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Protein

Ras-related protein Rab-11A

Gene

Rab11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: RGD
  • GTP binding Source: RGD
  • microtubule binding Source: Ensembl
  • myosin V binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processCell cycle, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-5620916 VxPx cargo-targeting to cilium
R-RNO-8854214 TBC/RABGAPs
R-RNO-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11A
Short name:
Rab-11
Alternative name(s):
24KG
Gene namesi
Name:Rab11a
Synonyms:Rab11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi619762 Rab11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211562 – 213Ras-related protein Rab-11AAdd BLAST212
PropeptideiPRO_0000370812214 – 216Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1
Modified residuei213Cysteine methyl esterSequence analysis1
Lipidationi213S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP62494
PRIDEiP62494

PTM databases

iPTMnetiP62494
PhosphoSitePlusiP62494

Expressioni

Tissue specificityi

Detected in various tissues, such as brain, testis, spleen, and heart.1 Publication

Gene expression databases

BgeeiENSRNOG00000011302 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiP62494 RN

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39 (By similarity). Interacts with EXOC6 in a GTP-dependent manner. Interacts with RIP11 (PubMed:11163216). Interacts with STXBP6 (PubMed:12145319). Interacts (GDP-bound form) with ZFYVE27 (PubMed:17082457). Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (By similarity). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249688, 1 interactor
DIPiDIP-46857N
IntActiP62494, 6 interactors
MINTiP62494
STRINGi10116.ENSRNOP00000015598

Structurei

3D structure databases

ProteinModelPortaliP62494
SMRiP62494
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP62494
KOiK07904
OMAiIAKHATY
OrthoDBiEOG091G0O1R
PhylomeDBiP62494
TreeFamiTF300099

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62494-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF
160 170 180 190 200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV
210
PPTTENKPKV QCCQNI
Length:216
Mass (Da):24,394
Last modified:January 23, 2007 - v3
Checksum:i76FC1E113A29B269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75153 mRNA Translation: AAA42012.1
BC085727 mRNA Translation: AAH85727.1
PIRiJN0056
RefSeqiNP_112414.1, NM_031152.2
UniGeneiRn.1016

Genome annotation databases

EnsembliENSRNOT00000015598; ENSRNOP00000015598; ENSRNOG00000011302
GeneIDi81830
KEGGirno:81830
UCSCiRGD:619762 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75153 mRNA Translation: AAA42012.1
BC085727 mRNA Translation: AAH85727.1
PIRiJN0056
RefSeqiNP_112414.1, NM_031152.2
UniGeneiRn.1016

3D structure databases

ProteinModelPortaliP62494
SMRiP62494
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249688, 1 interactor
DIPiDIP-46857N
IntActiP62494, 6 interactors
MINTiP62494
STRINGi10116.ENSRNOP00000015598

PTM databases

iPTMnetiP62494
PhosphoSitePlusiP62494

Proteomic databases

PaxDbiP62494
PRIDEiP62494

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015598; ENSRNOP00000015598; ENSRNOG00000011302
GeneIDi81830
KEGGirno:81830
UCSCiRGD:619762 rat

Organism-specific databases

CTDi8766
RGDi619762 Rab11a

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP62494
KOiK07904
OMAiIAKHATY
OrthoDBiEOG091G0O1R
PhylomeDBiP62494
TreeFamiTF300099

Enzyme and pathway databases

ReactomeiR-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-5620916 VxPx cargo-targeting to cilium
R-RNO-8854214 TBC/RABGAPs
R-RNO-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:P62494

Gene expression databases

BgeeiENSRNOG00000011302 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiP62494 RN

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB11A_RAT
AccessioniPrimary (citable) accession number: P62494
Secondary accession number(s): P24410, Q9JLX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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