UniProtKB - P62517 (OPGH_ECOLI)
Protein
Glucans biosynthesis glucosyltransferase H
Gene
mdoH
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
: osmoregulated periplasmic glucan (OPG) biosynthesis Pathwayi
This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.
GO - Molecular functioni
- transferase activity, transferring hexosyl groups Source: GO_Central
GO - Biological processi
- beta-glucan biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11886-MONOMER |
UniPathwayi | UPA00637 |
Protein family/group databases
TCDBi | 4.D.3.1.1, the glycan glucosyl transferase (opgh) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mdoH Synonyms:opgH Ordered Locus Names:b1049, JW1037 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 139 | CytoplasmicSequence analysisAdd BLAST | 139 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 193 | PeriplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 194 – 214 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 215 – 512 | CytoplasmicSequence analysisAdd BLAST | 298 | |
Transmembranei | 513 – 533 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 534 – 569 | PeriplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 570 – 590 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 591 – 602 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 603 – 625 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 626 – 679 | PeriplasmicSequence analysisAdd BLAST | 54 | |
Transmembranei | 680 – 700 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 701 – 847 | CytoplasmicSequence analysisAdd BLAST | 147 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210349 | 1 – 847 | Glucans biosynthesis glucosyltransferase HAdd BLAST | 847 |
Proteomic databases
jPOSTi | P62517 |
PaxDbi | P62517 |
PRIDEi | P62517 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260685, 160 interactors |
IntActi | P62517, 1 interactor |
STRINGi | 511145.b1049 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2943, Bacteria |
HOGENOMi | CLU_015730_1_0_6 |
InParanoidi | P62517 |
PhylomeDBi | P62517 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_01072, MdoH_OpgH, 1 hit |
InterProi | View protein in InterPro IPR023725, Glucans_biosynth_gluTrFase_H IPR001173, Glyco_trans_2-like IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P62517-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKTTEYIDA MPIAASEKAA LPKTDIRAVH QALDAEHRTW AREDDSPQGS
60 70 80 90 100
VKARLEQAWP DSLADGQLIK DDEGRDQLKA MPEAKRSSMF PDPWRTNPVG
110 120 130 140 150
RFWDRLRGRD VTPRYLARLT KEEQESEQKW RTVGTIRRYI LLILTLAQTV
160 170 180 190 200
VATWYMKTIL PYQGWALINP MDMVGQDLWV SFMQLLPYML QTGILILFAV
210 220 230 240 250
LFCWVSAGFW TALMGFLQLL IGRDKYSISA STVGDEPLNP EHRTALIMPI
260 270 280 290 300
CNEDVNRVFA GLRATWESVK ATGNAKHFDV YILSDSYNPD ICVAEQKAWM
310 320 330 340 350
ELIAEVGGEG QIFYRRRRRR VKRKSGNIDD FCRRWGSQYS YMVVLDADSV
360 370 380 390 400
MTGDCLCGLV RLMEANPNAG IIQSSPKASG MDTLYARCQQ FATRVYGPLF
410 420 430 440 450
TAGLHFWQLG ESHYWGHNAI IRVKPFIEHC ALAPLPGEGS FAGSILSHDF
460 470 480 490 500
VEAALMRRAG WGVWIAYDLP GSYEELPPNL LDELKRDRRW CHGNLMNFRL
510 520 530 540 550
FLVKGMHPVH RAVFLTGVMS YLSAPLWFMF LALSTALQVV HALTEPQYFL
560 570 580 590 600
QPRQLFPVWP QWRPELAIAL FASTMVLLFL PKLLSILLIW CKGTKEYGGF
610 620 630 640 650
WRVTLSLLLE VLFSVLLAPV RMLFHTVFVV SAFLGWEVVW NSPQRDDDST
660 670 680 690 700
SWGEAFKRHG SQLLLGLVWA VGMAWLDLRF LFWLAPIVFS LILSPFVSVI
710 720 730 740 750
SSRATVGLRT KRWKLFLIPE EYSPPQVLVD TDRFLEMNRQ RSLDDGFMHA
760 770 780 790 800
VFNPSFNALA TAMATARHRA SKVLEIARDR HVEQALNETP EKLNRDRRLV
810 820 830 840
LLSDPVTMAR LHFRVWNSPE RYSSWVSYYE GIKLNPLALR KPDAASQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | A → G in CAA45522 (PubMed:7934824).Curated | 1 | |
Sequence conflicti | 289 | P → L in CAA45522 (PubMed:7934824).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64197 Genomic DNA Translation: CAA45522.1 U00096 Genomic DNA Translation: AAC74133.1 AP009048 Genomic DNA Translation: BAA35848.1 |
PIRi | F64847 |
RefSeqi | NP_415567.1, NC_000913.3 WP_001295445.1, NZ_STEB01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC74133; AAC74133; b1049 BAA35848; BAA35848; BAA35848 |
GeneIDi | 58391542 945624 |
KEGGi | ecj:JW1037 eco:b1049 |
PATRICi | fig|511145.12.peg.1091 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64197 Genomic DNA Translation: CAA45522.1 U00096 Genomic DNA Translation: AAC74133.1 AP009048 Genomic DNA Translation: BAA35848.1 |
PIRi | F64847 |
RefSeqi | NP_415567.1, NC_000913.3 WP_001295445.1, NZ_STEB01000016.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260685, 160 interactors |
IntActi | P62517, 1 interactor |
STRINGi | 511145.b1049 |
Protein family/group databases
TCDBi | 4.D.3.1.1, the glycan glucosyl transferase (opgh) family |
Proteomic databases
jPOSTi | P62517 |
PaxDbi | P62517 |
PRIDEi | P62517 |
Genome annotation databases
EnsemblBacteriai | AAC74133; AAC74133; b1049 BAA35848; BAA35848; BAA35848 |
GeneIDi | 58391542 945624 |
KEGGi | ecj:JW1037 eco:b1049 |
PATRICi | fig|511145.12.peg.1091 |
Organism-specific databases
EchoBASEi | EB1832 |
Phylogenomic databases
eggNOGi | COG2943, Bacteria |
HOGENOMi | CLU_015730_1_0_6 |
InParanoidi | P62517 |
PhylomeDBi | P62517 |
Enzyme and pathway databases
UniPathwayi | UPA00637 |
BioCyci | EcoCyc:EG11886-MONOMER |
Miscellaneous databases
PROi | PR:P62517 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_01072, MdoH_OpgH, 1 hit |
InterProi | View protein in InterPro IPR023725, Glucans_biosynth_gluTrFase_H IPR001173, Glyco_trans_2-like IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OPGH_ECOLI | |
Accessioni | P62517Primary (citable) accession number: P62517 Secondary accession number(s): P33137, P77371 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families