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Protein

Epididymal-specific lipocalin-6

Gene

LCN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in male fertility.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-6
Alternative name(s):
Lipocalin-5
Gene namesi
Name:LCN6
Synonyms:LCN5
ORF Names:UNQ643/PRO1273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000267206.5
HGNCiHGNC:17337 LCN6
MIMi609379 gene
neXtProtiNX_P62502

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000267206
PharmGKBiPA30310

Polymorphism and mutation databases

BioMutaiLCN6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001791421 – 163Epididymal-specific lipocalin-6Add BLAST143

Proteomic databases

PaxDbiP62502
PRIDEiP62502
ProteomicsDBi57404

PTM databases

iPTMnetiP62502
PhosphoSitePlusiP62502

Expressioni

Tissue specificityi

Predominantly expressed in epididymis.

Gene expression databases

BgeeiENSG00000267206
CleanExiHS_LCN6
ExpressionAtlasiP62502 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi127644, 49 interactors
STRINGi9606.ENSP00000339621

Structurei

3D structure databases

ProteinModelPortaliP62502
SMRiP62502
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVYN Eukaryota
ENOG41117FC LUCA
GeneTreeiENSGT00440000034629
HOGENOMiHOG000113295
HOVERGENiHBG052316
InParanoidiP62502
OMAiFRDYAII
OrthoDBiEOG091G0OT4
PhylomeDBiP62502
TreeFamiTF353074

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLLLAAFL ALVSVPRAQA VWLGRLDPEQ LLGPWYVLAV ASREKGFAME
60 70 80 90 100
KDMKNVVGVV VTLTPENNLR TLSSQHGLGG CDQSVMDLIK RNSGWVFENP
110 120 130 140 150
SIGVLELWVL ATNFRDYAII FTQLEFGDEP FNTVELYSLT ETASQEAMGL
160
FTKWSRSLGF LSQ
Length:163
Mass (Da):18,045
Last modified:July 19, 2004 - v1
Checksum:i0860C3DD3EB0286C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303084 mRNA Translation: AAQ14494.1
AY301269 mRNA Translation: AAQ81974.1
AY358598 mRNA Translation: AAQ88961.1
AL355987 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88259.1
BC062746 mRNA Translation: AAH62746.1
CCDSiCCDS7005.1
RefSeqiNP_945184.1, NM_198946.2
UniGeneiHs.522504

Genome annotation databases

EnsembliENST00000341206; ENSP00000339621; ENSG00000267206
GeneIDi158062
KEGGihsa:158062
UCSCiuc004ciy.4 human

Similar proteinsi

Entry informationi

Entry nameiLCN6_HUMAN
AccessioniPrimary (citable) accession number: P62502
Secondary accession number(s): B0QZ80, Q71SF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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