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Protein

Sialidase A

Gene

nanA

Organism
Streptococcus pneumoniae
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei347SubstrateBy similarity1
Active sitei372Proton acceptorBy similarity1
Active sitei647By similarity1
Binding sitei663SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.18 1960
SABIO-RKiP62575

Protein family/group databases

CAZyiCBM40 Carbohydrate-Binding Module Family 40
GH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase A (EC:3.2.1.18)
Alternative name(s):
Neuraminidase A
Gene namesi
Name:nanA
OrganismiStreptococcus pneumoniae
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 53Sequence analysisAdd BLAST53
ChainiPRO_000001203454 – 1006Sialidase AAdd BLAST953
PropeptideiPRO_00000120351007 – 1035Removed by sortasePROSITE-ProRule annotationAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1006Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRIDEiP62575

Interactioni

Chemistry databases

BindingDBiP62575

Structurei

Secondary structure

11035
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62575
SMRiP62575
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62575

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati381 – 392BNR 1Add BLAST12
Repeati539 – 550BNR 2Add BLAST12
Repeati607 – 618BNR 3Add BLAST12
Repeati672 – 683BNR 4Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1003 – 1007LPXTG sorting signalPROSITE-ProRule annotation5

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4108478 Bacteria
COG4409 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR004124 Glyco_hydro_33_N
IPR001791 Laminin_G
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
IPR005877 YSIRK_signal_dom
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
PF02973 Sialidase, 1 hit
PF04650 YSIRK_signal, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 2 hits
TIGRFAMsiTIGR01168 YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYFRNRDID IERNSMNRSV QERKCRYSIR KLSVGAVSMI VGAVVFGTSP
60 70 80 90 100
VLAQEGASEQ PLANETQLSG ESSTLTDTEK SQPSSETELS GNKQEQERKD
110 120 130 140 150
KQEEKIPRDY YARDLENVET VIEKEDVETN ASNGQRVDLS SELDKLKKLE
160 170 180 190 200
NATVHMEFKP DAKAPAFYNL FSVSSATKKD EYFTMAVYNN TATLEGRGSD
210 220 230 240 250
GKQFYNNYND APLKVKPGQW NSVTFTVEKP TAELPKGRVR LYVNGVLSRT
260 270 280 290 300
SLRSGNFIKD MPDVTHVQIG ATKRANNTVW GSNLQIRNLT VYNRALTPEE
310 320 330 340 350
VQKRSQLFKR SDLEKKLPEG AALTEKTDIF ESGRNGKPNK DGIKSYRIPA
360 370 380 390 400
LLKTDKGTLI AGADERRLHS SDWGDIGMVI RRSEDNGKTW GDRVTITNLR
410 420 430 440 450
DNPKASDPSI GSPVNIDMVL VQDPETKRIF SIYDMFPEGK GIFGMSSQKE
460 470 480 490 500
EAYKKIDGKT YQILYREGEK GAYTIRENGT VYTPDGKATD YRVVVDPVKP
510 520 530 540 550
AYSDKGDLYK GNQLLGNIYF TTNKTSPFRI AKDSYLWMSY SDDDGKTWSA
560 570 580 590 600
PQDITPMVKA DWMKFLGVGP GTGIVLRNGP HKGRILIPVY TTNNVSHLNG
610 620 630 640 650
SQSSRIIYSD DHGKTWHAGE AVNDNRQVDG QKIHSSTMNN RRAQNTESTV
660 670 680 690 700
VQLNNGDVKL FMRGLTGDLQ VATSKDGGVT WEKDIKRYPQ VKDVYVQMSA
710 720 730 740 750
IHTMHEGKEY IILSNAGGPK RENGMVHLAR VEENGELTWL KHNPIQKGEF
760 770 780 790 800
AYNSLQELGN GEYGILYEHT EKGQNAYTLS FRKFNWDFLS KDLISPTEAK
810 820 830 840 850
VKRTREMGKG VIGLEFDSEV LVNKAPTLQL ANGKTARFMT QYDTKTLLFT
860 870 880 890 900
VDSEDMGQKV TGLAEGAIES MHNLPVSVAG TKLSNGMNGS EAAVHEVPEY
910 920 930 940 950
TGPLGTSGEE PAPTVEKPEY TGPLGTSGEE PAPTVEKPEY TGPLGTAGEE
960 970 980 990 1000
AAPTVEKPEF TGGVNGTEPA VHEIAEYKGS DSLVTLTTKE DYTYKAPLAQ
1010 1020 1030
QALPETGNKE SDLLASLGLT AFFLGLFTLG KKREQ
Length:1,035
Mass (Da):114,742
Last modified:July 19, 2004 - v1
Checksum:iC5B8A2D7A12E12F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72967 Genomic DNA Translation: CAA51473.1
U43526 Genomic DNA Translation: AAC44391.1
PIRiT30287
RefSeqiWP_010976603.1, NZ_NANP01000004.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72967 Genomic DNA Translation: CAA51473.1
U43526 Genomic DNA Translation: AAC44391.1
PIRiT30287
RefSeqiWP_010976603.1, NZ_NANP01000004.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VVZX-ray2.50A/B319-822[»]
2YA4X-ray1.80A/B318-791[»]
2YA5X-ray2.00A/B318-791[»]
2YA6X-ray2.00A/B318-791[»]
2YA7X-ray1.89A/B/C/D318-791[»]
2YA8X-ray1.75A/B318-791[»]
4C1XX-ray1.84A121-305[»]
4ZXKX-ray1.84A/B121-305[»]
5KKYX-ray2.39A/B318-792[»]
ProteinModelPortaliP62575
SMRiP62575
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP62575

Protein family/group databases

CAZyiCBM40 Carbohydrate-Binding Module Family 40
GH33 Glycoside Hydrolase Family 33

Proteomic databases

PRIDEiP62575

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108478 Bacteria
COG4409 LUCA

Enzyme and pathway databases

BRENDAi3.2.1.18 1960
SABIO-RKiP62575

Miscellaneous databases

EvolutionaryTraceiP62575

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR004124 Glyco_hydro_33_N
IPR001791 Laminin_G
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
IPR005877 YSIRK_signal_dom
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
PF02973 Sialidase, 1 hit
PF04650 YSIRK_signal, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 2 hits
TIGRFAMsiTIGR01168 YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNANA_STREE
AccessioniPrimary (citable) accession number: P62575
Secondary accession number(s): Q54722, Q59959
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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