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Protein

60S ribosomal protein L23a

Gene

RPL23A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Alternative name(s):
Large ribosomal subunit protein uL231 Publication
Gene namesi
Name:RPL23A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198242.13
HGNCiHGNC:10317 RPL23A
MIMi602326 gene
neXtProtiNX_P62750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6147
OpenTargetsiENSG00000198242
PharmGKBiPA34691

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRPL23A
DMDMi51338637

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001294672 – 15660S ribosomal protein L23aAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanineBy similarity1
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei41CitrullineBy similarity1
Modified residuei43PhosphoserineCombined sources1
Modified residuei45PhosphothreonineCombined sources1
Modified residuei70N6-acetyllysineBy similarity1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62750
MaxQBiP62750
PaxDbiP62750
PeptideAtlasiP62750
PRIDEiP62750
ProteomicsDBi57421
TopDownProteomicsiP62750

2D gel databases

SWISS-2DPAGEiP62750

PTM databases

iPTMnetiP62750
PhosphoSitePlusiP62750
SwissPalmiP62750

Expressioni

Inductioni

May be down-regulated by GNL2 (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000198242 Expressed in 89 organ(s), highest expression level in endocervix
CleanExiHS_RPL23A
ExpressionAtlasiP62750 baseline and differential
GenevisibleiP62750 HS

Organism-specific databases

HPAiHPA051754

Interactioni

Subunit structurei

Interacts with LYAR and GNL2 (PubMed:26203195). Interacts with MDM2; this interaction may promote MDM2-mediated p53/TP53 polyubiquitination (PubMed:26203195).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-353254,EBI-5323863

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112067, 240 interactors
CORUMiP62750
IntActiP62750, 49 interactors
MINTiP62750
STRINGi9606.ENSP00000389103

Structurei

3D structure databases

ProteinModelPortaliP62750
SMRiP62750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1751 Eukaryota
COG0089 LUCA
GeneTreeiENSGT00390000003263
HOGENOMiHOG000231365
HOVERGENiHBG056619
InParanoidiP62750
KOiK02893
PhylomeDBiP62750
TreeFamiTF314116

Family and domain databases

Gene3Di3.30.70.330, 1 hit
HAMAPiMF_01369_A Ribosomal_L23_A, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR019985 Ribosomal_L23
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001014 Ribosomal_L23/L25_CS
IPR005633 Ribosomal_L23/L25_N
IPR013025 Ribosomal_L25/23
PfamiView protein in Pfam
PF00276 Ribosomal_L23, 1 hit
PF03939 Ribosomal_L23eN, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
TIGRFAMsiTIGR03636 uL23_arch, 1 hit
PROSITEiView protein in PROSITE
PS00050 RIBOSOMAL_L23, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P62750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUS3A8MUS3_HUMAN
60S ribosomal protein L23a
RPL23A hCG_1988529
194Annotation score:
K7ERT8K7ERT8_HUMAN
60S ribosomal protein L23a
RPL23A
175Annotation score:
K7EJV9K7EJV9_HUMAN
60S ribosomal protein L23a
RPL23A
170Annotation score:
H7BY10H7BY10_HUMAN
60S ribosomal protein L23a
RPL23A
158Annotation score:
K7EMA7K7EMA7_HUMAN
60S ribosomal protein L23a
RPL23A
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → IP in AAA03341 (Ref. 2) Curated1
Sequence conflicti78K → N in AAB17510 (PubMed:8662070).Curated1
Sequence conflicti110K → S in AAB17510 (PubMed:8662070).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06922199I → T Rare variant found in Diamond-Blackfan anemia patients; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151327030Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43701 mRNA Translation: AAB03210.1
U02032 mRNA Translation: AAA03341.1
U37230 mRNA Translation: AAB17510.1
AF001689 Genomic DNA Translation: AAC51934.1
AK312123 mRNA Translation: BAG35059.1
CH471159 Genomic DNA Translation: EAW51132.1
BC014459 mRNA Translation: AAH14459.1
BC058041 mRNA Translation: AAH58041.1
L13799 mRNA Translation: AAA35681.1
CCDSiCCDS11241.1
RefSeqiNP_000975.2, NM_000984.5
UniGeneiHs.419463

Genome annotation databases

EnsembliENST00000422514; ENSP00000389103; ENSG00000198242
GeneIDi6147
KEGGihsa:6147
UCSCiuc002hci.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43701 mRNA Translation: AAB03210.1
U02032 mRNA Translation: AAA03341.1
U37230 mRNA Translation: AAB17510.1
AF001689 Genomic DNA Translation: AAC51934.1
AK312123 mRNA Translation: BAG35059.1
CH471159 Genomic DNA Translation: EAW51132.1
BC014459 mRNA Translation: AAH14459.1
BC058041 mRNA Translation: AAH58041.1
L13799 mRNA Translation: AAA35681.1
CCDSiCCDS11241.1
RefSeqiNP_000975.2, NM_000984.5
UniGeneiHs.419463

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LX1-156[»]
4V6Xelectron microscopy5.00CX1-156[»]
5AJ0electron microscopy3.50AX1-156[»]
5LKSelectron microscopy3.60LX1-156[»]
5T2Celectron microscopy3.60R1-156[»]
6EK0electron microscopy2.90LX1-156[»]
ProteinModelPortaliP62750
SMRiP62750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112067, 240 interactors
CORUMiP62750
IntActiP62750, 49 interactors
MINTiP62750
STRINGi9606.ENSP00000389103

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

PTM databases

iPTMnetiP62750
PhosphoSitePlusiP62750
SwissPalmiP62750

Polymorphism and mutation databases

BioMutaiRPL23A
DMDMi51338637

2D gel databases

SWISS-2DPAGEiP62750

Proteomic databases

EPDiP62750
MaxQBiP62750
PaxDbiP62750
PeptideAtlasiP62750
PRIDEiP62750
ProteomicsDBi57421
TopDownProteomicsiP62750

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422514; ENSP00000389103; ENSG00000198242
GeneIDi6147
KEGGihsa:6147
UCSCiuc002hci.4 human

Organism-specific databases

CTDi6147
DisGeNETi6147
EuPathDBiHostDB:ENSG00000198242.13
GeneCardsiRPL23A
H-InvDBiHIX0016623
HGNCiHGNC:10317 RPL23A
HPAiHPA051754
MIMi602326 gene
neXtProtiNX_P62750
OpenTargetsiENSG00000198242
PharmGKBiPA34691
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1751 Eukaryota
COG0089 LUCA
GeneTreeiENSGT00390000003263
HOGENOMiHOG000231365
HOVERGENiHBG056619
InParanoidiP62750
KOiK02893
PhylomeDBiP62750
TreeFamiTF314116

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPL23A human
GeneWikiiRPL23A
GenomeRNAii6147
PROiPR:P62750
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198242 Expressed in 89 organ(s), highest expression level in endocervix
CleanExiHS_RPL23A
ExpressionAtlasiP62750 baseline and differential
GenevisibleiP62750 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
HAMAPiMF_01369_A Ribosomal_L23_A, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR019985 Ribosomal_L23
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001014 Ribosomal_L23/L25_CS
IPR005633 Ribosomal_L23/L25_N
IPR013025 Ribosomal_L25/23
PfamiView protein in Pfam
PF00276 Ribosomal_L23, 1 hit
PF03939 Ribosomal_L23eN, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
TIGRFAMsiTIGR03636 uL23_arch, 1 hit
PROSITEiView protein in PROSITE
PS00050 RIBOSOMAL_L23, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL23A_HUMAN
AccessioniPrimary (citable) accession number: P62750
Secondary accession number(s): B2R5B2
, P29316, P39024, Q92774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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