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Protein

60S ribosomal protein L23a

Gene

Rpl23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:Rpl23a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3040672 Rpl23a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001294682 – 15660S ribosomal protein L23aAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine; by NTM11 Publication1
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei41Citrulline1 Publication1
Modified residuei43PhosphoserineBy similarity1
Modified residuei45PhosphothreonineBy similarity1
Modified residuei70N6-acetyllysineCombined sources1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication
Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62751
PaxDbiP62751
PeptideAtlasiP62751
PRIDEiP62751

PTM databases

iPTMnetiP62751
PhosphoSitePlusiP62751

Expressioni

Gene expression databases

BgeeiENSMUSG00000058546
CleanExiMM_RPL23A
ExpressionAtlasiP62751 baseline and differential
GenevisibleiP62751 MM

Interactioni

Subunit structurei

Interacts with LYAR and GNL2. Interacts with MDM2; this interaction may promote MDM2-mediated p53/TP53 polyubiquitination.By similarity

Protein-protein interaction databases

BioGridi234500, 5 interactors
DIPiDIP-59973N
IntActiP62751, 11 interactors
MINTiP62751
STRINGi10090.ENSMUSP00000099541

Structurei

3D structure databases

ProteinModelPortaliP62751
SMRiP62751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1751 Eukaryota
COG0089 LUCA
GeneTreeiENSGT00390000003263
HOGENOMiHOG000231365
HOVERGENiHBG056619
InParanoidiP62751
KOiK02893
OMAiHKVIIHP
OrthoDBiEOG091G0UYL
PhylomeDBiP62751
TreeFamiTF314116

Family and domain databases

Gene3Di3.30.70.330, 1 hit
HAMAPiMF_01369_A Ribosomal_L23_A, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR019985 Ribosomal_L23
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001014 Ribosomal_L23/L25_CS
IPR005633 Ribosomal_L23/L25_N
IPR013025 Ribosomal_L25/23
PfamiView protein in Pfam
PF00276 Ribosomal_L23, 1 hit
PF03939 Ribosomal_L23eN, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
TIGRFAMsiTIGR03636 uL23_arch, 1 hit
PROSITEiView protein in PROSITE
PS00050 RIBOSOMAL_L23, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452721 mRNA Translation: AAQ04686.1
BC026656 mRNA Translation: AAH26656.1
BC029892 mRNA Translation: AAH29892.1
CCDSiCCDS25093.1
RefSeqiNP_997406.1, NM_207523.2
UniGeneiMm.22723
Mm.304790
Mm.352675

Genome annotation databases

EnsembliENSMUST00000102483; ENSMUSP00000099541; ENSMUSG00000058546
GeneIDi268449
KEGGimmu:268449
UCSCiuc007kil.3 mouse

Similar proteinsi

Entry informationi

Entry nameiRL23A_MOUSE
AccessioniPrimary (citable) accession number: P62751
Secondary accession number(s): P29316, P39024, Q92774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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