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Entry version 131 (17 Jun 2020)
Sequence version 1 (21 Jul 1986)
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Protein

Beta-lactamase TEM

Gene

bla

more
Organism
Escherichia coli
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

Miscellaneous

The beta-lactamase present on pBR322 was cloned from plasmid R1 (R7268).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei68Acyl-ester intermediate1
Active sitei166Proton acceptor1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.2.6 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P62593

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-lactamase TEM (EC:3.5.2.6)
Alternative name(s):
IRT-4
Penicillinase
TEM-1
TEM-16/CAZ-7
TEM-2
TEM-24/CAZ-6
TEM-3
TEM-4
TEM-5
TEM-6
TEM-8/CAZ-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bla
AND
Name:blaT-3
AND
Name:blaT-4
AND
Name:blaT-5
AND
Name:blaT-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid R1 (R7268)2 Publications
Plasmid IncFII R100 (NR1)1 Publication
Plasmid R6K1 Publication
Plasmid pUD161 Publication
Plasmid pCFF042 Publications
Plasmid pCFF14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

This protein is used as a marker in many commonly used cloning vectors, such as pBR322 and the pUC series.

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2065
CHEMBL2364670

Drug and drug target database

More...
DrugBanki
DB07466 (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID
DB07464 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID
DB02614 1(R)-1-Acetamido-2-(3-Carboxyphenyl)Ethyl Boronic Acid
DB04430 3-(4-Phenylamino-Phenylamino)-2-(1h-Tetrazol-5-Yl)-Acrylonitrile
DB08551 3-{(R)-(Dihydroxyboryl)[(2-thienylacetyl)amino]methyl}benzoic acid
DB07599 [(2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLYLACETYL)AMINO]METHYLBORONIC ACID
DB02841 [(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic Acid
DB02642 [[N-(Benzyloxycarbonyl)Amino]Methyl]Phosphate
DB09060 Avibactam
DB01053 Benzylpenicillin
DB04035 Ceftazidime BATSI
DB01598 Imipenem
DB04037 N,N-Bis(4-Chlorobenzyl)-1h-1,2,3,4-Tetraazol-5-Amine
DB12377 Relebactam
DB12107 Vaborbactam

DrugCentral

More...
DrugCentrali
P62593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 232 PublicationsAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001697824 – 286Beta-lactamase TEMAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 121

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P62593

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P62593, 1 interactor

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P62593

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1286
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62593

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P62593

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni232 – 234Substrate binding3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K18698

Database of Orthologous Groups

More...
OrthoDBi
991474at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00118 BLACTAMASEA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56601 SSF56601, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P62593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN
60 70 80 90 100
SGKILESFRP EERFPMMSTF KVLLCGAVLS RVDAGQEQLG RRIHYSQNDL
110 120 130 140 150
VEYSPVTEKH LTDGMTVREL CSAAITMSDN TAANLLLTTI GGPKELTAFL
160 170 180 190 200
HNMGDHVTRL DRWEPELNEA IPNDERDTTM PAAMATTLRK LLTGELLTLA
210 220 230 240 250
SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS RGIIAALGPD
260 270 280
GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW
Length:286
Mass (Da):31,515
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB678943BB18934B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti19L → F in TEM-4. 1
Natural varianti37Q → K in TEM-2, TEM-3, TEM-8, TEM-16 and TEM-24. 1
Natural varianti67M → L in IRT-4. 1
Natural varianti102E → K in TEM-3, TEM-4, TEM-6, TEM-8, TEM-16 and TEM-24. 1
Natural varianti162R → H in TEM-6 and TEM-16. 1
Natural varianti162R → S in TEM-5, TEM-8 and TEM-24. 1
Natural varianti235A → T in TEM-5 and TEM-24. 1
Natural varianti236G → S in TEM-3, TEM-4 and TEM-8. 1
Natural varianti237E → K in TEM-5 and TEM-24. 1
Natural varianti261T → M in TEM-4. 1
Natural varianti272N → D in IRT-4. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01749 Genomic DNA Translation: AAB59737.1
V00613 Genomic DNA Translation: CAA23886.1
X64523 Genomic DNA Translation: CAA45828.1
X57972 Genomic DNA Translation: CAA41038.1
X65252 Genomic DNA Translation: CAA46344.1
X65253 Genomic DNA Translation: CAA46345.1
X65254 Genomic DNA Translation: CAA46346.1
U89928 Genomic DNA Translation: AAB64386.1
U66885 Genomic DNA Translation: AAC48875.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93821 PNECP
S30113

NCBI Reference Sequences

More...
RefSeqi
NP_943295.1, NC_005248.1
NP_957565.1, NC_005327.1
WP_000027057.1, NZ_WSIV01000123.1
WP_063864949.1, NZ_BGKM01000047.1
WP_063865014.1, NZ_BGLS01000178.1
YP_001096393.1, NC_009132.1
YP_001693174.1, NC_010378.1
YP_001816609.1, NC_010558.1
YP_003108102.1, NC_013120.1
YP_003108210.1, NC_013121.1
YP_003829069.1, NC_014383.1
YP_003829170.1, NC_014384.1
YP_003937675.1, NC_014615.1
YP_004119720.1, NC_014843.1
YP_004119734.1, NC_014843.1
YP_006903139.1, NC_019047.1
YP_006939984.1, NC_018994.1
YP_006940092.1, NC_018995.1
YP_006952181.1, NC_019056.1
YP_006952421.1, NC_019062.1
YP_006952427.1, NC_019063.1
YP_006953479.1, NC_019073.1
YP_006953762.1, NC_019088.1
YP_006953988.1, NC_019091.1
YP_006954235.1, NC_019095.1
YP_007447512.1, NC_020278.2
YP_008864019.1, NC_022992.1
YP_008864686.1, NC_022996.1
YP_008995211.1, NC_023277.2
YP_009060387.1, NC_024960.1
YP_009060444.1, NC_024961.1
YP_009060580.1, NC_024967.1
YP_009061316.1, NC_024977.1
YP_009066523.1, NC_025106.1
YP_009068284.1, NC_025139.1
YP_009068507.1, NC_025141.1
YP_009070232.1, NC_025167.1
YP_009070558.1, NC_025175.1
YP_009071512.1, NC_025183.1
YP_190222.1, NC_006671.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10076131
10076142
13876868
13877052
13903673
13905334
13905363
13906404
13906709
13906924
13909533
13909568
14612524
17824300
17824435
18157686
20466965
20466993
20467118
20468340
20471961
20491414
20491639
20492529
20492626
20493584
2716540
3244915
3722457
43090221
4924718
5961992
6276043
8319064
8319163
9537966
9538101
9846067

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAB59737
ag:CAA41038
ag:CAA45828
ag:CAA46344
ag:CAA46345
ag:CAA46346

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01749 Genomic DNA Translation: AAB59737.1
V00613 Genomic DNA Translation: CAA23886.1
X64523 Genomic DNA Translation: CAA45828.1
X57972 Genomic DNA Translation: CAA41038.1
X65252 Genomic DNA Translation: CAA46344.1
X65253 Genomic DNA Translation: CAA46345.1
X65254 Genomic DNA Translation: CAA46346.1
U89928 Genomic DNA Translation: AAB64386.1
U66885 Genomic DNA Translation: AAC48875.1
PIRiA93821 PNECP
S30113
RefSeqiNP_943295.1, NC_005248.1
NP_957565.1, NC_005327.1
WP_000027057.1, NZ_WSIV01000123.1
WP_063864949.1, NZ_BGKM01000047.1
WP_063865014.1, NZ_BGLS01000178.1
YP_001096393.1, NC_009132.1
YP_001693174.1, NC_010378.1
YP_001816609.1, NC_010558.1
YP_003108102.1, NC_013120.1
YP_003108210.1, NC_013121.1
YP_003829069.1, NC_014383.1
YP_003829170.1, NC_014384.1
YP_003937675.1, NC_014615.1
YP_004119720.1, NC_014843.1
YP_004119734.1, NC_014843.1
YP_006903139.1, NC_019047.1
YP_006939984.1, NC_018994.1
YP_006940092.1, NC_018995.1
YP_006952181.1, NC_019056.1
YP_006952421.1, NC_019062.1
YP_006952427.1, NC_019063.1
YP_006953479.1, NC_019073.1
YP_006953762.1, NC_019088.1
YP_006953988.1, NC_019091.1
YP_006954235.1, NC_019095.1
YP_007447512.1, NC_020278.2
YP_008864019.1, NC_022992.1
YP_008864686.1, NC_022996.1
YP_008995211.1, NC_023277.2
YP_009060387.1, NC_024960.1
YP_009060444.1, NC_024961.1
YP_009060580.1, NC_024967.1
YP_009061316.1, NC_024977.1
YP_009066523.1, NC_025106.1
YP_009068284.1, NC_025139.1
YP_009068507.1, NC_025141.1
YP_009070232.1, NC_025167.1
YP_009070558.1, NC_025175.1
YP_009071512.1, NC_025183.1
YP_190222.1, NC_006671.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXBX-ray2.00A24-286[»]
1BT5X-ray1.80A24-286[»]
1BTLX-ray1.80A24-286[»]
1CK3X-ray2.28A24-284[»]
1ERMX-ray1.70A24-286[»]
1EROX-ray2.10A24-286[»]
1ERQX-ray1.90A24-286[»]
1ESUX-ray2.00A24-284[»]
1FQGX-ray1.70A24-286[»]
1JTDX-ray2.30A24-286[»]
1JTGX-ray1.73A/C24-286[»]
1JVJX-ray1.73A24-286[»]
1JWPX-ray1.75A24-286[»]
1JWVX-ray1.85A24-286[»]
1JWZX-ray1.80A24-286[»]
1LHYX-ray2.00A24-284[»]
1LI0X-ray1.61A24-284[»]
1LI9X-ray1.52A24-284[»]
1M40X-ray0.85A24-286[»]
1NXYX-ray1.60A24-286[»]
1NY0X-ray1.75A24-286[»]
1NYMX-ray1.20A24-286[»]
1NYYX-ray1.90A24-286[»]
1PZOX-ray1.90A24-284[»]
1PZPX-ray1.45A24-284[»]
1S0WX-ray2.30A/B24-286[»]
1TEMX-ray1.95A24-286[»]
1XPBX-ray1.90A24-286[»]
1XXMX-ray1.90A/B24-286[»]
1YT4X-ray1.40A24-284[»]
1ZG4X-ray1.55A1-284[»]
1ZG6X-ray2.10A1-284[»]
2B5RX-ray1.65A/B24-286[»]
2V1ZX-ray1.60A25-38[»]
A41-286[»]
2V20X-ray1.67A25-38[»]
A41-286[»]
3C7UX-ray2.20A/C24-286[»]
3C7VX-ray2.07A/C24-286[»]
3CMZX-ray1.92A24-286[»]
3DTMX-ray2.00A24-286[»]
3JYIX-ray2.70A/B/C/D/E/F24-286[»]
3TOIX-ray1.90A/B39-283[»]
4DXBX-ray2.29A/B24-226[»]
4DXCX-ray2.30A24-226[»]
4GKUX-ray1.92A24-286[»]
4IBRX-ray2.20A24-286[»]
4IBXX-ray2.68A/B/C/D/E24-286[»]
4ID4X-ray1.05A24-147[»]
A189-286[»]
4MEZX-ray2.05A/B24-286[»]
4QY5X-ray1.50A24-147[»]
A189-286[»]
4QY6X-ray1.15A24-147[»]
A189-286[»]
4R4RX-ray1.20A24-147[»]
A189-286[»]
4R4SX-ray1.10A24-149[»]
A189-286[»]
4RVAX-ray1.44A24-286[»]
4RX2X-ray2.31A/B/C/D/E/F/G/H24-286[»]
4RX3X-ray1.39A24-286[»]
4ZJ1X-ray1.54A1-286[»]
4ZJ2X-ray1.80A1-286[»]
4ZJ3X-ray1.70A1-286[»]
5HVIX-ray1.64A/B/C/D24-286[»]
5HW1X-ray1.70A/B/C/D24-286[»]
5HW5X-ray1.41A/B/C/D24-286[»]
5I52X-ray1.75A/B/C/D24-286[»]
5I63X-ray1.95A/B/C/D24-286[»]
5IQ8X-ray2.06A/B/C/D24-286[»]
5KKFX-ray1.82A/B/C/D24-286[»]
5KPUX-ray1.50A/B/C/D24-286[»]
5NPOX-ray1.95A24-286[»]
6APAX-ray1.86A/B/C/D24-286[»]
6AYKX-ray1.44A/B/C/D24-286[»]
6B2NX-ray2.00A/B/C/D24-286[»]
SMRiP62593
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP62593, 1 interactor

Chemistry databases

BindingDBiP62593
ChEMBLiCHEMBL2065
CHEMBL2364670
DrugBankiDB07466 (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID
DB07464 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID
DB02614 1(R)-1-Acetamido-2-(3-Carboxyphenyl)Ethyl Boronic Acid
DB04430 3-(4-Phenylamino-Phenylamino)-2-(1h-Tetrazol-5-Yl)-Acrylonitrile
DB08551 3-{(R)-(Dihydroxyboryl)[(2-thienylacetyl)amino]methyl}benzoic acid
DB07599 [(2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLYLACETYL)AMINO]METHYLBORONIC ACID
DB02841 [(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic Acid
DB02642 [[N-(Benzyloxycarbonyl)Amino]Methyl]Phosphate
DB09060 Avibactam
DB01053 Benzylpenicillin
DB04035 Ceftazidime BATSI
DB01598 Imipenem
DB04037 N,N-Bis(4-Chlorobenzyl)-1h-1,2,3,4-Tetraazol-5-Amine
DB12377 Relebactam
DB12107 Vaborbactam
DrugCentraliP62593

Proteomic databases

PRIDEiP62593

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P62593 7 sequenced antibodies

Genome annotation databases

GeneIDi10076131
10076142
13876868
13877052
13903673
13905334
13905363
13906404
13906709
13906924
13909533
13909568
14612524
17824300
17824435
18157686
20466965
20466993
20467118
20468340
20471961
20491414
20491639
20492529
20492626
20493584
2716540
3244915
3722457
43090221
4924718
5961992
6276043
8319064
8319163
9537966
9538101
9846067
KEGGiag:AAB59737
ag:CAA41038
ag:CAA45828
ag:CAA46344
ag:CAA46345
ag:CAA46346

Phylogenomic databases

KOiK18698
OrthoDBi991474at2

Enzyme and pathway databases

BRENDAi3.5.2.6 2026
SABIO-RKiP62593

Miscellaneous databases

EvolutionaryTraceiP62593

Protein Ontology

More...
PROi
PR:P62593

Family and domain databases

Gene3Di3.40.710.10, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBLAT_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62593
Secondary accession number(s): P00810, Q47313
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 17, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid, Transposable element

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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