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Protein

Protection of telomeres protein 1

Gene

POT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex that is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to at least two telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand). Its activity is TERT dependent but it does not increase TERT activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-418124 Telomere maintenance

Names & Taxonomyi

Protein namesi
Recommended name:
Protection of telomeres protein 1
Short name:
cPot1
Alternative name(s):
POT1-like telomere end-binding protein
Gene namesi
Name:POT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217311 – 778Protection of telomeres protein 1Add BLAST778

Proteomic databases

PaxDbiP62597
PRIDEiP62597

Interactioni

Subunit structurei

Homodimer or homooligomer. Component of the telomerase ribonucleoprotein complex. Binds single-stranded telomeric DNA as a monomer (By similarity). Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014206

Structurei

3D structure databases

ProteinModelPortaliP62597
SMRiP62597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the telombin family.Curated

Phylogenomic databases

eggNOGiKOG4757 Eukaryota
ENOG410Z1J0 LUCA
HOGENOMiHOG000015271
HOVERGENiHBG053641
InParanoidiP62597
KOiK11109
PhylomeDBiP62597

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR028389 POT1
IPR032042 POT1PC
IPR011564 Telomer_end-bd_POT1/Cdc13
PANTHERiPTHR14513 PTHR14513, 1 hit
PfamiView protein in Pfam
PF02765 POT1, 1 hit
PF16686 POT1PC, 1 hit
SMARTiView protein in SMART
SM00976 Telo_bind, 1 hit
SUPFAMiSSF50249 SSF50249, 2 hits

Sequencei

Sequence statusi: Complete.

P62597-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVQVLKIIK GKPETQLPSH LQREDLKHLQ TGLDHTNKYF QGIVILSYPL
60 70 80 90 100
TKLGDGTDFF KIVLQDDTCS RINSINVLMY GKMAEDCAKL IRNGDTFIVA
110 120 130 140 150
GFKVAESPTA REDGRHACHL QVSEESGSAI FICTQPSITP FSEATSPSVA
160 170 180 190 200
PKYVYTPLNC LKDGTVVNLY GIVKFFKPPY ISKGTDYCSV VTLVDQSNVK
210 220 230 240 250
LTCTLFNGNL DSLPKIYKNG DIVRFHRVKI REYNGQMQGI TSAGFASLTF
260 270 280 290 300
DGTVGAPVVP RASSKVYTFV DEEQKTVEEL RIWAASNLSV SGPEAKLSDV
310 320 330 340 350
KPMMFFDLTC QLVGKAKVDG SSFLLKVWDG TKCPYPTWKV PVEAKELEGD
360 370 380 390 400
RVLLHHLRNL TVDVLVYDNH VQLAKSLKTG SFLRIYSIHT KQASAKNEDM
410 420 430 440 450
SSHIEFHLHG GTCYGRGIGI LPENNPDVEE LKSFLECVEL TDSQNMESVS
460 470 480 490 500
SLELGDTFDS YTDLESPLQR CQQLSATVLT DHQDMSNTVL KTVLNSSAPQ
510 520 530 540 550
QYRIRAKLRS FKPQKLYQSV KLHCSKCNTL QEVPNGDAID FILQGCAATA
560 570 580 590 600
PNPELQSMSW YESVVWTTEE DQGRKITIHF VKHYEMLQRP ENTLLMIEGG
610 620 630 640 650
TLKEIWKLTR RFKCVIPVKS KEDDLELLDL SAPFLLQGNI KYYGCKKCST
660 670 680 690 700
PKSIKNLSSL AEKREPSWEP TEIAQVLGIE PLQYVFVMKF TLVDGTGVLN
710 720 730 740 750
AYLFDYEKFF QIPASEILTN SFLQQKMEMT MNTLSPPGRK LDDLPWLECF
760 770
IKSYNVADGM KHQVYYQIFD TTVAEDVV
Length:778
Mass (Da):87,484
Last modified:July 19, 2004 - v1
Checksum:iBD11397FAC6D0A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555718 mRNA Translation: AAS64745.1
RefSeqiNP_996875.1, NM_206992.1
UniGeneiGga.11620

Genome annotation databases

GeneIDi404538
KEGGigga:404538

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555718 mRNA Translation: AAS64745.1
RefSeqiNP_996875.1, NM_206992.1
UniGeneiGga.11620

3D structure databases

ProteinModelPortaliP62597
SMRiP62597
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014206

Proteomic databases

PaxDbiP62597
PRIDEiP62597

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi404538
KEGGigga:404538

Organism-specific databases

CTDi25913

Phylogenomic databases

eggNOGiKOG4757 Eukaryota
ENOG410Z1J0 LUCA
HOGENOMiHOG000015271
HOVERGENiHBG053641
InParanoidiP62597
KOiK11109
PhylomeDBiP62597

Enzyme and pathway databases

ReactomeiR-GGA-418124 Telomere maintenance

Miscellaneous databases

PROiPR:P62597

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR028389 POT1
IPR032042 POT1PC
IPR011564 Telomer_end-bd_POT1/Cdc13
PANTHERiPTHR14513 PTHR14513, 1 hit
PfamiView protein in Pfam
PF02765 POT1, 1 hit
PF16686 POT1PC, 1 hit
SMARTiView protein in SMART
SM00976 Telo_bind, 1 hit
SUPFAMiSSF50249 SSF50249, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPOTE1_CHICK
AccessioniPrimary (citable) accession number: P62597
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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