Esrrg

Functionⁱ

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.1 Publication

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	125 – 200	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	128 – 148	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	164 – 188	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

calmodulin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12715898
DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10428842
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 15149736
nuclear receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10072763
retinoic acid receptor activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 15149736
steroid binding Source: InterPro
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development
Source: UniProtKB
Non-traceable author statementⁱ
- 10428842
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 17229846
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10428842
- 12715898
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 15149736
regulation of transcription, DNA-templated Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Estrogen-related receptor gamma Alternative name(s): Estrogen receptor-related protein 3 Nuclear receptor subfamily 3 group B member 3
Gene namesⁱ	Name:Esrrg Synonyms:Err3, Kiaa0832, Nr3b3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1347056 Esrrg

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Cardiomyocyte-specific double konckout for ESRRA and ESRRG are slower at gaining weight, smaller and shorter from 5 to 7 days of age compared to controls. They show decreased absolute weight of most internal organs except the heart. They have about 70% decreased plasma IGF1 levels but normal plasma growth hormone levels. At 14-15 days, mutants develop lethal dilated cardiomyopathy and heart failure.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	449	L → A: Loss of transcriptional activation; when associated with A-450. 1 Publication	1
Mutagenesisⁱ	450	F → A: Loss of transcriptional activation; when associated with A-449. 1 Publication	1
Mutagenesisⁱ	453	M → A: Loss of transcriptional activation; when associated with A-454. 1 Publication	1
Mutagenesisⁱ	454	L → A: Loss of transcriptional activation; when associated with A-453. 1 Publication	1

Chemistry databases

ChEMBLⁱ	CHEMBL3585238

ChEMBLⁱ

CHEMBL3585238

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053666	1 – 458	Estrogen-related receptor gammaAdd BLAST		458

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	40	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	45	PhosphoserineCurated		1

Post-translational modificationⁱ

Acetylated by PCAF/KAT2 (in vitro).By similarity

Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.By similarity

Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62509
PaxDbⁱ	P62509
PeptideAtlas More...PeptideAtlasⁱ	P62509
PRIDEⁱ	P62509

PTM databases

iPTMnetⁱ	P62509
PhosphoSitePlusⁱ	P62509

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the heart, brain and kidney and low expression in the liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000026610 Expressed in 242 organ(s), highest expression level in pontine nuclear group
CleanExⁱ	MM_ESRRG
ExpressionAtlasⁱ	P62509 baseline and differential
Genevisibleⁱ	P62509 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2 (By similarity). Binds TLE1, PNRC1 and PNRC2 (By similarity). Binds GRIP1.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CREBZF	Q9NS37	3	EBI-5274019,EBI-632965	From Homo sapiens.
Crebzf	Q91ZR3	3	EBI-5274019,EBI-5274001

GO - Molecular functionⁱ

calmodulin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12715898

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204939, 4 interactors
IntActⁱ	P62509, 7 interactors
STRINGⁱ	10090.ENSMUSP00000027906

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	236 – 243	Combined sources	8
Helixⁱ	261 – 283	Combined sources	23
Turnⁱ	287 – 291	Combined sources	5
Helixⁱ	294 – 316	Combined sources	23
Turnⁱ	317 – 319	Combined sources	3
Beta strandⁱ	320 – 322	Combined sources	3
Beta strandⁱ	324 – 327	Combined sources	4
Beta strandⁱ	330 – 332	Combined sources	3
Helixⁱ	334 – 338	Combined sources	5
Turnⁱ	339 – 341	Combined sources	3
Helixⁱ	343 – 359	Combined sources	17
Helixⁱ	363 – 375	Combined sources	13
Helixⁱ	385 – 406	Combined sources	22
Helixⁱ	413 – 418	Combined sources	6
Helixⁱ	421 – 440	Combined sources	20
Helixⁱ	448 – 455	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P62509
SMRⁱ	P62509
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	233 – 457	NR LBDPROSITE-ProRule annotationAdd BLAST		225

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	128 – 148	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	164 – 188	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000233467
HOVERGENⁱ	HBG108344
InParanoidⁱ	P62509
KEGG Orthology (KO) More...KOⁱ	K08554
OMAⁱ	MDPVELC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DYP
PhylomeDBⁱ	P62509
TreeFamⁱ	TF323751

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR027289 Oest-rel_rcp IPR024178 Oest_rcpt/oest-rel_rcp IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002527 ER-like_NR, 1 hit PIRSF500939 ERR1-2-3, 1 hit
PRINTSⁱ	PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P62509-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT 
        60         70         80         90        100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL 
       110        120        130        140        150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA 
       160        170        180        190        200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL 
       210        220        230        240        250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY 
       260        270        280        290        300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL 
       310        320        330        340        350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL 
       360        370        380        390        400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ 
       410        420        430        440        450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF 

LEMLEAKV

Length:458

Mass (Da):51,306

Last modified:July 19, 2004 - v1

Checksum:ⁱ63D36CFD37573152

GO

Isoform 2 (identifier: P62509-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
1-23: Missing.

« Hide

        10         20         30         40         50
MSNKDRHIDS SCSSFIKTEP SSPASLTDSV NHHSPGGSSD ASGSYSSTMN 
        60         70         80         90        100
GHQNGLDSPP LYPSAPILGG SGPVRKLYDD CSSTIVEDPQ TKCEYMLNSM 
       110        120        130        140        150
PKRLCLVCGD IASGYHYGVA SCEACKAFFK RTIQGNIEYS CPATNECEIT 
       160        170        180        190        200
KRRRKSCQAC RFMKCLKVGM LKEGVRLDRV RGGRQKYKRR IDAENSPYLN 
       210        220        230        240        250
PQLVQPAKKP YNKIVSHLLV AEPEKIYAMP DPTVPDSDIK ALTTLCDLAD 
       260        270        280        290        300
RELVVIIGWA KHIPGFSTLS LADQMSLLQS AWMEILILGV VYRSLSFEDE 
       310        320        330        340        350
LVYADDYIMD EDQSKLAGLL DLNNAILQLV KKYKSMKLEK EEFVTLKAIA 
       360        370        380        390        400
LANSDSMHIE DVEAVQKLQD VLHEALQDYE AGQHMEDPRR AGKMLMTLPL 
       410        420        430 
LRQTSTKAVQ HFYNIKLEGK VPMHKLFLEM LEAKV

Show »

Length:435

Mass (Da):48,581

Checksum:ⁱ63F81CDBE3A9C2D5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3Z2J0	D3Z2J0_MOUSE		Estrogen-related receptor gamma Estrogen-related receptor gamma	Esrrg	52	Annotation score:

Sequence cautionⁱ

The sequence BAC41450 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	153	K → N in BAC41450 (PubMed:12465718).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010766	1 – 23	Missing in isoform 2. 2 PublicationsAdd BLAST		23

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF117254 mRNA Translation: AAD48369.1 AB093266 mRNA Translation: BAC41450.1 Different initiation. AK052731 mRNA Translation: BAC35120.1 BC082324 mRNA Translation: AAH82324.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15606.1 [P62509-1] CCDS56666.1 [P62509-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001230721.1, NM_001243792.1 [P62509-2] NP_036065.1, NM_011935.3 [P62509-1] XP_006497227.1, XM_006497164.3 XP_006497228.1, XM_006497165.3 [P62509-2] XP_006497230.1, XM_006497167.3 XP_006497233.1, XM_006497170.1 [P62509-2]
UniGeneⁱ	Mm.388156 Mm.421613 Mm.89989

Genome annotation databases

Ensemblⁱ	ENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610 [P62509-1] ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610 [P62509-2] ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610 [P62509-2]
GeneIDⁱ	26381
KEGGⁱ	mmu:26381
UCSC genome browser More...UCSCⁱ	uc007eaa.2 mouse [P62509-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62509	Estrogen-related receptor gamma	)	HUMAN		458	UniRef100_P62508
Estrogen-related receptor gamma		RAT		458
ESRRG isoform 16		PANTR		458
Estrogen-related receptor gamma isoform 1		CALJA		458
Estrogen related receptor gamma		RHIBE		458
+24
P62509-2	Estrogen-related nuclear receptor gamma variant 2		HUMAN		435	UniRef100_F1D8R6
estrogen-related receptor gamma isoform X3		ERIEU		273
estrogen-related receptor gamma-like isoform X8		LEPWE		273
estrogen-related receptor gamma-like isoform X2		LIPVE		273
estrogen-related receptor gamma isoform X5		TURTR		273
+33

Protein	Similar proteins		Species	Score	Length	Source
P62509	Estrogen-related receptor gamma	)	HUMAN		458	UniRef90_P62508
Estrogen-related receptor gamma		RAT		458
ESRRG isoform 16		PANTR		458
Estrogen-related receptor gamma isoform 1		CALJA		458
Estrogen related receptor gamma		RHIBE		458
+328
P62509-2	Estrogen-related receptor gamma		PONAB		435	UniRef90_Q5RAM2
Estrogen-related receptor gamma		HUMAN		436
estrogen-related receptor gamma isoform X3		ERIEU		273
estrogen-related receptor gamma-like isoform X8		LEPWE		273
estrogen-related receptor gamma-like isoform X2		LIPVE		273
+58

Protein	Similar proteins		Species	Score	Length	Source
P62509	Steroid hormone receptor ERR2		MOUSE		433	UniRef50_Q61539
Steroid hormone receptor ERR2		RAT		433
Estrogen-related receptor gamma		PONAB		435
Steroid hormone receptor ERR2	)	HUMAN		433
Estrogen related receptor beta		AILME		501
+1004

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF117254 mRNA Translation: AAD48369.1 AB093266 mRNA Translation: BAC41450.1 Different initiation. AK052731 mRNA Translation: BAC35120.1 BC082324 mRNA Translation: AAH82324.1
CCDSⁱ	CCDS15606.1 [P62509-1] CCDS56666.1 [P62509-2]
RefSeqⁱ	NP_001230721.1, NM_001243792.1 [P62509-2] NP_036065.1, NM_011935.3 [P62509-1] XP_006497227.1, XM_006497164.3 XP_006497228.1, XM_006497165.3 [P62509-2] XP_006497230.1, XM_006497167.3 XP_006497233.1, XM_006497170.1 [P62509-2]
UniGeneⁱ	Mm.388156 Mm.421613 Mm.89989

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1S9P	X-ray	2.13	A/B/C/D	232-458	[»]
	1S9Q	X-ray	2.20	A/B	229-456	[»]
ProteinModelPortalⁱ	P62509
SMRⁱ	P62509
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204939, 4 interactors
IntActⁱ	P62509, 7 interactors
STRINGⁱ	10090.ENSMUSP00000027906

Chemistry databases

ChEMBLⁱ	CHEMBL3585238

ChEMBLⁱ

CHEMBL3585238

PTM databases

iPTMnetⁱ	P62509
PhosphoSitePlusⁱ	P62509

Proteomic databases

MaxQBⁱ	P62509
PaxDbⁱ	P62509
PeptideAtlasⁱ	P62509
PRIDEⁱ	P62509

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610 [P62509-1] ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610 [P62509-2] ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610 [P62509-2]
GeneIDⁱ	26381
KEGGⁱ	mmu:26381
UCSCⁱ	uc007eaa.2 mouse [P62509-1]

Organism-specific databases

CTDⁱ	2104
MGIⁱ	MGI:1347056 Esrrg
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000233467
HOVERGENⁱ	HBG108344
InParanoidⁱ	P62509
KOⁱ	K08554
OMAⁱ	MDPVELC
OrthoDBⁱ	EOG091G0DYP
PhylomeDBⁱ	P62509
TreeFamⁱ	TF323751

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSⁱ	Esrrg mouse
Protein Ontology More...PROⁱ	PR:P62509
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026610 Expressed in 242 organ(s), highest expression level in pontine nuclear group
CleanExⁱ	MM_ESRRG
ExpressionAtlasⁱ	P62509 baseline and differential
Genevisibleⁱ	P62509 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR027289 Oest-rel_rcp IPR024178 Oest_rcpt/oest-rel_rcp IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002527 ER-like_NR, 1 hit PIRSF500939 ERR1-2-3, 1 hit
PRINTSⁱ	PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ERR3_MOUSE
Accessionⁱ	P62509Primary (citable) accession number: P62509 Secondary accession number(s): O75454 , O96021, Q8CHC9, Q9R1F3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	July 19, 2004
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62509 (ERR3_MOUSE)

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Estrogen-related receptor gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ