Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-directed RNA polymerase II subunit RPB7

Gene

Polr2g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-RNO-112382 Formation of RNA Pol II elongation complex
R-RNO-113418 Formation of the Early Elongation Complex
R-RNO-5578749 Transcriptional regulation by small RNAs
R-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-6803529 FGFR2 alternative splicing
R-RNO-6807505 RNA polymerase II transcribes snRNA genes
R-RNO-72086 mRNA Capping
R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72165 mRNA Splicing - Minor Pathway
R-RNO-72203 Processing of Capped Intron-Containing Pre-mRNA
R-RNO-73776 RNA Polymerase II Promoter Escape
R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-RNO-75953 RNA Polymerase II Transcription Initiation
R-RNO-75955 RNA Polymerase II Transcription Elongation
R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-RNO-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-RNO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB7
Short name:
RNA polymerase II subunit B7
Alternative name(s):
DNA-directed RNA polymerase II subunit G
Gene namesi
Name:Polr2g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621284 Polr2g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739881 – 172DNA-directed RNA polymerase II subunit RPB7Add BLAST172

Proteomic databases

PaxDbiP62489
PRIDEiP62489

Expressioni

Gene expression databases

BgeeiENSRNOG00000019439 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiP62489 RN

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250618, 1 interactor
STRINGi10116.ENSRNOP00000026313

Structurei

3D structure databases

ProteinModelPortaliP62489
SMRiP62489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3298 Eukaryota
COG1095 LUCA
GeneTreeiENSGT00390000008975
HOGENOMiHOG000158201
HOVERGENiHBG055233
InParanoidiP62489
KOiK03015
OMAiMRQPGLG
OrthoDBiEOG091G0MF6
PhylomeDBiP62489
TreeFamiTF103042

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF00575 S1, 1 hit
PF03876 SHS2_Rpb7-N, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF88798 SSF88798, 1 hit

Sequencei

Sequence statusi: Complete.

P62489-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT
60 70 80 90 100
IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE
110 120 130 140 150
IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT
160 170
RVDKNDIFAI GSLMDDYLGL VS
Length:172
Mass (Da):19,294
Last modified:July 19, 2004 - v1
Checksum:iAF3CE655F658CD5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71925 mRNA Translation: CAA96468.1
BC060550 mRNA Translation: AAH60550.1
BC060595 mRNA Translation: AAH60595.1
RefSeqiNP_446400.1, NM_053948.4
XP_006231035.1, XM_006230973.1
UniGeneiRn.106248

Genome annotation databases

EnsembliENSRNOT00000026313; ENSRNOP00000026313; ENSRNOG00000019439
GeneIDi117017
KEGGirno:117017
UCSCiRGD:621284 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71925 mRNA Translation: CAA96468.1
BC060550 mRNA Translation: AAH60550.1
BC060595 mRNA Translation: AAH60595.1
RefSeqiNP_446400.1, NM_053948.4
XP_006231035.1, XM_006230973.1
UniGeneiRn.106248

3D structure databases

ProteinModelPortaliP62489
SMRiP62489
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250618, 1 interactor
STRINGi10116.ENSRNOP00000026313

Proteomic databases

PaxDbiP62489
PRIDEiP62489

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026313; ENSRNOP00000026313; ENSRNOG00000019439
GeneIDi117017
KEGGirno:117017
UCSCiRGD:621284 rat

Organism-specific databases

CTDi5436
RGDi621284 Polr2g

Phylogenomic databases

eggNOGiKOG3298 Eukaryota
COG1095 LUCA
GeneTreeiENSGT00390000008975
HOGENOMiHOG000158201
HOVERGENiHBG055233
InParanoidiP62489
KOiK03015
OMAiMRQPGLG
OrthoDBiEOG091G0MF6
PhylomeDBiP62489
TreeFamiTF103042

Enzyme and pathway databases

ReactomeiR-RNO-112382 Formation of RNA Pol II elongation complex
R-RNO-113418 Formation of the Early Elongation Complex
R-RNO-5578749 Transcriptional regulation by small RNAs
R-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6781823 Formation of TC-NER Pre-Incision Complex
R-RNO-6782135 Dual incision in TC-NER
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-6803529 FGFR2 alternative splicing
R-RNO-6807505 RNA polymerase II transcribes snRNA genes
R-RNO-72086 mRNA Capping
R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72165 mRNA Splicing - Minor Pathway
R-RNO-72203 Processing of Capped Intron-Containing Pre-mRNA
R-RNO-73776 RNA Polymerase II Promoter Escape
R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-RNO-75953 RNA Polymerase II Transcription Initiation
R-RNO-75955 RNA Polymerase II Transcription Elongation
R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-RNO-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-RNO-9018519 Estrogen-dependent gene expression

Miscellaneous databases

PROiPR:P62489

Gene expression databases

BgeeiENSRNOG00000019439 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiP62489 RN

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF00575 S1, 1 hit
PF03876 SHS2_Rpb7-N, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF88798 SSF88798, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPB7_RAT
AccessioniPrimary (citable) accession number: P62489
Secondary accession number(s): P52433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again