UniProtKB - P62775 (MTPN_RAT)
Protein
Myotrophin
Gene
Mtpn
Organism
Rattus norvegicus (Rat)
Status
Functioni
Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.By similarity2 Publications
GO - Molecular functioni
- sequence-specific DNA binding Source: RGD
GO - Biological processi
- catecholamine metabolic process Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cerebellar granule cell differentiation Source: RGD
- neuron differentiation Source: UniProtKB
- positive regulation of cardiac muscle hypertrophy Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of macromolecule biosynthetic process Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of protein metabolic process Source: UniProtKB
- regulation of barbed-end actin filament capping Source: UniProtKB
- regulation of cell size Source: RGD
- skeletal muscle tissue regeneration Source: RGD
- striated muscle cell differentiation Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: MyotrophinAlternative name(s): Granule cell differentiation protein Protein V-1 |
Gene namesi | Name:Mtpn Synonyms:Gcdp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619806, Mtpn |
Subcellular locationi
Nucleus
Other locations
Cytoskeleton
- F-actin capping protein complex Source: RGD
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon Source: RGD
- cytoplasm Source: RGD
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 33 | E → A: Reduced interaction with RELA. Reduced translocation to the nucleus. Reduced activation of NF-kappa-B transcription factor activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000067033 | 2 – 118 | MyotrophinAdd BLAST | 117 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteine1 Publication | 1 | |
Modified residuei | 4 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 11 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 24 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 31 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P62775 |
PaxDbi | P62775 |
PRIDEi | P62775 |
PTM databases
iPTMneti | P62775 |
PhosphoSitePlusi | P62775 |
Expressioni
Developmental stagei
At the completion of differentiation and migration of granular cells and at the initiation of the formation of synapses in cerebellar neurons.
Gene expression databases
Bgeei | ENSRNOG00000011857, Expressed in brain and 21 other tissues |
Genevisiblei | P62775, RN |
Interactioni
Subunit structurei
Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity).
Interacts with RELA.
By similarity1 PublicationBinary interactionsi
P62775
With | #Exp. | IntAct |
---|---|---|
Capzb [Q5XI32] | 3 | EBI-2128047,EBI-2128068 |
Protein-protein interaction databases
IntActi | P62775, 1 interactor |
STRINGi | 10116.ENSRNOP00000015808 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P62775 |
SMRi | P62775 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62775 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 2 – 30 | ANK 1Add BLAST | 29 | |
Repeati | 34 – 66 | ANK 2Add BLAST | 33 | |
Repeati | 67 – 99 | ANK 3Add BLAST | 33 |
Sequence similaritiesi
Belongs to the myotrophin family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4214, Eukaryota |
GeneTreei | ENSGT00430000031071 |
HOGENOMi | CLU_000134_45_7_1 |
InParanoidi | P62775 |
OMAi | TALIDCT |
OrthoDBi | 1435166at2759 |
PhylomeDBi | P62775 |
TreeFami | TF327387 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P62775-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26179 mRNA Translation: BAA05167.1 U21661 mRNA Translation: AAC52498.1 AY951952 mRNA Translation: AAX54865.1 BC088136 mRNA Translation: AAH88136.1 |
PIRi | A54412 |
RefSeqi | NP_077350.1, NM_024374.4 |
Genome annotation databases
Ensembli | ENSRNOT00000015808; ENSRNOP00000015808; ENSRNOG00000011857 |
GeneIDi | 79215 |
KEGGi | rno:79215 |
UCSCi | RGD:619806, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26179 mRNA Translation: BAA05167.1 U21661 mRNA Translation: AAC52498.1 AY951952 mRNA Translation: AAX54865.1 BC088136 mRNA Translation: AAH88136.1 |
PIRi | A54412 |
RefSeqi | NP_077350.1, NM_024374.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MYO | NMR | - | A | 1-118 | [»] | |
2MYO | NMR | - | A | 1-118 | [»] | |
BMRBi | P62775 | |||||
SMRi | P62775 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P62775, 1 interactor |
STRINGi | 10116.ENSRNOP00000015808 |
PTM databases
iPTMneti | P62775 |
PhosphoSitePlusi | P62775 |
Proteomic databases
jPOSTi | P62775 |
PaxDbi | P62775 |
PRIDEi | P62775 |
Genome annotation databases
Ensembli | ENSRNOT00000015808; ENSRNOP00000015808; ENSRNOG00000011857 |
GeneIDi | 79215 |
KEGGi | rno:79215 |
UCSCi | RGD:619806, rat |
Organism-specific databases
CTDi | 136319 |
RGDi | 619806, Mtpn |
Phylogenomic databases
eggNOGi | KOG4214, Eukaryota |
GeneTreei | ENSGT00430000031071 |
HOGENOMi | CLU_000134_45_7_1 |
InParanoidi | P62775 |
OMAi | TALIDCT |
OrthoDBi | 1435166at2759 |
PhylomeDBi | P62775 |
TreeFami | TF327387 |
Miscellaneous databases
EvolutionaryTracei | P62775 |
PROi | PR:P62775 |
Gene expression databases
Bgeei | ENSRNOG00000011857, Expressed in brain and 21 other tissues |
Genevisiblei | P62775, RN |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTPN_RAT | |
Accessioni | P62775Primary (citable) accession number: P62775 Secondary accession number(s): P80144, Q58HB3, Q9DCN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | October 7, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families