UniProtKB - P62492 (RB11A_MOUSE)
Ras-related protein Rab-11A
Rab11a
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | GTPBy similarity | 9 | |
Nucleotide bindingi | 37 – 43 | GTPBy similarity | 7 | |
Nucleotide bindingi | 66 – 70 | GTPBy similarity | 5 | |
Nucleotide bindingi | 124 – 127 | GTPBy similarity | 4 | |
Nucleotide bindingi | 154 – 156 | GTPBy similarity | 3 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB
- GTP binding Source: MGI
- microtubule binding Source: MGI
- myosin V binding Source: MGI
GO - Biological processi
- amyloid-beta clearance by transcytosis Source: MGI
- astral microtubule organization Source: MGI
- establishment of protein localization to membrane Source: MGI
- establishment of protein localization to organelle Source: MGI
- establishment of vesicle localization Source: MGI
- exocytosis Source: GO_Central
- exosomal secretion Source: MGI
- melanosome transport Source: UniProtKB
- mitotic metaphase plate congression Source: MGI
- mitotic spindle assembly Source: MGI
- multivesicular body assembly Source: MGI
- neuron projection development Source: UniProtKB
- neurotransmitter receptor transport, endosome to postsynaptic membrane Source: MGI
- positive regulation of axon extension Source: MGI
- positive regulation of epithelial cell migration Source: MGI
- positive regulation of G2/M transition of mitotic cell cycle Source: MGI
- positive regulation of protein localization to plasma membrane Source: MGI
- protein localization to plasma membrane Source: UniProtKB
- regulation of cytokinesis Source: MGI
- regulation of long-term neuronal synaptic plasticity Source: MGI
- regulation of multivesicular body size Source: MGI
- regulation of protein transport Source: MGI
- regulation of vesicle-mediated transport Source: MGI
- vesicle-mediated transport Source: MGI
- vesicle-mediated transport in synapse Source: MGI
Keywordsi
Biological process | Cell cycle, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-MMU-5620912, Anchoring of the basal body to the plasma membrane R-MMU-5620916, VxPx cargo-targeting to cilium R-MMU-8854214, TBC/RABGAPs R-MMU-8873719, RAB geranylgeranylation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-11AShort name: Rab-11 |
Gene namesi | Name:Rab11a Synonyms:Rab11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858202, Rab11a |
Subcellular locationi
Endosome
- Recycling endosome membrane 1 Publication; Lipid-anchor Curated
Plasma membrane
- Cell membrane By similarity; Lipid-anchor Curated
Other locations
- Cleavage furrow By similarity
- phagosome By similarity
- Cytoplasmic vesicle membrane By similarity
Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis.By similarity
Cytoskeleton
- centriolar satellite Source: MGI
- kinetochore microtubule Source: Ensembl
- spindle pole Source: MGI
Endosome
- endosome Source: GO_Central
- multivesicular body Source: MGI
- postsynaptic recycling endosome Source: MGI
- recycling endosome Source: UniProtKB
- recycling endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: MGI
Golgi apparatus
- trans-Golgi network Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Plasma Membrane
- cleavage furrow Source: UniProtKB
Other locations
- axon Source: MGI
- cytoplasm Source: MGI
- cytoplasmic vesicle Source: MGI
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- glutamatergic synapse Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: MGI
- perinuclear region of cytoplasm Source: MGI
- phagocytic vesicle Source: UniProtKB
- protein-containing complex Source: MGI
- Schaffer collateral - CA1 synapse Source: MGI
- transport vesicle Source: MGI
- vesicle Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121152 | 2 – 213 | Ras-related protein Rab-11AAdd BLAST | 212 | |
PropeptideiPRO_0000370808 | 214 – 216 | Removed in mature formSequence analysis | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineBy similarity | 1 | |
Lipidationi | 212 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 213 | Cysteine methyl esterSequence analysis | 1 | |
Lipidationi | 213 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, PrenylationProteomic databases
jPOSTi | P62492 |
PaxDbi | P62492 |
PeptideAtlasi | P62492 |
PRIDEi | P62492 |
TopDownProteomicsi | P62492 |
PTM databases
iPTMneti | P62492 |
PhosphoSitePlusi | P62492 |
SwissPalmi | P62492 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004771, Expressed in ileum and 312 other tissues |
ExpressionAtlasi | P62492, baseline and differential |
Genevisiblei | P62492, MM |
Interactioni
Subunit structurei
Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity).
Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity).
Interacts with RIP11 and STXBP6.
Interacts (GDP-bound form) with ZFYVE27 (By similarity).
Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39 (PubMed:17509819, PubMed:20190753).
Interacts with EXOC6 in a GTP-dependent manner (PubMed:15292201).
Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity).
Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309).
Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity).
Interacts (GDP-bound form) with RELCH (PubMed:29514919).
Found in a complex composed of RELCH, OSBP1 and RAB11A (PubMed:29514919).
Interacts with TBC1D12 (PubMed:28384198).
By similarity5 PublicationsBinary interactionsi
Hide detailsP62492
With | #Exp. | IntAct |
---|---|---|
Vps33b [P59016] | 3 | EBI-770256,EBI-2656383 |
Rab3ip [Q62739] from Rattus norvegicus. | 4 | EBI-770256,EBI-2028671 |
GO - Molecular functioni
- microtubule binding Source: MGI
- myosin V binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207498, 16 interactors |
IntActi | P62492, 29 interactors |
MINTi | P62492 |
STRINGi | 10090.ENSMUSP00000129163 |
Miscellaneous databases
RNActi | P62492, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 48 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0087, Eukaryota |
GeneTreei | ENSGT00940000154914 |
HOGENOMi | CLU_041217_23_0_1 |
InParanoidi | P62492 |
OMAi | SMKEDYY |
OrthoDBi | 1133775at2759 |
PhylomeDBi | P62492 |
TreeFami | TF300099 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF
160 170 180 190 200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV
210
PPTTENKPKV QCCQNI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PZB2 | E9PZB2_MOUSE | Ras-related protein Rab-11A | Rab11a | 80 | Annotation score: | ||
E9Q6B3 | E9Q6B3_MOUSE | Ras-related protein Rab-11A | Rab11a | 86 | Annotation score: | ||
E9Q3P9 | E9Q3P9_MOUSE | Ras-related protein Rab-11A | Rab11a | 153 | Annotation score: | ||
F8WGS1 | F8WGS1_MOUSE | Ras-related protein Rab-11A | Rab11a | 155 | Annotation score: | ||
F6R2Z5 | F6R2Z5_MOUSE | Ras-related protein Rab-11A | Rab11a | 87 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 180 | Q → H in AAF36458 (PubMed:10708602).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF127669 Genomic DNA Translation: AAF36458.1 AK014268 mRNA Translation: BAB29233.1 AK132072 mRNA Translation: BAE20971.1 AK132159 mRNA Translation: BAE21003.1 AK147122 mRNA Translation: BAE27693.1 BC010722 mRNA Translation: AAH10722.1 |
CCDSi | CCDS23282.1 |
RefSeqi | NP_059078.2, NM_017382.5 |
Genome annotation databases
Ensembli | ENSMUST00000172298; ENSMUSP00000129163; ENSMUSG00000004771 |
GeneIDi | 53869 |
KEGGi | mmu:53869 |
UCSCi | uc009qce.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF127669 Genomic DNA Translation: AAF36458.1 AK014268 mRNA Translation: BAB29233.1 AK132072 mRNA Translation: BAE20971.1 AK132159 mRNA Translation: BAE21003.1 AK147122 mRNA Translation: BAE27693.1 BC010722 mRNA Translation: AAH10722.1 |
CCDSi | CCDS23282.1 |
RefSeqi | NP_059078.2, NM_017382.5 |
3D structure databases
SMRi | P62492 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207498, 16 interactors |
IntActi | P62492, 29 interactors |
MINTi | P62492 |
STRINGi | 10090.ENSMUSP00000129163 |
PTM databases
iPTMneti | P62492 |
PhosphoSitePlusi | P62492 |
SwissPalmi | P62492 |
Proteomic databases
jPOSTi | P62492 |
PaxDbi | P62492 |
PeptideAtlasi | P62492 |
PRIDEi | P62492 |
TopDownProteomicsi | P62492 |
Protocols and materials databases
Antibodypediai | 4588, 482 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000172298; ENSMUSP00000129163; ENSMUSG00000004771 |
GeneIDi | 53869 |
KEGGi | mmu:53869 |
UCSCi | uc009qce.1, mouse |
Organism-specific databases
CTDi | 8766 |
MGIi | MGI:1858202, Rab11a |
Phylogenomic databases
eggNOGi | KOG0087, Eukaryota |
GeneTreei | ENSGT00940000154914 |
HOGENOMi | CLU_041217_23_0_1 |
InParanoidi | P62492 |
OMAi | SMKEDYY |
OrthoDBi | 1133775at2759 |
PhylomeDBi | P62492 |
TreeFami | TF300099 |
Enzyme and pathway databases
Reactomei | R-MMU-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-MMU-5620912, Anchoring of the basal body to the plasma membrane R-MMU-5620916, VxPx cargo-targeting to cilium R-MMU-8854214, TBC/RABGAPs R-MMU-8873719, RAB geranylgeranylation |
Miscellaneous databases
BioGRID-ORCSi | 53869, 2 hits in 18 CRISPR screens |
ChiTaRSi | Rab11a, mouse |
PROi | PR:P62492 |
RNActi | P62492, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004771, Expressed in ileum and 312 other tissues |
ExpressionAtlasi | P62492, baseline and differential |
Genevisiblei | P62492, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RB11A_MOUSE | |
Accessioni | P62492Primary (citable) accession number: P62492 Secondary accession number(s): P24410, Q3V1Z6, Q9JLX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families