Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TSC22 domain family protein 1

Gene

Tsc22d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
TSC22-related inducible leucine zipper 1b
Transforming growth factor beta-1-induced transcript 4 protein
Gene namesi
Name:Tsc22d1
Synonyms:Kiaa1994, Tgfb1i4, Tilz1b, Tsc22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109127 Tsc22d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193661 – 1077TSC22 domain family protein 1Add BLAST1077

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP62500
PaxDbiP62500
PeptideAtlasiP62500
PRIDEiP62500

PTM databases

iPTMnetiP62500
PhosphoSitePlusiP62500

Expressioni

Inductioni

By transforming growth factor beta-1 and other growth factors.

Gene expression databases

BgeeiENSMUSG00000022010 Expressed in 381 organ(s), highest expression level in adrenal gland
CleanExiMM_TSC22D1
ExpressionAtlasiP62500 baseline and differential
GenevisibleiP62500 MM

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Tsc22d4Q9EQN32EBI-8296837,EBI-7821198

Protein-protein interaction databases

BioGridi204159, 1 interactor
IntActiP62500, 1 interactor
MINTiP62500
STRINGi10090.ENSMUSP00000044517

Structurei

3D structure databases

ProteinModelPortaliP62500
SMRiP62500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1010 – 1031Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 82Pro-richAdd BLAST24
Compositional biasi195 – 241His-richAdd BLAST47
Compositional biasi396 – 404Poly-Gln9
Compositional biasi464 – 492Ser-richAdd BLAST29
Compositional biasi505 – 822Gln-richAdd BLAST318

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000090196
HOVERGENiHBG108540
InParanoidiP62500

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGGGSASA LNAAGTGVSG
60 70 80 90 100
AAPSSEDFPP PSLLQPPPPA ASSTQGPQPP PPQSLNLLSQ AQLQGQPLAP
110 120 130 140 150
GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS
160 170 180 190 200
SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH
210 220 230 240 250
LPHLPQQNVV INGNAHPHHL HHHHHPHHGH HLHHGHHHSS HAAVAGPSIP
260 270 280 290 300
GGPPSSPVSR KLSTTGSSDG GVPVAPPPAV PSSGLPASVM TNIRTPSTTG
310 320 330 340 350
SLGINSVTGT SATNNVNIAA VGSFSPSVTN SVHGNANINT SNIPNAASIS
360 370 380 390 400
GGPGVTSVVN SSILSGMGNG TVSSSPVANS VLNAAAGITV GVVSSQQQQQ
410 420 430 440 450
QQQQPTVNTS RFRVVKLDST SEPFKKGRWT CTEFYEKENA VPATEGVAIN
460 470 480 490 500
KVVETVKQTP TEASSSERES TSGSSVSSSV STLSHYTESV GSGEMMGAPA
510 520 530 540 550
VVAPQQPPLP PAPPGLQGVA LQQLEFSSPA PQSIAAVSMP QSISQSQMSQ
560 570 580 590 600
VQLQPQELSF QQKQTLQPVP LQATMSAATG IQPSPVSVVG VTAAVGQQPS
610 620 630 640 650
VSSLAQPQLP YSQTAPPVQT PLPGAPPQQL QYGQQQPMVP AQIAPGHGQP
660 670 680 690 700
VTQNPTSEYV QQQQQPIFQA ALSSGQSSST GTGAGISVIP VAQAQGIQLP
710 720 730 740 750
GQPTAVQTQP AGAAGQPIGQ AQTAVSTVPT GGQIASIGQQ ANIPTAVQQP
760 770 780 790 800
STQVTPSVIQ QGAPPSSQVV LPAPTGIIHQ GVQTRASSLP QQLVIAPQST
810 820 830 840 850
LVTVPPQPQG VETVAQGVVS QQLPTGSPLP SASTISVTNQ VSSAAPSGMP
860 870 880 890 900
SVPTNLVPPQ NIAQPPATQN GSLVQSVSQS PLIATNINLP LAQQIPLSST
910 920 930 940 950
QFSTQSLAQA IGSQMEDARR PAEPSLGGLP QTMSGDSGGM SAVSDGSSSS
960 970 980 990 1000
LAAPASLFPL KVLPLTTPLV DGEDESSGAS VVAIDNKIEQ AMDLVKSHLM
1010 1020 1030 1040 1050
YAVREEVEVL KEQIKELIEK NSQLEQENNL LKTLASPEQL AQFQAQLQTG
1060 1070
SPPATTQPQG TTQPPAQPAS QGSGSTA
Length:1,077
Mass (Da):109,811
Last modified:September 2, 2008 - v2
Checksum:i35749C0C1CA1E1B6
GO
Isoform 2 (identifier: P62500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.
     935-975: GDSGGMSAVS...TTPLVDGEDE → MKSQWCRPVA...TENASVRLDN

Show »
Length:143
Mass (Da):15,583
Checksum:i729D4688572496F0
GO
Isoform 3 (identifier: P62500-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-384: Missing.

Note: No experimental confirmation available.
Show »
Length:995
Mass (Da):102,086
Checksum:i7EA26AE92A87B0E9
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLZ1E9QLZ1_MOUSE
TSC22 domain family protein 1
Tsc22d1
1,077Annotation score:
D3YW86D3YW86_MOUSE
TSC22 domain family protein 1
Tsc22d1
107Annotation score:
D3Z0V7D3Z0V7_MOUSE
TSC22 domain family protein 1
Tsc22d1
995Annotation score:
H3BLI9H3BLI9_MOUSE
TSC22 domain family protein 1
Tsc22d1
86Annotation score:
H3BLH4H3BLH4_MOUSE
TSC22 domain family protein 1
Tsc22d1
132Annotation score:
H3BK98H3BK98_MOUSE
TSC22 domain family protein 1
Tsc22d1
133Annotation score:
H3BK07H3BK07_MOUSE
TSC22 domain family protein 1
Tsc22d1
128Annotation score:
H3BJ00H3BJ00_MOUSE
TSC22 domain family protein 1
Tsc22d1
95Annotation score:
H3BJV9H3BJV9_MOUSE
TSC22 domain family protein 1
Tsc22d1
82Annotation score:

Sequence cautioni

The sequence AAG41218 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58660 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32600 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti395S → SQ in AAG41218 (Ref. 4) Curated1
Sequence conflicti396 – 398Missing in BAD32600 (PubMed:15368895).Curated3
Sequence conflicti449I → V in AAG41218 (Ref. 4) Curated1
Sequence conflicti449I → V in AAH58660 (PubMed:15489334).Curated1
Sequence conflicti551V → L in AAG41218 (Ref. 4) Curated1
Sequence conflicti591V → I in AAG41218 (Ref. 4) Curated1
Sequence conflicti591V → I in AAH58660 (PubMed:15489334).Curated1
Sequence conflicti660V → VQQ in BAD32600 (PubMed:15368895).Curated1
Sequence conflicti714A → P in BAD32600 (PubMed:15368895).Curated1
Sequence conflicti720Q → P in AAG41218 (Ref. 4) Curated1
Sequence conflicti737I → T in AAG41218 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0353271 – 934Missing in isoform 2. 1 PublicationAdd BLAST934
Alternative sequenceiVSP_035328303 – 384Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_035329935 – 975GDSGG…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62940 mRNA Translation: CAA44712.1
AK173322 mRNA Translation: BAD32600.1 Different initiation.
BC058660 mRNA Translation: AAH58660.1 Different initiation.
AF201285 mRNA Translation: AAG41218.1 Different initiation.
CCDSiCCDS27285.2 [P62500-1]
CCDS27286.1 [P62500-2]
CCDS79344.1 [P62500-3]
PIRiS23255
RefSeqiNP_033392.1, NM_009366.4 [P62500-2]
NP_997535.2, NM_207652.3
UniGeneiMm.153272

Genome annotation databases

EnsembliENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2]
GeneIDi21807
KEGGimmu:21807

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62940 mRNA Translation: CAA44712.1
AK173322 mRNA Translation: BAD32600.1 Different initiation.
BC058660 mRNA Translation: AAH58660.1 Different initiation.
AF201285 mRNA Translation: AAG41218.1 Different initiation.
CCDSiCCDS27285.2 [P62500-1]
CCDS27286.1 [P62500-2]
CCDS79344.1 [P62500-3]
PIRiS23255
RefSeqiNP_033392.1, NM_009366.4 [P62500-2]
NP_997535.2, NM_207652.3
UniGeneiMm.153272

3D structure databases

ProteinModelPortaliP62500
SMRiP62500
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204159, 1 interactor
IntActiP62500, 1 interactor
MINTiP62500
STRINGi10090.ENSMUSP00000044517

PTM databases

iPTMnetiP62500
PhosphoSitePlusiP62500

Proteomic databases

MaxQBiP62500
PaxDbiP62500
PeptideAtlasiP62500
PRIDEiP62500

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022587; ENSMUSP00000022587; ENSMUSG00000022010 [P62500-2]
GeneIDi21807
KEGGimmu:21807

Organism-specific databases

CTDi8848
MGIiMGI:109127 Tsc22d1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000090196
HOVERGENiHBG108540
InParanoidiP62500

Miscellaneous databases

ChiTaRSiTsc22d1 mouse
PROiPR:P62500
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022010 Expressed in 381 organ(s), highest expression level in adrenal gland
CleanExiMM_TSC22D1
ExpressionAtlasiP62500 baseline and differential
GenevisibleiP62500 MM

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT22D1_MOUSE
AccessioniPrimary (citable) accession number: P62500
Secondary accession number(s): Q00992
, Q69Z44, Q6PDK1, Q9EQN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again