UniProtKB - P62717 (RL18A_MOUSE)
Protein
60S ribosomal protein L18a
Gene
Rpl18a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- cytoplasmic translation Source: MGI
- response to antineoplastic agent Source: Ensembl
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L18a |
Gene namesi | Name:Rpl18a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924058, Rpl18a |
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: MGI
Other locations
- polysomal ribosome Source: MGI
- postsynaptic density Source: MGI
- ribosome Source: MGI
- synapse Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213926 | 1 – 176 | 60S ribosomal protein L18aAdd BLAST | 176 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 11 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 63 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 71 | PhosphoserineCombined sources | 1 | |
Modified residuei | 76 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Cross-linki | 128 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 170 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P62717 |
jPOSTi | P62717 |
MaxQBi | P62717 |
PaxDbi | P62717 |
PeptideAtlasi | P62717 |
PRIDEi | P62717 |
PTM databases
iPTMneti | P62717 |
PhosphoSitePlusi | P62717 |
SwissPalmi | P62717 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000045128, Expressed in forelimb bud and 54 other tissues |
ExpressionAtlasi | P62717, baseline and differential |
Genevisiblei | P62717, MM |
Interactioni
Subunit structurei
Binds IPO9 with high affinity.
By similarityProtein-protein interaction databases
BioGRIDi | 218328, 82 interactors |
ComplexPortali | CPX-5262, 60S cytosolic large ribosomal subunit |
CORUMi | P62717 |
IntActi | P62717, 6 interactors |
MINTi | P62717 |
STRINGi | 10090.ENSMUSP00000058368 |
Miscellaneous databases
RNActi | P62717, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL20 family.Curated
Phylogenomic databases
eggNOGi | KOG0829, Eukaryota |
GeneTreei | ENSGT00390000015797 |
HOGENOMi | CLU_080773_2_0_1 |
InParanoidi | P62717 |
OMAi | RFWYFMK |
OrthoDBi | 1265349at2759 |
PhylomeDBi | P62717 |
TreeFami | TF300086 |
Family and domain databases
HAMAPi | MF_00273, Ribosomal_L18Ae, 1 hit |
InterProi | View protein in InterPro IPR028877, 50S_L18Ae/Ribosomal_L18a/L20 IPR023573, Ribosomal_L18a//L18Ae/LX IPR021138, Ribosomal_L18a/L20_eukaryotes |
PANTHERi | PTHR10052, PTHR10052, 1 hit |
Pfami | View protein in Pfam PF01775, Ribosomal_L18A, 1 hit |
PIRSFi | PIRSF002190, Ribosomal_L18a, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P62717-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ
60 70 80 90 100
LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAAGKCRRP AVKQFHDSKI
160 170
KFPLPHRVLR RQHKPRFTTK RPNTFF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RLW5 | A0A1D5RLW5_MOUSE | 60S ribosomal protein L18a | Rpl18a | 147 | Annotation score: | ||
A0A1D5RM85 | A0A1D5RM85_MOUSE | 60S ribosomal protein L18a | Rpl18a | 219 | Annotation score: | ||
A0A1D5RM79 | A0A1D5RM79_MOUSE | 60S ribosomal protein L18a | Rpl18a | 109 | Annotation score: | ||
A0A1D5RMC7 | A0A1D5RMC7_MOUSE | 60S ribosomal protein L18a | Rpl18a | 70 | Annotation score: | ||
A0A1D5RME4 | A0A1D5RME4_MOUSE | 60S ribosomal protein L18a | Rpl18a | 123 | Annotation score: | ||
A0A1D5RLA0 | A0A1D5RLA0_MOUSE | 60S ribosomal protein L18a | Rpl18a | 59 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010983 mRNA Translation: BAB27304.1 AK146543 mRNA Translation: BAE27248.1 AK161942 mRNA Translation: BAE36645.1 AK162047 mRNA Translation: BAE36696.1 BC037146 mRNA Translation: AAH37146.1 |
CCDSi | CCDS22386.1 |
RefSeqi | NP_084027.1, NM_029751.4 |
Genome annotation databases
Ensembli | ENSMUST00000054220; ENSMUSP00000058368; ENSMUSG00000045128 |
GeneIDi | 76808 |
KEGGi | mmu:76808 |
UCSCi | uc009mca.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010983 mRNA Translation: BAB27304.1 AK146543 mRNA Translation: BAE27248.1 AK161942 mRNA Translation: BAE36645.1 AK162047 mRNA Translation: BAE36696.1 BC037146 mRNA Translation: AAH37146.1 |
CCDSi | CCDS22386.1 |
RefSeqi | NP_084027.1, NM_029751.4 |
3D structure databases
SMRi | P62717 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 218328, 82 interactors |
ComplexPortali | CPX-5262, 60S cytosolic large ribosomal subunit |
CORUMi | P62717 |
IntActi | P62717, 6 interactors |
MINTi | P62717 |
STRINGi | 10090.ENSMUSP00000058368 |
PTM databases
iPTMneti | P62717 |
PhosphoSitePlusi | P62717 |
SwissPalmi | P62717 |
Proteomic databases
EPDi | P62717 |
jPOSTi | P62717 |
MaxQBi | P62717 |
PaxDbi | P62717 |
PeptideAtlasi | P62717 |
PRIDEi | P62717 |
Protocols and materials databases
Antibodypediai | 27861, 143 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000054220; ENSMUSP00000058368; ENSMUSG00000045128 |
GeneIDi | 76808 |
KEGGi | mmu:76808 |
UCSCi | uc009mca.2, mouse |
Organism-specific databases
CTDi | 6142 |
MGIi | MGI:1924058, Rpl18a |
Phylogenomic databases
eggNOGi | KOG0829, Eukaryota |
GeneTreei | ENSGT00390000015797 |
HOGENOMi | CLU_080773_2_0_1 |
InParanoidi | P62717 |
OMAi | RFWYFMK |
OrthoDBi | 1265349at2759 |
PhylomeDBi | P62717 |
TreeFami | TF300086 |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 76808, 9 hits in 18 CRISPR screens |
ChiTaRSi | Rpl18a, mouse |
PROi | PR:P62717 |
RNActi | P62717, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045128, Expressed in forelimb bud and 54 other tissues |
ExpressionAtlasi | P62717, baseline and differential |
Genevisiblei | P62717, MM |
Family and domain databases
HAMAPi | MF_00273, Ribosomal_L18Ae, 1 hit |
InterProi | View protein in InterPro IPR028877, 50S_L18Ae/Ribosomal_L18a/L20 IPR023573, Ribosomal_L18a//L18Ae/LX IPR021138, Ribosomal_L18a/L20_eukaryotes |
PANTHERi | PTHR10052, PTHR10052, 1 hit |
Pfami | View protein in Pfam PF01775, Ribosomal_L18A, 1 hit |
PIRSFi | PIRSF002190, Ribosomal_L18a, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL18A_MOUSE | |
Accessioni | P62717Primary (citable) accession number: P62717 Secondary accession number(s): P11249, Q3TSN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries