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Protein

40S ribosomal protein S6

Gene

Rps6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

GO - Molecular functioni

GO - Biological processi

  • activation-induced cell death of T cells Source: MGI
  • erythrocyte development Source: MGI
  • G1/S transition of mitotic cell cycle Source: MGI
  • gastrulation Source: MGI
  • glucose homeostasis Source: UniProtKB
  • mammalian oogenesis stage Source: MGI
  • mitotic cell cycle Source: MGI
  • mitotic cell cycle checkpoint Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • placenta development Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • ribosomal small subunit biogenesis Source: MGI
  • rRNA processing Source: MGI
  • T cell differentiation in thymus Source: MGI
  • T cell proliferation involved in immune response Source: MGI
  • TOR signaling Source: MGI
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-166208 mTORC1-mediated signalling
R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6
Alternative name(s):
Phosphoprotein NP33
Gene namesi
Name:Rps6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98159 Rps6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373131 – 24940S ribosomal protein S6Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei148PhosphoserineBy similarity1
Modified residuei211N6-acetyllysineCombined sources1
Modified residuei235Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASKBy similarity1
Modified residuei236Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASKBy similarity1
Modified residuei240Phosphoserine2 Publications1
Modified residuei242PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources2 Publications1
Modified residuei247Phosphoserine1 Publication1

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62754
PaxDbiP62754
PeptideAtlasiP62754
PRIDEiP62754

PTM databases

iPTMnetiP62754
PhosphoSitePlusiP62754
SwissPalmiP62754

Expressioni

Gene expression databases

BgeeiENSMUSG00000028495
CleanExiMM_RPS6
ExpressionAtlasiP62754 baseline and differential
GenevisibleiP62754 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203013, 6 interactors
CORUMiP62754
DIPiDIP-42772N
IntActiP62754, 13 interactors
MINTiP62754
STRINGi10090.ENSMUSP00000099878

Structurei

3D structure databases

ProteinModelPortaliP62754
SMRiP62754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1646 Eukaryota
COG2125 LUCA
GeneTreeiENSGT00390000009819
HOGENOMiHOG000190952
HOVERGENiHBG011441
InParanoidiP62754
KOiK02991
OMAiKGYIFRI
OrthoDBiEOG091G089B
PhylomeDBiP62754
TreeFamiTF300035

Family and domain databases

InterProiView protein in InterPro
IPR014401 Ribosomal_S6_euk
IPR001377 Ribosomal_S6e
IPR018282 Ribosomal_S6e_CS
PANTHERiPTHR11502 PTHR11502, 1 hit
PfamiView protein in Pfam
PF01092 Ribosomal_S6e, 1 hit
PIRSFiPIRSF002129 Ribosom_S6_euk, 1 hit
SMARTiView protein in SMART
SM01405 Ribosomal_S6e, 1 hit
PROSITEiView protein in PROSITE
PS00578 RIBOSOMAL_S6E, 1 hit

Sequencei

Sequence statusi: Complete.

P62754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV
60 70 80 90 100
RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC
110 120 130 140 150
IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE
160 170 180 190 200
DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV TPRVLQHKRR RIALKKQRTK
210 220 230 240
KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS TSKSESSQK
Length:249
Mass (Da):28,681
Last modified:August 1, 1988 - v1
Checksum:iA61E435884E636AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00348 mRNA Translation: CAA68430.1
Z54209 Genomic DNA Translation: CAA90936.1
AK012284 mRNA Translation: BAB28142.1
AK012828 mRNA Translation: BAB28498.1
AK013333 mRNA Translation: BAB28796.1
AK050609 mRNA Translation: BAC34340.1
BC010604 mRNA Translation: AAH10604.1
CCDSiCCDS18310.1
PIRiS00660 R3MS6
RefSeqiNP_033122.1, NM_009096.3
XP_011238179.1, XM_011239877.1
UniGeneiMm.379007
Mm.425090

Genome annotation databases

EnsembliENSMUST00000102814; ENSMUSP00000099878; ENSMUSG00000028495
GeneIDi105244208
20104
KEGGimmu:105244208
mmu:20104
UCSCiuc008tme.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRS6_MOUSE
AccessioniPrimary (citable) accession number: P62754
Secondary accession number(s): P08227, P10660
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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