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Entry version 116 (10 Feb 2021)
Sequence version 1 (19 Jul 2004)
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Protein

Glucans biosynthesis glucosyltransferase H

Gene

mdoH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • beta-glucan biosynthetic process Source: EcoCyc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG11886-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00637

Protein family/group databases

Transport Classification Database

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TCDBi
4.D.3.1.1, the glycan glucosyl transferase (opgh) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucans biosynthesis glucosyltransferase H (EC:2.4.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdoH
Synonyms:opgH
Ordered Locus Names:b1049, JW1037
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 139CytoplasmicSequence analysisAdd BLAST139
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 193PeriplasmicSequence analysisAdd BLAST33
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 512CytoplasmicSequence analysisAdd BLAST298
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 569PeriplasmicSequence analysisAdd BLAST36
Transmembranei570 – 590HelicalSequence analysisAdd BLAST21
Topological domaini591 – 602CytoplasmicSequence analysisAdd BLAST12
Transmembranei603 – 625HelicalSequence analysisAdd BLAST23
Topological domaini626 – 679PeriplasmicSequence analysisAdd BLAST54
Transmembranei680 – 700HelicalSequence analysisAdd BLAST21
Topological domaini701 – 847CytoplasmicSequence analysisAdd BLAST147

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002103491 – 847Glucans biosynthesis glucosyltransferase HAdd BLAST847

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62517

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62517

PRoteomics IDEntifications database

More...
PRIDEi
P62517

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260685, 160 interactors

Protein interaction database and analysis system

More...
IntActi
P62517, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b1049

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2943, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015730_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62517

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62517

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01072, MdoH_OpgH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023725, Glucans_biosynth_gluTrFase_H
IPR001173, Glyco_trans_2-like
IPR029044, Nucleotide-diphossugar_trans

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00535, Glycos_transf_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P62517-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKTTEYIDA MPIAASEKAA LPKTDIRAVH QALDAEHRTW AREDDSPQGS
60 70 80 90 100
VKARLEQAWP DSLADGQLIK DDEGRDQLKA MPEAKRSSMF PDPWRTNPVG
110 120 130 140 150
RFWDRLRGRD VTPRYLARLT KEEQESEQKW RTVGTIRRYI LLILTLAQTV
160 170 180 190 200
VATWYMKTIL PYQGWALINP MDMVGQDLWV SFMQLLPYML QTGILILFAV
210 220 230 240 250
LFCWVSAGFW TALMGFLQLL IGRDKYSISA STVGDEPLNP EHRTALIMPI
260 270 280 290 300
CNEDVNRVFA GLRATWESVK ATGNAKHFDV YILSDSYNPD ICVAEQKAWM
310 320 330 340 350
ELIAEVGGEG QIFYRRRRRR VKRKSGNIDD FCRRWGSQYS YMVVLDADSV
360 370 380 390 400
MTGDCLCGLV RLMEANPNAG IIQSSPKASG MDTLYARCQQ FATRVYGPLF
410 420 430 440 450
TAGLHFWQLG ESHYWGHNAI IRVKPFIEHC ALAPLPGEGS FAGSILSHDF
460 470 480 490 500
VEAALMRRAG WGVWIAYDLP GSYEELPPNL LDELKRDRRW CHGNLMNFRL
510 520 530 540 550
FLVKGMHPVH RAVFLTGVMS YLSAPLWFMF LALSTALQVV HALTEPQYFL
560 570 580 590 600
QPRQLFPVWP QWRPELAIAL FASTMVLLFL PKLLSILLIW CKGTKEYGGF
610 620 630 640 650
WRVTLSLLLE VLFSVLLAPV RMLFHTVFVV SAFLGWEVVW NSPQRDDDST
660 670 680 690 700
SWGEAFKRHG SQLLLGLVWA VGMAWLDLRF LFWLAPIVFS LILSPFVSVI
710 720 730 740 750
SSRATVGLRT KRWKLFLIPE EYSPPQVLVD TDRFLEMNRQ RSLDDGFMHA
760 770 780 790 800
VFNPSFNALA TAMATARHRA SKVLEIARDR HVEQALNETP EKLNRDRRLV
810 820 830 840
LLSDPVTMAR LHFRVWNSPE RYSSWVSYYE GIKLNPLALR KPDAASQ
Length:847
Mass (Da):96,937
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DCAF93640180944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19A → G in CAA45522 (PubMed:7934824).Curated1
Sequence conflicti289P → L in CAA45522 (PubMed:7934824).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64197 Genomic DNA Translation: CAA45522.1
U00096 Genomic DNA Translation: AAC74133.1
AP009048 Genomic DNA Translation: BAA35848.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F64847

NCBI Reference Sequences

More...
RefSeqi
NP_415567.1, NC_000913.3
WP_001295445.1, NZ_STEB01000016.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74133; AAC74133; b1049
BAA35848; BAA35848; BAA35848

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58391542
945624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1037
eco:b1049

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.1091

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64197 Genomic DNA Translation: CAA45522.1
U00096 Genomic DNA Translation: AAC74133.1
AP009048 Genomic DNA Translation: BAA35848.1
PIRiF64847
RefSeqiNP_415567.1, NC_000913.3
WP_001295445.1, NZ_STEB01000016.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260685, 160 interactors
IntActiP62517, 1 interactor
STRINGi511145.b1049

Protein family/group databases

TCDBi4.D.3.1.1, the glycan glucosyl transferase (opgh) family

Proteomic databases

jPOSTiP62517
PaxDbiP62517
PRIDEiP62517

Genome annotation databases

EnsemblBacteriaiAAC74133; AAC74133; b1049
BAA35848; BAA35848; BAA35848
GeneIDi58391542
945624
KEGGiecj:JW1037
eco:b1049
PATRICifig|511145.12.peg.1091

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1832

Phylogenomic databases

eggNOGiCOG2943, Bacteria
HOGENOMiCLU_015730_1_0_6
InParanoidiP62517
PhylomeDBiP62517

Enzyme and pathway databases

UniPathwayiUPA00637
BioCyciEcoCyc:EG11886-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P62517

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_01072, MdoH_OpgH, 1 hit
InterProiView protein in InterPro
IPR023725, Glucans_biosynth_gluTrFase_H
IPR001173, Glyco_trans_2-like
IPR029044, Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00535, Glycos_transf_2, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPGH_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62517
Secondary accession number(s): P33137, P77371
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: February 10, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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