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Protein

DNA-directed RNA polymerase II subunit RPB7

Gene

Polr2g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB7
Short name:
RNA polymerase II subunit B7
Alternative name(s):
DNA-directed RNA polymerase II subunit G
Gene namesi
Name:Polr2g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914960 Polr2g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739871 – 172DNA-directed RNA polymerase II subunit RPB7Add BLAST172

Proteomic databases

EPDiP62488
MaxQBiP62488
PaxDbiP62488
PeptideAtlasiP62488
PRIDEiP62488

2D gel databases

REPRODUCTION-2DPAGEiP62488

PTM databases

iPTMnetiP62488
PhosphoSitePlusiP62488

Expressioni

Gene expression databases

BgeeiENSMUSG00000071662 Expressed in 289 organ(s), highest expression level in primary oocyte
CleanExiMM_POLR2G
GenevisibleiP62488 MM

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212385, 1 interactor
IntActiP62488, 1 interactor
STRINGi10090.ENSMUSP00000093980

Structurei

3D structure databases

ProteinModelPortaliP62488
SMRiP62488
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3298 Eukaryota
COG1095 LUCA
GeneTreeiENSGT00390000008975
HOGENOMiHOG000158201
HOVERGENiHBG055233
InParanoidiP62488
KOiK03015
OMAiMRQPGLG
OrthoDBiEOG091G0MF6
PhylomeDBiP62488
TreeFamiTF103042

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF00575 S1, 1 hit
PF03876 SHS2_Rpb7-N, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF88798 SSF88798, 1 hit

Sequencei

Sequence statusi: Complete.

P62488-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT
60 70 80 90 100
IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE
110 120 130 140 150
IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT
160 170
RVDKNDIFAI GSLMDDYLGL VS
Length:172
Mass (Da):19,294
Last modified:July 19, 2004 - v1
Checksum:iAF3CE655F658CD5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010687 mRNA Translation: BAB27119.1
AK011627 mRNA Translation: BAB27743.1
AK013134 mRNA Translation: BAB28670.1
AK017473 mRNA Translation: BAB30760.1
BC005580 mRNA Translation: AAH05580.3
BC055278 mRNA Translation: AAH55278.1
CCDSiCCDS29547.1
RefSeqiNP_080605.1, NM_026329.2
UniGeneiMm.22117

Genome annotation databases

EnsembliENSMUST00000096261; ENSMUSP00000093980; ENSMUSG00000071662
GeneIDi67710
KEGGimmu:67710
UCSCiuc008gna.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010687 mRNA Translation: BAB27119.1
AK011627 mRNA Translation: BAB27743.1
AK013134 mRNA Translation: BAB28670.1
AK017473 mRNA Translation: BAB30760.1
BC005580 mRNA Translation: AAH05580.3
BC055278 mRNA Translation: AAH55278.1
CCDSiCCDS29547.1
RefSeqiNP_080605.1, NM_026329.2
UniGeneiMm.22117

3D structure databases

ProteinModelPortaliP62488
SMRiP62488
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212385, 1 interactor
IntActiP62488, 1 interactor
STRINGi10090.ENSMUSP00000093980

PTM databases

iPTMnetiP62488
PhosphoSitePlusiP62488

2D gel databases

REPRODUCTION-2DPAGEiP62488

Proteomic databases

EPDiP62488
MaxQBiP62488
PaxDbiP62488
PeptideAtlasiP62488
PRIDEiP62488

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096261; ENSMUSP00000093980; ENSMUSG00000071662
GeneIDi67710
KEGGimmu:67710
UCSCiuc008gna.1 mouse

Organism-specific databases

CTDi5436
MGIiMGI:1914960 Polr2g

Phylogenomic databases

eggNOGiKOG3298 Eukaryota
COG1095 LUCA
GeneTreeiENSGT00390000008975
HOGENOMiHOG000158201
HOVERGENiHBG055233
InParanoidiP62488
KOiK03015
OMAiMRQPGLG
OrthoDBiEOG091G0MF6
PhylomeDBiP62488
TreeFamiTF103042

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

PROiPR:P62488
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071662 Expressed in 289 organ(s), highest expression level in primary oocyte
CleanExiMM_POLR2G
GenevisibleiP62488 MM

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF00575 S1, 1 hit
PF03876 SHS2_Rpb7-N, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF88798 SSF88798, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPB7_MOUSE
AccessioniPrimary (citable) accession number: P62488
Secondary accession number(s): P52433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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