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Protein

Disintegrin albolabrin

Gene
N/A
Organism
Trimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits fibrinogen interaction with platelet receptors. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.

Miscellaneous

The disintegrin belongs to the medium disintegrin subfamily.

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin albolabrin
Alternative name(s):
Platelet aggregation activation inhibitor
OrganismiTrimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris)
Taxonomic identifieri8765 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeTrimeresurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018091 – 73Disintegrin albolabrinAdd BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 151 Publication
Disulfide bondi8 ↔ 161 Publication
Disulfide bondi21 ↔ 351 Publication
Disulfide bondi29 ↔ 59PROSITE-ProRule annotation1 Publication
Disulfide bondi34 ↔ 381 Publication
Disulfide bondi47 ↔ 66PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer (disintegrin).By similarity

Protein-protein interaction databases

ELMiP62384

Structurei

3D structure databases

ProteinModelPortaliP62384
SMRiP62384
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73DisintegrinPROSITE-ProRule annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 53Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P62384-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EAGEDCDCGS PANPCCDAAT CKLLPGAQCG EGLCCDQCSF MKKGTICRRA
60 70
RGDDLDDYCN GISAGCPRNP LHA
Length:73
Mass (Da):7,574
Last modified:July 5, 2004 - v1
Checksum:iF7E011E2F46FEF14
GO

Sequence databases

PIRiA23731

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA23731

3D structure databases

ProteinModelPortaliP62384
SMRiP62384
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP62384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVM2G_TRIAB
AccessioniPrimary (citable) accession number: P62384
Secondary accession number(s): P17496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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