RAB11A

Functionⁱ

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.6 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	18 – 26	GTP3 Publications	9
Nucleotide bindingⁱ	66 – 70	GTP3 Publications	5
Nucleotide bindingⁱ	124 – 127	GTP3 Publications	4
Nucleotide bindingⁱ	154 – 156	GTP3 Publications	3

GO - Molecular functionⁱ

GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
GTP binding Source: UniProtKB-KW
microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24561039
myosin V binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24006491
syntaxin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12145319

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astral microtubule organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24561039
ciliary basal body-plasma membrane docking Source: Reactome
establishment of protein localization to membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24006491
establishment of protein localization to organelle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24561039
establishment of vesicle localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24561039
exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exosomal secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15634213
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
melanosome transport Source: UniProtKB
mitotic metaphase plate congression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24561039
mitotic spindle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24561039
multivesicular body assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15634213
neuron projection development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17082457
neurotransmitter receptor transport, endosome to postsynaptic membrane
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
plasma membrane to endosome transport
Source: UniProtKB
Non-traceable author statementⁱ
- 11163216
positive regulation of axon extension Source: Ensembl
positive regulation of epithelial cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22613965
positive regulation of G2/M transition of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24561039
positive regulation of protein localization to plasma membrane Source: Ensembl
post-translational protein modification Source: Reactome
protein localization to plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 17082457
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15601896
regulation of long-term neuronal synaptic plasticity Source: Ensembl
regulation of multivesicular body size
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15634213
regulation of protein transport Source: Ensembl
regulation of vesicle-mediated transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22613965
renal water homeostasis Source: Reactome
vesicle-mediated transport
Source: UniProtKB
Inferred from direct assayⁱ
- 17462998
- 19542231
vesicle-mediated transport in synapse Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5620916 VxPx cargo-targeting to cilium R-HSA-8854214 TBC/RABGAPs R-HSA-8873719 RAB geranylgeranylation
SignaLinkⁱ	P62491

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-11A Short name: Rab-11 Alternative name(s): YL8
Gene namesⁱ	Name:RAB11A Synonyms:RAB11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103769.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9760 RAB11A
MIMⁱ	605570 gene
neXtProtⁱ	NX_P62491

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	25	S → N: Dominant-negative mutant. Induces increased number of binucleated cells, indicating defects in cytokinesis. Inhibits the transport of NPC1L1 to the plama membrane. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. 3 Publications		1
Mutagenesisⁱ	70	Q → L: Constitutively active mutant. Decreases GTPase activity. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. 5 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8766
MalaCards human disease database More...MalaCardsⁱ	RAB11A
Open Targets More...OpenTargetsⁱ	ENSG00000103769
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA34101

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB01864 5'-Guanosine-Diphosphate-Monothiophosphate DB04315 Guanosine-5'-Diphosphate

DrugBankⁱ

DB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaⁱ	RAB11A
DMDMⁱ	50402542

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000121151	2 – 213	Ras-related protein Rab-11AAdd BLAST	212
PropeptideⁱPRO_0000370807	214 – 216	Removed in mature formSequence analysis	3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycine1 Publication	1
Lipidationⁱ	212	S-geranylgeranyl cysteine1 Publication	1
Modified residueⁱ	213	Cysteine methyl esterSequence analysis	1
Lipidationⁱ	213	S-geranylgeranyl cysteine1 Publication	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	P62491
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62491
PaxDbⁱ	P62491
PeptideAtlas More...PeptideAtlasⁱ	P62491
PRIDEⁱ	P62491
ProteomicsDBⁱ	57402
TopDownProteomicsⁱ	P62491-1 [P62491-1]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P62491

OGPⁱ

P62491

PTM databases

iPTMnetⁱ	P62491
PhosphoSitePlusⁱ	P62491
SwissPalmⁱ	P62491

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000103769 Expressed in 233 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_RAB11A
ExpressionAtlasⁱ	P62491 baseline and differential
Genevisibleⁱ	P62491 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013097 HPA051697 HPA060686

HPAⁱ

CAB013097
HPA051697
HPA060686

Interactionⁱ

Subunit structureⁱ

Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27 (PubMed:21976701, PubMed:17082457). Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity).By similarity24 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CHMP1B	Q7LBR1	3	EBI-745098,EBI-2118090
EVI5	O60447	6	EBI-745098,EBI-852291
PI4KB	Q9UBF8-2	5	EBI-745098,EBI-16107849
RAB11FIP2	Q7L804	8	EBI-745098,EBI-1049676
RAB11FIP3	O75154-1	16	EBI-745098,EBI-15605207
RAB11FIP4	Q86YS3-1	2	EBI-745098,EBI-15605259
RAB11FIP5	Q9BXF6	3	EBI-745098,EBI-1387068
RAB3IP	Q96QF0-2	8	EBI-745098,EBI-747865
YAP1	P46937	2	EBI-745098,EBI-1044059
ZFYVE27	Q5T4F4	4	EBI-745098,EBI-3892947

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24561039
myosin V binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24006491
syntaxin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12145319

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114299, 94 interactors
CORUMⁱ	P62491
Database of interacting proteins More...DIPⁱ	DIP-29138N
IntActⁱ	P62491, 141 interactors
Molecular INTeraction database More...MINTⁱ	P62491
STRINGⁱ	9606.ENSP00000261890

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	9 – 18	Combined sources	10
Helixⁱ	24 – 33	Combined sources	10
Beta strandⁱ	45 – 55	Combined sources	11
Beta strandⁱ	58 – 67	Combined sources	10
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	78 – 81	Combined sources	4
Beta strandⁱ	86 – 92	Combined sources	7
Helixⁱ	96 – 100	Combined sources	5
Helixⁱ	102 – 112	Combined sources	11
Beta strandⁱ	118 – 124	Combined sources	7
Helixⁱ	126 – 131	Combined sources	6
Helixⁱ	136 – 145	Combined sources	10
Beta strandⁱ	149 – 152	Combined sources	4
Turnⁱ	155 – 157	Combined sources	3
Helixⁱ	161 – 172	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P62491
SMRⁱ	P62491
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P62491

EvolutionaryTraceⁱ

P62491

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	40 – 48	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0087 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118841
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P62491
KEGG Orthology (KO) More...KOⁱ	K07904
OMAⁱ	IAKHATY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O1R
PhylomeDBⁱ	P62491
TreeFamⁱ	TF300099

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P62491-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT 
        60         70         80         90        100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 
       110        120        130        140        150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF 
       160        170        180        190        200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV 
       210 
PPTTENKPKV QCCQNI

Length:216

Mass (Da):24,394

Last modified:January 23, 2007 - v3

Checksum:ⁱ76FC1E113A29B269

GO

Isoform 2 (identifier: P62491-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
147-216: GLSFIETSAL...KPKVQCCQNI → EANVRQTRK

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT 
        60         70         80         90        100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 
       110        120        130        140        150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNEANV 

RQTRK

Note: No experimental confirmation available.

Show »

Length:155

Mass (Da):17,659

Checksum:ⁱ70C3A0F378C9893A

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4DQU5	B4DQU5_HUMAN	cDNA FLJ57160, highly similar to Ra... cDNA FLJ57160, highly similar to Ras-related protein Rab-11A	RAB11A	146	Annotation score:
H3BSC1	H3BSC1_HUMAN	Ras-related protein Rab-11A Ras-related protein Rab-11A	RAB11A	198	Annotation score:
H3BMH2	H3BMH2_HUMAN	Ras-related protein Rab-11A Ras-related protein Rab-11A	RAB11A	155	Annotation score:
H3BN38	H3BN38_HUMAN	Ras-related protein Rab-11A Ras-related protein Rab-11A	RAB11A	81	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046755	147 – 216	GLSFI…CCQNI → EANVRQTRK in isoform 2. 1 PublicationAdd BLAST		70

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53143 mRNA Translation: CAA37300.1 X56740 mRNA Translation: CAA40064.1 AF000231 mRNA Translation: AAC32887.1 AF498946 mRNA Translation: AAM21094.1 CR407669 mRNA Translation: CAG28597.1 CR536493 mRNA Translation: CAG38732.1 BT020151 mRNA Translation: AAV38953.1 BT020154 mRNA Translation: AAV38956.1 AK300008 mRNA Translation: BAG61825.1 AK311770 mRNA Translation: BAG34713.1 AC011939 Genomic DNA No translation available. AC084854 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77752.1 BC013348 mRNA Translation: AAH13348.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10212.1 [P62491-1] CCDS58373.1 [P62491-2]
PIRⁱ	S47169
NCBI Reference Sequences More...RefSeqⁱ	NP_001193765.1, NM_001206836.1 [P62491-2] NP_004654.1, NM_004663.4 [P62491-1]
UniGeneⁱ	Hs.321541

Genome annotation databases

Ensemblⁱ	ENST00000261890; ENSP00000261890; ENSG00000103769 [P62491-1] ENST00000569896; ENSP00000456420; ENSG00000103769 [P62491-2]
GeneIDⁱ	8766
KEGGⁱ	hsa:8766
UCSC genome browser More...UCSCⁱ	uc002apk.4 human [P62491-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62491	Ras-related protein Rab-11A		CANLF		216	UniRef100_P62491
Ras-related protein Rab-11A		MOUSE		216
Ras-related protein Rab-11A		PIG		216
Ras-related protein Rab-11A		PONAB		216
Ras-related protein Rab-11A		RABIT		216
+49
P62491-2	Ras-related protein Rab-11A		MOUSE		153	UniRef100_E9Q3P9
RAB11A isoform 2		PONAB		155
RAB11A isoform 2		PANTR		155
Uncharacterized protein		MANLE		155
Uncharacterized protein		NOMLE		155
+1

Protein	Similar proteins		Species	Score	Length	Source
P62491	Ras-related protein Rab-11A		CANLF		216	UniRef90_P62491
Ras-related protein Rab-11A		MOUSE		216
Ras-related protein Rab-11A		PIG		216
Ras-related protein Rab-11A		PONAB		216
Ras-related protein Rab-11A		RABIT		216
+50
P62491-2	Ras-related protein Rab-11A		MOUSE		153	UniRef90_E9Q3P9
RAB11A isoform 2		PONAB		155
RAB11A isoform 2		PANTR		155
Uncharacterized protein		MANLE		155
Uncharacterized protein		NOMLE		155
+9

Protein	Similar proteins		Species	Score	Length	Source
P62491	Ras-related protein Rab-11A		CANLF		216	UniRef50_P62491
Ras-related protein Rab-11A		MOUSE		216
Ras-related protein Rab-11A		PIG		216
Ras-related protein Rab-11A		PONAB		216
Ras-related protein Rab-11A		RABIT		216
+324
P62491-2	Ras-related protein Rab-11A		MOUSE		153	UniRef50_E9Q3P9
RAB11A isoform 2		PONAB		155
RAB11A isoform 2		PANTR		155
Uncharacterized protein		MANLE		155
Uncharacterized protein		NOMLE		155
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53143 mRNA Translation: CAA37300.1 X56740 mRNA Translation: CAA40064.1 AF000231 mRNA Translation: AAC32887.1 AF498946 mRNA Translation: AAM21094.1 CR407669 mRNA Translation: CAG28597.1 CR536493 mRNA Translation: CAG38732.1 BT020151 mRNA Translation: AAV38953.1 BT020154 mRNA Translation: AAV38956.1 AK300008 mRNA Translation: BAG61825.1 AK311770 mRNA Translation: BAG34713.1 AC011939 Genomic DNA No translation available. AC084854 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77752.1 BC013348 mRNA Translation: AAH13348.1
CCDSⁱ	CCDS10212.1 [P62491-1] CCDS58373.1 [P62491-2]
PIRⁱ	S47169
RefSeqⁱ	NP_001193765.1, NM_001206836.1 [P62491-2] NP_004654.1, NM_004663.4 [P62491-1]
UniGeneⁱ	Hs.321541

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1OIV	X-ray	1.98	A/B	1-173	[»]
	1OIW	X-ray	2.05	A	1-173	[»]
	1OIX	X-ray	1.70	A	1-173	[»]
	1YZK	X-ray	2.00	A	8-175	[»]
	2D7C	X-ray	1.75	A/B	7-173	[»]
	2GZD	X-ray	2.44	A/B	2-173	[»]
	2GZH	X-ray	2.47	A	2-173	[»]
	2HV8	X-ray	1.86	A/B/C	6-175	[»]
	4C4P	X-ray	2.00	A	1-173	[»]
	4D0L	X-ray	2.94	B/D/F	1-216	[»]
	4D0M	X-ray	6.00	B/D/H/J/N/P/R/T/X/Z/d/h	1-216	[»]
	4LWZ	X-ray	2.55	A/C	1-177	[»]
	4LX0	X-ray	2.19	A/C	1-177	[»]
	4UJ3	X-ray	3.00	A/D/G/J/M/P/S/V	4-186	[»]
	4UJ4	X-ray	4.20	A/D/G/J	4-186	[»]
	4UJ5	X-ray	2.60	A/B	6-186	[»]
	5C46	X-ray	2.65	F	1-216	[»]
	5C4G	X-ray	3.20	B	1-216	[»]
	5EUQ	X-ray	3.20	B	1-216	[»]
	5EZ5	X-ray	2.40	A/B	8-175	[»]
	5FBL	X-ray	3.37	B	1-216	[»]
	5FBQ	X-ray	3.79	B	1-216	[»]
	5FBR	X-ray	3.28	B	1-216	[»]
	5FBV	X-ray	3.29	B	1-216	[»]
	5FBW	X-ray	3.49	B	1-216	[»]
	5JCZ	X-ray	2.06	A/D/I	1-177	[»]
	6DJL	X-ray	3.10	A/F/G/H	1-216	[»]
ProteinModelPortalⁱ	P62491
SMRⁱ	P62491
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114299, 94 interactors
CORUMⁱ	P62491
DIPⁱ	DIP-29138N
IntActⁱ	P62491, 141 interactors
MINTⁱ	P62491
STRINGⁱ	9606.ENSP00000261890

Chemistry databases

DrugBankⁱ	DB01864 5'-Guanosine-Diphosphate-Monothiophosphate DB04315 Guanosine-5'-Diphosphate

DrugBankⁱ

DB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB04315 Guanosine-5'-Diphosphate

PTM databases

iPTMnetⁱ	P62491
PhosphoSitePlusⁱ	P62491
SwissPalmⁱ	P62491

Polymorphism and mutation databases

BioMutaⁱ	RAB11A
DMDMⁱ	50402542

2D gel databases

OGPⁱ	P62491

OGPⁱ

P62491

Proteomic databases

EPDⁱ	P62491
MaxQBⁱ	P62491
PaxDbⁱ	P62491
PeptideAtlasⁱ	P62491
PRIDEⁱ	P62491
ProteomicsDBⁱ	57402
TopDownProteomicsⁱ	P62491-1 [P62491-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8766
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261890; ENSP00000261890; ENSG00000103769 [P62491-1] ENST00000569896; ENSP00000456420; ENSG00000103769 [P62491-2]
GeneIDⁱ	8766
KEGGⁱ	hsa:8766
UCSCⁱ	uc002apk.4 human [P62491-1]

Organism-specific databases

CTDⁱ	8766
DisGeNETⁱ	8766
EuPathDBⁱ	HostDB:ENSG00000103769.9
GeneCardsⁱ	RAB11A
HGNCⁱ	HGNC:9760 RAB11A
HPAⁱ	CAB013097 HPA051697 HPA060686
MalaCardsⁱ	RAB11A
MIMⁱ	605570 gene
neXtProtⁱ	NX_P62491
OpenTargetsⁱ	ENSG00000103769
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA34101
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0087 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00760000118841
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P62491
KOⁱ	K07904
OMAⁱ	IAKHATY
OrthoDBⁱ	EOG091G0O1R
PhylomeDBⁱ	P62491
TreeFamⁱ	TF300099

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5620916 VxPx cargo-targeting to cilium R-HSA-8854214 TBC/RABGAPs R-HSA-8873719 RAB geranylgeranylation
SignaLinkⁱ	P62491

Miscellaneous databases

ChiTaRSⁱ	RAB11A human
EvolutionaryTraceⁱ	P62491
GeneWikiⁱ	RAB11A
GenomeRNAiⁱ	8766
Protein Ontology More...PROⁱ	PR:P62491
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103769 Expressed in 233 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_RAB11A
ExpressionAtlasⁱ	P62491 baseline and differential
Genevisibleⁱ	P62491 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RB11A_HUMAN
Accessionⁱ	P62491Primary (citable) accession number: P62491 Secondary accession number(s): B2R4B6 , B4DT13, P24410, Q5TZN9, Q9JLX1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - P62491 (RB11A_HUMAN)

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Ras-related protein Rab-11A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Cytoskeleton

Cytosol

Endosome

Extracellular region or secreted

Golgi apparatus

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Keywords - Cellular componenti

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Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

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Phylogenomic databases

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Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ