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UniProtKB - P62491 (RB11A_HUMAN)

Entry version 190 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Ras-related protein Rab-11A

Gene

RAB11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 26GTPCombined sources3 Publications9
Nucleotide bindingi37 – 43GTPCombined sources7
Nucleotide bindingi66 – 70GTPCombined sources3 Publications5
Nucleotide bindingi124 – 127GTPCombined sources3 Publications4
Nucleotide bindingi154 – 156GTPCombined sources3 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P62491

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620916, VxPx cargo-targeting to cilium
R-HSA-8854214, TBC/RABGAPs
R-HSA-8873719, RAB geranylgeranylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P62491

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-related protein Rab-11A
Short name:
Rab-11
Alternative name(s):
YL8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB11A
Synonyms:RAB11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000103769.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:9760, RAB11A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605570, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P62491

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi13K → N: Abolishes SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi22V → M: Impairs protein folding. 1 Publication1
Mutagenesisi24K → R: Impairs protein folding and decreases affinity for guanine nucleotides. 1 Publication1
Mutagenesisi25S → N: Dominant-negative mutant. Induces increased number of binucleated cells, indicating defects in cytokinesis. Inhibits the transport of NPC1L1 to the plama membrane. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. 4 Publications1
Mutagenesisi36F → A: Nearly abolishes SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi38L → P: Decreases SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi38L → P: Nearly abolishes SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi40S → F: Nearly abolishes SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi41K → A: Mildly decreases SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi41K → P: Abolishes SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi44I → A: Abolishes SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi70Q → L: Constitutively active mutant. Decreases GTPase activity. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. 6 Publications1
Mutagenesisi82R → C: Decreases SH3BP5-mediated guanine nucleotide exchange. 1 Publication1
Mutagenesisi154S → L: Impairs protein folding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8766

MalaCards human disease database

More...MalaCardsi		RAB11A

Open Targets

More...OpenTargetsi		ENSG00000103769

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469, Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34101

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P62491, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01864, 5'-Guanosine-Diphosphate-Monothiophosphate
DB04315, Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAB11A

Domain mapping of disease mutations (DMDM)

More...DMDMi		50402542

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001211512 – 213Ras-related protein Rab-11AAdd BLAST212
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000370807214 – 216Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi212S-geranylgeranyl cysteine1 Publication1
Modified residuei213Cysteine methyl esterSequence analysis1
Lipidationi213S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P62491

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P62491

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P62491

MaxQB - The MaxQuant DataBase

More...MaxQBi		P62491

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62491

PeptideAtlas

More...PeptideAtlasi		P62491

PRoteomics IDEntifications database

More...PRIDEi		P62491

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5063
57402 [P62491-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P62491-1 [P62491-1]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P62491

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62491

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62491

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P62491

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103769, Expressed in esophagus squamous epithelium and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P62491, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62491, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103769, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RIP11 and STXBP6.

Interacts with SGSM1, SGSM2 and SGSM3 (By similarity).

Interacts with EXOC6 in a GTP-dependent manner (By similarity).

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4.

Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A.

Interacts with VIPAS39.

Interacts with MYO5B.

Found in a complex with MYO5B and CFTR.

Interacts with NPC1L1.

Interacts (GDP-bound form) with ZFYVE27 (PubMed:21976701, PubMed:17082457).

Interacts with BIRC6/bruce. May interact with TBC1D14.

Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309, PubMed:30217979).

Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).

Interacts (GDP-bound form) with RELCH (By similarity).

Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity).

Interacts with TBC1D12 (PubMed:28384198).

By similarity26 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114299, 215 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P62491

Database of interacting proteins

More...DIPi		DIP-29138N

Protein interaction database and analysis system

More...IntActi		P62491, 156 interactors

Molecular INTeraction database

More...MINTi		P62491

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261890

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62491, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62491

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P62491

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi40 – 48Effector regionBy similarity9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0087, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154914

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041217_23_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62491

Identification of Orthologs from Complete Genome Data

More...OMAi		SMKEDYY

Database for complete collections of gene phylogenies

More...PhylomeDBi		P62491

TreeFam database of animal gene trees

More...TreeFami		TF300099

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51419, RAB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62491-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT 
        60         70         80         90        100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 
       110        120        130        140        150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF 
       160        170        180        190        200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV 
       210 
PPTTENKPKV QCCQNI
Length:216
Mass (Da):24,394
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76FC1E113A29B269
GO
Isoform 2 (identifier: P62491-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-216: GLSFIETSAL...KPKVQCCQNI → EANVRQTRK

Show »
Length:155
Mass (Da):17,659
Checksum:i70C3A0F378C9893A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSC1H3BSC1_HUMAN
Ras-related protein Rab-11A
RAB11A
198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DQU5B4DQU5_HUMAN
Ras-related protein Rab-11A
RAB11A
146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN38H3BN38_HUMAN
Ras-related protein Rab-11A
RAB11A
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMH2H3BMH2_HUMAN
Ras-related protein Rab-11A
RAB11A
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046755147 – 216GLSFI…CCQNI → EANVRQTRK in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X53143 mRNA Translation: CAA37300.1
X56740 mRNA Translation: CAA40064.1
AF000231 mRNA Translation: AAC32887.1
AF498946 mRNA Translation: AAM21094.1
CR407669 mRNA Translation: CAG28597.1
CR536493 mRNA Translation: CAG38732.1
BT020151 mRNA Translation: AAV38953.1
BT020154 mRNA Translation: AAV38956.1
AK300008 mRNA Translation: BAG61825.1
AK311770 mRNA Translation: BAG34713.1
AC011939 Genomic DNA No translation available.
AC084854 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77752.1
BC013348 mRNA Translation: AAH13348.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10212.1 [P62491-1]
CCDS58373.1 [P62491-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S47169

NCBI Reference Sequences

More...RefSeqi		NP_001193765.1, NM_001206836.1 [P62491-2]
NP_004654.1, NM_004663.4 [P62491-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261890; ENSP00000261890; ENSG00000103769 [P62491-1]
ENST00000569896; ENSP00000456420; ENSG00000103769 [P62491-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8766

UCSC genome browser

More...UCSCi		uc002apk.4, human [P62491-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53143 mRNA Translation: CAA37300.1
X56740 mRNA Translation: CAA40064.1
AF000231 mRNA Translation: AAC32887.1
AF498946 mRNA Translation: AAM21094.1
CR407669 mRNA Translation: CAG28597.1
CR536493 mRNA Translation: CAG38732.1
BT020151 mRNA Translation: AAV38953.1
BT020154 mRNA Translation: AAV38956.1
AK300008 mRNA Translation: BAG61825.1
AK311770 mRNA Translation: BAG34713.1
AC011939 Genomic DNA No translation available.
AC084854 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77752.1
BC013348 mRNA Translation: AAH13348.1
CCDSiCCDS10212.1 [P62491-1]
CCDS58373.1 [P62491-2]
PIRiS47169
RefSeqiNP_001193765.1, NM_001206836.1 [P62491-2]
NP_004654.1, NM_004663.4 [P62491-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OIVX-ray1.98A/B1-173[»]
1OIWX-ray2.05A1-173[»]
1OIXX-ray1.70A1-173[»]
1YZKX-ray2.00A8-175[»]
2D7CX-ray1.75A/B7-173[»]
2GZDX-ray2.44A/B2-173[»]
2GZHX-ray2.47A2-173[»]
2HV8X-ray1.86A/B/C6-175[»]
4C4PX-ray2.00A1-173[»]
4D0LX-ray2.94B/D/F1-216[»]
4D0MX-ray6.00B/D/H/J/N/P/R/T/X/Z/d/h1-216[»]
4LWZX-ray2.55A/C1-177[»]
4LX0X-ray2.19A/C1-177[»]
4UJ3X-ray3.00A/D/G/J/M/P/S/V4-186[»]
4UJ4X-ray4.20A/D/G/J4-186[»]
4UJ5X-ray2.60A/B6-186[»]
5C46X-ray2.65F1-216[»]
5C4GX-ray3.20B1-216[»]
5EUQX-ray3.20B1-216[»]
5EZ5X-ray2.40A/B8-175[»]
5FBLX-ray3.37B1-216[»]
5FBQX-ray3.79B1-216[»]
5FBRX-ray3.28B1-216[»]
5FBVX-ray3.29B1-216[»]
5FBWX-ray3.49B1-216[»]
5JCZX-ray2.06A/D/I1-177[»]
6DJLX-ray3.10A/F/G/H1-216[»]
6IXVX-ray3.80E/F/G/H1-173[»]
SMRiP62491
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114299, 215 interactors
CORUMiP62491
DIPiDIP-29138N
IntActiP62491, 156 interactors
MINTiP62491
STRINGi9606.ENSP00000261890

Chemistry databases

DrugBankiDB01864, 5'-Guanosine-Diphosphate-Monothiophosphate
DB04315, Guanosine-5'-Diphosphate

PTM databases

iPTMnetiP62491
PhosphoSitePlusiP62491
SwissPalmiP62491

Polymorphism and mutation databases

BioMutaiRAB11A
DMDMi50402542

2D gel databases

OGPiP62491

Proteomic databases

EPDiP62491
jPOSTiP62491
MassIVEiP62491
MaxQBiP62491
PaxDbiP62491
PeptideAtlasiP62491
PRIDEiP62491
ProteomicsDBi5063
57402 [P62491-1]
TopDownProteomicsiP62491-1 [P62491-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4588, 482 antibodies

The DNASU plasmid repository

More...DNASUi		8766

Genome annotation databases

EnsembliENST00000261890; ENSP00000261890; ENSG00000103769 [P62491-1]
ENST00000569896; ENSP00000456420; ENSG00000103769 [P62491-2]
GeneIDi8766
KEGGihsa:8766
UCSCiuc002apk.4, human [P62491-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8766
DisGeNETi8766
EuPathDBiHostDB:ENSG00000103769.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAB11A
HGNCiHGNC:9760, RAB11A
HPAiENSG00000103769, Low tissue specificity
MalaCardsiRAB11A
MIMi605570, gene
neXtProtiNX_P62491
OpenTargetsiENSG00000103769
Orphaneti178469, Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA34101

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0087, Eukaryota
GeneTreeiENSGT00940000154914
HOGENOMiCLU_041217_23_0_1
InParanoidiP62491
OMAiSMKEDYY
PhylomeDBiP62491
TreeFamiTF300099

Enzyme and pathway databases

PathwayCommonsiP62491
ReactomeiR-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620916, VxPx cargo-targeting to cilium
R-HSA-8854214, TBC/RABGAPs
R-HSA-8873719, RAB geranylgeranylation
SignaLinkiP62491

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8766, 79 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAB11A, human
EvolutionaryTraceiP62491

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAB11A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8766
PharosiP62491, Tbio

Protein Ontology

More...PROi		PR:P62491
RNActiP62491, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103769, Expressed in esophagus squamous epithelium and 247 other tissues
ExpressionAtlasiP62491, baseline and differential
GenevisibleiP62491, HS

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419, RAB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRB11A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62491
Secondary accession number(s): B2R4B6
, B4DT13, P24410, Q5TZN9, Q9JLX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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