UniProtKB - P62736 (ACTA_HUMAN)
Protein
Actin, aortic smooth muscle
Gene
ACTA2
Organism
Homo sapiens (Human)
Status
Functioni
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Miscellaneous
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- glomerular mesangial cell development Source: UniProtKB
- mesenchyme migration Source: AgBase
- muscle contraction Source: Reactome
- positive regulation of gene expression Source: AgBase
- positive regulation of transcription, DNA-templated Source: Reactome
- regulation of blood pressure Source: Ensembl
- response to virus Source: UniProtKB
- vascular associated smooth muscle contraction Source: GO_Central
Keywordsi
Molecular function | Muscle protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P62736 |
Reactomei | R-HSA-445355, Smooth Muscle Contraction R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | P62736 |
SIGNORi | P62736 |
Names & Taxonomyi
Protein namesi | Recommended name: Actin, aortic smooth muscleAlternative name(s): Alpha-actin-2 Cell growth-inhibiting gene 46 protein Cleaved into the following chain: |
Gene namesi | Name:ACTA2 Synonyms:ACTSA, ACTVS ORF Names:GIG46 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:130, ACTA2 |
MIMi | 102620, gene |
neXtProti | NX_P62736 |
VEuPathDBi | HostDB:ENSG00000107796.12 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- dynactin complex Source: GO_Central
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Other locations
- cell body Source: AgBase
- cytoplasm Source: UniProtKB
- filopodium Source: AgBase
- lamellipodium Source: AgBase
- protein-containing complex Source: MGI
- smooth muscle contractile fiber Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease (CAD), premature ischemic strokes and Moyamoya disease.1 Publication
Aortic aneurysm, familial thoracic 6 (AAT6)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062577 | 39 | R → H in AAT6. 1 PublicationCorresponds to variant dbSNP:rs794728021EnsemblClinVar. | 1 | |
Natural variantiVAR_045915 | 117 | N → T in AAT6. 2 Publications | 1 | |
Natural variantiVAR_045916 | 118 | R → Q in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs112602953EnsemblClinVar. | 1 | |
Natural variantiVAR_045917 | 135 | Y → H in AAT6. 1 PublicationCorresponds to variant dbSNP:rs751300489EnsemblClinVar. | 1 | |
Natural variantiVAR_062578 | 145 | Y → C in AAT6. 1 Publication | 1 | |
Natural variantiVAR_045918 | 149 | R → C in AAT6. 3 PublicationsCorresponds to variant dbSNP:rs121434526EnsemblClinVar. | 1 | |
Natural variantiVAR_045919 | 154 | V → A in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs1554841298EnsemblClinVar. | 1 | |
Natural variantiVAR_062579 | 185 | R → Q in AAT6. 1 PublicationCorresponds to variant dbSNP:rs1057521105EnsemblClinVar. | 1 | |
Natural variantiVAR_062580 | 212 | R → Q in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs397516685EnsemblClinVar. | 1 | |
Natural variantiVAR_045920 | 258 | R → C in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs121434528EnsemblClinVar. | 1 | |
Natural variantiVAR_045921 | 258 | R → H in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs121434527EnsemblClinVar. | 1 | |
Natural variantiVAR_045922 | 292 | R → G in AAT6. 1 Publication | 1 | |
Natural variantiVAR_062581 | 326 | T → N in AAT6. 1 PublicationCorresponds to variant dbSNP:rs777832794EnsemblClinVar. | 1 | |
Natural variantiVAR_045923 | 353 | T → N in AAT6. 2 Publications | 1 |
Moyamoya disease 5 (MYMY5)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064516 | 179 | R → H in MYMY5 and MSMDS; disease phenotype include smooth muscle cells dysfunction in organs throughout the body with decreased contractile function in the iris, bladder and gastrointestinal tract. 2 PublicationsCorresponds to variant dbSNP:rs387906592EnsemblClinVar. | 1 |
Multisystemic smooth muscle dysfunction syndrome (MSMDS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by dysfunction of smooth muscle cells throughout the body, leading to aortic and cerebrovascular disease, fixed dilated pupils, hypotonic bladder, malrotation, and hypoperistalsis of the gut and pulmonary hypertension.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064516 | 179 | R → H in MYMY5 and MSMDS; disease phenotype include smooth muscle cells dysfunction in organs throughout the body with decreased contractile function in the iris, bladder and gastrointestinal tract. 2 PublicationsCorresponds to variant dbSNP:rs387906592EnsemblClinVar. | 1 |
Keywords - Diseasei
Aortic aneurysm, Disease variantOrganism-specific databases
DisGeNETi | 59 |
GeneReviewsi | ACTA2 |
MalaCardsi | ACTA2 |
MIMi | 611788, phenotype 613834, phenotype 614042, phenotype |
OpenTargetsi | ENSG00000107796 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection 2573, Moyamoya disease 404463, Multisystemic smooth muscle dysfunction syndrome |
PharmGKBi | PA24456 |
Miscellaneous databases
Pharosi | P62736, Tbio |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | ACTA2 |
DMDMi | 51316972 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000442603 | 2 – 377 | Actin, aortic smooth muscle, intermediate formBy similarityAdd BLAST | 376 | |
ChainiPRO_0000442604 | 3 – 377 | Actin, aortic smooth muscleAdd BLAST | 375 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteine; in intermediate formBy similarity | 1 | |
Modified residuei | 3 | N-acetylglutamate; in Actin, aortic smooth muscleCombined sources | 1 | |
Modified residuei | 46 | Methionine (R)-sulfoxideBy similarity | 1 | |
Modified residuei | 49 | Methionine (R)-sulfoxideBy similarity | 1 | |
Cross-linki | 52 | Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-272); by Vibrio toxins RtxA and VgrG1By similarity | ||
Modified residuei | 75 | Tele-methylhistidine1 Publication | 1 | |
Modified residuei | 86 | N6-methyllysineBy similarity | 1 | |
Cross-linki | 272 | Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-52); by Vibrio toxins RtxA and VgrG1By similarity |
Post-translational modificationi
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.By similarity
Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.By similarity
Methylated at His-75 by SETD3.1 Publication
(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).2 Publications
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, OxidationProteomic databases
EPDi | P62736 |
jPOSTi | P62736 |
MassIVEi | P62736 |
MaxQBi | P62736 |
PaxDbi | P62736 |
PeptideAtlasi | P62736 |
PRIDEi | P62736 |
ProteomicsDBi | 57419 |
TopDownProteomicsi | P62736 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00008603 |
UCD-2DPAGEi | P62736 |
PTM databases
GlyGeni | P62736, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P62736 |
MetOSitei | P62736 |
PhosphoSitePlusi | P62736 |
SwissPalmi | P62736 |
Expressioni
Inductioni
Up-regulated in response to enterovirus 71 (EV71) infection.1 Publication
Gene expression databases
Bgeei | ENSG00000107796, Expressed in thoracic aorta and 247 other tissues |
ExpressionAtlasi | P62736, baseline and differential |
Genevisiblei | P62736, HS |
Organism-specific databases
HPAi | ENSG00000107796, Low tissue specificity |
Interactioni
Subunit structurei
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
GO - Molecular functioni
- protein kinase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 106574, 181 interactors |
CORUMi | P62736 |
ELMi | P62736 |
IntActi | P62736, 99 interactors |
MINTi | P62736 |
STRINGi | 9606.ENSP00000402373 |
Miscellaneous databases
RNActi | P62736, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the actin family.Curated
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000154148 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | P62736 |
OMAi | AMCEEED |
OrthoDBi | 649708at2759 |
PhylomeDBi | P62736 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P62736-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG
60 70 80 90 100
QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP
110 120 130 140 150
EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT
160 170 180 190 200
TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY
210 220 230 240 250
SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI
260 270 280 290 300
TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
310 320 330 340 350
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS
360 370
LSTFQQMWIS KQEYDEAGPS IVHRKCF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6QUT6 | F6QUT6_HUMAN | Actin, aortic smooth muscle | ACTA2 | 151 | Annotation score: | ||
F6UVQ4 | F6UVQ4_HUMAN | Actin, aortic smooth muscle | ACTA2 | 151 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 234 | S → W in AAA51577 (PubMed:2295650).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062577 | 39 | R → H in AAT6. 1 PublicationCorresponds to variant dbSNP:rs794728021EnsemblClinVar. | 1 | |
Natural variantiVAR_045915 | 117 | N → T in AAT6. 2 Publications | 1 | |
Natural variantiVAR_045916 | 118 | R → Q in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs112602953EnsemblClinVar. | 1 | |
Natural variantiVAR_045917 | 135 | Y → H in AAT6. 1 PublicationCorresponds to variant dbSNP:rs751300489EnsemblClinVar. | 1 | |
Natural variantiVAR_062578 | 145 | Y → C in AAT6. 1 Publication | 1 | |
Natural variantiVAR_045918 | 149 | R → C in AAT6. 3 PublicationsCorresponds to variant dbSNP:rs121434526EnsemblClinVar. | 1 | |
Natural variantiVAR_045919 | 154 | V → A in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs1554841298EnsemblClinVar. | 1 | |
Natural variantiVAR_064516 | 179 | R → H in MYMY5 and MSMDS; disease phenotype include smooth muscle cells dysfunction in organs throughout the body with decreased contractile function in the iris, bladder and gastrointestinal tract. 2 PublicationsCorresponds to variant dbSNP:rs387906592EnsemblClinVar. | 1 | |
Natural variantiVAR_062579 | 185 | R → Q in AAT6. 1 PublicationCorresponds to variant dbSNP:rs1057521105EnsemblClinVar. | 1 | |
Natural variantiVAR_011944 | 196 | T → S. Corresponds to variant dbSNP:rs1803028Ensembl. | 1 | |
Natural variantiVAR_062580 | 212 | R → Q in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs397516685EnsemblClinVar. | 1 | |
Natural variantiVAR_045920 | 258 | R → C in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs121434528EnsemblClinVar. | 1 | |
Natural variantiVAR_045921 | 258 | R → H in AAT6. 2 PublicationsCorresponds to variant dbSNP:rs121434527EnsemblClinVar. | 1 | |
Natural variantiVAR_045922 | 292 | R → G in AAT6. 1 Publication | 1 | |
Natural variantiVAR_011945 | 320 | T → A. Corresponds to variant dbSNP:rs1803027Ensembl. | 1 | |
Natural variantiVAR_062581 | 326 | T → N in AAT6. 1 PublicationCorresponds to variant dbSNP:rs777832794EnsemblClinVar. | 1 | |
Natural variantiVAR_045923 | 353 | T → N in AAT6. 2 Publications | 1 | |
Natural variantiVAR_011946 | 373 | H → P. Corresponds to variant dbSNP:rs1062398Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13839 mRNA Translation: CAA32064.1 J05192 mRNA Translation: AAA51577.1 AY692464 mRNA Translation: AAW29811.1 CR536518 mRNA Translation: CAG38756.1 AK313294 mRNA Translation: BAG36101.1 AL157394 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50153.1 BC017554 mRNA Translation: AAH17554.1 BC093052 mRNA Translation: AAH93052.1 K01741 Genomic DNA No translation available. K01742 Genomic DNA No translation available. K01743 Genomic DNA No translation available. M33216 Genomic DNA Translation: AAA60560.1 |
CCDSi | CCDS7392.1 |
PIRi | A35020, ATHUSM |
RefSeqi | NP_001135417.1, NM_001141945.2 NP_001307784.1, NM_001320855.1 NP_001604.1, NM_001613.2 |
Genome annotation databases
Ensembli | ENST00000224784; ENSP00000224784; ENSG00000107796 |
GeneIDi | 59 |
KEGGi | hsa:59 |
UCSCi | uc001kfp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13839 mRNA Translation: CAA32064.1 J05192 mRNA Translation: AAA51577.1 AY692464 mRNA Translation: AAW29811.1 CR536518 mRNA Translation: CAG38756.1 AK313294 mRNA Translation: BAG36101.1 AL157394 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50153.1 BC017554 mRNA Translation: AAH17554.1 BC093052 mRNA Translation: AAH93052.1 K01741 Genomic DNA No translation available. K01742 Genomic DNA No translation available. K01743 Genomic DNA No translation available. M33216 Genomic DNA Translation: AAA60560.1 |
CCDSi | CCDS7392.1 |
PIRi | A35020, ATHUSM |
RefSeqi | NP_001135417.1, NM_001141945.2 NP_001307784.1, NM_001320855.1 NP_001604.1, NM_001613.2 |
3D structure databases
SMRi | P62736 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106574, 181 interactors |
CORUMi | P62736 |
ELMi | P62736 |
IntActi | P62736, 99 interactors |
MINTi | P62736 |
STRINGi | 9606.ENSP00000402373 |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
PTM databases
GlyGeni | P62736, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P62736 |
MetOSitei | P62736 |
PhosphoSitePlusi | P62736 |
SwissPalmi | P62736 |
Genetic variation databases
BioMutai | ACTA2 |
DMDMi | 51316972 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00008603 |
UCD-2DPAGEi | P62736 |
Proteomic databases
EPDi | P62736 |
jPOSTi | P62736 |
MassIVEi | P62736 |
MaxQBi | P62736 |
PaxDbi | P62736 |
PeptideAtlasi | P62736 |
PRIDEi | P62736 |
ProteomicsDBi | 57419 |
TopDownProteomicsi | P62736 |
Protocols and materials databases
Antibodypediai | 30207, 1447 antibodies |
DNASUi | 59 |
Genome annotation databases
Ensembli | ENST00000224784; ENSP00000224784; ENSG00000107796 |
GeneIDi | 59 |
KEGGi | hsa:59 |
UCSCi | uc001kfp.4, human |
Organism-specific databases
CTDi | 59 |
DisGeNETi | 59 |
GeneCardsi | ACTA2 |
GeneReviewsi | ACTA2 |
HGNCi | HGNC:130, ACTA2 |
HPAi | ENSG00000107796, Low tissue specificity |
MalaCardsi | ACTA2 |
MIMi | 102620, gene 611788, phenotype 613834, phenotype 614042, phenotype |
neXtProti | NX_P62736 |
OpenTargetsi | ENSG00000107796 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection 2573, Moyamoya disease 404463, Multisystemic smooth muscle dysfunction syndrome |
PharmGKBi | PA24456 |
VEuPathDBi | HostDB:ENSG00000107796.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000154148 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | P62736 |
OMAi | AMCEEED |
OrthoDBi | 649708at2759 |
PhylomeDBi | P62736 |
TreeFami | TF354237 |
Enzyme and pathway databases
PathwayCommonsi | P62736 |
Reactomei | R-HSA-445355, Smooth Muscle Contraction R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | P62736 |
SIGNORi | P62736 |
Miscellaneous databases
BioGRID-ORCSi | 59, 5 hits in 872 CRISPR screens |
ChiTaRSi | ACTA2, human |
GeneWikii | ACTA2 |
GenomeRNAii | 59 |
Pharosi | P62736, Tbio |
PROi | PR:P62736 |
RNActi | P62736, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107796, Expressed in thoracic aorta and 247 other tissues |
ExpressionAtlasi | P62736, baseline and differential |
Genevisiblei | P62736, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTA_HUMAN | |
Accessioni | P62736Primary (citable) accession number: P62736 Secondary accession number(s): B2R8A4 Q6FI19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 1986 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants