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Protein

60S ribosomal protein L7a

Gene

RPL7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Alternative name(s):
Large ribosomal subunit protein eL81 Publication
PLA-X polypeptide
Surfeit locus protein 3
Gene namesi
Name:RPL7A
Synonyms:SURF-3, SURF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148303.16
HGNCiHGNC:10364 RPL7A
MIMi185640 gene
neXtProtiNX_P62424

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.

Organism-specific databases

DisGeNETi6130
OpenTargetsiENSG00000148303
PharmGKBiPA34760

Polymorphism and mutation databases

BioMutaiRPL7A
DMDMi54039239

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367471 – 26660S ribosomal protein L7aAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei34N6-acetyllysineCombined sources1
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei97N6-acetyllysine; alternateCombined sources1
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei217N6-acetyllysineCombined sources1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62424
PaxDbiP62424
PeptideAtlasiP62424
PRIDEiP62424
ProteomicsDBi57400
TopDownProteomicsiP62424

2D gel databases

SWISS-2DPAGEiP62424

PTM databases

iPTMnetiP62424
PhosphoSitePlusiP62424
SwissPalmiP62424

Expressioni

Gene expression databases

BgeeiENSG00000148303 Expressed in 89 organ(s), highest expression level in left ovary
CleanExiHS_RPL7A
ExpressionAtlasiP62424 baseline and differential
GenevisibleiP62424 HS

Organism-specific databases

HPAiHPA046794

Interactioni

Subunit structurei

Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STAU1O957932EBI-354172,EBI-358174

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112050, 183 interactors
CORUMiP62424
DIPiDIP-31502N
IntActiP62424, 50 interactors
MINTiP62424
STRINGi9606.ENSP00000361076

Structurei

3D structure databases

ProteinModelPortaliP62424
SMRiP62424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3166 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000004753
HOGENOMiHOG000216644
HOVERGENiHBG002936
InParanoidiP62424
KOiK02936
OMAiRQRSILY
OrthoDBiEOG091G0HPD
PhylomeDBiP62424
TreeFamiTF300788

Family and domain databases

Gene3Di3.30.1330.210, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR001921 Ribosomal_L7A/L8
IPR038524 Ribosomal_L7A/L8_sf
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00882 RIBOSOMALL7A
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P62424-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD
60 70 80 90 100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH
110 120 130 140 150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK
160 170 180 190 200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GRLVHRKTCT
210 220 230 240 250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI
260
AKLEKAKAKE LATKLG
Length:266
Mass (Da):29,996
Last modified:January 23, 2007 - v2
Checksum:i54EF43F221D9F704
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T8U2Q5T8U2_HUMAN
60S ribosomal protein L7a
RPL7A RP11-244N20.10-005
151Annotation score:
Q5T8U3Q5T8U3_HUMAN
60S ribosomal protein L7a
RPL7A RP11-244N20.10-004
191Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06705 mRNA Translation: CAA29889.1
X52138 Genomic DNA Translation: CAA36383.1
X61923 Genomic DNA Translation: CAA43925.1
M36072 mRNA Translation: AAA60282.1
AK291123 mRNA Translation: BAF83812.1
AK311743 mRNA Translation: BAG34686.1
AL158826 Genomic DNA Translation: CAI12832.1
CH471090 Genomic DNA Translation: EAW88063.1
BC005128 mRNA Translation: AAH05128.1
BC021979 mRNA Translation: AAH21979.1
BC023594 mRNA Translation: AAH23594.1
BC023624 mRNA Translation: AAH23624.1
BC071900 mRNA Translation: AAH71900.1
BC071901 mRNA Translation: AAH71901.1
BC073802 mRNA Translation: AAH73802.1
BC105290 mRNA Translation: AAI05291.1
CCDSiCCDS6965.1
PIRiS19717 R5HU7A
RefSeqiNP_000963.1, NM_000972.2
UniGeneiHs.499839

Genome annotation databases

EnsembliENST00000323345; ENSP00000361076; ENSG00000148303
ENST00000630979; ENSP00000487443; ENSG00000280858
GeneIDi6130
KEGGihsa:6130
UCSCiuc004cde.2 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiRL7A_HUMAN
AccessioniPrimary (citable) accession number: P62424
Secondary accession number(s): P11518, Q5T8U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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