Myotrophin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy."
    Gupta S., Sen S.
    Biochim Biophys Acta 1589:247-260(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• catecholamine metabolic process Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells."
    Suzuki T., Inagaki H., Yamakuni T., Nagatsu T., Ichinose H.
    Biochem Biophys Res Commun 293:962-968(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy."
    Gupta S., Sen S.
    Biochim Biophys Acta 1589:247-260(2002) [PubMed] [Europe PMC] [Abstract]
• cerebellar granule cell differentiation Source: RGDInferred from expression patternⁱ
  • Ref.1

    "Murine cerebellar neurons express a novel gene encoding a protein related to cell cycle control and cell fate determination proteins."
    Taoka M., Isobe T., Okuyama T., Watanabe M., Kondo H., Yamakawa Y., Ozawa F., Hishinuma F., Kubota M., Minegishi A., Song S.-Y., Yamakuni T.
    J. Biol. Chem. 269:9946-9951(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• neuron differentiation Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.2

    "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro."
    Sivasubramanian N.C., Adhikary G., Sil P.C., Sen S.
    J. Biol. Chem. 271:2812-2816(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of cardiac muscle hypertrophy Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.8

    "Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops."
    Das B., Gupta S., Vasanji A., Xu Z., Misra S., Sen S.
    J. Biol. Chem. 283:27947-27956(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RELA, MUTAGENESIS OF GLU-33, FUNCTION.
• positive regulation of cell growth Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops."
    Das B., Gupta S., Vasanji A., Xu Z., Misra S., Sen S.
    J. Biol. Chem. 283:27947-27956(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RELA, MUTAGENESIS OF GLU-33, FUNCTION.
• positive regulation of macromolecule biosynthetic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops."
    Das B., Gupta S., Vasanji A., Xu Z., Misra S., Sen S.
    J. Biol. Chem. 283:27947-27956(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RELA, MUTAGENESIS OF GLU-33, FUNCTION.
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops."
    Das B., Gupta S., Vasanji A., Xu Z., Misra S., Sen S.
    J. Biol. Chem. 283:27947-27956(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RELA, MUTAGENESIS OF GLU-33, FUNCTION.
• positive regulation of protein metabolic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops."
    Das B., Gupta S., Vasanji A., Xu Z., Misra S., Sen S.
    J. Biol. Chem. 283:27947-27956(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RELA, MUTAGENESIS OF GLU-33, FUNCTION.
• regulation of barbed-end actin filament capping Source: UniProtKB
• regulation of cell size Source: RGD
• skeletal muscle tissue regeneration Source: RGDInferred from expression patternⁱ
  • "Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy."
    Furukawa Y., Hashimoto N., Yamakuni T., Ishida Y., Kato C., Ogashiwa M., Kobayashi M., Kobayashi T., Nonaka I., Mizusawa H., Song S.Y.
    Neuromuscul Disord 13:32-41(2003) [PubMed] [Europe PMC] [Abstract]
• striated muscle cell differentiation Source: RGDInferred from expression patternⁱ
  • "Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy."
    Furukawa Y., Hashimoto N., Yamakuni T., Ishida Y., Kato C., Ogashiwa M., Kobayashi M., Kobayashi T., Nonaka I., Mizusawa H., Song S.Y.
    Neuromuscul Disord 13:32-41(2003) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI 
        60         70         80         90        100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD 
       110 
GLTALEATDN QAIKALLQ                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families