Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Estrogen-related receptor gamma

Gene

Esrrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.1 Publication

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 200Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:Esrrg
Synonyms:Err3, Kiaa0832, Nr3b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1347056 Esrrg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Cardiomyocyte-specific double konckout for ESRRA and ESRRG are slower at gaining weight, smaller and shorter from 5 to 7 days of age compared to controls. They show decreased absolute weight of most internal organs except the heart. They have about 70% decreased plasma IGF1 levels but normal plasma growth hormone levels. At 14-15 days, mutants develop lethal dilated cardiomyopathy and heart failure.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi449L → A: Loss of transcriptional activation; when associated with A-450. 1 Publication1
Mutagenesisi450F → A: Loss of transcriptional activation; when associated with A-449. 1 Publication1
Mutagenesisi453M → A: Loss of transcriptional activation; when associated with A-454. 1 Publication1
Mutagenesisi454L → A: Loss of transcriptional activation; when associated with A-453. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3585238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536661 – 458Estrogen-related receptor gammaAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei45PhosphoserineCurated1

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.By similarity
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP62509
PaxDbiP62509
PeptideAtlasiP62509
PRIDEiP62509

PTM databases

iPTMnetiP62509
PhosphoSitePlusiP62509

Expressioni

Tissue specificityi

Highly expressed in the heart, brain and kidney and low expression in the liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000026610 Expressed in 242 organ(s), highest expression level in pontine nuclear group
CleanExiMM_ESRRG
ExpressionAtlasiP62509 baseline and differential
GenevisibleiP62509 MM

Interactioni

Subunit structurei

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2 (By similarity). Binds TLE1, PNRC1 and PNRC2 (By similarity). Binds GRIP1.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204939, 4 interactors
IntActiP62509, 7 interactors
STRINGi10090.ENSMUSP00000027906

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62509
SMRiP62509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 457NR LBDPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000233467
HOVERGENiHBG108344
InParanoidiP62509
KOiK08554
OMAiPRLLCRM
OrthoDBiEOG091G0DYP
PhylomeDBiP62509
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR027289 Oest-rel_rcp
IPR024178 Oest_rcpt/oest-rel_rcp
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002527 ER-like_NR, 1 hit
PIRSF500939 ERR1-2-3, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: P62509-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62509-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2J0D3Z2J0_MOUSE
Estrogen-related receptor gamma
Esrrg
52Annotation score:

Sequence cautioni

The sequence BAC41450 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153K → N in BAC41450 (PubMed:12465718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107661 – 23Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117254 mRNA Translation: AAD48369.1
AB093266 mRNA Translation: BAC41450.1 Different initiation.
AK052731 mRNA Translation: BAC35120.1
BC082324 mRNA Translation: AAH82324.1
CCDSiCCDS15606.1 [P62509-1]
CCDS56666.1 [P62509-2]
RefSeqiNP_001230721.1, NM_001243792.1 [P62509-2]
NP_036065.1, NM_011935.3 [P62509-1]
XP_006497227.1, XM_006497164.3
XP_006497228.1, XM_006497165.3 [P62509-2]
XP_006497230.1, XM_006497167.3
XP_006497233.1, XM_006497170.1 [P62509-2]
UniGeneiMm.388156
Mm.421613
Mm.89989

Genome annotation databases

EnsembliENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610 [P62509-1]
ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610 [P62509-2]
ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610 [P62509-2]
GeneIDi26381
KEGGimmu:26381
UCSCiuc007eaa.2 mouse [P62509-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117254 mRNA Translation: AAD48369.1
AB093266 mRNA Translation: BAC41450.1 Different initiation.
AK052731 mRNA Translation: BAC35120.1
BC082324 mRNA Translation: AAH82324.1
CCDSiCCDS15606.1 [P62509-1]
CCDS56666.1 [P62509-2]
RefSeqiNP_001230721.1, NM_001243792.1 [P62509-2]
NP_036065.1, NM_011935.3 [P62509-1]
XP_006497227.1, XM_006497164.3
XP_006497228.1, XM_006497165.3 [P62509-2]
XP_006497230.1, XM_006497167.3
XP_006497233.1, XM_006497170.1 [P62509-2]
UniGeneiMm.388156
Mm.421613
Mm.89989

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S9PX-ray2.13A/B/C/D232-458[»]
1S9QX-ray2.20A/B229-456[»]
ProteinModelPortaliP62509
SMRiP62509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204939, 4 interactors
IntActiP62509, 7 interactors
STRINGi10090.ENSMUSP00000027906

Chemistry databases

ChEMBLiCHEMBL3585238

PTM databases

iPTMnetiP62509
PhosphoSitePlusiP62509

Proteomic databases

MaxQBiP62509
PaxDbiP62509
PeptideAtlasiP62509
PRIDEiP62509

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610 [P62509-1]
ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610 [P62509-2]
ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610 [P62509-2]
GeneIDi26381
KEGGimmu:26381
UCSCiuc007eaa.2 mouse [P62509-1]

Organism-specific databases

CTDi2104
MGIiMGI:1347056 Esrrg
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000233467
HOVERGENiHBG108344
InParanoidiP62509
KOiK08554
OMAiPRLLCRM
OrthoDBiEOG091G0DYP
PhylomeDBiP62509
TreeFamiTF323751

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSiEsrrg mouse
PROiPR:P62509
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026610 Expressed in 242 organ(s), highest expression level in pontine nuclear group
CleanExiMM_ESRRG
ExpressionAtlasiP62509 baseline and differential
GenevisibleiP62509 MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR027289 Oest-rel_rcp
IPR024178 Oest_rcpt/oest-rel_rcp
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002527 ER-like_NR, 1 hit
PIRSF500939 ERR1-2-3, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERR3_MOUSE
AccessioniPrimary (citable) accession number: P62509
Secondary accession number(s): O75454
, O96021, Q8CHC9, Q9R1F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again