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Protein

Ras-related protein Rab-11A

Gene

RAB11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTP3 Publications9
Nucleotide bindingi66 – 70GTP3 Publications5
Nucleotide bindingi124 – 127GTP3 Publications4
Nucleotide bindingi154 – 156GTP3 Publications3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • microtubule binding Source: UniProtKB
  • myosin V binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
SignaLinkiP62491

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11A
Short name:
Rab-11
Alternative name(s):
YL8
Gene namesi
Name:RAB11A
Synonyms:RAB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103769.9
HGNCiHGNC:9760 RAB11A
MIMi605570 gene
neXtProtiNX_P62491

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25S → N: Dominant-negative mutant. Induces increased number of binucleated cells, indicating defects in cytokinesis. Inhibits the transport of NPC1L1 to the plama membrane. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. 3 Publications1
Mutagenesisi70Q → L: Constitutively active mutant. Decreases GTPase activity. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. 5 Publications1

Organism-specific databases

DisGeNETi8766
MalaCardsiRAB11A
OpenTargetsiENSG00000103769
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA34101

Chemistry databases

DrugBankiDB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaiRAB11A
DMDMi50402542

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001211512 – 213Ras-related protein Rab-11AAdd BLAST212
PropeptideiPRO_0000370807214 – 216Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Lipidationi212S-geranylgeranyl cysteine1 Publication1
Modified residuei213Cysteine methyl esterSequence analysis1
Lipidationi213S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP62491
MaxQBiP62491
PaxDbiP62491
PeptideAtlasiP62491
PRIDEiP62491
ProteomicsDBi57402
TopDownProteomicsiP62491-1 [P62491-1]

2D gel databases

OGPiP62491

PTM databases

iPTMnetiP62491
PhosphoSitePlusiP62491
SwissPalmiP62491

Expressioni

Gene expression databases

BgeeiENSG00000103769 Expressed in 233 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_RAB11A
ExpressionAtlasiP62491 baseline and differential
GenevisibleiP62491 HS

Organism-specific databases

HPAiCAB013097
HPA051697
HPA060686

Interactioni

Subunit structurei

Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27 (PubMed:21976701, PubMed:17082457). Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity).By similarity24 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114299, 94 interactors
CORUMiP62491
DIPiDIP-29138N
IntActiP62491, 141 interactors
MINTiP62491
STRINGi9606.ENSP00000261890

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62491
SMRiP62491
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62491

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP62491
KOiK07904
OMAiIAKHATY
OrthoDBiEOG091G0O1R
PhylomeDBiP62491
TreeFamiTF300099

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62491-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF
160 170 180 190 200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV
210
PPTTENKPKV QCCQNI
Length:216
Mass (Da):24,394
Last modified:January 23, 2007 - v3
Checksum:i76FC1E113A29B269
GO
Isoform 2 (identifier: P62491-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-216: GLSFIETSAL...KPKVQCCQNI → EANVRQTRK

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,659
Checksum:i70C3A0F378C9893A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DQU5B4DQU5_HUMAN
cDNA FLJ57160, highly similar to Ra...
RAB11A
146Annotation score:
H3BSC1H3BSC1_HUMAN
Ras-related protein Rab-11A
RAB11A
198Annotation score:
H3BMH2H3BMH2_HUMAN
Ras-related protein Rab-11A
RAB11A
155Annotation score:
H3BN38H3BN38_HUMAN
Ras-related protein Rab-11A
RAB11A
81Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046755147 – 216GLSFI…CCQNI → EANVRQTRK in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53143 mRNA Translation: CAA37300.1
X56740 mRNA Translation: CAA40064.1
AF000231 mRNA Translation: AAC32887.1
AF498946 mRNA Translation: AAM21094.1
CR407669 mRNA Translation: CAG28597.1
CR536493 mRNA Translation: CAG38732.1
BT020151 mRNA Translation: AAV38953.1
BT020154 mRNA Translation: AAV38956.1
AK300008 mRNA Translation: BAG61825.1
AK311770 mRNA Translation: BAG34713.1
AC011939 Genomic DNA No translation available.
AC084854 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77752.1
BC013348 mRNA Translation: AAH13348.1
CCDSiCCDS10212.1 [P62491-1]
CCDS58373.1 [P62491-2]
PIRiS47169
RefSeqiNP_001193765.1, NM_001206836.1 [P62491-2]
NP_004654.1, NM_004663.4 [P62491-1]
UniGeneiHs.321541

Genome annotation databases

EnsembliENST00000261890; ENSP00000261890; ENSG00000103769 [P62491-1]
ENST00000569896; ENSP00000456420; ENSG00000103769 [P62491-2]
GeneIDi8766
KEGGihsa:8766
UCSCiuc002apk.4 human [P62491-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53143 mRNA Translation: CAA37300.1
X56740 mRNA Translation: CAA40064.1
AF000231 mRNA Translation: AAC32887.1
AF498946 mRNA Translation: AAM21094.1
CR407669 mRNA Translation: CAG28597.1
CR536493 mRNA Translation: CAG38732.1
BT020151 mRNA Translation: AAV38953.1
BT020154 mRNA Translation: AAV38956.1
AK300008 mRNA Translation: BAG61825.1
AK311770 mRNA Translation: BAG34713.1
AC011939 Genomic DNA No translation available.
AC084854 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77752.1
BC013348 mRNA Translation: AAH13348.1
CCDSiCCDS10212.1 [P62491-1]
CCDS58373.1 [P62491-2]
PIRiS47169
RefSeqiNP_001193765.1, NM_001206836.1 [P62491-2]
NP_004654.1, NM_004663.4 [P62491-1]
UniGeneiHs.321541

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OIVX-ray1.98A/B1-173[»]
1OIWX-ray2.05A1-173[»]
1OIXX-ray1.70A1-173[»]
1YZKX-ray2.00A8-175[»]
2D7CX-ray1.75A/B7-173[»]
2GZDX-ray2.44A/B2-173[»]
2GZHX-ray2.47A2-173[»]
2HV8X-ray1.86A/B/C6-175[»]
4C4PX-ray2.00A1-173[»]
4D0LX-ray2.94B/D/F1-216[»]
4D0MX-ray6.00B/D/H/J/N/P/R/T/X/Z/d/h1-216[»]
4LWZX-ray2.55A/C1-177[»]
4LX0X-ray2.19A/C1-177[»]
4UJ3X-ray3.00A/D/G/J/M/P/S/V4-186[»]
4UJ4X-ray4.20A/D/G/J4-186[»]
4UJ5X-ray2.60A/B6-186[»]
5C46X-ray2.65F1-216[»]
5C4GX-ray3.20B1-216[»]
5EUQX-ray3.20B1-216[»]
5EZ5X-ray2.40A/B8-175[»]
5FBLX-ray3.37B1-216[»]
5FBQX-ray3.79B1-216[»]
5FBRX-ray3.28B1-216[»]
5FBVX-ray3.29B1-216[»]
5FBWX-ray3.49B1-216[»]
5JCZX-ray2.06A/D/I1-177[»]
6DJLX-ray3.10A/F/G/H1-216[»]
ProteinModelPortaliP62491
SMRiP62491
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114299, 94 interactors
CORUMiP62491
DIPiDIP-29138N
IntActiP62491, 141 interactors
MINTiP62491
STRINGi9606.ENSP00000261890

Chemistry databases

DrugBankiDB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB04315 Guanosine-5'-Diphosphate

PTM databases

iPTMnetiP62491
PhosphoSitePlusiP62491
SwissPalmiP62491

Polymorphism and mutation databases

BioMutaiRAB11A
DMDMi50402542

2D gel databases

OGPiP62491

Proteomic databases

EPDiP62491
MaxQBiP62491
PaxDbiP62491
PeptideAtlasiP62491
PRIDEiP62491
ProteomicsDBi57402
TopDownProteomicsiP62491-1 [P62491-1]

Protocols and materials databases

DNASUi8766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261890; ENSP00000261890; ENSG00000103769 [P62491-1]
ENST00000569896; ENSP00000456420; ENSG00000103769 [P62491-2]
GeneIDi8766
KEGGihsa:8766
UCSCiuc002apk.4 human [P62491-1]

Organism-specific databases

CTDi8766
DisGeNETi8766
EuPathDBiHostDB:ENSG00000103769.9
GeneCardsiRAB11A
HGNCiHGNC:9760 RAB11A
HPAiCAB013097
HPA051697
HPA060686
MalaCardsiRAB11A
MIMi605570 gene
neXtProtiNX_P62491
OpenTargetsiENSG00000103769
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA34101
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP62491
KOiK07904
OMAiIAKHATY
OrthoDBiEOG091G0O1R
PhylomeDBiP62491
TreeFamiTF300099

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
SignaLinkiP62491

Miscellaneous databases

ChiTaRSiRAB11A human
EvolutionaryTraceiP62491
GeneWikiiRAB11A
GenomeRNAii8766
PROiPR:P62491
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103769 Expressed in 233 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_RAB11A
ExpressionAtlasiP62491 baseline and differential
GenevisibleiP62491 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB11A_HUMAN
AccessioniPrimary (citable) accession number: P62491
Secondary accession number(s): B2R4B6
, B4DT13, P24410, Q5TZN9, Q9JLX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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