Mtpn

Functionⁱ

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.By similarity1 Publication

GO - Molecular functionⁱ

sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

catecholamine metabolic process Source: Ensembl
cellular response to mechanical stimulus Source: Ensembl
cerebellar granule cell differentiation Source: Ensembl
positive regulation of cardiac muscle hypertrophy Source: UniProtKB
positive regulation of cell growth Source: UniProtKB
positive regulation of macromolecule biosynthetic process Source: UniProtKB
positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
positive regulation of protein metabolic process Source: UniProtKB
regulation of barbed-end actin filament capping Source: UniProtKB
regulation of cell size Source: MGI
skeletal muscle tissue regeneration Source: Ensembl
striated muscle cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myotrophin Alternative name(s): Granule cell differentiation protein Protein V-1
Gene namesⁱ	Name:Mtpn Synonyms:Gcdp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:99445 Mtpn

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000067032	2 – 118	MyotrophinAdd BLAST		117

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylcysteineCombined sources	1
Modified residueⁱ	4	N6-acetyllysineCombined sources	1
Modified residueⁱ	11	N6-acetyllysineBy similarity	1
Modified residueⁱ	24	N6-acetyllysineBy similarity	1
Modified residueⁱ	31	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P62774
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62774
PaxDbⁱ	P62774
PeptideAtlas More...PeptideAtlasⁱ	P62774
PRIDEⁱ	P62774

PTM databases

iPTMnetⁱ	P62774
PhosphoSitePlusⁱ	P62774
SwissPalmⁱ	P62774

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029840 Expressed in 320 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	MM_MTPN
ExpressionAtlasⁱ	P62774 baseline and differential
Genevisibleⁱ	P62774 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	199860, 1 interactor
IntActⁱ	P62774, 3 interactors
Molecular INTeraction database More...MINTⁱ	P62774
STRINGⁱ	10090.ENSMUSP00000031866

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 7	Combined sources	5
Helixⁱ	9 – 12	Combined sources	4
Helixⁱ	15 – 22	Combined sources	8
Turnⁱ	23 – 25	Combined sources	3
Beta strandⁱ	32 – 35	Combined sources	4
Helixⁱ	40 – 45	Combined sources	6
Turnⁱ	47 – 49	Combined sources	3
Helixⁱ	53 – 56	Combined sources	4
Turnⁱ	60 – 62	Combined sources	3
Helixⁱ	71 – 76	Combined sources	6
Helixⁱ	82 – 88	Combined sources	7
Beta strandⁱ	96 – 101	Combined sources	6
Helixⁱ	102 – 106	Combined sources	5
Helixⁱ	111 – 114	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P62774
SMRⁱ	P62774
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	2 – 30	ANK 1Add BLAST	29
Repeatⁱ	34 – 66	ANK 2Add BLAST	33
Repeatⁱ	67 – 99	ANK 3Add BLAST	33

Sequence similaritiesⁱ

Belongs to the myotrophin family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4214 Eukaryota ENOG4111U90 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00430000031071
HOGENOMⁱ	HOG000276399
HOVERGENⁱ	HBG019067
InParanoidⁱ	P62774
OMAⁱ	TALIDCT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y4J
PhylomeDBⁱ	P62774
TreeFamⁱ	TF327387

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P62774-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI 
        60         70         80         90        100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD 
       110 
GLTALEATDN QAIKALLQ

Length:118

Mass (Da):12,861

Last modified:January 23, 2007 - v2

Checksum:ⁱ9097FFDF61DB8BA2

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0J9YV46	A0A0J9YV46_MOUSE		Myotrophin Myotrophin	Mtpn	73	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	26	E → K in BAB22235 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20290 mRNA Translation: AAA86719.1 AK002620 mRNA Translation: BAB22235.1 AK028027 mRNA Translation: BAC25707.1 AK049398 mRNA Translation: BAC33734.1 AK083888 mRNA Translation: BAC39050.1 AK132029 mRNA Translation: BAE20953.1 AK145755 mRNA Translation: BAE26630.1 AK146305 mRNA Translation: BAE27061.1 AK146473 mRNA Translation: BAE27198.1 AK150750 mRNA Translation: BAE29820.1 AK151106 mRNA Translation: BAE30116.1 AK151147 mRNA Translation: BAE30153.1 AK151485 mRNA Translation: BAE30438.1 AK151564 mRNA Translation: BAE30506.1 AK151640 mRNA Translation: BAE30570.1 AK151687 mRNA Translation: BAE30611.1 AK152272 mRNA Translation: BAE31088.1 BC043084 mRNA Translation: AAH43084.1 BC054811 mRNA Translation: AAH54811.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20002.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032124.1, NM_008098.4
UniGeneⁱ	Mm.182746

Genome annotation databases

Ensemblⁱ	ENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840
GeneIDⁱ	14489
KEGGⁱ	mmu:14489
UCSC genome browser More...UCSCⁱ	uc009bit.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62774	Myotrophin	)	RAT		118	UniRef100_P62774
Uncharacterized protein		LOXAF		118
Uncharacterized protein		RABIT		118
Myotrophin		FUKDA		118
Uncharacterized protein		CAVPO		118
+2

Protein	Similar proteins		Species	Score	Length	Source
P62774	Myotrophin	)	HUMAN		118	UniRef90_P58546
Myotrophin		BOVIN		118
Myotrophin		CANLF		118
Myotrophin	)	RAT		118
Myotrophin		CHICK		118
+101

Protein	Similar proteins		Species	Score	Length	Source
P62774	Myotrophin	)	HUMAN		118	UniRef50_P58546
Myotrophin		BOVIN		118
Myotrophin		CANLF		118
Myotrophin		CHICK		118
Myotrophin	)	RAT		118
+105

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20290 mRNA Translation: AAA86719.1 AK002620 mRNA Translation: BAB22235.1 AK028027 mRNA Translation: BAC25707.1 AK049398 mRNA Translation: BAC33734.1 AK083888 mRNA Translation: BAC39050.1 AK132029 mRNA Translation: BAE20953.1 AK145755 mRNA Translation: BAE26630.1 AK146305 mRNA Translation: BAE27061.1 AK146473 mRNA Translation: BAE27198.1 AK150750 mRNA Translation: BAE29820.1 AK151106 mRNA Translation: BAE30116.1 AK151147 mRNA Translation: BAE30153.1 AK151485 mRNA Translation: BAE30438.1 AK151564 mRNA Translation: BAE30506.1 AK151640 mRNA Translation: BAE30570.1 AK151687 mRNA Translation: BAE30611.1 AK152272 mRNA Translation: BAE31088.1 BC043084 mRNA Translation: AAH43084.1 BC054811 mRNA Translation: AAH54811.1
CCDSⁱ	CCDS20002.1
RefSeqⁱ	NP_032124.1, NM_008098.4
UniGeneⁱ	Mm.182746

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KXP	NMR	-	C	1-118	[»]
ProteinModelPortalⁱ	P62774
SMRⁱ	P62774
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199860, 1 interactor
IntActⁱ	P62774, 3 interactors
MINTⁱ	P62774
STRINGⁱ	10090.ENSMUSP00000031866

PTM databases

iPTMnetⁱ	P62774
PhosphoSitePlusⁱ	P62774
SwissPalmⁱ	P62774

Proteomic databases

EPDⁱ	P62774
MaxQBⁱ	P62774
PaxDbⁱ	P62774
PeptideAtlasⁱ	P62774
PRIDEⁱ	P62774

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031866; ENSMUSP00000031866; ENSMUSG00000029840
GeneIDⁱ	14489
KEGGⁱ	mmu:14489
UCSCⁱ	uc009bit.2 mouse

Organism-specific databases

CTDⁱ	136319
MGIⁱ	MGI:99445 Mtpn

Phylogenomic databases

eggNOGⁱ	KOG4214 Eukaryota ENOG4111U90 LUCA
GeneTreeⁱ	ENSGT00430000031071
HOGENOMⁱ	HOG000276399
HOVERGENⁱ	HBG019067
InParanoidⁱ	P62774
OMAⁱ	TALIDCT
OrthoDBⁱ	EOG091G0Y4J
PhylomeDBⁱ	P62774
TreeFamⁱ	TF327387

Miscellaneous databases

ChiTaRSⁱ	Mtpn mouse
Protein Ontology More...PROⁱ	PR:P62774
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029840 Expressed in 320 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	MM_MTPN
ExpressionAtlasⁱ	P62774 baseline and differential
Genevisibleⁱ	P62774 MM

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTPN_MOUSE
Accessionⁱ	P62774Primary (citable) accession number: P62774 Secondary accession number(s): P80144, Q543M6, Q9DCN8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Supporting data

UniProtKB - P62774 (MTPN_MOUSE)

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Myotrophin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ