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Protein

Beta-crystallin B2

Gene

Crybb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein homodimerization activity Source: MGI
  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • camera-type eye development Source: MGI
  • visual perception Source: MGI

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin B2
Alternative name(s):
Beta-B2 crystallin
Beta-crystallin Bp
Gene namesi
Name:Crybb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88519 Crybb2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000575552 – 205Beta-crystallin B2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62696
PaxDbiP62696
PRIDEiP62696

PTM databases

iPTMnetiP62696
PhosphoSitePlusiP62696

Expressioni

Gene expression databases

BgeeiENSMUSG00000042240 Expressed in 57 organ(s), highest expression level in camera-type eye
CleanExiMM_CRYBB2
GenevisibleiP62696 MM

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198914, 1 interactor
STRINGi10090.ENSMUSP00000031295

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62696
SMRiP62696
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62696

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 56Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini57 – 101Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST45
Domaini107 – 148Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini149 – 191Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 16N-terminal armAdd BLAST15
Regioni102 – 106Connecting peptide5
Regioni193 – 205C-terminal armAdd BLAST13

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJYD Eukaryota
ENOG410Y7P1 LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiP62696
OMAiYEQASCK
OrthoDBiEOG091G0KRX
PhylomeDBiP62696
TreeFamiTF331401

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033058 CRYBB2
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF11 PTHR11818:SF11, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDHQTQAG KPQPLNPKII IFEQENFQGH SHELSGPCPN LKETGMEKAG
60 70 80 90 100
SVLVQAGPWV GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI
110 120 130 140 150
KVDSQEHKII LYENPNFTGK KMEIVDDDVP SFHAHGYQEK VSSVRVQSGT
160 170 180 190 200
WVGYQYPGYR GLQYLLEKGD YKDNSDFGAP HPQVQSVRRI RDMQWHQRGA

FHPSS
Length:205
Mass (Da):23,381
Last modified:January 23, 2007 - v2
Checksum:i73B4C4789D79B9FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60559 mRNA Translation: AAA21181.1
AK020891 mRNA Translation: BAB32243.1
BC085185 mRNA Translation: AAH85185.1
CCDSiCCDS19546.1
PIRiA39757
RefSeqiNP_031799.1, NM_007773.4
XP_006534822.1, XM_006534759.1
XP_006534823.1, XM_006534760.1
XP_017176141.1, XM_017320652.1
UniGeneiMm.1215

Genome annotation databases

EnsembliENSMUST00000031295; ENSMUSP00000031295; ENSMUSG00000042240
ENSMUST00000112336; ENSMUSP00000107955; ENSMUSG00000042240
GeneIDi12961
KEGGimmu:12961
UCSCiuc008ytx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60559 mRNA Translation: AAA21181.1
AK020891 mRNA Translation: BAB32243.1
BC085185 mRNA Translation: AAH85185.1
CCDSiCCDS19546.1
PIRiA39757
RefSeqiNP_031799.1, NM_007773.4
XP_006534822.1, XM_006534759.1
XP_006534823.1, XM_006534760.1
XP_017176141.1, XM_017320652.1
UniGeneiMm.1215

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7NX-ray2.35A/B2-104[»]
ProteinModelPortaliP62696
SMRiP62696
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198914, 1 interactor
STRINGi10090.ENSMUSP00000031295

PTM databases

iPTMnetiP62696
PhosphoSitePlusiP62696

Proteomic databases

MaxQBiP62696
PaxDbiP62696
PRIDEiP62696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031295; ENSMUSP00000031295; ENSMUSG00000042240
ENSMUST00000112336; ENSMUSP00000107955; ENSMUSG00000042240
GeneIDi12961
KEGGimmu:12961
UCSCiuc008ytx.2 mouse

Organism-specific databases

CTDi1415
MGIiMGI:88519 Crybb2

Phylogenomic databases

eggNOGiENOG410IJYD Eukaryota
ENOG410Y7P1 LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiP62696
OMAiYEQASCK
OrthoDBiEOG091G0KRX
PhylomeDBiP62696
TreeFamiTF331401

Miscellaneous databases

EvolutionaryTraceiP62696
PROiPR:P62696
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042240 Expressed in 57 organ(s), highest expression level in camera-type eye
CleanExiMM_CRYBB2
GenevisibleiP62696 MM

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033058 CRYBB2
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF11 PTHR11818:SF11, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRBB2_MOUSE
AccessioniPrimary (citable) accession number: P62696
Secondary accession number(s): P19942, P26775, Q0VGT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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