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UniProtKB - P62500 (T22D1_MOUSE)
Protein
TSC22 domain family protein 1
Gene
Tsc22d1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: TSC22 domain family protein 1Alternative name(s): Regulatory protein TSC-22 TGFB-stimulated clone 22 homolog TSC22-related inducible leucine zipper 1b Transforming growth factor beta-1-induced transcript 4 protein |
Gene namesi | Name:Tsc22d1 Synonyms:Kiaa1994, Tgfb1i4, Tilz1b, Tsc22 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109127, Tsc22d1 |
VEuPathDBi | HostDB:ENSMUSG00000022010 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219366 | 1 – 1077 | TSC22 domain family protein 1Add BLAST | 1077 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 263 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P62500 |
PaxDbi | P62500 |
PeptideAtlasi | P62500 |
PRIDEi | P62500 |
ProteomicsDBi | 254628 [P62500-1] 254629 [P62500-2] 254630 [P62500-3] |
PTM databases
iPTMneti | P62500 |
PhosphoSitePlusi | P62500 |
Expressioni
Inductioni
By transforming growth factor beta-1 and other growth factors.
Gene expression databases
Bgeei | ENSMUSG00000022010, Expressed in adrenal gland and 396 other tissues |
ExpressionAtlasi | P62500, baseline and differential |
Genevisiblei | P62500, MM |
Interactioni
Subunit structurei
Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).
By similarityBinary interactionsi
P62500
With | #Exp. | IntAct |
---|---|---|
Tsc22d4 [Q9EQN3] | 2 | EBI-8296837,EBI-7821198 |
Protein-protein interaction databases
BioGRIDi | 204159, 4 interactors |
IntActi | P62500, 1 interactor |
MINTi | P62500 |
STRINGi | 10090.ENSMUSP00000044517 |
Miscellaneous databases
RNActi | P62500, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 112 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 125 – 283 | DisorderedSequence analysisAdd BLAST | 159 | |
Regioni | 458 – 492 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 842 – 874 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 909 – 947 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1010 – 1031 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 1042 – 1077 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 84 | Pro residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 85 – 99 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 172 – 188 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 216 – 240 | Basic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 458 – 489 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 930 – 947 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the TSC-22/Dip/Bun family.Curated
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000159144 |
HOGENOMi | CLU_148757_0_0_1 |
InParanoidi | P62500 |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P62500-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGGGSASA LNAAGTGVSG
60 70 80 90 100
AAPSSEDFPP PSLLQPPPPA ASSTQGPQPP PPQSLNLLSQ AQLQGQPLAP
110 120 130 140 150
GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS
160 170 180 190 200
SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH
210 220 230 240 250
LPHLPQQNVV INGNAHPHHL HHHHHPHHGH HLHHGHHHSS HAAVAGPSIP
260 270 280 290 300
GGPPSSPVSR KLSTTGSSDG GVPVAPPPAV PSSGLPASVM TNIRTPSTTG
310 320 330 340 350
SLGINSVTGT SATNNVNIAA VGSFSPSVTN SVHGNANINT SNIPNAASIS
360 370 380 390 400
GGPGVTSVVN SSILSGMGNG TVSSSPVANS VLNAAAGITV GVVSSQQQQQ
410 420 430 440 450
QQQQPTVNTS RFRVVKLDST SEPFKKGRWT CTEFYEKENA VPATEGVAIN
460 470 480 490 500
KVVETVKQTP TEASSSERES TSGSSVSSSV STLSHYTESV GSGEMMGAPA
510 520 530 540 550
VVAPQQPPLP PAPPGLQGVA LQQLEFSSPA PQSIAAVSMP QSISQSQMSQ
560 570 580 590 600
VQLQPQELSF QQKQTLQPVP LQATMSAATG IQPSPVSVVG VTAAVGQQPS
610 620 630 640 650
VSSLAQPQLP YSQTAPPVQT PLPGAPPQQL QYGQQQPMVP AQIAPGHGQP
660 670 680 690 700
VTQNPTSEYV QQQQQPIFQA ALSSGQSSST GTGAGISVIP VAQAQGIQLP
710 720 730 740 750
GQPTAVQTQP AGAAGQPIGQ AQTAVSTVPT GGQIASIGQQ ANIPTAVQQP
760 770 780 790 800
STQVTPSVIQ QGAPPSSQVV LPAPTGIIHQ GVQTRASSLP QQLVIAPQST
810 820 830 840 850
LVTVPPQPQG VETVAQGVVS QQLPTGSPLP SASTISVTNQ VSSAAPSGMP
860 870 880 890 900
SVPTNLVPPQ NIAQPPATQN GSLVQSVSQS PLIATNINLP LAQQIPLSST
910 920 930 940 950
QFSTQSLAQA IGSQMEDARR PAEPSLGGLP QTMSGDSGGM SAVSDGSSSS
960 970 980 990 1000
LAAPASLFPL KVLPLTTPLV DGEDESSGAS VVAIDNKIEQ AMDLVKSHLM
1010 1020 1030 1040 1050
YAVREEVEVL KEQIKELIEK NSQLEQENNL LKTLASPEQL AQFQAQLQTG
1060 1070
SPPATTQPQG TTQPPAQPAS QGSGSTA
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QLZ1 | E9QLZ1_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 1,077 | Annotation score: | ||
D3Z0V7 | D3Z0V7_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 995 | Annotation score: | ||
D3YW86 | D3YW86_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 107 | Annotation score: | ||
H3BLI9 | H3BLI9_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 86 | Annotation score: | ||
H3BJ00 | H3BJ00_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 95 | Annotation score: | ||
H3BLH4 | H3BLH4_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 132 | Annotation score: | ||
H3BK98 | H3BK98_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 133 | Annotation score: | ||
H3BJV9 | H3BJV9_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 82 | Annotation score: | ||
H3BK07 | H3BK07_MOUSE | TSC22 domain family protein 1 | Tsc22d1 | 128 | Annotation score: |
Sequence cautioni
The sequence AAG41218 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58660 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32600 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 395 | S → SQ in AAG41218 (Ref. 4) Curated | 1 | |
Sequence conflicti | 396 – 398 | Missing in BAD32600 (PubMed:15368895).Curated | 3 | |
Sequence conflicti | 449 | I → V in AAG41218 (Ref. 4) Curated | 1 | |
Sequence conflicti | 449 | I → V in AAH58660 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 551 | V → L in AAG41218 (Ref. 4) Curated | 1 | |
Sequence conflicti | 591 | V → I in AAG41218 (Ref. 4) Curated | 1 | |
Sequence conflicti | 591 | V → I in AAH58660 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 660 | V → VQQ in BAD32600 (PubMed:15368895).Curated | 1 | |
Sequence conflicti | 714 | A → P in BAD32600 (PubMed:15368895).Curated | 1 | |
Sequence conflicti | 720 | Q → P in AAG41218 (Ref. 4) Curated | 1 | |
Sequence conflicti | 737 | I → T in AAG41218 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035327 | 1 – 934 | Missing in isoform 2. 1 PublicationAdd BLAST | 934 | |
Alternative sequenceiVSP_035328 | 303 – 384 | Missing in isoform 3. 1 PublicationAdd BLAST | 82 | |
Alternative sequenceiVSP_035329 | 935 – 975 | GDSGG…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62940 mRNA Translation: CAA44712.1 AK173322 mRNA Translation: BAD32600.1 Different initiation. BC058660 mRNA Translation: AAH58660.1 Different initiation. AF201285 mRNA Translation: AAG41218.1 Different initiation. |
CCDSi | CCDS27285.2 [P62500-1] CCDS27286.1 [P62500-2] CCDS79344.1 [P62500-3] |
PIRi | S23255 |
RefSeqi | NP_033392.1, NM_009366.4 [P62500-2] NP_997535.2, NM_207652.3 |
Genome annotation databases
Ensembli | ENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2] |
GeneIDi | 21807 |
KEGGi | mmu:21807 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62940 mRNA Translation: CAA44712.1 AK173322 mRNA Translation: BAD32600.1 Different initiation. BC058660 mRNA Translation: AAH58660.1 Different initiation. AF201285 mRNA Translation: AAG41218.1 Different initiation. |
CCDSi | CCDS27285.2 [P62500-1] CCDS27286.1 [P62500-2] CCDS79344.1 [P62500-3] |
PIRi | S23255 |
RefSeqi | NP_033392.1, NM_009366.4 [P62500-2] NP_997535.2, NM_207652.3 |
3D structure databases
SMRi | P62500 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204159, 4 interactors |
IntActi | P62500, 1 interactor |
MINTi | P62500 |
STRINGi | 10090.ENSMUSP00000044517 |
PTM databases
iPTMneti | P62500 |
PhosphoSitePlusi | P62500 |
Proteomic databases
MaxQBi | P62500 |
PaxDbi | P62500 |
PeptideAtlasi | P62500 |
PRIDEi | P62500 |
ProteomicsDBi | 254628 [P62500-1] 254629 [P62500-2] 254630 [P62500-3] |
Protocols and materials databases
Antibodypediai | 23553, 447 antibodies from 31 providers |
DNASUi | 21807 |
Genome annotation databases
Ensembli | ENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2] |
GeneIDi | 21807 |
KEGGi | mmu:21807 |
Organism-specific databases
CTDi | 8848 |
MGIi | MGI:109127, Tsc22d1 |
VEuPathDBi | HostDB:ENSMUSG00000022010 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000159144 |
HOGENOMi | CLU_148757_0_0_1 |
InParanoidi | P62500 |
Miscellaneous databases
BioGRID-ORCSi | 21807, 0 hits in 61 CRISPR screens |
ChiTaRSi | Tsc22d1, mouse |
PROi | PR:P62500 |
RNActi | P62500, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022010, Expressed in adrenal gland and 396 other tissues |
ExpressionAtlasi | P62500, baseline and differential |
Genevisiblei | P62500, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | T22D1_MOUSE | |
Accessioni | P62500Primary (citable) accession number: P62500 Secondary accession number(s): Q00992 Q9EQN4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | September 2, 2008 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families