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Protein

Dynein light chain roadblock-type 1

Gene

Dynlrb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

GO - Molecular functioni

  • dynein intermediate chain binding Source: GO_Central
  • identical protein binding Source: UniProtKB
  • motor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain roadblock-type 1
Alternative name(s):
Dynein light chain 2A, cytoplasmic
Gene namesi
Name:Dynlrb1
Synonyms:Dncl2a, Dnlc2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914318 Dynlrb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002209562 – 96Dynein light chain roadblock-type 1Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62627
MaxQBiP62627
PaxDbiP62627
PRIDEiP62627
TopDownProteomicsiP62627

2D gel databases

UCD-2DPAGEiP62627

PTM databases

iPTMnetiP62627
PhosphoSitePlusiP62627

Expressioni

Gene expression databases

BgeeiENSMUSG00000047459 Expressed in 294 organ(s), highest expression level in telencephalon
CleanExiMM_DYNLRB1
ExpressionAtlasiP62627 baseline and differential
GenevisibleiP62627 MM

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB2. Interacts with RAB6A; the interaction is direct. Interacts with RAB6B (GDP-bound) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211916, 15 interactors
IntActiP62627, 15 interactors
MINTiP62627
STRINGi10090.ENSMUSP00000105304

Structurei

Secondary structure

196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62627
SMRiP62627
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62627

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4115 Eukaryota
ENOG4111NDV LUCA
GeneTreeiENSGT00390000011067
HOGENOMiHOG000232033
HOVERGENiHBG058598
InParanoidiP62627
KOiK10419
OMAiQYAGLMH
PhylomeDBiP62627
TreeFamiTF315165

Family and domain databases

InterProiView protein in InterPro
IPR016561 DYNLRB1/2
IPR004942 Roadblock/LAMTOR2_dom
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
PIRSFiPIRSF009998 DLC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYANLMHNFI
60 70 80 90
LKARSTVREI DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTE
Length:96
Mass (Da):10,990
Last modified:January 23, 2007 - v3
Checksum:i666734B413AFE7D0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AVR9A2AVR9_MOUSE
Dynein light chain roadblock
Dynlrb1
104Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3E → D in BAB25768 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002359 mRNA Translation: BAB22038.1
AK003435 mRNA Translation: BAB22788.1
AK008595 mRNA Translation: BAB25768.1
AK166685 mRNA Translation: BAE38944.1
AL929588 Genomic DNA No translation available.
BC099423 mRNA Translation: AAH99423.1
BC125610 mRNA Translation: AAI25611.1
BC125648 mRNA Translation: AAI25649.1
CCDSiCCDS38294.1
RefSeqiNP_080223.2, NM_025947.3
UniGeneiMm.23693

Genome annotation databases

EnsembliENSMUST00000109682; ENSMUSP00000105304; ENSMUSG00000047459
GeneIDi67068
KEGGimmu:67068
UCSCiuc008nkg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002359 mRNA Translation: BAB22038.1
AK003435 mRNA Translation: BAB22788.1
AK008595 mRNA Translation: BAB25768.1
AK166685 mRNA Translation: BAE38944.1
AL929588 Genomic DNA No translation available.
BC099423 mRNA Translation: AAH99423.1
BC125610 mRNA Translation: AAI25611.1
BC125648 mRNA Translation: AAI25649.1
CCDSiCCDS38294.1
RefSeqiNP_080223.2, NM_025947.3
UniGeneiMm.23693

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y4ONMR-A/B2-96[»]
ProteinModelPortaliP62627
SMRiP62627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211916, 15 interactors
IntActiP62627, 15 interactors
MINTiP62627
STRINGi10090.ENSMUSP00000105304

PTM databases

iPTMnetiP62627
PhosphoSitePlusiP62627

2D gel databases

UCD-2DPAGEiP62627

Proteomic databases

EPDiP62627
MaxQBiP62627
PaxDbiP62627
PRIDEiP62627
TopDownProteomicsiP62627

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109682; ENSMUSP00000105304; ENSMUSG00000047459
GeneIDi67068
KEGGimmu:67068
UCSCiuc008nkg.2 mouse

Organism-specific databases

CTDi83658
MGIiMGI:1914318 Dynlrb1

Phylogenomic databases

eggNOGiKOG4115 Eukaryota
ENOG4111NDV LUCA
GeneTreeiENSGT00390000011067
HOGENOMiHOG000232033
HOVERGENiHBG058598
InParanoidiP62627
KOiK10419
OMAiQYAGLMH
PhylomeDBiP62627
TreeFamiTF315165

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSiDynlrb1 mouse
EvolutionaryTraceiP62627
PROiPR:P62627
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047459 Expressed in 294 organ(s), highest expression level in telencephalon
CleanExiMM_DYNLRB1
ExpressionAtlasiP62627 baseline and differential
GenevisibleiP62627 MM

Family and domain databases

InterProiView protein in InterPro
IPR016561 DYNLRB1/2
IPR004942 Roadblock/LAMTOR2_dom
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
PIRSFiPIRSF009998 DLC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLRB1_MOUSE
AccessioniPrimary (citable) accession number: P62627
Secondary accession number(s): A2AVR8
, O88567, Q4FZJ8, Q9D812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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