Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 153 (05 Jun 2019)
Sequence version 1 (19 Jul 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Cellular nucleic acid-binding protein

Gene

CNBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P62633

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNBP
Synonyms:RNF163, ZNF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13164 CNBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116955 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62633

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystrophia myotonica 2 (DM2)
The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
Disease descriptionA multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25R → K: Significantly reduces methylation; when associated with K-27. 1 Publication1
Mutagenesisi27R → K: Significantly reduces methylation; when associated with K-25. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7555

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CNBP

MalaCards human disease database

More...
MalaCardsi
CNBP
MIMi602668 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169714

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
606 Proximal myotonic myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37737

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401852

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899652 – 177Cellular nucleic acid-binding proteinAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei25Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei27Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei49PhosphoserineBy similarity1
Modified residuei79Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: P62633-2)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Isoform 5 (identifier: P62633-5)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Isoform 8 (identifier: P62633-8)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Modified residuei73Omega-N-methylarginineCombined sources1
Isoform 4 (identifier: P62633-4)
Modified residuei80Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P62633

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62633

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P62633

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62633

PeptideAtlas

More...
PeptideAtlasi
P62633

PRoteomics IDEntifications database

More...
PRIDEi
P62633

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57408
57409 [P62633-2]
57410 [P62633-3]
57411 [P62633-4]
57412 [P62633-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62633

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62633

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62633

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in all tissues examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169714 Expressed in 230 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P62633 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P62633 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063097

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Prmt1Q630092EBI-1047529,EBI-78708From Rattus norvegicus.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113387, 165 interactors

Protein interaction database and analysis system

More...
IntActi
P62633, 18 interactors

Molecular INTeraction database

More...
MINTi
P62633

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000410769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62633

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 42Arg/Gly-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4400 Eukaryota
COG5082 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183041

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186262

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62633

KEGG Orthology (KO)

More...
KOi
K09250

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRECDEK

Database of Orthologous Groups

More...
OrthoDBi
1535084at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62633

TreeFam database of animal gene trees

More...
TreeFami
TF316974

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00098 zf-CCHC, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756 SSF57756, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P62633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL
60 70 80 90 100
PDICYRCGES GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN
110 120 130 140 150
CGKPGHLARD CDHADEQKCY SCGEFGHIQK DCTKVKCYRC GETGHVAINC
160 170
SKTSEVNCYR CGESGHLARE CTIEATA
Length:177
Mass (Da):19,463
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i996F398285F52618
GO
Isoform 2 (identifier: P62633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.

Show »
Length:170
Mass (Da):18,742
Checksum:i152BEC42881358E8
GO
Isoform 3 (identifier: P62633-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-51: Missing.

Show »
Length:167
Mass (Da):18,413
Checksum:iD59B4E42A6477FF2
GO
Isoform 4 (identifier: P62633-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: D → DE

Show »
Length:178
Mass (Da):19,592
Checksum:iDF0CDAB9BF3D96BB
GO
Isoform 5 (identifier: P62633-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     72-72: D → DVE

Note: No experimental confirmation available.Combined sources
Show »
Length:172
Mass (Da):18,970
Checksum:iE2C0B3EF2820CD94
GO
Isoform 6 (identifier: P62633-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: D → DVE

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):19,691
Checksum:iAB793FABFDE0C072
GO
Isoform 7 (identifier: P62633-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,692
Checksum:i1C2D9D62F90EFCFB
GO
Isoform 8 (identifier: P62633-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     72-72: D → DE

Show »
Length:171
Mass (Da):18,871
Checksum:i46809E6C7F3070C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAT4D6RAT4_HUMAN
Cellular nucleic acid-binding prote...
CNBP
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6C → R in BAF84808 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05508435 – 51Missing in isoform 7. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_01098136 – 42Missing in isoform 2, isoform 5 and isoform 8. 2 Publications7
Alternative sequenceiVSP_01098242 – 51Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_04330472D → DE in isoform 4 and isoform 8. 2 Publications1
Alternative sequenceiVSP_04342472D → DVE in isoform 5 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M28372 mRNA Translation: AAA61975.1
U19765 Genomic DNA Translation: AAA91782.1
AY329622 Genomic DNA Translation: AAR89462.1
DQ092366 mRNA Translation: AAY96754.1
DQ092367 mRNA Translation: AAY96755.1
DQ091187 mRNA Translation: AAY89856.1
AK054592 mRNA Translation: BAB70769.1
AK298154 mRNA Translation: BAG60429.1
AK292119 mRNA Translation: BAF84808.1
AK314380 mRNA Translation: BAG37006.1
BT019613 mRNA Translation: AAV38419.1
AC108673 Genomic DNA No translation available.
AC135587 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79271.1
CH471052 Genomic DNA Translation: EAW79272.1
CH471052 Genomic DNA Translation: EAW79273.1
CH471052 Genomic DNA Translation: EAW79274.1
CH471052 Genomic DNA Translation: EAW79275.1
CH471052 Genomic DNA Translation: EAW79277.1
BC000288 mRNA Translation: AAH00288.1
BC014911 mRNA Translation: AAH14911.1
BC093058 mRNA Translation: AAH93058.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3056.1 [P62633-1]
CCDS46906.1 [P62633-6]
CCDS46907.1 [P62633-4]
CCDS46908.1 [P62633-5]
CCDS54637.1 [P62633-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A32760

NCBI Reference Sequences

More...
RefSeqi
NP_001120664.1, NM_001127192.1 [P62633-6]
NP_001120665.1, NM_001127193.1 [P62633-4]
NP_001120666.1, NM_001127194.1 [P62633-5]
NP_001120667.1, NM_001127195.1 [P62633-8]
NP_001120668.1, NM_001127196.1 [P62633-2]
NP_003409.1, NM_003418.4 [P62633-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000422453; ENSP00000410619; ENSG00000169714 [P62633-1]
ENST00000441626; ENSP00000410769; ENSG00000169714 [P62633-6]
ENST00000446936; ENSP00000400444; ENSG00000169714 [P62633-5]
ENST00000451728; ENSP00000399488; ENSG00000169714 [P62633-4]
ENST00000500450; ENSP00000426223; ENSG00000169714 [P62633-7]
ENST00000502976; ENSP00000421323; ENSG00000169714 [P62633-2]
ENST00000504813; ENSP00000422110; ENSG00000169714 [P62633-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7555

UCSC genome browser

More...
UCSCi
uc003elq.5 human [P62633-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28372 mRNA Translation: AAA61975.1
U19765 Genomic DNA Translation: AAA91782.1
AY329622 Genomic DNA Translation: AAR89462.1
DQ092366 mRNA Translation: AAY96754.1
DQ092367 mRNA Translation: AAY96755.1
DQ091187 mRNA Translation: AAY89856.1
AK054592 mRNA Translation: BAB70769.1
AK298154 mRNA Translation: BAG60429.1
AK292119 mRNA Translation: BAF84808.1
AK314380 mRNA Translation: BAG37006.1
BT019613 mRNA Translation: AAV38419.1
AC108673 Genomic DNA No translation available.
AC135587 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79271.1
CH471052 Genomic DNA Translation: EAW79272.1
CH471052 Genomic DNA Translation: EAW79273.1
CH471052 Genomic DNA Translation: EAW79274.1
CH471052 Genomic DNA Translation: EAW79275.1
CH471052 Genomic DNA Translation: EAW79277.1
BC000288 mRNA Translation: AAH00288.1
BC014911 mRNA Translation: AAH14911.1
BC093058 mRNA Translation: AAH93058.1
CCDSiCCDS3056.1 [P62633-1]
CCDS46906.1 [P62633-6]
CCDS46907.1 [P62633-4]
CCDS46908.1 [P62633-5]
CCDS54637.1 [P62633-2]
PIRiA32760
RefSeqiNP_001120664.1, NM_001127192.1 [P62633-6]
NP_001120665.1, NM_001127193.1 [P62633-4]
NP_001120666.1, NM_001127194.1 [P62633-5]
NP_001120667.1, NM_001127195.1 [P62633-8]
NP_001120668.1, NM_001127196.1 [P62633-2]
NP_003409.1, NM_003418.4 [P62633-1]

3D structure databases

SMRiP62633
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113387, 165 interactors
IntActiP62633, 18 interactors
MINTiP62633
STRINGi9606.ENSP00000410769

PTM databases

iPTMnetiP62633
PhosphoSitePlusiP62633
SwissPalmiP62633

Polymorphism and mutation databases

BioMutaiCNBP
DMDMi50401852

Proteomic databases

EPDiP62633
jPOSTiP62633
MaxQBiP62633
PaxDbiP62633
PeptideAtlasiP62633
PRIDEiP62633
ProteomicsDBi57408
57409 [P62633-2]
57410 [P62633-3]
57411 [P62633-4]
57412 [P62633-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7555
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422453; ENSP00000410619; ENSG00000169714 [P62633-1]
ENST00000441626; ENSP00000410769; ENSG00000169714 [P62633-6]
ENST00000446936; ENSP00000400444; ENSG00000169714 [P62633-5]
ENST00000451728; ENSP00000399488; ENSG00000169714 [P62633-4]
ENST00000500450; ENSP00000426223; ENSG00000169714 [P62633-7]
ENST00000502976; ENSP00000421323; ENSG00000169714 [P62633-2]
ENST00000504813; ENSP00000422110; ENSG00000169714 [P62633-3]
GeneIDi7555
KEGGihsa:7555
UCSCiuc003elq.5 human [P62633-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7555
DisGeNETi7555

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CNBP
GeneReviewsiCNBP
HGNCiHGNC:13164 CNBP
HPAiHPA063097
MalaCardsiCNBP
MIMi116955 gene
602668 phenotype
neXtProtiNX_P62633
OpenTargetsiENSG00000169714
Orphaneti606 Proximal myotonic myopathy
PharmGKBiPA37737

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4400 Eukaryota
COG5082 LUCA
GeneTreeiENSGT00950000183041
HOGENOMiHOG000186262
InParanoidiP62633
KOiK09250
OMAiRRECDEK
OrthoDBi1535084at2759
PhylomeDBiP62633
TreeFamiTF316974

Enzyme and pathway databases

SIGNORiP62633

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CNBP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CNBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7555

Protein Ontology

More...
PROi
PR:P62633

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169714 Expressed in 230 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
ExpressionAtlasiP62633 baseline and differential
GenevisibleiP62633 HS

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 7 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 7 hits
SUPFAMiSSF57756 SSF57756, 4 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62633
Secondary accession number(s): A8K7V4
, B2RAV9, B4DP17, D3DNB9, D3DNC0, D3DNC1, E9PDR7, P20694, Q4JGY0, Q4JGY1, Q5QJR0, Q5U0E9, Q6PJI7, Q96NV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 5, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again