UniProtKB - P62508 (ERR3_HUMAN)
Estrogen-related receptor gamma
ESRRG
Functioni
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).
Induces the expression of PERM1 in the skeletal muscle.
By similarity4 PublicationsMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 125 – 200 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 128 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 164 – 188 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- AF-2 domain binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- estrogen response element binding Source: Ensembl
- identical protein binding Source: IntAct
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- steroid binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- retinoic acid receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P62508 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | P62508 |
SIGNORi | P62508 |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen-related receptor gammaAlternative name(s): ERR gamma-2 Estrogen receptor-related protein 3 Nuclear receptor subfamily 3 group B member 3 |
Gene namesi | Name:ESRRG Synonyms:ERR3, ERRG2, KIAA0832, NR3B3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3474, ESRRG |
MIMi | 602969, gene |
neXtProti | NX_P62508 |
VEuPathDBi | HostDB:ENSG00000196482 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | F → A or E: No effect on transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 39 | I → A: 4-fold increase in transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 40 | K → R: Abolishes sumoylation. 7-fold increase in transcriptional activity. 3 Publications | 1 | |
Mutagenesisi | 41 | T → A: No effect on transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 42 | E → A: 4-fold increase in transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 44 | S → A or E: No effect on transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 45 | S → A: Abolishes sumoylation. Increased transcriptional activity. 2 Publications | 1 | |
Mutagenesisi | 45 | S → D: No change in sumoylation nor transcriptional activity. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 2104 |
OpenTargetsi | ENSG00000196482 |
PharmGKBi | PA27891 |
Miscellaneous databases
Pharosi | P62508, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4245 |
DrugBanki | DB06884, 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE DB04468, Afimoxifene DB06973, Bisphenol A DB07485, Bisphenol Z DB02659, Cholic Acid DB00255, Diethylstilbestrol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB06902, p-Cumylphenol DB00675, Tamoxifen DB00197, Troglitazone |
DrugCentrali | P62508 |
GuidetoPHARMACOLOGYi | 624 |
Genetic variation databases
BioMutai | ESRRG |
DMDMi | 50402102 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053665 | 1 – 458 | Estrogen-related receptor gammaAdd BLAST | 458 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 40 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||
Modified residuei | 45 | Phosphoserine2 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | P62508 |
MaxQBi | P62508 |
PaxDbi | P62508 |
PeptideAtlasi | P62508 |
PRIDEi | P62508 |
ProteomicsDBi | 20283 30159 57405 57406 [P62508-2] 57407 [P62508-3] |
PTM databases
iPTMneti | P62508 |
PhosphoSitePlusi | P62508 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000196482, Expressed in stomach and 202 other tissues |
ExpressionAtlasi | P62508, baseline and differential |
Genevisiblei | P62508, HS |
Organism-specific databases
HPAi | ENSG00000196482, Tissue enhanced (brain, parathyroid gland, retina, stomach) |
Interactioni
Subunit structurei
Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity).
Interacts with NRIP1, NCOA1 and NCOR2.
By similarity3 PublicationsBinary interactionsi
P62508
ESRRG - isoform 3 [P62508-3]
GO - Molecular functioni
- AF-2 domain binding Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 108407, 67 interactors |
IntActi | P62508, 52 interactors |
MINTi | P62508 |
STRINGi | 9606.ENSP00000355904 |
Chemistry databases
BindingDBi | P62508 |
Miscellaneous databases
RNActi | P62508, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | P62508 |
SMRi | P62508 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62508 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 233 – 457 | NR LBDPROSITE-ProRule annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 85 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 80 | Polar residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 128 – 148 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 164 – 188 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
InParanoidi | P62508 |
OMAi | KYRRSTD |
OrthoDBi | 669799at2759 |
PhylomeDBi | P62508 |
TreeFami | TF323751 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00057 |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF
LEMLEAKV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JU32 | C9JU32_HUMAN | Estrogen-related receptor gamma | ESRRG | 354 | Annotation score: | ||
C9J5W9 | C9J5W9_HUMAN | Estrogen-related receptor gamma | ESRRG | 92 | Annotation score: | ||
C9JNX5 | C9JNX5_HUMAN | Estrogen-related receptor gamma | ESRRG | 55 | Annotation score: | ||
C9J0E3 | C9J0E3_HUMAN | Estrogen-related receptor gamma | ESRRG | 50 | Annotation score: | ||
K7EM35 | K7EM35_HUMAN | Estrogen-related receptor gamma | ESRRG | 47 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | E → K in AAQ93376 (PubMed:10707956).Curated | 1 | |
Sequence conflicti | 151 | F → S in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 155 | T → K in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 158 | G → A in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 227 | V → A in BAG54746 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 271 | L → C in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 313 | V → F in AAC39899 (PubMed:9676434).Curated | 1 | |
Sequence conflicti | 449 | L → P in CAH18320 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 458 | V → VC in AAC39899 (PubMed:9676434).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019229 | 50 | T → M1 PublicationCorresponds to variant dbSNP:rs11572693Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003702 | 1 – 23 | Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_047156 | 1 – 19 | MDSVE…HYEEE → MWRECDWGLGAVKSDLACVP SAKR in isoform 5. CuratedAdd BLAST | 19 | |
Alternative sequenceiVSP_045980 | 158 – 196 | Missing in isoform 4. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_013301 | 234 | Y → LLWSDPAD in isoform 3 and isoform 5. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KV6 | X-ray | 2.70 | A/B | 229-458 | [»] | |
1TFC | X-ray | 2.40 | A/B | 229-458 | [»] | |
1VJB | X-ray | 3.20 | A/B | 229-458 | [»] | |
2E2R | X-ray | 1.60 | A | 222-458 | [»] | |
2EWP | X-ray | 2.30 | A/B/C/D/E | 233-458 | [»] | |
2GP7 | X-ray | 2.45 | A/B/C/D | 229-458 | [»] | |
2GPO | X-ray | 1.95 | A | 229-458 | [»] | |
2GPP | X-ray | 2.60 | A/B | 229-458 | [»] | |
2GPU | X-ray | 1.70 | A | 229-458 | [»] | |
2GPV | X-ray | 2.85 | A/B/C/D/E/F | 229-458 | [»] | |
2P7A | X-ray | 2.30 | A | 229-458 | [»] | |
2P7G | X-ray | 2.10 | A | 229-458 | [»] | |
2P7Z | X-ray | 2.50 | A | 229-458 | [»] | |
2ZAS | X-ray | 2.00 | A | 222-458 | [»] | |
2ZBS | X-ray | 1.80 | A | 222-458 | [»] | |
2ZKC | X-ray | 1.70 | A | 222-458 | [»] | |
5YSO | X-ray | 2.50 | A/B/C | 221-458 | [»] | |
6A6K | X-ray | 2.90 | A/B/C | 221-458 | [»] | |
6I61 | X-ray | 1.65 | A | 222-458 | [»] | |
6I62 | X-ray | 1.65 | A | 222-458 | [»] | |
6I63 | X-ray | 2.23 | A | 222-458 | [»] | |
6I64 | X-ray | 1.91 | A | 222-458 | [»] | |
6I65 | X-ray | 1.50 | A | 222-458 | [»] | |
6I66 | X-ray | 1.60 | A | 222-458 | [»] | |
6I67 | X-ray | 1.75 | A | 222-458 | [»] | |
6K3N | X-ray | 1.97 | A | 232-458 | [»] | |
6KNR | X-ray | 2.80 | A/B | 222-458 | [»] | |
6XXC | X-ray | 1.30 | B | 174-182 | [»] | |
6XY5 | X-ray | 1.30 | B | 174-182 | [»] | |
6Y18 | X-ray | 1.30 | B | 174-182 | [»] | |
6Y1D | X-ray | 1.38 | B | 174-182 | [»] | |
6Y3W | X-ray | 1.34 | B | 174-182 | [»] | |
6Y58 | X-ray | 1.90 | P | 314-321 | [»] | |
SASBDBi | P62508 | |||||
SMRi | P62508 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108407, 67 interactors |
IntActi | P62508, 52 interactors |
MINTi | P62508 |
STRINGi | 9606.ENSP00000355904 |
Chemistry databases
BindingDBi | P62508 |
ChEMBLi | CHEMBL4245 |
DrugBanki | DB06884, 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE DB04468, Afimoxifene DB06973, Bisphenol A DB07485, Bisphenol Z DB02659, Cholic Acid DB00255, Diethylstilbestrol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB06902, p-Cumylphenol DB00675, Tamoxifen DB00197, Troglitazone |
DrugCentrali | P62508 |
GuidetoPHARMACOLOGYi | 624 |
PTM databases
iPTMneti | P62508 |
PhosphoSitePlusi | P62508 |
Genetic variation databases
BioMutai | ESRRG |
DMDMi | 50402102 |
Proteomic databases
MassIVEi | P62508 |
MaxQBi | P62508 |
PaxDbi | P62508 |
PeptideAtlasi | P62508 |
PRIDEi | P62508 |
ProteomicsDBi | 20283 30159 57405 57406 [P62508-2] 57407 [P62508-3] |
Protocols and materials databases
Antibodypediai | 20728, 506 antibodies from 39 providers |
DNASUi | 2104 |
Genome annotation databases
Organism-specific databases
CTDi | 2104 |
DisGeNETi | 2104 |
GeneCardsi | ESRRG |
HGNCi | HGNC:3474, ESRRG |
HPAi | ENSG00000196482, Tissue enhanced (brain, parathyroid gland, retina, stomach) |
MIMi | 602969, gene |
neXtProti | NX_P62508 |
OpenTargetsi | ENSG00000196482 |
PharmGKBi | PA27891 |
VEuPathDBi | HostDB:ENSG00000196482 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
InParanoidi | P62508 |
OMAi | KYRRSTD |
OrthoDBi | 669799at2759 |
PhylomeDBi | P62508 |
TreeFami | TF323751 |
Enzyme and pathway databases
PathwayCommonsi | P62508 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | P62508 |
SIGNORi | P62508 |
Miscellaneous databases
BioGRID-ORCSi | 2104, 7 hits in 1058 CRISPR screens |
ChiTaRSi | ESRRG, human |
EvolutionaryTracei | P62508 |
GeneWikii | Estrogen-related_receptor_gamma |
GenomeRNAii | 2104 |
Pharosi | P62508, Tchem |
PROi | PR:P62508 |
RNActi | P62508, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196482, Expressed in stomach and 202 other tissues |
ExpressionAtlasi | P62508, baseline and differential |
Genevisiblei | P62508, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00057 |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ERR3_HUMAN | |
Accessioni | P62508Primary (citable) accession number: P62508 Secondary accession number(s): A8K4I0 Q9UNJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families