UniProtKB - P62508 (ERR3_HUMAN)
Protein
Estrogen-related receptor gamma
Gene
ESRRG
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.By similarity4 Publications
Miscellaneous
No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 125 – 200 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 128 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 164 – 188 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- AF-2 domain binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- steroid binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- retinoic acid receptor signaling pathway Source: InterPro
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P62508 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | P62508 |
SIGNORi | P62508 |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen-related receptor gammaAlternative name(s): ERR gamma-2 Estrogen receptor-related protein 3 Nuclear receptor subfamily 3 group B member 3 |
Gene namesi | Name:ESRRG Synonyms:ERR3, ERRG2, KIAA0832, NR3B3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196482.16 |
HGNCi | HGNC:3474, ESRRG |
MIMi | 602969, gene |
neXtProti | NX_P62508 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | F → A or E: No effect on transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 39 | I → A: 4-fold increase in transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 40 | K → R: Abolishes sumoylation. 7-fold increase in transcriptional activity. 3 Publications | 1 | |
Mutagenesisi | 41 | T → A: No effect on transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 42 | E → A: 4-fold increase in transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 44 | S → A or E: No effect on transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 45 | S → A: Abolishes sumoylation. Increased transcriptional activity. 2 Publications | 1 | |
Mutagenesisi | 45 | S → D: No change in sumoylation nor transcriptional activity. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 2104 |
OpenTargetsi | ENSG00000196482 |
PharmGKBi | PA27891 |
Miscellaneous databases
Pharosi | P62508, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4245 |
DrugBanki | DB06884, 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE DB04468, Afimoxifene DB06973, Bisphenol A DB07485, Bisphenol Z DB02659, Cholic Acid DB00255, Diethylstilbestrol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB06902, p-Cumylphenol DB00675, Tamoxifen DB00197, Troglitazone |
DrugCentrali | P62508 |
GuidetoPHARMACOLOGYi | 624 |
Polymorphism and mutation databases
BioMutai | ESRRG |
DMDMi | 50402102 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053665 | 1 – 458 | Estrogen-related receptor gammaAdd BLAST | 458 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 40 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||
Modified residuei | 45 | Phosphoserine2 Publications | 1 |
Post-translational modificationi
Acetylated by PCAF/KAT2 (in vitro).1 Publication
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.3 Publications
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.3 Publications
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | P62508 |
MaxQBi | P62508 |
PaxDbi | P62508 |
PeptideAtlasi | P62508 |
PRIDEi | P62508 |
ProteomicsDBi | 20283 30159 57405 57406 [P62508-2] 57407 [P62508-3] |
PTM databases
iPTMneti | P62508 |
PhosphoSitePlusi | P62508 |
Expressioni
Tissue specificityi
Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.2 Publications
Developmental stagei
Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000196482, Expressed in stomach and 201 other tissues |
ExpressionAtlasi | P62508, baseline and differential |
Genevisiblei | P62508, HS |
Organism-specific databases
HPAi | ENSG00000196482, Tissue enhanced (brain, parathyroid gland, placenta) |
Interactioni
Subunit structurei
Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity).
Interacts with NRIP1, NCOA1 and NCOR2.
By similarity3 PublicationsBinary interactionsi
Hide detailsP62508
ESRRG - isoform 3 [P62508-3]
GO - Molecular functioni
- AF-2 domain binding Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 108407, 57 interactors |
IntActi | P62508, 51 interactors |
MINTi | P62508 |
STRINGi | 9606.ENSP00000355904 |
Chemistry databases
BindingDBi | P62508 |
Miscellaneous databases
RNActi | P62508, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P62508 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62508 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 233 – 457 | NR LBDPROSITE-ProRule annotationAdd BLAST | 225 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 128 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 164 – 188 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
InParanoidi | P62508 |
OMAi | MDPVELC |
OrthoDBi | 669799at2759 |
PhylomeDBi | P62508 |
TreeFami | TF323751 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00057 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR024178, Oest_rcpt/oest-rel_rcp IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P62508-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF
LEMLEAKV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JU32 | C9JU32_HUMAN | Estrogen-related receptor gamma | ESRRG | 354 | Annotation score: | ||
C9J5W9 | C9J5W9_HUMAN | Estrogen-related receptor gamma | ESRRG | 92 | Annotation score: | ||
C9JNX5 | C9JNX5_HUMAN | Estrogen-related receptor gamma | ESRRG | 55 | Annotation score: | ||
C9J0E3 | C9J0E3_HUMAN | Estrogen-related receptor gamma | ESRRG | 50 | Annotation score: | ||
K7EM35 | K7EM35_HUMAN | Estrogen-related receptor gamma | ESRRG | 47 | Annotation score: |
Sequence cautioni
The sequence AAH08218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74855 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | E → K in AAQ93376 (PubMed:10707956).Curated | 1 | |
Sequence conflicti | 151 | F → S in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 155 | T → K in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 158 | G → A in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 227 | V → A in BAG54746 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 271 | L → C in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 313 | V → F in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 449 | L → P in CAH18320 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 458 | V → VC in AAC39899 (PubMed:9676434).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019229 | 50 | T → M1 PublicationCorresponds to variant dbSNP:rs11572693Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003702 | 1 – 23 | Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_047156 | 1 – 19 | MDSVE…HYEEE → MWRECDWGLGAVKSDLACVP SAKR in isoform 5. CuratedAdd BLAST | 19 | |
Alternative sequenceiVSP_045980 | 158 – 196 | Missing in isoform 4. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_013301 | 234 | Y → LLWSDPAD in isoform 3 and isoform 5. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KV6 | X-ray | 2.70 | A/B | 229-458 | [»] | |
1TFC | X-ray | 2.40 | A/B | 229-458 | [»] | |
1VJB | X-ray | 3.20 | A/B | 229-458 | [»] | |
2E2R | X-ray | 1.60 | A | 222-458 | [»] | |
2EWP | X-ray | 2.30 | A/B/C/D/E | 233-458 | [»] | |
2GP7 | X-ray | 2.45 | A/B/C/D | 229-458 | [»] | |
2GPO | X-ray | 1.95 | A | 229-458 | [»] | |
2GPP | X-ray | 2.60 | A/B | 229-458 | [»] | |
2GPU | X-ray | 1.70 | A | 229-458 | [»] | |
2GPV | X-ray | 2.85 | A/B/C/D/E/F | 229-458 | [»] | |
2P7A | X-ray | 2.30 | A | 229-458 | [»] | |
2P7G | X-ray | 2.10 | A | 229-458 | [»] | |
2P7Z | X-ray | 2.50 | A | 229-458 | [»] | |
2ZAS | X-ray | 2.00 | A | 222-458 | [»] | |
2ZBS | X-ray | 1.80 | A | 222-458 | [»] | |
2ZKC | X-ray | 1.70 | A | 222-458 | [»] | |
5YSO | X-ray | 2.50 | A/B/C | 221-458 | [»] | |
6A6K | X-ray | 2.90 | A/B/C | 221-458 | [»] | |
6I61 | X-ray | 1.65 | A | 222-458 | [»] | |
6I62 | X-ray | 1.65 | A | 222-458 | [»] | |
6I63 | X-ray | 2.23 | A | 222-458 | [»] | |
6I64 | X-ray | 1.91 | A | 222-458 | [»] | |
6I65 | X-ray | 1.50 | A | 222-458 | [»] | |
6I66 | X-ray | 1.60 | A | 222-458 | [»] | |
6I67 | X-ray | 1.75 | A | 222-458 | [»] | |
6K3N | X-ray | 1.97 | A | 232-458 | [»] | |
6KNR | X-ray | 2.80 | A/B | 222-458 | [»] | |
SMRi | P62508 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108407, 57 interactors |
IntActi | P62508, 51 interactors |
MINTi | P62508 |
STRINGi | 9606.ENSP00000355904 |
Chemistry databases
BindingDBi | P62508 |
ChEMBLi | CHEMBL4245 |
DrugBanki | DB06884, 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE DB04468, Afimoxifene DB06973, Bisphenol A DB07485, Bisphenol Z DB02659, Cholic Acid DB00255, Diethylstilbestrol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB06902, p-Cumylphenol DB00675, Tamoxifen DB00197, Troglitazone |
DrugCentrali | P62508 |
GuidetoPHARMACOLOGYi | 624 |
PTM databases
iPTMneti | P62508 |
PhosphoSitePlusi | P62508 |
Polymorphism and mutation databases
BioMutai | ESRRG |
DMDMi | 50402102 |
Proteomic databases
MassIVEi | P62508 |
MaxQBi | P62508 |
PaxDbi | P62508 |
PeptideAtlasi | P62508 |
PRIDEi | P62508 |
ProteomicsDBi | 20283 30159 57405 57406 [P62508-2] 57407 [P62508-3] |
Protocols and materials databases
Antibodypediai | 20728, 493 antibodies |
DNASUi | 2104 |
Genome annotation databases
Organism-specific databases
CTDi | 2104 |
DisGeNETi | 2104 |
EuPathDBi | HostDB:ENSG00000196482.16 |
GeneCardsi | ESRRG |
HGNCi | HGNC:3474, ESRRG |
HPAi | ENSG00000196482, Tissue enhanced (brain, parathyroid gland, placenta) |
MIMi | 602969, gene |
neXtProti | NX_P62508 |
OpenTargetsi | ENSG00000196482 |
PharmGKBi | PA27891 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
InParanoidi | P62508 |
OMAi | MDPVELC |
OrthoDBi | 669799at2759 |
PhylomeDBi | P62508 |
TreeFami | TF323751 |
Enzyme and pathway databases
PathwayCommonsi | P62508 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | P62508 |
SIGNORi | P62508 |
Miscellaneous databases
BioGRID-ORCSi | 2104, 7 hits in 864 CRISPR screens |
ChiTaRSi | ESRRG, human |
EvolutionaryTracei | P62508 |
GeneWikii | Estrogen-related_receptor_gamma |
GenomeRNAii | 2104 |
Pharosi | P62508, Tchem |
PROi | PR:P62508 |
RNActi | P62508, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196482, Expressed in stomach and 201 other tissues |
ExpressionAtlasi | P62508, baseline and differential |
Genevisiblei | P62508, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00057 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR024178, Oest_rcpt/oest-rel_rcp IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERR3_HUMAN | |
Accessioni | P62508Primary (citable) accession number: P62508 Secondary accession number(s): A8K4I0 Q9UNJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | December 2, 2020 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations