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Protein

Estrogen-related receptor gamma

Gene

ESRRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.By similarity4 Publications

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 200Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
SignaLinkiP62508
SIGNORiP62508

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
ERR gamma-2
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:ESRRG
Synonyms:ERR3, ERRG2, KIAA0832, NR3B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196482.16
HGNCiHGNC:3474 ESRRG
MIMi602969 gene
neXtProtiNX_P62508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38F → A or E: No effect on transcriptional activity. 1 Publication1
Mutagenesisi39I → A: 4-fold increase in transcriptional activity. 1 Publication1
Mutagenesisi40K → R: Abolishes sumoylation. 7-fold increase in transcriptional activity. 3 Publications1
Mutagenesisi41T → A: No effect on transcriptional activity. 1 Publication1
Mutagenesisi42E → A: 4-fold increase in transcriptional activity. 1 Publication1
Mutagenesisi44S → A or E: No effect on transcriptional activity. 1 Publication1
Mutagenesisi45S → A: Abolishes sumoylation. Increased transcriptional activity. 2 Publications1
Mutagenesisi45S → D: No change in sumoylation nor transcriptional activity. 2 Publications1

Organism-specific databases

DisGeNETi2104
OpenTargetsiENSG00000196482
PharmGKBiPA27891

Chemistry databases

ChEMBLiCHEMBL4245
DrugBankiDB06902 4-(1-methyl-1-phenylethyl)phenol
DB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
DB04468 Afimoxifene
DB02659 Cholic Acid
DB00255 Diethylstilbestrol
DB00197 Troglitazone
GuidetoPHARMACOLOGYi624

Polymorphism and mutation databases

BioMutaiESRRG
DMDMi50402102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536651 – 458Estrogen-related receptor gammaAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei45Phosphoserine2 Publications1

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).1 Publication
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.3 Publications
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP62508
PaxDbiP62508
PeptideAtlasiP62508
PRIDEiP62508
ProteomicsDBi57405
57406 [P62508-2]
57407 [P62508-3]

PTM databases

iPTMnetiP62508
PhosphoSitePlusiP62508

Expressioni

Tissue specificityi

Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.2 Publications

Developmental stagei

Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000196482 Expressed in 185 organ(s), highest expression level in placenta
ExpressionAtlasiP62508 baseline and differential
GenevisibleiP62508 HS

Organism-specific databases

HPAiHPA044678

Interactioni

Subunit structurei

Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108407, 28 interactors
IntActiP62508, 46 interactors
MINTiP62508
STRINGi9606.ENSP00000386171

Chemistry databases

BindingDBiP62508

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62508
SMRiP62508
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62508

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 457NR LBDPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000233467
HOVERGENiHBG108344
InParanoidiP62508
KOiK08554
OMAiMDPVELC
OrthoDBiEOG091G0DYP
PhylomeDBiP62508
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR027289 Oest-rel_rcp
IPR024178 Oest_rcpt/oest-rel_rcp
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002527 ER-like_NR, 1 hit
PIRSF500939 ERR1-2-3, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62508-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62508-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO
Isoform 3 (identifier: P62508-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     234-234: Y → LLWSDPAD

Show »
Length:442
Mass (Da):49,316
Checksum:i09B8CD0EE90CAEF5
GO
Isoform 4 (identifier: P62508-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     158-196: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,073
Checksum:i614E044D8A31361C
GO
Isoform 5 (identifier: P62508-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MDSVELCLPESFSLHYEEE → MWRECDWGLGAVKSDLACVPSAKR
     234-234: Y → LLWSDPAD

Note: Gene prediction based on EST data.
Show »
Length:470
Mass (Da):52,462
Checksum:iC0C4BD53ABAF5CE4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JU32C9JU32_HUMAN
Estrogen-related receptor gamma
ESRRG
354Annotation score:
C9J5W9C9J5W9_HUMAN
Estrogen-related receptor gamma
ESRRG
92Annotation score:
C9J0E3C9J0E3_HUMAN
Estrogen-related receptor gamma
ESRRG
50Annotation score:
C9JNX5C9JNX5_HUMAN
Estrogen-related receptor gamma
ESRRG
55Annotation score:
K7EM35K7EM35_HUMAN
Estrogen-related receptor gamma
ESRRG
47Annotation score:

Sequence cautioni

The sequence AAH08218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74855 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19E → K in AAQ93376 (PubMed:10707956).Curated1
Sequence conflicti151F → S in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti155T → K in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti158G → A in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti227V → A in BAG54746 (PubMed:14702039).Curated1
Sequence conflicti271L → C in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti313V → F in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti449L → P in CAH18320 (PubMed:14702039).Curated1
Sequence conflicti458V → VC in AAC39899 (PubMed:9676434).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01922950T → M1 PublicationCorresponds to variant dbSNP:rs11572693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037021 – 23Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST23
Alternative sequenceiVSP_0471561 – 19MDSVE…HYEEE → MWRECDWGLGAVKSDLACVP SAKR in isoform 5. CuratedAdd BLAST19
Alternative sequenceiVSP_045980158 – 196Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_013301234Y → LLWSDPAD in isoform 3 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094518 mRNA Translation: AAC99410.1
AB020639 mRNA Translation: BAA74855.2 Different initiation.
AF058291 mRNA Translation: AAC39899.1
AY388456 mRNA Translation: AAQ93376.1
AY388457 mRNA Translation: AAQ93377.1
AY388458 mRNA Translation: AAQ93378.1
AY388459 mRNA Translation: AAQ93379.1
AY388460 mRNA Translation: AAQ93380.1
AY388461 mRNA Translation: AAQ93381.1
AK131193 mRNA Translation: BAG54746.1
AK290945 mRNA Translation: BAF83634.1
AK291028 mRNA Translation: BAF83717.1
AK291647 mRNA Translation: BAF84336.1
CR749497 mRNA Translation: CAH18320.1
AY528719 Genomic DNA Translation: AAS00098.1
AC096635 Genomic DNA No translation available.
AL445650 Genomic DNA No translation available.
AL512650 Genomic DNA No translation available.
AC096634 Genomic DNA No translation available.
AL391216 Genomic DNA No translation available.
AL512626 Genomic DNA No translation available.
AL513312 Genomic DNA No translation available.
AL603752 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93335.1
BC008218 mRNA Translation: AAH08218.1 Sequence problems.
BC064700 mRNA Translation: AAH64700.1
AF117255 mRNA Translation: AAD48370.1
CCDSiCCDS1517.1 [P62508-2]
CCDS41468.1
CCDS58060.1 [P62508-4]
CCDS58061.1 [P62508-5]
RefSeqiNP_001127757.1, NM_001134285.2 [P62508-2]
NP_001230434.1, NM_001243505.1
NP_001230435.1, NM_001243506.1
NP_001230436.1, NM_001243507.1 [P62508-4]
NP_001230438.1, NM_001243509.1 [P62508-2]
NP_001230439.1, NM_001243510.2 [P62508-2]
NP_001230440.1, NM_001243511.2 [P62508-2]
NP_001230441.1, NM_001243512.1 [P62508-2]
NP_001230442.1, NM_001243513.1 [P62508-2]
NP_001230443.1, NM_001243514.1 [P62508-2]
NP_001230444.1, NM_001243515.1 [P62508-2]
NP_001230447.1, NM_001243518.1 [P62508-5]
NP_001230448.1, NM_001243519.1 [P62508-2]
NP_001429.2, NM_001438.3 [P62508-1]
NP_996317.1, NM_206594.2 [P62508-2]
NP_996318.1, NM_206595.2 [P62508-2]
XP_011507569.1, XM_011509267.1 [P62508-5]
XP_011507570.1, XM_011509268.2 [P62508-5]
XP_011507571.1, XM_011509269.2 [P62508-5]
XP_011507576.1, XM_011509274.1 [P62508-3]
XP_011507577.1, XM_011509275.1 [P62508-3]
XP_011507578.1, XM_011509276.1 [P62508-3]
XP_011507579.1, XM_011509277.1 [P62508-3]
XP_011507580.1, XM_011509278.1 [P62508-3]
XP_011507581.1, XM_011509279.1 [P62508-3]
XP_011507582.1, XM_011509280.2 [P62508-3]
XP_016856120.1, XM_017000631.1 [P62508-3]
XP_016856121.1, XM_017000632.1 [P62508-3]
XP_016856122.1, XM_017000633.1 [P62508-3]
XP_016856123.1, XM_017000634.1 [P62508-3]
XP_016856124.1, XM_017000635.1 [P62508-3]
XP_016856125.1, XM_017000636.1 [P62508-3]
XP_016856126.1, XM_017000637.1 [P62508-3]
XP_016856127.1, XM_017000638.1 [P62508-2]
XP_016856128.1, XM_017000639.1 [P62508-2]
XP_016856129.1, XM_017000640.1
XP_016856130.1, XM_017000641.1 [P62508-2]
XP_016856131.1, XM_017000642.1
XP_016856132.1, XM_017000643.1
XP_016856133.1, XM_017000644.1 [P62508-2]
XP_016856134.1, XM_017000645.1 [P62508-2]
XP_016856135.1, XM_017000646.1
XP_016856136.1, XM_017000647.1
XP_016856137.1, XM_017000648.1
XP_016856138.1, XM_017000649.1
UniGeneiHs.444225
Hs.738938

Genome annotation databases

EnsembliENST00000359162; ENSP00000352077; ENSG00000196482 [P62508-2]
ENST00000360012; ENSP00000353108; ENSG00000196482 [P62508-2]
ENST00000361395; ENSP00000354584; ENSG00000196482 [P62508-2]
ENST00000361525; ENSP00000355225; ENSG00000196482 [P62508-2]
ENST00000366937; ENSP00000355904; ENSG00000196482 [P62508-5]
ENST00000366938; ENSP00000355905; ENSG00000196482 [P62508-2]
ENST00000366940; ENSP00000355907; ENSG00000196482 [P62508-2]
ENST00000391890; ENSP00000375761; ENSG00000196482 [P62508-2]
ENST00000408911; ENSP00000386171; ENSG00000196482 [P62508-1]
ENST00000463665; ENSP00000418629; ENSG00000196482 [P62508-4]
ENST00000487276; ENSP00000419155; ENSG00000196482 [P62508-2]
ENST00000493603; ENSP00000419594; ENSG00000196482 [P62508-2]
ENST00000493748; ENSP00000417374; ENSG00000196482 [P62508-2]
ENST00000616180; ENSP00000481528; ENSG00000196482 [P62508-2]
GeneIDi2104
KEGGihsa:2104
UCSCiuc001hkw.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094518 mRNA Translation: AAC99410.1
AB020639 mRNA Translation: BAA74855.2 Different initiation.
AF058291 mRNA Translation: AAC39899.1
AY388456 mRNA Translation: AAQ93376.1
AY388457 mRNA Translation: AAQ93377.1
AY388458 mRNA Translation: AAQ93378.1
AY388459 mRNA Translation: AAQ93379.1
AY388460 mRNA Translation: AAQ93380.1
AY388461 mRNA Translation: AAQ93381.1
AK131193 mRNA Translation: BAG54746.1
AK290945 mRNA Translation: BAF83634.1
AK291028 mRNA Translation: BAF83717.1
AK291647 mRNA Translation: BAF84336.1
CR749497 mRNA Translation: CAH18320.1
AY528719 Genomic DNA Translation: AAS00098.1
AC096635 Genomic DNA No translation available.
AL445650 Genomic DNA No translation available.
AL512650 Genomic DNA No translation available.
AC096634 Genomic DNA No translation available.
AL391216 Genomic DNA No translation available.
AL512626 Genomic DNA No translation available.
AL513312 Genomic DNA No translation available.
AL603752 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93335.1
BC008218 mRNA Translation: AAH08218.1 Sequence problems.
BC064700 mRNA Translation: AAH64700.1
AF117255 mRNA Translation: AAD48370.1
CCDSiCCDS1517.1 [P62508-2]
CCDS41468.1
CCDS58060.1 [P62508-4]
CCDS58061.1 [P62508-5]
RefSeqiNP_001127757.1, NM_001134285.2 [P62508-2]
NP_001230434.1, NM_001243505.1
NP_001230435.1, NM_001243506.1
NP_001230436.1, NM_001243507.1 [P62508-4]
NP_001230438.1, NM_001243509.1 [P62508-2]
NP_001230439.1, NM_001243510.2 [P62508-2]
NP_001230440.1, NM_001243511.2 [P62508-2]
NP_001230441.1, NM_001243512.1 [P62508-2]
NP_001230442.1, NM_001243513.1 [P62508-2]
NP_001230443.1, NM_001243514.1 [P62508-2]
NP_001230444.1, NM_001243515.1 [P62508-2]
NP_001230447.1, NM_001243518.1 [P62508-5]
NP_001230448.1, NM_001243519.1 [P62508-2]
NP_001429.2, NM_001438.3 [P62508-1]
NP_996317.1, NM_206594.2 [P62508-2]
NP_996318.1, NM_206595.2 [P62508-2]
XP_011507569.1, XM_011509267.1 [P62508-5]
XP_011507570.1, XM_011509268.2 [P62508-5]
XP_011507571.1, XM_011509269.2 [P62508-5]
XP_011507576.1, XM_011509274.1 [P62508-3]
XP_011507577.1, XM_011509275.1 [P62508-3]
XP_011507578.1, XM_011509276.1 [P62508-3]
XP_011507579.1, XM_011509277.1 [P62508-3]
XP_011507580.1, XM_011509278.1 [P62508-3]
XP_011507581.1, XM_011509279.1 [P62508-3]
XP_011507582.1, XM_011509280.2 [P62508-3]
XP_016856120.1, XM_017000631.1 [P62508-3]
XP_016856121.1, XM_017000632.1 [P62508-3]
XP_016856122.1, XM_017000633.1 [P62508-3]
XP_016856123.1, XM_017000634.1 [P62508-3]
XP_016856124.1, XM_017000635.1 [P62508-3]
XP_016856125.1, XM_017000636.1 [P62508-3]
XP_016856126.1, XM_017000637.1 [P62508-3]
XP_016856127.1, XM_017000638.1 [P62508-2]
XP_016856128.1, XM_017000639.1 [P62508-2]
XP_016856129.1, XM_017000640.1
XP_016856130.1, XM_017000641.1 [P62508-2]
XP_016856131.1, XM_017000642.1
XP_016856132.1, XM_017000643.1
XP_016856133.1, XM_017000644.1 [P62508-2]
XP_016856134.1, XM_017000645.1 [P62508-2]
XP_016856135.1, XM_017000646.1
XP_016856136.1, XM_017000647.1
XP_016856137.1, XM_017000648.1
XP_016856138.1, XM_017000649.1
UniGeneiHs.444225
Hs.738938

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KV6X-ray2.70A/B229-458[»]
1TFCX-ray2.40A/B229-458[»]
1VJBX-ray3.20A/B229-458[»]
2E2RX-ray1.60A222-458[»]
2EWPX-ray2.30A/B/C/D/E233-458[»]
2GP7X-ray2.45A/B/C/D229-458[»]
2GPOX-ray1.95A229-458[»]
2GPPX-ray2.60A/B229-458[»]
2GPUX-ray1.70A229-458[»]
2GPVX-ray2.85A/B/C/D/E/F229-458[»]
2P7AX-ray2.30A229-458[»]
2P7GX-ray2.10A229-458[»]
2P7ZX-ray2.50A229-458[»]
2ZASX-ray2.00A222-458[»]
2ZBSX-ray1.80A222-458[»]
2ZKCX-ray1.70A222-458[»]
ProteinModelPortaliP62508
SMRiP62508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108407, 28 interactors
IntActiP62508, 46 interactors
MINTiP62508
STRINGi9606.ENSP00000386171

Chemistry databases

BindingDBiP62508
ChEMBLiCHEMBL4245
DrugBankiDB06902 4-(1-methyl-1-phenylethyl)phenol
DB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
DB04468 Afimoxifene
DB02659 Cholic Acid
DB00255 Diethylstilbestrol
DB00197 Troglitazone
GuidetoPHARMACOLOGYi624

PTM databases

iPTMnetiP62508
PhosphoSitePlusiP62508

Polymorphism and mutation databases

BioMutaiESRRG
DMDMi50402102

Proteomic databases

MaxQBiP62508
PaxDbiP62508
PeptideAtlasiP62508
PRIDEiP62508
ProteomicsDBi57405
57406 [P62508-2]
57407 [P62508-3]

Protocols and materials databases

DNASUi2104
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359162; ENSP00000352077; ENSG00000196482 [P62508-2]
ENST00000360012; ENSP00000353108; ENSG00000196482 [P62508-2]
ENST00000361395; ENSP00000354584; ENSG00000196482 [P62508-2]
ENST00000361525; ENSP00000355225; ENSG00000196482 [P62508-2]
ENST00000366937; ENSP00000355904; ENSG00000196482 [P62508-5]
ENST00000366938; ENSP00000355905; ENSG00000196482 [P62508-2]
ENST00000366940; ENSP00000355907; ENSG00000196482 [P62508-2]
ENST00000391890; ENSP00000375761; ENSG00000196482 [P62508-2]
ENST00000408911; ENSP00000386171; ENSG00000196482 [P62508-1]
ENST00000463665; ENSP00000418629; ENSG00000196482 [P62508-4]
ENST00000487276; ENSP00000419155; ENSG00000196482 [P62508-2]
ENST00000493603; ENSP00000419594; ENSG00000196482 [P62508-2]
ENST00000493748; ENSP00000417374; ENSG00000196482 [P62508-2]
ENST00000616180; ENSP00000481528; ENSG00000196482 [P62508-2]
GeneIDi2104
KEGGihsa:2104
UCSCiuc001hkw.3 human

Organism-specific databases

CTDi2104
DisGeNETi2104
EuPathDBiHostDB:ENSG00000196482.16
GeneCardsiESRRG
HGNCiHGNC:3474 ESRRG
HPAiHPA044678
MIMi602969 gene
neXtProtiNX_P62508
OpenTargetsiENSG00000196482
PharmGKBiPA27891
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000233467
HOVERGENiHBG108344
InParanoidiP62508
KOiK08554
OMAiMDPVELC
OrthoDBiEOG091G0DYP
PhylomeDBiP62508
TreeFamiTF323751

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
SignaLinkiP62508
SIGNORiP62508

Miscellaneous databases

ChiTaRSiESRRG human
EvolutionaryTraceiP62508
GeneWikiiEstrogen-related_receptor_gamma
GenomeRNAii2104
PROiPR:P62508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196482 Expressed in 185 organ(s), highest expression level in placenta
ExpressionAtlasiP62508 baseline and differential
GenevisibleiP62508 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR027289 Oest-rel_rcp
IPR024178 Oest_rcpt/oest-rel_rcp
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002527 ER-like_NR, 1 hit
PIRSF500939 ERR1-2-3, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERR3_HUMAN
AccessioniPrimary (citable) accession number: P62508
Secondary accession number(s): A8K4I0
, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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