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Protein

TSC22 domain family protein 1

Gene

Tsc22d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
Transforming growth factor beta-1-induced transcript 4 protein
Gene namesi
Name:Tsc22d1
Synonyms:Tgfb1i4, Tsc22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi3850 Tsc22d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193671 – 143TSC22 domain family protein 1Add BLAST143

Proteomic databases

PaxDbiP62501
PRIDEiP62501

Expressioni

Tissue specificityi

Fairly ubiquitous, slightly higher in bone.

Inductioni

By transforming growth factor beta-1 and other growth factors.

Gene expression databases

BgeeiENSRNOG00000001030
ExpressionAtlasiP62501 baseline and differential
GenevisibleiP62501 RN

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi269855, 1 interactor
STRINGi10116.ENSRNOP00000055007

Structurei

3D structure databases

ProteinModelPortaliP62501
SMRiP62501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 97Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000015349
HOVERGENiHBG075918
InParanoidiP62501

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequencei

Sequence statusi: Complete.

P62501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSGASVVAI
60 70 80 90 100
DNKIEQAMDL VKSHLMYAVR EEVEVLKEQI KELIEKNSQL EQENNLLKTL
110 120 130 140
ASPEQLAQFQ AQLQTGSPPA TTQPQGTTQP PAQPASQGSG STA
Length:143
Mass (Da):15,583
Last modified:July 19, 2004 - v1
Checksum:i729D4688572496F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25785 mRNA Translation: AAA20685.1
BC059146 mRNA Translation: AAH59146.1
BC127547 mRNA Translation: AAI27548.1
RefSeqiNP_037175.1, NM_013043.2
UniGeneiRn.3545

Genome annotation databases

EnsembliENSRNOT00000001360; ENSRNOP00000001360; ENSRNOG00000001030
GeneIDi498545
KEGGirno:498545
UCSCiRGD:3850 rat

Similar proteinsi

Entry informationi

Entry nameiT22D1_RAT
AccessioniPrimary (citable) accession number: P62501
Secondary accession number(s): A0JPR0, Q00992
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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