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Protein

TATA box-binding protein-like protein 1

Gene

TBPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-like protein 1
Short name:
TBP-like protein 1
Alternative name(s):
21 kDa TBP-like protein
Second TBP of unique DNA protein
Short name:
STUD
TATA box-binding protein-related factor 2
Short name:
TBP-related factor 2
TBP-like factor
TBP-related protein
Gene namesi
Name:TBPL1
Synonyms:TLF, TLP, TLP21, TRF2, TRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000028839.9
HGNCiHGNC:11589 TBPL1
MIMi605521 gene
neXtProtiNX_P62380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9519
OpenTargetsiENSG00000028839
PharmGKBiPA36353

Polymorphism and mutation databases

BioMutaiTBPL1
DMDMi61248509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539921 – 186TATA box-binding protein-like protein 1Add BLAST186

Proteomic databases

EPDiP62380
MaxQBiP62380
PaxDbiP62380
PeptideAtlasiP62380
PRIDEiP62380
ProteomicsDBi57399

PTM databases

iPTMnetiP62380
PhosphoSitePlusiP62380

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in the testis and ovary.2 Publications

Gene expression databases

BgeeiENSG00000028839 Expressed in 223 organ(s), highest expression level in oocyte
CleanExiHS_TBPL1
ExpressionAtlasiP62380 baseline and differential
GenevisibleiP62380 HS

Organism-specific databases

HPAiHPA071810
HPA071813

Interactioni

Subunit structurei

Binds TFIIA and TFIIB.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114896, 23 interactors
CORUMiP62380
IntActiP62380, 13 interactors
MINTiP62380
STRINGi9606.ENSP00000237264

Structurei

3D structure databases

ProteinModelPortaliP62380
SMRiP62380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBP family.Curated

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105162
HOVERGENiHBG044997
InParanoidiP62380
KOiK03120
OMAiNCEYEPE
OrthoDBiEOG091G0K64
PhylomeDBiP62380
TreeFamiTF300102

Family and domain databases

CDDicd04517 TLF, 1 hit
Gene3Di3.30.310.10, 2 hits
InterProiView protein in InterPro
IPR000814 TBP
IPR015445 TBP-like
IPR012295 TBP_dom_sf
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P62380-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK
60 70 80 90 100
LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF
110 120 130 140 150
KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ
160 170 180
IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL
Length:186
Mass (Da):20,887
Last modified:July 5, 2004 - v1
Checksum:i2CDD9F5E7BDDE63F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z6U2Q7Z6U2_HUMAN
TATA box-binding protein-like prote...
TBPL1
163Annotation score:
Q7Z6U1Q7Z6U1_HUMAN
TATA box-binding protein-like prote...
TBPL1
128Annotation score:
Q7Z6U0Q7Z6U0_HUMAN
TATA box-binding protein-like prote...
TBPL1
91Annotation score:
Q7Z6T9Q7Z6T9_HUMAN
TATA box-binding protein-like prote...
TBPL1
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44V → A in AAH00381 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020881 mRNA Translation: BAA75218.1
AF136570 mRNA Translation: AAD28785.1
AF130312 mRNA Translation: AAD24800.1
AK292320 mRNA Translation: BAF85009.1
AK313645 mRNA Translation: BAG36402.1
AL035699 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47995.1
CH471051 Genomic DNA Translation: EAW47996.1
BC000381 mRNA Translation: AAH00381.1
BC017559 mRNA Translation: AAH17559.1
CCDSiCCDS5168.1
PIRiJG0162
RefSeqiNP_001240605.1, NM_001253676.1
NP_004856.1, NM_004865.3
XP_016867002.1, XM_017011513.1
UniGeneiHs.486507

Genome annotation databases

EnsembliENST00000237264; ENSP00000237264; ENSG00000028839
ENST00000613034; ENSP00000478795; ENSG00000028839
GeneIDi9519
KEGGihsa:9519
UCSCiuc003qel.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020881 mRNA Translation: BAA75218.1
AF136570 mRNA Translation: AAD28785.1
AF130312 mRNA Translation: AAD24800.1
AK292320 mRNA Translation: BAF85009.1
AK313645 mRNA Translation: BAG36402.1
AL035699 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47995.1
CH471051 Genomic DNA Translation: EAW47996.1
BC000381 mRNA Translation: AAH00381.1
BC017559 mRNA Translation: AAH17559.1
CCDSiCCDS5168.1
PIRiJG0162
RefSeqiNP_001240605.1, NM_001253676.1
NP_004856.1, NM_004865.3
XP_016867002.1, XM_017011513.1
UniGeneiHs.486507

3D structure databases

ProteinModelPortaliP62380
SMRiP62380
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114896, 23 interactors
CORUMiP62380
IntActiP62380, 13 interactors
MINTiP62380
STRINGi9606.ENSP00000237264

PTM databases

iPTMnetiP62380
PhosphoSitePlusiP62380

Polymorphism and mutation databases

BioMutaiTBPL1
DMDMi61248509

Proteomic databases

EPDiP62380
MaxQBiP62380
PaxDbiP62380
PeptideAtlasiP62380
PRIDEiP62380
ProteomicsDBi57399

Protocols and materials databases

DNASUi9519
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237264; ENSP00000237264; ENSG00000028839
ENST00000613034; ENSP00000478795; ENSG00000028839
GeneIDi9519
KEGGihsa:9519
UCSCiuc003qel.4 human

Organism-specific databases

CTDi9519
DisGeNETi9519
EuPathDBiHostDB:ENSG00000028839.9
GeneCardsiTBPL1
HGNCiHGNC:11589 TBPL1
HPAiHPA071810
HPA071813
MIMi605521 gene
neXtProtiNX_P62380
OpenTargetsiENSG00000028839
PharmGKBiPA36353
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105162
HOVERGENiHBG044997
InParanoidiP62380
KOiK03120
OMAiNCEYEPE
OrthoDBiEOG091G0K64
PhylomeDBiP62380
TreeFamiTF300102

Miscellaneous databases

ChiTaRSiTBPL1 human
GeneWikiiTBPL1
GenomeRNAii9519
PROiPR:P62380
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000028839 Expressed in 223 organ(s), highest expression level in oocyte
CleanExiHS_TBPL1
ExpressionAtlasiP62380 baseline and differential
GenevisibleiP62380 HS

Family and domain databases

CDDicd04517 TLF, 1 hit
Gene3Di3.30.310.10, 2 hits
InterProiView protein in InterPro
IPR000814 TBP
IPR015445 TBP-like
IPR012295 TBP_dom_sf
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
ProtoNetiSearch...

Entry informationi

Entry nameiTBPL1_HUMAN
AccessioniPrimary (citable) accession number: P62380
Secondary accession number(s): A8K8F5
, O95753, Q9BWD5, Q9Z2Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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