UniProtKB - P62509 (ERR3_MOUSE)
Estrogen-related receptor gamma
Esrrg
Functioni
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.
1 PublicationMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 125 – 200 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 128 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 164 – 188 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- estrogen response element binding Source: UniProtKB
- identical protein binding Source: MGI
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
- steroid binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- retinoic acid receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen-related receptor gammaAlternative name(s): Estrogen receptor-related protein 3 Nuclear receptor subfamily 3 group B member 3 |
Gene namesi | Name:Esrrg Synonyms:Err3, Kiaa0832, Nr3b3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1347056, Esrrg |
VEuPathDBi | HostDB:ENSMUSG00000026610 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 449 | L → A: Loss of transcriptional activation; when associated with A-450. 1 Publication | 1 | |
Mutagenesisi | 450 | F → A: Loss of transcriptional activation; when associated with A-449. 1 Publication | 1 | |
Mutagenesisi | 453 | M → A: Loss of transcriptional activation; when associated with A-454. 1 Publication | 1 | |
Mutagenesisi | 454 | L → A: Loss of transcriptional activation; when associated with A-453. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3585238 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053666 | 1 – 458 | Estrogen-related receptor gammaAdd BLAST | 458 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 40 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Modified residuei | 45 | PhosphoserineCurated | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P62509 |
PaxDbi | P62509 |
PeptideAtlasi | P62509 |
PRIDEi | P62509 |
ProteomicsDBi | 275945 [P62509-1] 275946 [P62509-2] |
PTM databases
iPTMneti | P62509 |
PhosphoSitePlusi | P62509 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000026610, Expressed in pontine nuclear group and 261 other tissues |
Genevisiblei | P62509, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with NRIP1, NCOA1 and NCOR2 (By similarity). Binds TLE1, PNRC1 and PNRC2 (By similarity). Binds GRIP1.
By similarity2 PublicationsBinary interactionsi
P62509
With | #Exp. | IntAct |
---|---|---|
Crebzf [Q91ZR3] | 3 | EBI-5274019,EBI-5274001 |
CREBZF [Q9NS37] from Homo sapiens. | 3 | EBI-5274019,EBI-632965 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204939, 4 interactors |
IntActi | P62509, 8 interactors |
STRINGi | 10090.ENSMUSP00000027906 |
Miscellaneous databases
RNActi | P62509, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P62509 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 233 – 457 | NR LBDPROSITE-ProRule annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 85 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 80 | Polar residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 128 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 164 – 188 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
HOGENOMi | CLU_007368_11_0_1 |
InParanoidi | P62509 |
OMAi | KYRRSTD |
OrthoDBi | 669799at2759 |
PhylomeDBi | P62509 |
TreeFami | TF323751 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF
LEMLEAKV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z2J0 | D3Z2J0_MOUSE | Estrogen-related receptor gamma | Esrrg | 52 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 153 | K → N in BAC41450 (PubMed:12465718).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010766 | 1 – 23 | Missing in isoform 2. 2 PublicationsAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117254 mRNA Translation: AAD48369.1 AB093266 mRNA Translation: BAC41450.1 Different initiation. AK052731 mRNA Translation: BAC35120.1 BC082324 mRNA Translation: AAH82324.1 |
CCDSi | CCDS15606.1 [P62509-1] CCDS56666.1 [P62509-2] |
RefSeqi | NP_001230721.1, NM_001243792.1 [P62509-2] NP_036065.1, NM_011935.3 [P62509-1] XP_006497227.1, XM_006497164.3 XP_006497228.1, XM_006497165.3 [P62509-2] XP_006497230.1, XM_006497167.3 XP_006497233.1, XM_006497170.1 [P62509-2] |
Genome annotation databases
Ensembli | ENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610 [P62509-1] ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610 [P62509-2] ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610 [P62509-2] |
GeneIDi | 26381 |
KEGGi | mmu:26381 |
UCSCi | uc007eaa.2, mouse [P62509-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117254 mRNA Translation: AAD48369.1 AB093266 mRNA Translation: BAC41450.1 Different initiation. AK052731 mRNA Translation: BAC35120.1 BC082324 mRNA Translation: AAH82324.1 |
CCDSi | CCDS15606.1 [P62509-1] CCDS56666.1 [P62509-2] |
RefSeqi | NP_001230721.1, NM_001243792.1 [P62509-2] NP_036065.1, NM_011935.3 [P62509-1] XP_006497227.1, XM_006497164.3 XP_006497228.1, XM_006497165.3 [P62509-2] XP_006497230.1, XM_006497167.3 XP_006497233.1, XM_006497170.1 [P62509-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S9P | X-ray | 2.13 | A/B/C/D | 232-458 | [»] | |
1S9Q | X-ray | 2.20 | A/B | 229-456 | [»] | |
SMRi | P62509 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204939, 4 interactors |
IntActi | P62509, 8 interactors |
STRINGi | 10090.ENSMUSP00000027906 |
Chemistry databases
ChEMBLi | CHEMBL3585238 |
PTM databases
iPTMneti | P62509 |
PhosphoSitePlusi | P62509 |
Proteomic databases
MaxQBi | P62509 |
PaxDbi | P62509 |
PeptideAtlasi | P62509 |
PRIDEi | P62509 |
ProteomicsDBi | 275945 [P62509-1] 275946 [P62509-2] |
Protocols and materials databases
Antibodypediai | 20728, 506 antibodies from 39 providers |
DNASUi | 26381 |
Genome annotation databases
Ensembli | ENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610 [P62509-1] ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610 [P62509-2] ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610 [P62509-2] |
GeneIDi | 26381 |
KEGGi | mmu:26381 |
UCSCi | uc007eaa.2, mouse [P62509-1] |
Organism-specific databases
CTDi | 2104 |
MGIi | MGI:1347056, Esrrg |
VEuPathDBi | HostDB:ENSMUSG00000026610 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
HOGENOMi | CLU_007368_11_0_1 |
InParanoidi | P62509 |
OMAi | KYRRSTD |
OrthoDBi | 669799at2759 |
PhylomeDBi | P62509 |
TreeFami | TF323751 |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway |
Miscellaneous databases
BioGRID-ORCSi | 26381, 2 hits in 64 CRISPR screens |
ChiTaRSi | Esrrg, mouse |
PROi | PR:P62509 |
RNActi | P62509, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026610, Expressed in pontine nuclear group and 261 other tissues |
Genevisiblei | P62509, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ERR3_MOUSE | |
Accessioni | P62509Primary (citable) accession number: P62509 Secondary accession number(s): O75454 Q9R1F3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families