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Entry version 167 (16 Oct 2019)
Sequence version 1 (01 Aug 1988)
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Protein

40S ribosomal protein S6

Gene

RPS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-166208 mTORC1-mediated signalling
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P62753

SIGNOR Signaling Network Open Resource

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SIGNORi
P62753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S61 Publication
Alternative name(s):
Phosphoprotein NP33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS61 PublicationImported
ORF Names:OK/SW-cl.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10429 RPS6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
180460 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P62753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi137R → X: Abolishes hydroxylation by KDM8. 1 Publication1
Mutagenesisi235 – 236SS → AA: Abolishes phosphorylation by PASK. 1 Publication2

Organism-specific databases

DisGeNET

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DisGeNETi
6194

Open Targets

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OpenTargetsi
ENSG00000137154

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34844

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P62753

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3351215

Drug and drug target database

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DrugBanki
DB11638 Artenimol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51338632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001373121 – 24940S ribosomal protein S6Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei137(3R)-3-hydroxyarginine1 Publication1
Modified residuei148PhosphoserineCombined sources1
Modified residuei211N6-acetyllysineCombined sources1
Modified residuei235Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASKCombined sources3 Publications1
Modified residuei236Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASKCombined sources3 Publications1
Modified residuei240PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.3 Publications
Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.1 Publication

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1331
CPTAC-1332
CPTAC-1333

Encyclopedia of Proteome Dynamics

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EPDi
P62753

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62753

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P62753

MaxQB - The MaxQuant DataBase

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MaxQBi
P62753

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62753

PeptideAtlas

More...
PeptideAtlasi
P62753

PRoteomics IDEntifications database

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PRIDEi
P62753

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57422

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62753

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62753

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137154 Expressed in 236 organ(s), highest expression level in connective tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62753 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62753 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004027
HPA031153

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112108, 451 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62753

Database of interacting proteins

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DIPi
DIP-31507N

Protein interaction database and analysis system

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IntActi
P62753, 319 interactors

Molecular INTeraction database

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MINTi
P62753

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369757

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62753

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1646 Eukaryota
COG2125 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000190952

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62753

KEGG Orthology (KO)

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KOi
K02991

Identification of Orthologs from Complete Genome Data

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OMAi
DSIGDEW

Database of Orthologous Groups

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OrthoDBi
1326714at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62753

TreeFam database of animal gene trees

More...
TreeFami
TF300035

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014401 Ribosomal_S6_euk
IPR001377 Ribosomal_S6e
IPR018282 Ribosomal_S6e_CS

The PANTHER Classification System

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PANTHERi
PTHR11502 PTHR11502, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01092 Ribosomal_S6e, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF002129 Ribosom_S6_euk, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01405 Ribosomal_S6e, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00578 RIBOSOMAL_S6E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P62753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV
60 70 80 90 100
RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC
110 120 130 140 150
IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE
160 170 180 190 200
DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV TPRVLQHKRR RIALKKQRTK
210 220 230 240
KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS TSKSESSQK
Length:249
Mass (Da):28,681
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA61E435884E636AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A3R5A2A3R5_HUMAN
40S ribosomal protein S6
RPS6 hCG_1741512
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3R7A2A3R7_HUMAN
40S ribosomal protein S6
RPS6
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23K → T in AAA60288 (PubMed:2840355).Curated1
Sequence conflicti144L → R in AAA60288 (PubMed:2840355).Curated1
Sequence conflicti155 – 156QY → EC in AAA60287 (PubMed:3279029).Curated2
Sequence conflicti168K → R in AAA60287 (PubMed:3279029).Curated1
Sequence conflicti196K → Q in AAA60288 (PubMed:2840355).Curated1
Sequence conflicti219E → Q in AAA60287 (PubMed:3279029).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025314221K → R1 PublicationCorresponds to variant dbSNP:rs17852447Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M20020 mRNA Translation: AAA60288.1
J03537 mRNA Translation: AAA60287.1
X67309 Genomic DNA Translation: CAA47719.1
M77232 Genomic DNA Translation: AAA60289.1
AB062123 mRNA Translation: BAB93455.1
BC000524 mRNA Translation: AAH00524.1
BC009427 mRNA Translation: AAH09427.2
BC027620 mRNA Translation: AAH27620.1
BC071907 mRNA Translation: AAH71907.1
BC071908 mRNA Translation: AAH71908.1
BC094826 mRNA Translation: AAH94826.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6492.1

Protein sequence database of the Protein Information Resource

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PIRi
JC1394 R3HU6

NCBI Reference Sequences

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RefSeqi
NP_001001.2, NM_001010.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380394; ENSP00000369757; ENSG00000137154

Database of genes from NCBI RefSeq genomes

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GeneIDi
6194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6194

UCSC genome browser

More...
UCSCi
uc003znv.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20020 mRNA Translation: AAA60288.1
J03537 mRNA Translation: AAA60287.1
X67309 Genomic DNA Translation: CAA47719.1
M77232 Genomic DNA Translation: AAA60289.1
AB062123 mRNA Translation: BAB93455.1
BC000524 mRNA Translation: AAH00524.1
BC009427 mRNA Translation: AAH09427.2
BC027620 mRNA Translation: AAH27620.1
BC071907 mRNA Translation: AAH71907.1
BC071908 mRNA Translation: AAH71908.1
BC094826 mRNA Translation: AAH94826.1
CCDSiCCDS6492.1
PIRiJC1394 R3HU6
RefSeqiNP_001001.2, NM_001010.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SG1-249[»]
4V6Xelectron microscopy5.00AG1-249[»]
5A2Qelectron microscopy3.90G1-249[»]
5AJ0electron microscopy3.50BG1-249[»]
5FLXelectron microscopy3.90G1-249[»]
5LKSelectron microscopy3.60SG1-249[»]
5OA3electron microscopy4.30G1-249[»]
5T2Celectron microscopy3.60AK1-249[»]
5VYCX-ray6.00G1/G2/G3/G4/G5/G61-249[»]
6EK0electron microscopy2.90SG1-249[»]
6F4PX-ray1.45B129-144[»]
6F4QX-ray1.12B129-144[»]
6FECelectron microscopy6.30q1-237[»]
6G18electron microscopy3.60G1-249[»]
6G4Selectron microscopy4.00G1-249[»]
6G4Welectron microscopy4.50G1-249[»]
6G51electron microscopy4.10G1-249[»]
6G53electron microscopy4.50G1-249[»]
6G5Helectron microscopy3.60G1-249[»]
6G5Ielectron microscopy3.50G1-249[»]
6IP5electron microscopy3.903H1-249[»]
6IP6electron microscopy4.503H1-249[»]
6IP8electron microscopy3.903H1-249[»]
6OLEelectron microscopy3.10SG1-237[»]
6OLFelectron microscopy3.90SG1-237[»]
6OLGelectron microscopy3.40BG1-232[»]
6OLIelectron microscopy3.50SG1-237[»]
6OLZelectron microscopy3.90BG1-232[»]
6OM0electron microscopy3.10SG1-237[»]
6OM7electron microscopy3.70SG1-237[»]
6QZPelectron microscopy2.90SG1-237[»]
SMRiP62753
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112108, 451 interactors
CORUMiP62753
DIPiDIP-31507N
IntActiP62753, 319 interactors
MINTiP62753
STRINGi9606.ENSP00000369757

Chemistry databases

ChEMBLiCHEMBL3351215
DrugBankiDB11638 Artenimol

PTM databases

iPTMnetiP62753
PhosphoSitePlusiP62753
SwissPalmiP62753

Polymorphism and mutation databases

BioMutaiRPS6
DMDMi51338632

Proteomic databases

CPTACiCPTAC-1331
CPTAC-1332
CPTAC-1333
EPDiP62753
jPOSTiP62753
MassIVEiP62753
MaxQBiP62753
PaxDbiP62753
PeptideAtlasiP62753
PRIDEiP62753
ProteomicsDBi57422
TopDownProteomicsiP62753

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6194

Genome annotation databases

EnsembliENST00000380394; ENSP00000369757; ENSG00000137154
GeneIDi6194
KEGGihsa:6194
UCSCiuc003znv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6194
DisGeNETi6194

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS6
HGNCiHGNC:10429 RPS6
HPAiCAB004027
HPA031153
MIMi180460 gene
neXtProtiNX_P62753
OpenTargetsiENSG00000137154
PharmGKBiPA34844

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1646 Eukaryota
COG2125 LUCA
GeneTreeiENSGT00390000009819
HOGENOMiHOG000190952
InParanoidiP62753
KOiK02991
OMAiDSIGDEW
OrthoDBi1326714at2759
PhylomeDBiP62753
TreeFamiTF300035

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-166208 mTORC1-mediated signalling
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiP62753
SIGNORiP62753

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6194
PharosiP62753

Protein Ontology

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PROi
PR:P62753

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000137154 Expressed in 236 organ(s), highest expression level in connective tissue
ExpressionAtlasiP62753 baseline and differential
GenevisibleiP62753 HS

Family and domain databases

InterProiView protein in InterPro
IPR014401 Ribosomal_S6_euk
IPR001377 Ribosomal_S6e
IPR018282 Ribosomal_S6e_CS
PANTHERiPTHR11502 PTHR11502, 1 hit
PfamiView protein in Pfam
PF01092 Ribosomal_S6e, 1 hit
PIRSFiPIRSF002129 Ribosom_S6_euk, 1 hit
SMARTiView protein in SMART
SM01405 Ribosomal_S6e, 1 hit
PROSITEiView protein in PROSITE
PS00578 RIBOSOMAL_S6E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62753
Secondary accession number(s): P08227
, P10660, Q4VBY7, Q8N6Z7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 16, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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