131.1
AND
Name:his-28
ORF Names:K06C4.2
AND
Name:his-31
ORF Names:F17E9.12
AND
Name:his-37
ORF Names:C50F4.7
AND
Name:his-38
ORF Names:K03A1.6
AND
Name:his-46
ORF Names:B0035.9
AND
Name:his-50
ORF Names:F07B7.9
AND
Name:his-56
ORF Names:F54E12.3
AND
Name:his-60
ORF Names:F55G1.11
AND
Name:his-64
ORF Names:F22B3.1
AND
Name:his-67
ORF Names:T23D8.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V, Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
B0035.9 ; CE03252 ; WBGene00001920 ; his-46
C50F4.7 ; CE03252 ; WBGene00001911 ; his-37
F07B7.9 ; CE03252 ; WBGene00001924 ; his-50
F17E9.12 ; CE03252 ; WBGene00001905 ; his-31
F22B3.1 ; CE03252 ; WBGene00001938 ; his-64
F45F2.3 ; CE03252 ; WBGene00001879 ; his-5
F54E12.3 ; CE03252 ; WBGene00001930 ; his-56
F55G1.11 ; CE03252 ; WBGene00001934 ; his-60
K03A1.6 ; CE03252 ; WBGene00001912 ; his-38
K06C4.10 ; CE03252 ; WBGene00001892 ; his-18
K06C4.2 ; CE03252 ; WBGene00001902 ; his-28
T10C6.14 ; CE03252 ; WBGene00001875 ; his-1
T23D8.5 ; CE03252 ; WBGene00001941 ; his-67
ZK131.1 ; CE03252 ; WBGene00001900 ; his-26
ZK131.4 ; CE03252 ; WBGene00001884 ; his-10
ZK131.8 ; CE03252 ; WBGene00001888 ; his-14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001582902 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei21N6-methyllysine1 Publication1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P62784

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62784

PeptideAtlas

More...
PeptideAtlasi
P62784

PRoteomics IDEntifications database

More...
PRIDEi
P62784

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62784

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001875 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
43149, 1 interactor
44273, 1 interactor
44379, 2 interactors
53446, 48 interactors
56168, 1 interactor
56177, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P62784, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZK131.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62784

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3467 Eukaryota
COG2036 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198478

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234654

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62784

KEGG Orthology (KO)

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KOi
K11254

Identification of Orthologs from Complete Genome Data

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OMAi
QKEHING

Database of Orthologous Groups

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OrthoDBi
1564596at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62784

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00076 H4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15511 CENP-T_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00623 HISTONEH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00417 H4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00047 HISTONE_H4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P62784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYCEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,369
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E5DFD3F8AF04FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3G → E AA sequence (PubMed:3665432).Curated1
Sequence conflicti29Missing AA sequence (PubMed:3665432).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15634 Genomic DNA Translation: CAA33643.1
FO081018 Genomic DNA Translation: CCD68533.1
FO081059 Genomic DNA Translation: CCD68871.1
FO081135 Genomic DNA Translation: CCD69398.1
FO081223 Genomic DNA Translation: CCD70020.1
FO081551 Genomic DNA Translation: CCD72360.1
FO081551 Genomic DNA Translation: CCD72370.1
FO081579 Genomic DNA Translation: CCD72542.1
Z68336 Genomic DNA Translation: CAA92734.1
Z70750 Genomic DNA Translation: CAA94742.1
Z73102 Genomic DNA Translation: CAA97407.1
Z81128 Genomic DNA Translation: CAB03396.1
Z82271 Genomic DNA Translation: CAB05210.1
Z83245 Genomic DNA Translation: CAB05835.4
Z83245 Genomic DNA Translation: CAB05837.1
Z83245 Genomic DNA Translation: CAB05839.1
Z93388 Genomic DNA Translation: CAB07657.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JS0314
S04240
T27741
T29230

NCBI Reference Sequences

More...
RefSeqi
NP_492641.1, NM_060240.4
NP_496889.1, NM_064488.1
NP_496893.1, NM_064492.1
NP_496896.1, NM_064495.1
NP_501203.2, NM_068802.5
NP_501406.1, NM_069005.1
NP_502133.1, NM_069732.1
NP_502139.1, NM_069738.1
NP_502154.1, NM_069753.3
NP_505200.1, NM_072799.3
NP_505275.1, NM_072874.1
NP_505291.1, NM_072890.1
NP_505298.1, NM_072897.4
NP_505466.1, NM_073065.6
NP_507034.1, NM_074633.1
NP_509231.1, NM_076830.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0035.9.1; B0035.9.1; WBGene00001920
C50F4.7.1; C50F4.7.1; WBGene00001911
F07B7.9.1; F07B7.9.1; WBGene00001924
F17E9.12.1; F17E9.12.1; WBGene00001905
F22B3.1.1; F22B3.1.1; WBGene00001938
F45F2.3.1; F45F2.3.1; WBGene00001879
F54E12.3.1; F54E12.3.1; WBGene00001930
F55G1.11.1; F55G1.11.1; WBGene00001934
K03A1.6.1; K03A1.6.1; WBGene00001912
K06C4.10.1; K06C4.10.1; WBGene00001892
K06C4.2.1; K06C4.2.1; WBGene00001902
T10C6.14.1; T10C6.14.1; WBGene00001875
T23D8.5.1; T23D8.5.1; WBGene00001941
ZK131.1.1; ZK131.1.1; WBGene00001900
ZK131.4.1; ZK131.4.1; WBGene00001884
ZK131.8.1; ZK131.8.1; WBGene00001888

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175027
175032
177522
178050
178055
178066
179233
179260
179264
179267
179341
188792
191667
191671
191677
191680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_B0035.9
cel:CELE_C50F4.7
cel:CELE_F07B7.9
cel:CELE_F17E9.12
cel:CELE_F22B3.1
cel:CELE_F45F2.3
cel:CELE_F54E12.3
cel:CELE_F55G1.11
cel:CELE_K03A1.6
cel:CELE_K06C4.10
cel:CELE_K06C4.2
cel:CELE_T10C6.14
cel:CELE_T23D8.5
cel:CELE_ZK131.1
cel:CELE_ZK131.4
cel:CELE_ZK131.8

UCSC genome browser

More...
UCSCi
T23D8.5 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA Translation: CAA33643.1
FO081018 Genomic DNA Translation: CCD68533.1
FO081059 Genomic DNA Translation: CCD68871.1
FO081135 Genomic DNA Translation: CCD69398.1
FO081223 Genomic DNA Translation: CCD70020.1
FO081551 Genomic DNA Translation: CCD72360.1
FO081551 Genomic DNA Translation: CCD72370.1
FO081579 Genomic DNA Translation: CCD72542.1
Z68336 Genomic DNA Translation: CAA92734.1
Z70750 Genomic DNA Translation: CAA94742.1
Z73102 Genomic DNA Translation: CAA97407.1
Z81128 Genomic DNA Translation: CAB03396.1
Z82271 Genomic DNA Translation: CAB05210.1
Z83245 Genomic DNA Translation: CAB05835.4
Z83245 Genomic DNA Translation: CAB05837.1
Z83245 Genomic DNA Translation: CAB05839.1
Z93388 Genomic DNA Translation: CAB07657.1
PIRiJS0314
S04240
T27741
T29230
RefSeqiNP_492641.1, NM_060240.4
NP_496889.1, NM_064488.1
NP_496893.1, NM_064492.1
NP_496896.1, NM_064495.1
NP_501203.2, NM_068802.5
NP_501406.1, NM_069005.1
NP_502133.1, NM_069732.1
NP_502139.1, NM_069738.1
NP_502154.1, NM_069753.3
NP_505200.1, NM_072799.3
NP_505275.1, NM_072874.1
NP_505291.1, NM_072890.1
NP_505298.1, NM_072897.4
NP_505466.1, NM_073065.6
NP_507034.1, NM_074633.1
NP_509231.1, NM_076830.1

3D structure databases

SMRiP62784
ModBaseiSearch...

Protein-protein interaction databases

BioGridi43149, 1 interactor
44273, 1 interactor
44379, 2 interactors
53446, 48 interactors
56168, 1 interactor
56177, 1 interactor
IntActiP62784, 2 interactors
STRINGi6239.ZK131.8

PTM databases

iPTMnetiP62784

Proteomic databases

EPDiP62784
PaxDbiP62784
PeptideAtlasiP62784
PRIDEiP62784

Genome annotation databases

EnsemblMetazoaiB0035.9.1; B0035.9.1; WBGene00001920
C50F4.7.1; C50F4.7.1; WBGene00001911
F07B7.9.1; F07B7.9.1; WBGene00001924
F17E9.12.1; F17E9.12.1; WBGene00001905
F22B3.1.1; F22B3.1.1; WBGene00001938
F45F2.3.1; F45F2.3.1; WBGene00001879
F54E12.3.1; F54E12.3.1; WBGene00001930
F55G1.11.1; F55G1.11.1; WBGene00001934
K03A1.6.1; K03A1.6.1; WBGene00001912
K06C4.10.1; K06C4.10.1; WBGene00001892
K06C4.2.1; K06C4.2.1; WBGene00001902
T10C6.14.1; T10C6.14.1; WBGene00001875
T23D8.5.1; T23D8.5.1; WBGene00001941
ZK131.1.1; ZK131.1.1; WBGene00001900
ZK131.4.1; ZK131.4.1; WBGene00001884
ZK131.8.1; ZK131.8.1; WBGene00001888
GeneIDi175027
175032
177522
178050
178055
178066
179233
179260
179264
179267
179341
188792
191667
191671
191677
191680
KEGGicel:CELE_B0035.9
cel:CELE_C50F4.7
cel:CELE_F07B7.9
cel:CELE_F17E9.12
cel:CELE_F22B3.1
cel:CELE_F45F2.3
cel:CELE_F54E12.3
cel:CELE_F55G1.11
cel:CELE_K03A1.6
cel:CELE_K06C4.10
cel:CELE_K06C4.2
cel:CELE_T10C6.14
cel:CELE_T23D8.5
cel:CELE_ZK131.1
cel:CELE_ZK131.4
cel:CELE_ZK131.8
UCSCiT23D8.5 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175027
175032
177522
178050
178055
178066
179233
179260
179264
179267
179341
188792
191667
191671
191677
191680
WormBaseiB0035.9 ; CE03252 ; WBGene00001920 ; his-46
C50F4.7 ; CE03252 ; WBGene00001911 ; his-37
F07B7.9 ; CE03252 ; WBGene00001924 ; his-50
F17E9.12 ; CE03252 ; WBGene00001905 ; his-31
F22B3.1 ; CE03252 ; WBGene00001938 ; his-64
F45F2.3 ; CE03252 ; WBGene00001879 ; his-5
F54E12.3 ; CE03252 ; WBGene00001930 ; his-56
F55G1.11 ; CE03252 ; WBGene00001934 ; his-60
K03A1.6 ; CE03252 ; WBGene00001912 ; his-38
K06C4.10 ; CE03252 ; WBGene00001892 ; his-18
K06C4.2 ; CE03252 ; WBGene00001902 ; his-28
T10C6.14 ; CE03252 ; WBGene00001875 ; his-1
T23D8.5 ; CE03252 ; WBGene00001941 ; his-67
ZK131.1 ; CE03252 ; WBGene00001900 ; his-26
ZK131.4 ; CE03252 ; WBGene00001884 ; his-10
ZK131.8 ; CE03252 ; WBGene00001888 ; his-14

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00980000198478
HOGENOMiHOG000234654
InParanoidiP62784
KOiK11254
OMAiQKEHING
OrthoDBi1564596at2759
PhylomeDBiP62784

Enzyme and pathway databases

ReactomeiR-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-212300 PRC2 methylates histones and DNA
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3214815 HDACs deacetylate histones
R-CEL-3214841 PKMTs methylate histone lysines
R-CEL-3214842 HDMs demethylate histones
R-CEL-3214847 HATs acetylate histones
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-427359 SIRT1 negatively regulates rRNA expression
R-CEL-427413 NoRC negatively regulates rRNA expression
R-CEL-4551638 SUMOylation of chromatin organization proteins
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-73772 RNA Polymerase I Promoter Escape
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P62784

Gene expression databases

BgeeiWBGene00001875 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH4_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62784
Secondary accession number(s): O02619
, P02306, P18678, Q7JNV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: December 11, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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