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UniProtKB - P62508 (ERR3_HUMAN)

Entry version 191 (23 Feb 2022)
Sequence version 1 (19 Jul 2004)
Previous versions | rss
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Protein

Estrogen-related receptor gamma

Gene

ESRRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).

Induces the expression of PERM1 in the skeletal muscle.

By similarity4 Publications

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi125 – 200Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P62508

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-383280, Nuclear Receptor transcription pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P62508

SIGNOR Signaling Network Open Resource

More...SIGNORi		P62508

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
ERR gamma-2
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESRRG
Synonyms:ERR3, ERRG2, KIAA0832, NR3B3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3474, ESRRG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602969, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P62508

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196482

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38F → A or E: No effect on transcriptional activity. 1 Publication1
Mutagenesisi39I → A: 4-fold increase in transcriptional activity. 1 Publication1
Mutagenesisi40K → R: Abolishes sumoylation. 7-fold increase in transcriptional activity. 3 Publications1
Mutagenesisi41T → A: No effect on transcriptional activity. 1 Publication1
Mutagenesisi42E → A: 4-fold increase in transcriptional activity. 1 Publication1
Mutagenesisi44S → A or E: No effect on transcriptional activity. 1 Publication1
Mutagenesisi45S → A: Abolishes sumoylation. Increased transcriptional activity. 2 Publications1
Mutagenesisi45S → D: No change in sumoylation nor transcriptional activity. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		2104

Open Targets

More...OpenTargetsi		ENSG00000196482

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27891

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P62508, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4245

Drug and drug target database

More...DrugBanki		DB06884, 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
DB04468, Afimoxifene
DB06973, Bisphenol A
DB07485, Bisphenol Z
DB02659, Cholic Acid
DB00255, Diethylstilbestrol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB06902, p-Cumylphenol
DB00675, Tamoxifen
DB00197, Troglitazone

DrugCentral

More...DrugCentrali		P62508

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		624

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ESRRG

Domain mapping of disease mutations (DMDM)

More...DMDMi		50402102

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000536651 – 458Estrogen-related receptor gammaAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45Phosphoserine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).1 Publication
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.3 Publications
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P62508

MaxQB - The MaxQuant DataBase

More...MaxQBi		P62508

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62508

PeptideAtlas

More...PeptideAtlasi		P62508

PRoteomics IDEntifications database

More...PRIDEi		P62508

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20283
30159
57405
57406 [P62508-2]
57407 [P62508-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196482, Expressed in stomach and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P62508, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62508, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196482, Tissue enhanced (brain, parathyroid gland, retina, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity).

Interacts with NRIP1, NCOA1 and NCOR2.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P62508
With#Exp.IntAct
DEUP1 [Q05D60]3EBI-2834260,EBI-748597
KIFC3 [Q9BVG8]3EBI-2834260,EBI-2125614
MEOX2 [P50222]3EBI-2834260,EBI-748397
NR0B1 [P51843]3EBI-2834260,EBI-946109
NUP160 [Q12769]3EBI-2834260,EBI-295715
PPARGC1A [Q9UBK2]4EBI-2834260,EBI-765486
SHTN1 [A0MZ66]3EBI-2834260,EBI-308778
SUMO1P1 [G2XKQ0]3EBI-2834260,EBI-10175576
ESRRG - isoform 3 [P62508-3]
With#Exp.IntAct
ADCY4 [Q8NFM4]6EBI-12001340,EBI-2838710
ATM [Q13315]3EBI-12001340,EBI-495465
BPHL - isoform 2 [Q86WA6-2]3EBI-12001340,EBI-21843491
C22orf23 [Q9BZE7]3EBI-12001340,EBI-10303102
CAMK2G - isoform 5 [Q13555-5]3EBI-12001340,EBI-12020154
DEUP1 [Q05D60]3EBI-12001340,EBI-748597
EFHC2 [Q5JST6]3EBI-12001340,EBI-2349927
ESRRA [P11474]3EBI-12001340,EBI-372412
ESRRB - isoform 2 [O95718-2]3EBI-12001340,EBI-13303537
itself3EBI-12001340,EBI-12001340
EXOSC7 [Q15024]3EBI-12001340,EBI-371841
FAM107A - isoform 4 [O95990-4]3EBI-12001340,EBI-11977223
FAM9A [Q8IZU1]3EBI-12001340,EBI-8468186
FASTK [Q14296]3EBI-12001340,EBI-1754067
MCC [P23508]3EBI-12001340,EBI-307531
MRM1 [Q6IN84]5EBI-12001340,EBI-5454865
NR0B1 [P51843]6EBI-12001340,EBI-946109
NR0B2 [Q15466]3EBI-12001340,EBI-3910729
NRIP1 [P48552]3EBI-12001340,EBI-746484
PAX6 [P26367]3EBI-12001340,EBI-747278
PNRC2 [Q9NPJ4]3EBI-12001340,EBI-726549
POMC [P01189]3EBI-12001340,EBI-12219503
PPARGC1A [Q9UBK2]5EBI-12001340,EBI-765486
PSMC5 [P62195]3EBI-12001340,EBI-357745
RBIS - isoform 2 [Q8N0T1-2]3EBI-12001340,EBI-13380894
REL - isoform 2 [Q04864-2]3EBI-12001340,EBI-10829018
RINT1 [Q6NUQ1]3EBI-12001340,EBI-726876
SHTN1 - isoform 4 [A0MZ66-4]3EBI-12001340,EBI-12097232
SNIP1 [Q8TAD8]3EBI-12001340,EBI-749336
TNNI1 [P19237]3EBI-12001340,EBI-746692
TNNI2 [P48788]3EBI-12001340,EBI-7746394
TRERF1 [Q96PN7]3EBI-12001340,EBI-3505166
UBL7 [Q96S82]3EBI-12001340,EBI-348604
VAX1 - isoform 2 [Q5SQQ9-2]3EBI-12001340,EBI-12227803
ZNF438 [Q7Z4V0]3EBI-12001340,EBI-11962468

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108407, 67 interactors

Protein interaction database and analysis system

More...IntActi		P62508, 52 interactors

Molecular INTeraction database

More...MINTi		P62508

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355904

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P62508

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62508, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		P62508

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62508

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P62508

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini233 – 457NR LBDPROSITE-ProRule annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 85DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 80Polar residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3575, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153433

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62508

Identification of Orthologs from Complete Genome Data

More...OMAi		KYRRSTD

Database of Orthologous Groups

More...OrthoDBi		669799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P62508

TreeFam database of animal gene trees

More...TreeFami		TF323751

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.565.10, 1 hit
3.30.50.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00057

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024178, Est_rcpt/est-rel_rcp
IPR035500, NHR-like_dom_sf
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR027289, Oest-rel_rcp
IPR003078, Retinoic_acid_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002527, ER-like_NR, 1 hit
PIRSF500939, ERR1-2-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01292, RETNOICACIDR
PR00398, STRDHORMONER
PR00047, STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48508, SSF48508, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62508-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT 
        60         70         80         90        100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL 
       110        120        130        140        150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA 
       160        170        180        190        200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL 
       210        220        230        240        250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY 
       260        270        280        290        300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL 
       310        320        330        340        350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL 
       360        370        380        390        400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ 
       410        420        430        440        450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF 

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62508-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO
Isoform 3 (identifier: P62508-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     234-234: Y → LLWSDPAD

Show »
Length:442
Mass (Da):49,316
Checksum:i09B8CD0EE90CAEF5
GO
Isoform 4 (identifier: P62508-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     158-196: Missing.

Show »
Length:396
Mass (Da):44,073
Checksum:i614E044D8A31361C
GO
Isoform 5 (identifier: P62508-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MDSVELCLPESFSLHYEEE → MWRECDWGLGAVKSDLACVPSAKR
     234-234: Y → LLWSDPAD

Show »
Length:470
Mass (Da):52,462
Checksum:iC0C4BD53ABAF5CE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JU32C9JU32_HUMAN
Estrogen-related receptor gamma
ESRRG
354Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5W9C9J5W9_HUMAN
Estrogen-related receptor gamma
ESRRG
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNX5C9JNX5_HUMAN
Estrogen-related receptor gamma
ESRRG
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0E3C9J0E3_HUMAN
Estrogen-related receptor gamma
ESRRG
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM35K7EM35_HUMAN
Estrogen-related receptor gamma
ESRRG
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74855 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19E → K in AAQ93376 (PubMed:10707956).Curated1
Sequence conflicti151F → S in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti155T → K in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti158G → A in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti227V → A in BAG54746 (PubMed:14702039).Curated1
Sequence conflicti271L → C in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti313V → F in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti449L → P in CAH18320 (PubMed:14702039).Curated1
Sequence conflicti458V → VC in AAC39899 (PubMed:9676434).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01922950T → M1 PublicationCorresponds to variant dbSNP:rs11572693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0037021 – 23Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST23
Alternative sequenceiVSP_0471561 – 19MDSVE…HYEEE → MWRECDWGLGAVKSDLACVP SAKR in isoform 5. CuratedAdd BLAST19
Alternative sequenceiVSP_045980158 – 196Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_013301234Y → LLWSDPAD in isoform 3 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF094518 mRNA Translation: AAC99410.1
AB020639 mRNA Translation: BAA74855.2 Different initiation.
AF058291 mRNA Translation: AAC39899.1
AY388456 mRNA Translation: AAQ93376.1
AY388457 mRNA Translation: AAQ93377.1
AY388458 mRNA Translation: AAQ93378.1
AY388459 mRNA Translation: AAQ93379.1
AY388460 mRNA Translation: AAQ93380.1
AY388461 mRNA Translation: AAQ93381.1
AK131193 mRNA Translation: BAG54746.1
AK290945 mRNA Translation: BAF83634.1
AK291028 mRNA Translation: BAF83717.1
AK291647 mRNA Translation: BAF84336.1
CR749497 mRNA Translation: CAH18320.1
AY528719 Genomic DNA Translation: AAS00098.1
AC096635 Genomic DNA No translation available.
AL445650 Genomic DNA No translation available.
AL512650 Genomic DNA No translation available.
AC096634 Genomic DNA No translation available.
AL391216 Genomic DNA No translation available.
AL512626 Genomic DNA No translation available.
AL513312 Genomic DNA No translation available.
AL603752 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93335.1
BC008218 mRNA Translation: AAH08218.1 Sequence problems.
BC064700 mRNA Translation: AAH64700.1
AF117255 mRNA Translation: AAD48370.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1517.1 [P62508-2]
CCDS41468.1
CCDS58060.1 [P62508-4]
CCDS58061.1 [P62508-5]

NCBI Reference Sequences

More...RefSeqi		NP_001127757.1, NM_001134285.2 [P62508-2]
NP_001230434.1, NM_001243505.1
NP_001230435.1, NM_001243506.1
NP_001230436.1, NM_001243507.1 [P62508-4]
NP_001230438.1, NM_001243509.1 [P62508-2]
NP_001230439.1, NM_001243510.2 [P62508-2]
NP_001230440.1, NM_001243511.2 [P62508-2]
NP_001230441.1, NM_001243512.1 [P62508-2]
NP_001230442.1, NM_001243513.1 [P62508-2]
NP_001230443.1, NM_001243514.1 [P62508-2]
NP_001230444.1, NM_001243515.1 [P62508-2]
NP_001230447.1, NM_001243518.1 [P62508-5]
NP_001230448.1, NM_001243519.1 [P62508-2]
NP_001429.2, NM_001438.3 [P62508-1]
NP_996317.1, NM_206594.2 [P62508-2]
NP_996318.1, NM_206595.2 [P62508-2]
XP_011507569.1, XM_011509267.1 [P62508-5]
XP_011507570.1, XM_011509268.2 [P62508-5]
XP_011507571.1, XM_011509269.2 [P62508-5]
XP_011507576.1, XM_011509274.1 [P62508-3]
XP_011507577.1, XM_011509275.1 [P62508-3]
XP_011507578.1, XM_011509276.1 [P62508-3]
XP_011507579.1, XM_011509277.1 [P62508-3]
XP_011507580.1, XM_011509278.1 [P62508-3]
XP_011507581.1, XM_011509279.1 [P62508-3]
XP_011507582.1, XM_011509280.2 [P62508-3]
XP_016856120.1, XM_017000631.1 [P62508-3]
XP_016856121.1, XM_017000632.1 [P62508-3]
XP_016856122.1, XM_017000633.1 [P62508-3]
XP_016856123.1, XM_017000634.1 [P62508-3]
XP_016856124.1, XM_017000635.1 [P62508-3]
XP_016856125.1, XM_017000636.1 [P62508-3]
XP_016856126.1, XM_017000637.1 [P62508-3]
XP_016856127.1, XM_017000638.1 [P62508-2]
XP_016856128.1, XM_017000639.1 [P62508-2]
XP_016856129.1, XM_017000640.1
XP_016856130.1, XM_017000641.1 [P62508-2]
XP_016856131.1, XM_017000642.1
XP_016856132.1, XM_017000643.1
XP_016856133.1, XM_017000644.1 [P62508-2]
XP_016856134.1, XM_017000645.1 [P62508-2]
XP_016856135.1, XM_017000646.1
XP_016856136.1, XM_017000647.1
XP_016856137.1, XM_017000648.1
XP_016856138.1, XM_017000649.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359162; ENSP00000352077; ENSG00000196482 [P62508-2]
ENST00000360012; ENSP00000353108; ENSG00000196482 [P62508-2]
ENST00000361395; ENSP00000354584; ENSG00000196482 [P62508-2]
ENST00000361525; ENSP00000355225; ENSG00000196482 [P62508-2]
ENST00000366937; ENSP00000355904; ENSG00000196482 [P62508-5]
ENST00000366938; ENSP00000355905; ENSG00000196482 [P62508-2]
ENST00000366940; ENSP00000355907; ENSG00000196482 [P62508-2]
ENST00000391890; ENSP00000375761; ENSG00000196482 [P62508-2]
ENST00000408911; ENSP00000386171; ENSG00000196482
ENST00000463665; ENSP00000418629; ENSG00000196482 [P62508-4]
ENST00000487276; ENSP00000419155; ENSG00000196482 [P62508-2]
ENST00000493603; ENSP00000419594; ENSG00000196482 [P62508-2]
ENST00000493748; ENSP00000417374; ENSG00000196482 [P62508-2]
ENST00000616180; ENSP00000481528; ENSG00000196482 [P62508-2]
ENST00000673908; ENSP00000500992; ENSG00000196482 [P62508-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2104

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000408911.8; ENSP00000386171.3; NM_001438.4; NP_001429.2

UCSC genome browser

More...UCSCi		uc001hkw.3, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094518 mRNA Translation: AAC99410.1
AB020639 mRNA Translation: BAA74855.2 Different initiation.
AF058291 mRNA Translation: AAC39899.1
AY388456 mRNA Translation: AAQ93376.1
AY388457 mRNA Translation: AAQ93377.1
AY388458 mRNA Translation: AAQ93378.1
AY388459 mRNA Translation: AAQ93379.1
AY388460 mRNA Translation: AAQ93380.1
AY388461 mRNA Translation: AAQ93381.1
AK131193 mRNA Translation: BAG54746.1
AK290945 mRNA Translation: BAF83634.1
AK291028 mRNA Translation: BAF83717.1
AK291647 mRNA Translation: BAF84336.1
CR749497 mRNA Translation: CAH18320.1
AY528719 Genomic DNA Translation: AAS00098.1
AC096635 Genomic DNA No translation available.
AL445650 Genomic DNA No translation available.
AL512650 Genomic DNA No translation available.
AC096634 Genomic DNA No translation available.
AL391216 Genomic DNA No translation available.
AL512626 Genomic DNA No translation available.
AL513312 Genomic DNA No translation available.
AL603752 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93335.1
BC008218 mRNA Translation: AAH08218.1 Sequence problems.
BC064700 mRNA Translation: AAH64700.1
AF117255 mRNA Translation: AAD48370.1
CCDSiCCDS1517.1 [P62508-2]
CCDS41468.1
CCDS58060.1 [P62508-4]
CCDS58061.1 [P62508-5]
RefSeqiNP_001127757.1, NM_001134285.2 [P62508-2]
NP_001230434.1, NM_001243505.1
NP_001230435.1, NM_001243506.1
NP_001230436.1, NM_001243507.1 [P62508-4]
NP_001230438.1, NM_001243509.1 [P62508-2]
NP_001230439.1, NM_001243510.2 [P62508-2]
NP_001230440.1, NM_001243511.2 [P62508-2]
NP_001230441.1, NM_001243512.1 [P62508-2]
NP_001230442.1, NM_001243513.1 [P62508-2]
NP_001230443.1, NM_001243514.1 [P62508-2]
NP_001230444.1, NM_001243515.1 [P62508-2]
NP_001230447.1, NM_001243518.1 [P62508-5]
NP_001230448.1, NM_001243519.1 [P62508-2]
NP_001429.2, NM_001438.3 [P62508-1]
NP_996317.1, NM_206594.2 [P62508-2]
NP_996318.1, NM_206595.2 [P62508-2]
XP_011507569.1, XM_011509267.1 [P62508-5]
XP_011507570.1, XM_011509268.2 [P62508-5]
XP_011507571.1, XM_011509269.2 [P62508-5]
XP_011507576.1, XM_011509274.1 [P62508-3]
XP_011507577.1, XM_011509275.1 [P62508-3]
XP_011507578.1, XM_011509276.1 [P62508-3]
XP_011507579.1, XM_011509277.1 [P62508-3]
XP_011507580.1, XM_011509278.1 [P62508-3]
XP_011507581.1, XM_011509279.1 [P62508-3]
XP_011507582.1, XM_011509280.2 [P62508-3]
XP_016856120.1, XM_017000631.1 [P62508-3]
XP_016856121.1, XM_017000632.1 [P62508-3]
XP_016856122.1, XM_017000633.1 [P62508-3]
XP_016856123.1, XM_017000634.1 [P62508-3]
XP_016856124.1, XM_017000635.1 [P62508-3]
XP_016856125.1, XM_017000636.1 [P62508-3]
XP_016856126.1, XM_017000637.1 [P62508-3]
XP_016856127.1, XM_017000638.1 [P62508-2]
XP_016856128.1, XM_017000639.1 [P62508-2]
XP_016856129.1, XM_017000640.1
XP_016856130.1, XM_017000641.1 [P62508-2]
XP_016856131.1, XM_017000642.1
XP_016856132.1, XM_017000643.1
XP_016856133.1, XM_017000644.1 [P62508-2]
XP_016856134.1, XM_017000645.1 [P62508-2]
XP_016856135.1, XM_017000646.1
XP_016856136.1, XM_017000647.1
XP_016856137.1, XM_017000648.1
XP_016856138.1, XM_017000649.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KV6X-ray2.70A/B229-458[»]
1TFCX-ray2.40A/B229-458[»]
1VJBX-ray3.20A/B229-458[»]
2E2RX-ray1.60A222-458[»]
2EWPX-ray2.30A/B/C/D/E233-458[»]
2GP7X-ray2.45A/B/C/D229-458[»]
2GPOX-ray1.95A229-458[»]
2GPPX-ray2.60A/B229-458[»]
2GPUX-ray1.70A229-458[»]
2GPVX-ray2.85A/B/C/D/E/F229-458[»]
2P7AX-ray2.30A229-458[»]
2P7GX-ray2.10A229-458[»]
2P7ZX-ray2.50A229-458[»]
2ZASX-ray2.00A222-458[»]
2ZBSX-ray1.80A222-458[»]
2ZKCX-ray1.70A222-458[»]
5YSOX-ray2.50A/B/C221-458[»]
6A6KX-ray2.90A/B/C221-458[»]
6I61X-ray1.65A222-458[»]
6I62X-ray1.65A222-458[»]
6I63X-ray2.23A222-458[»]
6I64X-ray1.91A222-458[»]
6I65X-ray1.50A222-458[»]
6I66X-ray1.60A222-458[»]
6I67X-ray1.75A222-458[»]
6K3NX-ray1.97A232-458[»]
6KNRX-ray2.80A/B222-458[»]
6XXCX-ray1.30B174-182[»]
6XY5X-ray1.30B174-182[»]
6Y18X-ray1.30B174-182[»]
6Y1DX-ray1.38B174-182[»]
6Y3WX-ray1.34B174-182[»]
6Y58X-ray1.90P314-321[»]
SASBDBiP62508
SMRiP62508
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108407, 67 interactors
IntActiP62508, 52 interactors
MINTiP62508
STRINGi9606.ENSP00000355904

Chemistry databases

BindingDBiP62508
ChEMBLiCHEMBL4245
DrugBankiDB06884, 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
DB04468, Afimoxifene
DB06973, Bisphenol A
DB07485, Bisphenol Z
DB02659, Cholic Acid
DB00255, Diethylstilbestrol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB06902, p-Cumylphenol
DB00675, Tamoxifen
DB00197, Troglitazone
DrugCentraliP62508
GuidetoPHARMACOLOGYi624

PTM databases

iPTMnetiP62508
PhosphoSitePlusiP62508

Genetic variation databases

BioMutaiESRRG
DMDMi50402102

Proteomic databases

MassIVEiP62508
MaxQBiP62508
PaxDbiP62508
PeptideAtlasiP62508
PRIDEiP62508
ProteomicsDBi20283
30159
57405
57406 [P62508-2]
57407 [P62508-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20728, 506 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		2104

Genome annotation databases

EnsembliENST00000359162; ENSP00000352077; ENSG00000196482 [P62508-2]
ENST00000360012; ENSP00000353108; ENSG00000196482 [P62508-2]
ENST00000361395; ENSP00000354584; ENSG00000196482 [P62508-2]
ENST00000361525; ENSP00000355225; ENSG00000196482 [P62508-2]
ENST00000366937; ENSP00000355904; ENSG00000196482 [P62508-5]
ENST00000366938; ENSP00000355905; ENSG00000196482 [P62508-2]
ENST00000366940; ENSP00000355907; ENSG00000196482 [P62508-2]
ENST00000391890; ENSP00000375761; ENSG00000196482 [P62508-2]
ENST00000408911; ENSP00000386171; ENSG00000196482
ENST00000463665; ENSP00000418629; ENSG00000196482 [P62508-4]
ENST00000487276; ENSP00000419155; ENSG00000196482 [P62508-2]
ENST00000493603; ENSP00000419594; ENSG00000196482 [P62508-2]
ENST00000493748; ENSP00000417374; ENSG00000196482 [P62508-2]
ENST00000616180; ENSP00000481528; ENSG00000196482 [P62508-2]
ENST00000673908; ENSP00000500992; ENSG00000196482 [P62508-3]
GeneIDi2104
KEGGihsa:2104
MANE-SelectiENST00000408911.8; ENSP00000386171.3; NM_001438.4; NP_001429.2
UCSCiuc001hkw.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2104
DisGeNETi2104

GeneCards: human genes, protein and diseases

More...GeneCardsi		ESRRG
HGNCiHGNC:3474, ESRRG
HPAiENSG00000196482, Tissue enhanced (brain, parathyroid gland, retina, stomach)
MIMi602969, gene
neXtProtiNX_P62508
OpenTargetsiENSG00000196482
PharmGKBiPA27891
VEuPathDBiHostDB:ENSG00000196482

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3575, Eukaryota
GeneTreeiENSGT00940000153433
InParanoidiP62508
OMAiKYRRSTD
OrthoDBi669799at2759
PhylomeDBiP62508
TreeFamiTF323751

Enzyme and pathway databases

PathwayCommonsiP62508
ReactomeiR-HSA-383280, Nuclear Receptor transcription pathway
SignaLinkiP62508
SIGNORiP62508

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2104, 7 hits in 1058 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ESRRG, human
EvolutionaryTraceiP62508

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Estrogen-related_receptor_gamma

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2104
PharosiP62508, Tchem

Protein Ontology

More...PROi		PR:P62508
RNActiP62508, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196482, Expressed in stomach and 202 other tissues
ExpressionAtlasiP62508, baseline and differential
GenevisibleiP62508, HS

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
IDEALiIID00057
InterProiView protein in InterPro
IPR024178, Est_rcpt/est-rel_rcp
IPR035500, NHR-like_dom_sf
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR027289, Oest-rel_rcp
IPR003078, Retinoic_acid_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA
PfamiView protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit
PIRSFiPIRSF002527, ER-like_NR, 1 hit
PIRSF500939, ERR1-2-3, 1 hit
PRINTSiPR01292, RETNOICACIDR
PR00398, STRDHORMONER
PR00047, STROIDFINGER
SMARTiView protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit
SUPFAMiSSF48508, SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62508
Secondary accession number(s): A8K4I0
, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: February 23, 2022
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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