UniProtKB - P62774 (MTPN_MOUSE)
Protein
Myotrophin
Gene
Mtpn
Organism
Mus musculus (Mouse)
Status
Functioni
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication
GO - Molecular functioni
- sequence-specific DNA binding Source: MGI
GO - Biological processi
- catecholamine metabolic process Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cerebellar granule cell differentiation Source: Ensembl
- positive regulation of cardiac muscle hypertrophy Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of macromolecule biosynthetic process Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of protein metabolic process Source: UniProtKB
- regulation of barbed-end actin filament capping Source: UniProtKB
- regulation of cell size Source: MGI
- skeletal muscle tissue regeneration Source: Ensembl
- striated muscle cell differentiation Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: MyotrophinAlternative name(s): Granule cell differentiation protein Protein V-1 |
Gene namesi | Name:Mtpn Synonyms:Gcdp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99445, Mtpn |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm Curated
- perinuclear region By similarity
Cytoskeleton
- F-actin capping protein complex Source: MGI
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon Source: MGI
- cytoplasm Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000067032 | 2 – 118 | MyotrophinAdd BLAST | 117 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteineCombined sources | 1 | |
Modified residuei | 4 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 11 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 24 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 31 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3730 |
EPDi | P62774 |
jPOSTi | P62774 |
MaxQBi | P62774 |
PaxDbi | P62774 |
PeptideAtlasi | P62774 |
PRIDEi | P62774 |
PTM databases
iPTMneti | P62774 |
PhosphoSitePlusi | P62774 |
SwissPalmi | P62774 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029840, Expressed in lens of camera-type eye and 331 other tissues |
ExpressionAtlasi | P62774, baseline and differential |
Genevisiblei | P62774, MM |
Interactioni
Subunit structurei
Interacts with RELA (By similarity).
Interacts with the heterodimer formed by CAPZA1 and CAPZB.
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 199860, 6 interactors |
IntActi | P62774, 3 interactors |
MINTi | P62774 |
STRINGi | 10090.ENSMUSP00000031866 |
Miscellaneous databases
RNActi | P62774, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P62774 |
SMRi | P62774 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 2 – 30 | ANK 1Add BLAST | 29 | |
Repeati | 34 – 66 | ANK 2Add BLAST | 33 | |
Repeati | 67 – 99 | ANK 3Add BLAST | 33 |
Sequence similaritiesi
Belongs to the myotrophin family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4214, Eukaryota |
GeneTreei | ENSGT00430000031071 |
InParanoidi | P62774 |
OMAi | TALIDCT |
OrthoDBi | 1435166at2759 |
PhylomeDBi | P62774 |
TreeFami | TF327387 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P62774-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YV46 | A0A0J9YV46_MOUSE | Myotrophin | Mtpn | 73 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | E → K in BAB22235 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20290 mRNA Translation: AAA86719.1 AK002620 mRNA Translation: BAB22235.1 AK028027 mRNA Translation: BAC25707.1 AK049398 mRNA Translation: BAC33734.1 AK083888 mRNA Translation: BAC39050.1 AK132029 mRNA Translation: BAE20953.1 AK145755 mRNA Translation: BAE26630.1 AK146305 mRNA Translation: BAE27061.1 AK146473 mRNA Translation: BAE27198.1 AK150750 mRNA Translation: BAE29820.1 AK151106 mRNA Translation: BAE30116.1 AK151147 mRNA Translation: BAE30153.1 AK151485 mRNA Translation: BAE30438.1 AK151564 mRNA Translation: BAE30506.1 AK151640 mRNA Translation: BAE30570.1 AK151687 mRNA Translation: BAE30611.1 AK152272 mRNA Translation: BAE31088.1 BC043084 mRNA Translation: AAH43084.1 BC054811 mRNA Translation: AAH54811.1 |
CCDSi | CCDS20002.1 |
RefSeqi | NP_032124.1, NM_008098.4 |
Genome annotation databases
Ensembli | ENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840 |
GeneIDi | 14489 |
KEGGi | mmu:14489 |
UCSCi | uc009bit.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20290 mRNA Translation: AAA86719.1 AK002620 mRNA Translation: BAB22235.1 AK028027 mRNA Translation: BAC25707.1 AK049398 mRNA Translation: BAC33734.1 AK083888 mRNA Translation: BAC39050.1 AK132029 mRNA Translation: BAE20953.1 AK145755 mRNA Translation: BAE26630.1 AK146305 mRNA Translation: BAE27061.1 AK146473 mRNA Translation: BAE27198.1 AK150750 mRNA Translation: BAE29820.1 AK151106 mRNA Translation: BAE30116.1 AK151147 mRNA Translation: BAE30153.1 AK151485 mRNA Translation: BAE30438.1 AK151564 mRNA Translation: BAE30506.1 AK151640 mRNA Translation: BAE30570.1 AK151687 mRNA Translation: BAE30611.1 AK152272 mRNA Translation: BAE31088.1 BC043084 mRNA Translation: AAH43084.1 BC054811 mRNA Translation: AAH54811.1 |
CCDSi | CCDS20002.1 |
RefSeqi | NP_032124.1, NM_008098.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KXP | NMR | - | C | 1-118 | [»] | |
BMRBi | P62774 | |||||
SMRi | P62774 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 199860, 6 interactors |
IntActi | P62774, 3 interactors |
MINTi | P62774 |
STRINGi | 10090.ENSMUSP00000031866 |
PTM databases
iPTMneti | P62774 |
PhosphoSitePlusi | P62774 |
SwissPalmi | P62774 |
Proteomic databases
CPTACi | non-CPTAC-3730 |
EPDi | P62774 |
jPOSTi | P62774 |
MaxQBi | P62774 |
PaxDbi | P62774 |
PeptideAtlasi | P62774 |
PRIDEi | P62774 |
Protocols and materials databases
Antibodypediai | 18167, 90 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840 |
GeneIDi | 14489 |
KEGGi | mmu:14489 |
UCSCi | uc009bit.2, mouse |
Organism-specific databases
CTDi | 136319 |
MGIi | MGI:99445, Mtpn |
Phylogenomic databases
eggNOGi | KOG4214, Eukaryota |
GeneTreei | ENSGT00430000031071 |
InParanoidi | P62774 |
OMAi | TALIDCT |
OrthoDBi | 1435166at2759 |
PhylomeDBi | P62774 |
TreeFami | TF327387 |
Miscellaneous databases
BioGRID-ORCSi | 14489, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mtpn, mouse |
PROi | PR:P62774 |
RNActi | P62774, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029840, Expressed in lens of camera-type eye and 331 other tissues |
ExpressionAtlasi | P62774, baseline and differential |
Genevisiblei | P62774, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTPN_MOUSE | |
Accessioni | P62774Primary (citable) accession number: P62774 Secondary accession number(s): P80144, Q543M6, Q9DCN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families