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UniProtKB - P62500 (T22D1_MOUSE)

Entry version 132 (23 Feb 2022)
Sequence version 2 (02 Sep 2008)
Previous versions | rss
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Protein

TSC22 domain family protein 1

Gene

Tsc22d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
TSC22-related inducible leucine zipper 1b
Transforming growth factor beta-1-induced transcript 4 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tsc22d1
Synonyms:Kiaa1994, Tgfb1i4, Tilz1b, Tsc22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:109127, Tsc22d1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022010

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193661 – 1077TSC22 domain family protein 1Add BLAST1077

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P62500

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62500

PeptideAtlas

More...PeptideAtlasi		P62500

PRoteomics IDEntifications database

More...PRIDEi		P62500

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		254628 [P62500-1]
254629 [P62500-2]
254630 [P62500-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62500

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62500

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By transforming growth factor beta-1 and other growth factors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022010, Expressed in adrenal gland and 396 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P62500, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62500, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		204159, 4 interactors

Protein interaction database and analysis system

More...IntActi		P62500, 1 interactor

Molecular INTeraction database

More...MINTi		P62500

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000044517

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62500, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62500

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 112DisorderedSequence analysisAdd BLAST91
Regioni125 – 283DisorderedSequence analysisAdd BLAST159
Regioni458 – 492DisorderedSequence analysisAdd BLAST35
Regioni842 – 874DisorderedSequence analysisAdd BLAST33
Regioni909 – 947DisorderedSequence analysisAdd BLAST39
Regioni1010 – 1031Leucine-zipperAdd BLAST22
Regioni1042 – 1077DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 84Pro residuesSequence analysisAdd BLAST26
Compositional biasi85 – 99Polar residuesSequence analysisAdd BLAST15
Compositional biasi172 – 188Polar residuesSequence analysisAdd BLAST17
Compositional biasi216 – 240Basic residuesSequence analysisAdd BLAST25
Compositional biasi458 – 489Polar residuesSequence analysisAdd BLAST32
Compositional biasi930 – 947Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4797, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_148757_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62500

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000580, TSC-22_Dip_Bun

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01166, TSC22, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01289, TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGGGSASA LNAAGTGVSG 
        60         70         80         90        100
AAPSSEDFPP PSLLQPPPPA ASSTQGPQPP PPQSLNLLSQ AQLQGQPLAP 
       110        120        130        140        150
GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS 
       160        170        180        190        200
SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH 
       210        220        230        240        250
LPHLPQQNVV INGNAHPHHL HHHHHPHHGH HLHHGHHHSS HAAVAGPSIP 
       260        270        280        290        300
GGPPSSPVSR KLSTTGSSDG GVPVAPPPAV PSSGLPASVM TNIRTPSTTG 
       310        320        330        340        350
SLGINSVTGT SATNNVNIAA VGSFSPSVTN SVHGNANINT SNIPNAASIS 
       360        370        380        390        400
GGPGVTSVVN SSILSGMGNG TVSSSPVANS VLNAAAGITV GVVSSQQQQQ 
       410        420        430        440        450
QQQQPTVNTS RFRVVKLDST SEPFKKGRWT CTEFYEKENA VPATEGVAIN 
       460        470        480        490        500
KVVETVKQTP TEASSSERES TSGSSVSSSV STLSHYTESV GSGEMMGAPA 
       510        520        530        540        550
VVAPQQPPLP PAPPGLQGVA LQQLEFSSPA PQSIAAVSMP QSISQSQMSQ 
       560        570        580        590        600
VQLQPQELSF QQKQTLQPVP LQATMSAATG IQPSPVSVVG VTAAVGQQPS 
       610        620        630        640        650
VSSLAQPQLP YSQTAPPVQT PLPGAPPQQL QYGQQQPMVP AQIAPGHGQP 
       660        670        680        690        700
VTQNPTSEYV QQQQQPIFQA ALSSGQSSST GTGAGISVIP VAQAQGIQLP 
       710        720        730        740        750
GQPTAVQTQP AGAAGQPIGQ AQTAVSTVPT GGQIASIGQQ ANIPTAVQQP 
       760        770        780        790        800
STQVTPSVIQ QGAPPSSQVV LPAPTGIIHQ GVQTRASSLP QQLVIAPQST 
       810        820        830        840        850
LVTVPPQPQG VETVAQGVVS QQLPTGSPLP SASTISVTNQ VSSAAPSGMP 
       860        870        880        890        900
SVPTNLVPPQ NIAQPPATQN GSLVQSVSQS PLIATNINLP LAQQIPLSST 
       910        920        930        940        950
QFSTQSLAQA IGSQMEDARR PAEPSLGGLP QTMSGDSGGM SAVSDGSSSS 
       960        970        980        990       1000
LAAPASLFPL KVLPLTTPLV DGEDESSGAS VVAIDNKIEQ AMDLVKSHLM 
      1010       1020       1030       1040       1050
YAVREEVEVL KEQIKELIEK NSQLEQENNL LKTLASPEQL AQFQAQLQTG 
      1060       1070 
SPPATTQPQG TTQPPAQPAS QGSGSTA
Length:1,077
Mass (Da):109,811
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35749C0C1CA1E1B6
GO
Isoform 2 (identifier: P62500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.
     935-975: GDSGGMSAVS...TTPLVDGEDE → MKSQWCRPVA...TENASVRLDN

Show »
Length:143
Mass (Da):15,583
Checksum:i729D4688572496F0
GO
Isoform 3 (identifier: P62500-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-384: Missing.

Show »
Length:995
Mass (Da):102,086
Checksum:i7EA26AE92A87B0E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLZ1E9QLZ1_MOUSE
TSC22 domain family protein 1
Tsc22d1
1,077Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z0V7D3Z0V7_MOUSE
TSC22 domain family protein 1
Tsc22d1
995Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YW86D3YW86_MOUSE
TSC22 domain family protein 1
Tsc22d1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLI9H3BLI9_MOUSE
TSC22 domain family protein 1
Tsc22d1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJ00H3BJ00_MOUSE
TSC22 domain family protein 1
Tsc22d1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLH4H3BLH4_MOUSE
TSC22 domain family protein 1
Tsc22d1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK98H3BK98_MOUSE
TSC22 domain family protein 1
Tsc22d1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJV9H3BJV9_MOUSE
TSC22 domain family protein 1
Tsc22d1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK07H3BK07_MOUSE
TSC22 domain family protein 1
Tsc22d1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG41218 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58660 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32600 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395S → SQ in AAG41218 (Ref. 4) Curated1
Sequence conflicti396 – 398Missing in BAD32600 (PubMed:15368895).Curated3
Sequence conflicti449I → V in AAG41218 (Ref. 4) Curated1
Sequence conflicti449I → V in AAH58660 (PubMed:15489334).Curated1
Sequence conflicti551V → L in AAG41218 (Ref. 4) Curated1
Sequence conflicti591V → I in AAG41218 (Ref. 4) Curated1
Sequence conflicti591V → I in AAH58660 (PubMed:15489334).Curated1
Sequence conflicti660V → VQQ in BAD32600 (PubMed:15368895).Curated1
Sequence conflicti714A → P in BAD32600 (PubMed:15368895).Curated1
Sequence conflicti720Q → P in AAG41218 (Ref. 4) Curated1
Sequence conflicti737I → T in AAG41218 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0353271 – 934Missing in isoform 2. 1 PublicationAdd BLAST934
Alternative sequenceiVSP_035328303 – 384Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_035329935 – 975GDSGG…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X62940 mRNA Translation: CAA44712.1
AK173322 mRNA Translation: BAD32600.1 Different initiation.
BC058660 mRNA Translation: AAH58660.1 Different initiation.
AF201285 mRNA Translation: AAG41218.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27285.2 [P62500-1]
CCDS27286.1 [P62500-2]
CCDS79344.1 [P62500-3]

Protein sequence database of the Protein Information Resource

More...PIRi		S23255

NCBI Reference Sequences

More...RefSeqi		NP_033392.1, NM_009366.4 [P62500-2]
NP_997535.2, NM_207652.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		21807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:21807

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62940 mRNA Translation: CAA44712.1
AK173322 mRNA Translation: BAD32600.1 Different initiation.
BC058660 mRNA Translation: AAH58660.1 Different initiation.
AF201285 mRNA Translation: AAG41218.1 Different initiation.
CCDSiCCDS27285.2 [P62500-1]
CCDS27286.1 [P62500-2]
CCDS79344.1 [P62500-3]
PIRiS23255
RefSeqiNP_033392.1, NM_009366.4 [P62500-2]
NP_997535.2, NM_207652.3

3D structure databases

SMRiP62500
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204159, 4 interactors
IntActiP62500, 1 interactor
MINTiP62500
STRINGi10090.ENSMUSP00000044517

PTM databases

iPTMnetiP62500
PhosphoSitePlusiP62500

Proteomic databases

MaxQBiP62500
PaxDbiP62500
PeptideAtlasiP62500
PRIDEiP62500
ProteomicsDBi254628 [P62500-1]
254629 [P62500-2]
254630 [P62500-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23553, 447 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		21807

Genome annotation databases

EnsembliENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2]
GeneIDi21807
KEGGimmu:21807

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8848
MGIiMGI:109127, Tsc22d1
VEuPathDBiHostDB:ENSMUSG00000022010

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG4797, Eukaryota
GeneTreeiENSGT00940000159144
HOGENOMiCLU_148757_0_0_1
InParanoidiP62500

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		21807, 0 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tsc22d1, mouse

Protein Ontology

More...PROi		PR:P62500
RNActiP62500, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022010, Expressed in adrenal gland and 396 other tissues
ExpressionAtlasiP62500, baseline and differential
GenevisibleiP62500, MM

Family and domain databases

InterProiView protein in InterPro
IPR000580, TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166, TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289, TSC22, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT22D1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62500
Secondary accession number(s): Q00992
, Q69Z44, Q6PDK1, Q9EQN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 2, 2008
Last modified: February 23, 2022
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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