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Protein

Elongation factor 1-alpha 2

Gene

Eef1a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi153 – 156GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: MGI
  • translation elongation factor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha 2
Short name:
EF-1-alpha-2
Alternative name(s):
Eukaryotic elongation factor 1 A-2
Short name:
eEF1A-2
Statin-S1
Gene namesi
Name:Eef1a2
Synonyms:Eef1al, Stn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1096317 Eef1a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000908922 – 463Elongation factor 1-alpha 2Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylglycineBy similarity1
Modified residuei36N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei36N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei36N6-methyllysine; alternateBy similarity1
Modified residuei55N6,N6,N6-trimethyllysineBy similarity1
Modified residuei79N6,N6,N6-trimethyllysineBy similarity1
Modified residuei165N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT3By similarity1
Modified residuei165N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei165N6-methyllysine; alternateBy similarity1
Modified residuei179N6-acetyllysineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei3015-glutamyl glycerylphosphorylethanolamineBy similarity1
Modified residuei3745-glutamyl glycerylphosphorylethanolamineBy similarity1
Modified residuei439N6-acetyllysineBy similarity1

Post-translational modificationi

Trimethylated at Lys-165 by EEF1AKMT3. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP62631
MaxQBiP62631
PaxDbiP62631
PeptideAtlasiP62631
PRIDEiP62631

PTM databases

iPTMnetiP62631
PhosphoSitePlusiP62631
SwissPalmiP62631

Expressioni

Tissue specificityi

Found in a wide range of tissues.

Developmental stagei

The statin expression is specific for nonproliferating cells. Its message is most abundant in G0 phase of 3T3 mouse fibroblasts, but becomes significantly reduced in G1 and S1 phases cells.

Gene expression databases

BgeeiENSMUSG00000016349 Expressed in 246 organ(s), highest expression level in primary motor cortex
GenevisibleiP62631 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199386, 8 interactors
IntActiP62631, 13 interactors
MINTiP62631
STRINGi10090.ENSMUSP00000054556

Structurei

3D structure databases

ProteinModelPortaliP62631
SMRiP62631
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 242tr-type GAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni153 – 156G4By similarity4
Regioni194 – 196G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0052 Eukaryota
COG5256 LUCA
GeneTreeiENSGT00910000144046
HOGENOMiHOG000229291
HOVERGENiHBG000179
InParanoidiP62631
KOiK03231
OMAiEMHHKSV
OrthoDBiEOG091G05LW
TreeFamiTF300304

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62631-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV
160 170 180 190 200
GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK IGYNPATVPF VPISGWHGDN
210 220 230 240 250
MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR PTDKPLRLPL
260 270 280 290 300
QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS
310 320 330 340 350
EALPGDNVGF NVKNVSVKDI RRGNVCGDSK ADPPQEAAQF TSQVIILNHP
360 370 380 390 400
GQISAGYSPV IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA
410 420 430 440 450
IVEMVPGKPM CVESFSQYPP LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK
460
VTKSAQKAQK AGK
Length:463
Mass (Da):50,454
Last modified:July 19, 2004 - v1
Checksum:i31E4F59BC05D8F8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26479 mRNA Translation: AAA91870.1
BC018235 mRNA Translation: AAH18235.1
CCDSiCCDS17201.1
PIRiJC2445
RefSeqiNP_031932.1, NM_007906.2
UniGeneiMm.2645
Mm.469467

Genome annotation databases

EnsembliENSMUST00000055990; ENSMUSP00000054556; ENSMUSG00000016349
GeneIDi13628
KEGGimmu:13628
UCSCiuc008olh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26479 mRNA Translation: AAA91870.1
BC018235 mRNA Translation: AAH18235.1
CCDSiCCDS17201.1
PIRiJC2445
RefSeqiNP_031932.1, NM_007906.2
UniGeneiMm.2645
Mm.469467

3D structure databases

ProteinModelPortaliP62631
SMRiP62631
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199386, 8 interactors
IntActiP62631, 13 interactors
MINTiP62631
STRINGi10090.ENSMUSP00000054556

PTM databases

iPTMnetiP62631
PhosphoSitePlusiP62631
SwissPalmiP62631

Proteomic databases

EPDiP62631
MaxQBiP62631
PaxDbiP62631
PeptideAtlasiP62631
PRIDEiP62631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055990; ENSMUSP00000054556; ENSMUSG00000016349
GeneIDi13628
KEGGimmu:13628
UCSCiuc008olh.1 mouse

Organism-specific databases

CTDi1917
MGIiMGI:1096317 Eef1a2

Phylogenomic databases

eggNOGiKOG0052 Eukaryota
COG5256 LUCA
GeneTreeiENSGT00910000144046
HOGENOMiHOG000229291
HOVERGENiHBG000179
InParanoidiP62631
KOiK03231
OMAiEMHHKSV
OrthoDBiEOG091G05LW
TreeFamiTF300304

Miscellaneous databases

PROiPR:P62631
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016349 Expressed in 246 organ(s), highest expression level in primary motor cortex
GenevisibleiP62631 MM

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEF1A2_MOUSE
AccessioniPrimary (citable) accession number: P62631
Secondary accession number(s): P27706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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