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Protein

Myotrophin

Gene

Mtpn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Granule cell differentiation protein
Protein V-1
Gene namesi
Name:Mtpn
Synonyms:Gcdp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99445 Mtpn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000670322 – 118MyotrophinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineCombined sources1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei11N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei31PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62774
MaxQBiP62774
PaxDbiP62774
PeptideAtlasiP62774
PRIDEiP62774

PTM databases

iPTMnetiP62774
PhosphoSitePlusiP62774
SwissPalmiP62774

Expressioni

Gene expression databases

BgeeiENSMUSG00000029840 Expressed in 320 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_MTPN
ExpressionAtlasiP62774 baseline and differential
GenevisibleiP62774 MM

Interactioni

Subunit structurei

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity1 Publication

Protein-protein interaction databases

BioGridi199860, 1 interactor
IntActiP62774, 3 interactors
MINTiP62774
STRINGi10090.ENSMUSP00000031866

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62774
SMRiP62774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 30ANK 1Add BLAST29
Repeati34 – 66ANK 2Add BLAST33
Repeati67 – 99ANK 3Add BLAST33

Sequence similaritiesi

Belongs to the myotrophin family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214 Eukaryota
ENOG4111U90 LUCA
GeneTreeiENSGT00430000031071
HOGENOMiHOG000276399
HOVERGENiHBG019067
InParanoidiP62774
OMAiTALIDCT
OrthoDBiEOG091G0Y4J
PhylomeDBiP62774
TreeFamiTF327387

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62774-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTALEATDN QAIKALLQ
Length:118
Mass (Da):12,861
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61DB8BA2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YV46A0A0J9YV46_MOUSE
Myotrophin
Mtpn
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → K in BAB22235 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA Translation: AAA86719.1
AK002620 mRNA Translation: BAB22235.1
AK028027 mRNA Translation: BAC25707.1
AK049398 mRNA Translation: BAC33734.1
AK083888 mRNA Translation: BAC39050.1
AK132029 mRNA Translation: BAE20953.1
AK145755 mRNA Translation: BAE26630.1
AK146305 mRNA Translation: BAE27061.1
AK146473 mRNA Translation: BAE27198.1
AK150750 mRNA Translation: BAE29820.1
AK151106 mRNA Translation: BAE30116.1
AK151147 mRNA Translation: BAE30153.1
AK151485 mRNA Translation: BAE30438.1
AK151564 mRNA Translation: BAE30506.1
AK151640 mRNA Translation: BAE30570.1
AK151687 mRNA Translation: BAE30611.1
AK152272 mRNA Translation: BAE31088.1
BC043084 mRNA Translation: AAH43084.1
BC054811 mRNA Translation: AAH54811.1
CCDSiCCDS20002.1
RefSeqiNP_032124.1, NM_008098.4
UniGeneiMm.182746

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840
GeneIDi14489
KEGGimmu:14489
UCSCiuc009bit.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20290 mRNA Translation: AAA86719.1
AK002620 mRNA Translation: BAB22235.1
AK028027 mRNA Translation: BAC25707.1
AK049398 mRNA Translation: BAC33734.1
AK083888 mRNA Translation: BAC39050.1
AK132029 mRNA Translation: BAE20953.1
AK145755 mRNA Translation: BAE26630.1
AK146305 mRNA Translation: BAE27061.1
AK146473 mRNA Translation: BAE27198.1
AK150750 mRNA Translation: BAE29820.1
AK151106 mRNA Translation: BAE30116.1
AK151147 mRNA Translation: BAE30153.1
AK151485 mRNA Translation: BAE30438.1
AK151564 mRNA Translation: BAE30506.1
AK151640 mRNA Translation: BAE30570.1
AK151687 mRNA Translation: BAE30611.1
AK152272 mRNA Translation: BAE31088.1
BC043084 mRNA Translation: AAH43084.1
BC054811 mRNA Translation: AAH54811.1
CCDSiCCDS20002.1
RefSeqiNP_032124.1, NM_008098.4
UniGeneiMm.182746

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KXPNMR-C1-118[»]
ProteinModelPortaliP62774
SMRiP62774
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199860, 1 interactor
IntActiP62774, 3 interactors
MINTiP62774
STRINGi10090.ENSMUSP00000031866

PTM databases

iPTMnetiP62774
PhosphoSitePlusiP62774
SwissPalmiP62774

Proteomic databases

EPDiP62774
MaxQBiP62774
PaxDbiP62774
PeptideAtlasiP62774
PRIDEiP62774

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840
GeneIDi14489
KEGGimmu:14489
UCSCiuc009bit.2 mouse

Organism-specific databases

CTDi136319
MGIiMGI:99445 Mtpn

Phylogenomic databases

eggNOGiKOG4214 Eukaryota
ENOG4111U90 LUCA
GeneTreeiENSGT00430000031071
HOGENOMiHOG000276399
HOVERGENiHBG019067
InParanoidiP62774
OMAiTALIDCT
OrthoDBiEOG091G0Y4J
PhylomeDBiP62774
TreeFamiTF327387

Miscellaneous databases

ChiTaRSiMtpn mouse
PROiPR:P62774
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029840 Expressed in 320 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_MTPN
ExpressionAtlasiP62774 baseline and differential
GenevisibleiP62774 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_MOUSE
AccessioniPrimary (citable) accession number: P62774
Secondary accession number(s): P80144, Q543M6, Q9DCN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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