Selenot

Functionⁱ

Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (PubMed:23913443).By similarity3 Publications

Catalytic activityⁱ

Thioredoxin + NADP⁺ = thioredoxin disulfide + NADPH.By similarity

GO - Molecular functionⁱ

thioredoxin-disulfide reductase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26866473
cellular oxidant detoxification Source: UniProtKB
glucose homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 23913443
insulin secretion involved in cellular response to glucose stimulus
Source: MGI
Inferred from mutant phenotypeⁱ
- 23913443
pancreas development
Source: MGI
Inferred from mutant phenotypeⁱ
- 23913443
positive regulation of cytosolic calcium ion concentration Source: UniProtKB
positive regulation of growth hormone secretion Source: UniProtKB
response to glucose
Source: MGI
Inferred from mutant phenotypeⁱ
- 23913443

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NADP

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thioredoxin reductase-like selenoprotein TCurated (EC:1.8.1.9By similarity) Short name: SelTBy similarity
Gene namesⁱ	Name:SelenotImported Synonyms:SeltImported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1916477 Selenot

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	85 – 103	HelicalSequence analysisAdd BLAST		19

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Knockout embryos die before E8 (PubMed:26866473). Male conditional pancreatic beta-cell knockout mice display impaired glucose tolerance with an increased number of smaller islets compared to wild-type littermates (PubMed:23913443). Brain conditional knockout mice treated with Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rapidly show tremor and absence of movement to die within 2h after treatment (PubMed:26866473).2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000032291	20 – 195	Thioredoxin reductase-like selenoprotein TAdd BLAST		176

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	46 ↔ 49	Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Post-translational modificationⁱ

May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).By similarity

Proteomic databases

EPDⁱ	P62342
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62342
PaxDbⁱ	P62342
PeptideAtlas More...PeptideAtlasⁱ	P62342
PRIDEⁱ	P62342

PTM databases

iPTMnetⁱ	P62342
PhosphoSitePlusⁱ	P62342

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in the endocrine pancreas (PubMed:23913443). Expressed at low levels in the adult brain (PubMed:26866473).2 Publications

Inductionⁱ

Rapidly induced by ADCYAP1/PACAP neuropeptide (PubMed:23913443). In striatum neurons and astrocytes, induced by Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or rotenone (PubMed:26866473).2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000075700 Expressed in 283 organ(s), highest expression level in olfactory epithelium
CleanExⁱ	MM_2810407C02RIK
Genevisibleⁱ	P62342 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000103557

STRINGⁱ

10090.ENSMUSP00000103557

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P62342
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SelWTH family. Selenoprotein T subfamily.Curated

Keywords - Domainⁱ

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3286 Eukaryota ENOG4111J49 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011725
HOGENOMⁱ	HOG000045222
HOVERGENⁱ	HBG056808
InParanoidⁱ	P62342
KEGG Orthology (KO) More...KOⁱ	K22366
OMAⁱ	PEVLFQI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LUT
PhylomeDBⁱ	P62342
TreeFamⁱ	TF321235

Family and domain databases

InterProⁱ	View protein in InterPro IPR011893 Selenoprotein_Rdx-typ IPR019389 Selenoprotein_T IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR13544 PTHR13544, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10262 Rdx, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR02174 CXXU_selWTH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P62342-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLLLLLLVA ASAVVRSEAS ANLGGVPSKR LKMQYATGPL LKFQICVSUG 
        60         70         80         90        100
YRRVFEEYMR VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI 
       110        120        130        140        150
IVGKDPFAFF GMQAPSIWQW GQENKVYACM MVFFLSNMIE NQCMSTGAFE 
       160        170        180        190 
ITLNDVPVWS KLESGHLPSM QQLVQILDNE MKLNVHMDSI PHHRS

Length:195

Mass (Da):22,292

Last modified:February 26, 2008 - v2

Checksum:ⁱ4F2602FA6C1ABE96

GO

Sequence cautionⁱ

The sequence AAH19970 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH38867 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC55254 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC55259 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC55261 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Non-standard residue

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-standard residueⁱ	49	SelenocysteineBy similarity		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK013022 mRNA Translation: BAC55254.1 Different initiation. AK032838 mRNA Translation: BAC55259.1 Different initiation. AK047958 mRNA Translation: BAC55261.1 Different initiation. BC019970 mRNA Translation: AAH19970.1 Different initiation. BC038867 mRNA Translation: AAH38867.2 Different initiation. BC132453 mRNA Translation: AAI32454.2 BC138424 mRNA Translation: AAI38425.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38437.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001035486.2, NM_001040396.2
UniGeneⁱ	Mm.270950

Genome annotation databases

Ensemblⁱ	ENSMUST00000107924; ENSMUSP00000103557; ENSMUSG00000075700
GeneIDⁱ	69227
KEGGⁱ	mmu:69227
UCSC genome browser More...UCSCⁱ	uc008phx.2 mouse

Keywords - Coding sequence diversityⁱ

Selenocysteine

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62342	Thioredoxin reductase-like selenoprotein T		RAT		195	UniRef100_P62342

Protein	Similar proteins		Species	Score	Length	Source
P62342	Thioredoxin reductase-like selenoprotein T		RAT		195	UniRef90_P62342
Thioredoxin reductase-like selenoprotein T		HUMAN		195
Thioredoxin reductase-like selenoprotein T		BOVIN		195
Selenoprotein T		RABIT		197
Selenoprotein T		SHEEP		197
+100

Protein	Similar proteins		Species	Score	Length	Source
P62342	Thioredoxin reductase-like selenoprotein T		RAT		195	UniRef50_P62342
Thioredoxin reductase-like selenoprotein T		BOVIN		195
Thioredoxin reductase-like selenoprotein T		HUMAN		195
Thioredoxin reductase-like selenoprotein T		XENTR		201
Thioredoxin reductase-like selenoprotein T		CHICK		199
+263

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK013022 mRNA Translation: BAC55254.1 Different initiation. AK032838 mRNA Translation: BAC55259.1 Different initiation. AK047958 mRNA Translation: BAC55261.1 Different initiation. BC019970 mRNA Translation: AAH19970.1 Different initiation. BC038867 mRNA Translation: AAH38867.2 Different initiation. BC132453 mRNA Translation: AAI32454.2 BC138424 mRNA Translation: AAI38425.1
CCDSⁱ	CCDS38437.1
RefSeqⁱ	NP_001035486.2, NM_001040396.2
UniGeneⁱ	Mm.270950

3D structure databases

ProteinModelPortalⁱ	P62342
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000103557

STRINGⁱ

10090.ENSMUSP00000103557

PTM databases

iPTMnetⁱ	P62342
PhosphoSitePlusⁱ	P62342

Proteomic databases

EPDⁱ	P62342
MaxQBⁱ	P62342
PaxDbⁱ	P62342
PeptideAtlasⁱ	P62342
PRIDEⁱ	P62342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000107924; ENSMUSP00000103557; ENSMUSG00000075700
GeneIDⁱ	69227
KEGGⁱ	mmu:69227
UCSCⁱ	uc008phx.2 mouse

Organism-specific databases

CTDⁱ	51714
MGIⁱ	MGI:1916477 Selenot

Phylogenomic databases

eggNOGⁱ	KOG3286 Eukaryota ENOG4111J49 LUCA
GeneTreeⁱ	ENSGT00390000011725
HOGENOMⁱ	HOG000045222
HOVERGENⁱ	HBG056808
InParanoidⁱ	P62342
KOⁱ	K22366
OMAⁱ	PEVLFQI
OrthoDBⁱ	EOG091G0LUT
PhylomeDBⁱ	P62342
TreeFamⁱ	TF321235

Miscellaneous databases

ChiTaRSⁱ	Selt mouse
Protein Ontology More...PROⁱ	PR:P62342
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000075700 Expressed in 283 organ(s), highest expression level in olfactory epithelium
CleanExⁱ	MM_2810407C02RIK
Genevisibleⁱ	P62342 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011893 Selenoprotein_Rdx-typ IPR019389 Selenoprotein_T IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR13544 PTHR13544, 1 hit
Pfamⁱ	View protein in Pfam PF10262 Rdx, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR02174 CXXU_selWTH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SELT_MOUSE
Accessionⁱ	P62342Primary (citable) accession number: P62342 Secondary accession number(s): A2RTC6 , O95904, Q8CHV4, Q9CZ45, Q9NZJ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	February 26, 2008
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62342 (SELT_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Thioredoxin reductase-like selenoprotein T

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Non-standard residue

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ