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Entry version 124 (22 Apr 2020)
Sequence version 2 (02 Sep 2008)
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Protein

TSC22 domain family protein 1

Gene

Tsc22d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
TSC22-related inducible leucine zipper 1b
Transforming growth factor beta-1-induced transcript 4 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tsc22d1
Synonyms:Kiaa1994, Tgfb1i4, Tilz1b, Tsc22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:109127 Tsc22d1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193661 – 1077TSC22 domain family protein 1Add BLAST1077

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P62500

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62500

PeptideAtlas

More...
PeptideAtlasi
P62500

PRoteomics IDEntifications database

More...
PRIDEi
P62500

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62500

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62500

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By transforming growth factor beta-1 and other growth factors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022010 Expressed in adrenal gland and 380 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P62500 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62500 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204159, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P62500, 1 interactor

Molecular INTeraction database

More...
MINTi
P62500

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044517

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P62500 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62500

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1010 – 1031Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 82Pro-richAdd BLAST24
Compositional biasi195 – 241His-richAdd BLAST47
Compositional biasi396 – 404Poly-Gln9
Compositional biasi464 – 492Ser-richAdd BLAST29
Compositional biasi505 – 822Gln-richAdd BLAST318

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4797 Eukaryota
ENOG411251N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_148757_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62500

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000580 TSC-22_Dip_Bun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01166 TSC22, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01289 TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGGGSASA LNAAGTGVSG
60 70 80 90 100
AAPSSEDFPP PSLLQPPPPA ASSTQGPQPP PPQSLNLLSQ AQLQGQPLAP
110 120 130 140 150
GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS
160 170 180 190 200
SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH
210 220 230 240 250
LPHLPQQNVV INGNAHPHHL HHHHHPHHGH HLHHGHHHSS HAAVAGPSIP
260 270 280 290 300
GGPPSSPVSR KLSTTGSSDG GVPVAPPPAV PSSGLPASVM TNIRTPSTTG
310 320 330 340 350
SLGINSVTGT SATNNVNIAA VGSFSPSVTN SVHGNANINT SNIPNAASIS
360 370 380 390 400
GGPGVTSVVN SSILSGMGNG TVSSSPVANS VLNAAAGITV GVVSSQQQQQ
410 420 430 440 450
QQQQPTVNTS RFRVVKLDST SEPFKKGRWT CTEFYEKENA VPATEGVAIN
460 470 480 490 500
KVVETVKQTP TEASSSERES TSGSSVSSSV STLSHYTESV GSGEMMGAPA
510 520 530 540 550
VVAPQQPPLP PAPPGLQGVA LQQLEFSSPA PQSIAAVSMP QSISQSQMSQ
560 570 580 590 600
VQLQPQELSF QQKQTLQPVP LQATMSAATG IQPSPVSVVG VTAAVGQQPS
610 620 630 640 650
VSSLAQPQLP YSQTAPPVQT PLPGAPPQQL QYGQQQPMVP AQIAPGHGQP
660 670 680 690 700
VTQNPTSEYV QQQQQPIFQA ALSSGQSSST GTGAGISVIP VAQAQGIQLP
710 720 730 740 750
GQPTAVQTQP AGAAGQPIGQ AQTAVSTVPT GGQIASIGQQ ANIPTAVQQP
760 770 780 790 800
STQVTPSVIQ QGAPPSSQVV LPAPTGIIHQ GVQTRASSLP QQLVIAPQST
810 820 830 840 850
LVTVPPQPQG VETVAQGVVS QQLPTGSPLP SASTISVTNQ VSSAAPSGMP
860 870 880 890 900
SVPTNLVPPQ NIAQPPATQN GSLVQSVSQS PLIATNINLP LAQQIPLSST
910 920 930 940 950
QFSTQSLAQA IGSQMEDARR PAEPSLGGLP QTMSGDSGGM SAVSDGSSSS
960 970 980 990 1000
LAAPASLFPL KVLPLTTPLV DGEDESSGAS VVAIDNKIEQ AMDLVKSHLM
1010 1020 1030 1040 1050
YAVREEVEVL KEQIKELIEK NSQLEQENNL LKTLASPEQL AQFQAQLQTG
1060 1070
SPPATTQPQG TTQPPAQPAS QGSGSTA
Length:1,077
Mass (Da):109,811
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35749C0C1CA1E1B6
GO
Isoform 2 (identifier: P62500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.
     935-975: GDSGGMSAVS...TTPLVDGEDE → MKSQWCRPVA...TENASVRLDN

Show »
Length:143
Mass (Da):15,583
Checksum:i729D4688572496F0
GO
Isoform 3 (identifier: P62500-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-384: Missing.

Show »
Length:995
Mass (Da):102,086
Checksum:i7EA26AE92A87B0E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLZ1E9QLZ1_MOUSE
TSC22 domain family protein 1
Tsc22d1
1,077Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z0V7D3Z0V7_MOUSE
TSC22 domain family protein 1
Tsc22d1
995Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YW86D3YW86_MOUSE
TSC22 domain family protein 1
Tsc22d1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLI9H3BLI9_MOUSE
TSC22 domain family protein 1
Tsc22d1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLH4H3BLH4_MOUSE
TSC22 domain family protein 1
Tsc22d1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJ00H3BJ00_MOUSE
TSC22 domain family protein 1
Tsc22d1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK98H3BK98_MOUSE
TSC22 domain family protein 1
Tsc22d1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJV9H3BJV9_MOUSE
TSC22 domain family protein 1
Tsc22d1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK07H3BK07_MOUSE
TSC22 domain family protein 1
Tsc22d1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG41218 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58660 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32600 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395S → SQ in AAG41218 (Ref. 4) Curated1
Sequence conflicti396 – 398Missing in BAD32600 (PubMed:15368895).Curated3
Sequence conflicti449I → V in AAG41218 (Ref. 4) Curated1
Sequence conflicti449I → V in AAH58660 (PubMed:15489334).Curated1
Sequence conflicti551V → L in AAG41218 (Ref. 4) Curated1
Sequence conflicti591V → I in AAG41218 (Ref. 4) Curated1
Sequence conflicti591V → I in AAH58660 (PubMed:15489334).Curated1
Sequence conflicti660V → VQQ in BAD32600 (PubMed:15368895).Curated1
Sequence conflicti714A → P in BAD32600 (PubMed:15368895).Curated1
Sequence conflicti720Q → P in AAG41218 (Ref. 4) Curated1
Sequence conflicti737I → T in AAG41218 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0353271 – 934Missing in isoform 2. 1 PublicationAdd BLAST934
Alternative sequenceiVSP_035328303 – 384Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_035329935 – 975GDSGG…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X62940 mRNA Translation: CAA44712.1
AK173322 mRNA Translation: BAD32600.1 Different initiation.
BC058660 mRNA Translation: AAH58660.1 Different initiation.
AF201285 mRNA Translation: AAG41218.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27285.2 [P62500-1]
CCDS27286.1 [P62500-2]
CCDS79344.1 [P62500-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S23255

NCBI Reference Sequences

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RefSeqi
NP_033392.1, NM_009366.4 [P62500-2]
NP_997535.2, NM_207652.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21807

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62940 mRNA Translation: CAA44712.1
AK173322 mRNA Translation: BAD32600.1 Different initiation.
BC058660 mRNA Translation: AAH58660.1 Different initiation.
AF201285 mRNA Translation: AAG41218.1 Different initiation.
CCDSiCCDS27285.2 [P62500-1]
CCDS27286.1 [P62500-2]
CCDS79344.1 [P62500-3]
PIRiS23255
RefSeqiNP_033392.1, NM_009366.4 [P62500-2]
NP_997535.2, NM_207652.3

3D structure databases

SMRiP62500
ModBaseiSearch...

Protein-protein interaction databases

BioGridi204159, 1 interactor
IntActiP62500, 1 interactor
MINTiP62500
STRINGi10090.ENSMUSP00000044517

PTM databases

iPTMnetiP62500
PhosphoSitePlusiP62500

Proteomic databases

MaxQBiP62500
PaxDbiP62500
PeptideAtlasiP62500
PRIDEiP62500

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23553 424 antibodies

Genome annotation databases

EnsembliENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2]
GeneIDi21807
KEGGimmu:21807

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8848
MGIiMGI:109127 Tsc22d1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00940000159144
HOGENOMiCLU_148757_0_0_1
InParanoidiP62500

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tsc22d1 mouse

Protein Ontology

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PROi
PR:P62500
RNActiP62500 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022010 Expressed in adrenal gland and 380 other tissues
ExpressionAtlasiP62500 baseline and differential
GenevisibleiP62500 MM

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT22D1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62500
Secondary accession number(s): Q00992
, Q69Z44, Q6PDK1, Q9EQN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 2, 2008
Last modified: April 22, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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