Rab11a

Functionⁱ

The small GTPases Rab areR key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	18 – 26	GTPBy similarity	9
Nucleotide bindingⁱ	66 – 70	GTPBy similarity	5
Nucleotide bindingⁱ	124 – 127	GTPBy similarity	4
Nucleotide bindingⁱ	154 – 156	GTPBy similarity	3

GO - Molecular functionⁱ

GTPase activity Source: UniProtKB
GTP binding Source: MGI
microtubule binding Source: MGI
myosin V binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astral microtubule organization Source: MGI
establishment of protein localization to membrane Source: MGI
establishment of protein localization to organelle Source: MGI
establishment of vesicle localization Source: MGI
exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exosomal secretion Source: MGI
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
melanosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21291502
mitotic metaphase plate congression Source: MGI
mitotic spindle assembly Source: MGI
multivesicular body assembly Source: MGI
neuron projection development Source: UniProtKB
neurotransmitter receptor transport, endosome to postsynaptic membrane Source: MGI
positive regulation of axon extension
Source: MGI
Inferred from mutant phenotypeⁱ
- 22573681
positive regulation of epithelial cell migration Source: MGI
positive regulation of G2/M transition of mitotic cell cycle Source: MGI
positive regulation of protein localization to plasma membrane Source: MGI
protein localization to plasma membrane Source: UniProtKB
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cytokinesis Source: MGI
regulation of long-term neuronal synaptic plasticity Source: MGI
regulation of multivesicular body size Source: MGI
regulation of protein transport Source: MGI
regulation of vesicle-mediated transport Source: MGI
vesicle-mediated transport Source: MGI
vesicle-mediated transport in synapse Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-5620916 VxPx cargo-targeting to cilium R-MMU-8854214 TBC/RABGAPs R-MMU-8873719 RAB geranylgeranylation

Reactomeⁱ

R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-5620916 VxPx cargo-targeting to cilium
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-11A Short name: Rab-11
Gene namesⁱ	Name:Rab11a Synonyms:Rab11
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1858202 Rab11a

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000121152	2 – 213	Ras-related protein Rab-11AAdd BLAST	212
PropeptideⁱPRO_0000370808	214 – 216	Removed in mature formSequence analysis	3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycineBy similarity	1
Lipidationⁱ	212	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	213	Cysteine methyl esterSequence analysis	1
Lipidationⁱ	213	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbⁱ	P62492
PeptideAtlas More...PeptideAtlasⁱ	P62492
PRIDEⁱ	P62492
TopDownProteomicsⁱ	P62492

PTM databases

iPTMnetⁱ	P62492
PhosphoSitePlusⁱ	P62492
SwissPalmⁱ	P62492

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000004771 Expressed in 296 organ(s), highest expression level in ileum
CleanExⁱ	MM_RAB11A
ExpressionAtlasⁱ	P62492 baseline and differential
Genevisibleⁱ	P62492 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with RIP11 and STXBP6. Interacts (GDP-bound form) with ZFYVE27 (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39 (PubMed:17509819, PubMed:20190753). Interacts with EXOC6 in a GTP-dependent manner (PubMed:15292201). Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts (GDP-bound form) with RELCH (PubMed:29514919). Found in a complex composed of RELCH, OSBP1 and RAB11A (PubMed:29514919).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Rab3ip	Q62739	4	EBI-770256,EBI-2028671	From Rattus norvegicus.
Vps33b	P59016	3	EBI-770256,EBI-2656383

GO - Molecular functionⁱ

microtubule binding Source: MGI
myosin V binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207498, 14 interactors
IntActⁱ	P62492, 29 interactors
Molecular INTeraction database More...MINTⁱ	P62492
STRINGⁱ	10090.ENSMUSP00000129163

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P62492
SMRⁱ	P62492
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	40 – 48	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0087 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118841
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P62492
KEGG Orthology (KO) More...KOⁱ	K07904
OMAⁱ	IAKHATY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O1R
PhylomeDBⁱ	P62492
TreeFamⁱ	TF300099

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P62492-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT 
        60         70         80         90        100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 
       110        120        130        140        150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF 
       160        170        180        190        200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV 
       210 
PPTTENKPKV QCCQNI

Length:216

Mass (Da):24,394

Last modified:January 23, 2007 - v3

Checksum:ⁱ76FC1E113A29B269

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q3P9	E9Q3P9_MOUSE	Ras-related protein Rab-11A Ras-related protein Rab-11A	Rab11a	153	Annotation score:
E9Q6B3	E9Q6B3_MOUSE	Ras-related protein Rab-11A Ras-related protein Rab-11A	Rab11a	86	Annotation score:
E9PZB2	E9PZB2_MOUSE	Ras-related protein Rab-11A Ras-related protein Rab-11A	Rab11a	80	Annotation score:
F6R2Z5	F6R2Z5_MOUSE	Ras-related protein Rab-11A Ras-related protein Rab-11A	Rab11a	87	Annotation score:
F8WGS1	F8WGS1_MOUSE	Ras-related protein Rab-11A Ras-related protein Rab-11A	Rab11a	155	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	180	Q → H in AAF36458 (PubMed:10708602).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF127669 Genomic DNA Translation: AAF36458.1 AK014268 mRNA Translation: BAB29233.1 AK132072 mRNA Translation: BAE20971.1 AK132159 mRNA Translation: BAE21003.1 AK147122 mRNA Translation: BAE27693.1 BC010722 mRNA Translation: AAH10722.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23282.1
NCBI Reference Sequences More...RefSeqⁱ	NP_059078.2, NM_017382.5
UniGeneⁱ	Mm.1387

Genome annotation databases

Ensemblⁱ	ENSMUST00000172298; ENSMUSP00000129163; ENSMUSG00000004771
GeneIDⁱ	53869
KEGGⁱ	mmu:53869
UCSC genome browser More...UCSCⁱ	uc009qce.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62492	Ras-related protein Rab-11A	)	HUMAN		216	UniRef100_P62491
Ras-related protein Rab-11A		CANLF		216
Ras-related protein Rab-11A		PIG		216
Ras-related protein Rab-11A		PONAB		216
Ras-related protein Rab-11A		RABIT		216
+49

Protein	Similar proteins		Species	Score	Length	Source
P62492	Ras-related protein Rab-11A	)	HUMAN		216	UniRef90_P62491
Ras-related protein Rab-11A		CANLF		216
Ras-related protein Rab-11A		PIG		216
Ras-related protein Rab-11A		PONAB		216
Ras-related protein Rab-11A		RABIT		216
+50

Protein	Similar proteins		Species	Score	Length	Source
P62492	Ras-related protein Rab-11A	)	HUMAN		216	UniRef50_P62491
Ras-related protein Rab-11A		CANLF		216
Ras-related protein Rab-11A		PIG		216
Ras-related protein Rab-11A		PONAB		216
Ras-related protein Rab-11A		RABIT		216
+324

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF127669 Genomic DNA Translation: AAF36458.1 AK014268 mRNA Translation: BAB29233.1 AK132072 mRNA Translation: BAE20971.1 AK132159 mRNA Translation: BAE21003.1 AK147122 mRNA Translation: BAE27693.1 BC010722 mRNA Translation: AAH10722.1
CCDSⁱ	CCDS23282.1
RefSeqⁱ	NP_059078.2, NM_017382.5
UniGeneⁱ	Mm.1387

3D structure databases

ProteinModelPortalⁱ	P62492
SMRⁱ	P62492
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207498, 14 interactors
IntActⁱ	P62492, 29 interactors
MINTⁱ	P62492
STRINGⁱ	10090.ENSMUSP00000129163

PTM databases

iPTMnetⁱ	P62492
PhosphoSitePlusⁱ	P62492
SwissPalmⁱ	P62492

Proteomic databases

PaxDbⁱ	P62492
PeptideAtlasⁱ	P62492
PRIDEⁱ	P62492
TopDownProteomicsⁱ	P62492

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000172298; ENSMUSP00000129163; ENSMUSG00000004771
GeneIDⁱ	53869
KEGGⁱ	mmu:53869
UCSCⁱ	uc009qce.1 mouse

Organism-specific databases

CTDⁱ	8766
MGIⁱ	MGI:1858202 Rab11a

Phylogenomic databases

eggNOGⁱ	KOG0087 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00760000118841
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P62492
KOⁱ	K07904
OMAⁱ	IAKHATY
OrthoDBⁱ	EOG091G0O1R
PhylomeDBⁱ	P62492
TreeFamⁱ	TF300099

Enzyme and pathway databases

Reactomeⁱ	R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-5620916 VxPx cargo-targeting to cilium R-MMU-8854214 TBC/RABGAPs R-MMU-8873719 RAB geranylgeranylation

Reactomeⁱ

R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-5620916 VxPx cargo-targeting to cilium
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P62492
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000004771 Expressed in 296 organ(s), highest expression level in ileum
CleanExⁱ	MM_RAB11A
ExpressionAtlasⁱ	P62492 baseline and differential
Genevisibleⁱ	P62492 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RB11A_MOUSE
Accessionⁱ	P62492Primary (citable) accession number: P62492 Secondary accession number(s): P24410, Q3V1Z6, Q9JLX1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Help

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Supporting data

UniProtKB - P62492 (RB11A_MOUSE)

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Ras-related protein Rab-11A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Cytoskeleton

Endosome

Extracellular region or secreted

Golgi apparatus

Mitochondrion

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ