UniProtKB - P62342 (SELT_MOUSE)
Protein
Thioredoxin reductase-like selenoprotein T
Gene
Selenot
Organism
Mus musculus (Mouse)
Status
Functioni
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (PubMed:23913443).By similarity3 Publications
Catalytic activityi
- EC:1.8.1.9By similarity
GO - Molecular functioni
- thioredoxin-disulfide reductase activity Source: UniProtKB
GO - Biological processi
- cell redox homeostasis Source: UniProtKB
- cellular oxidant detoxification Source: UniProtKB
- glucose homeostasis Source: MGI
- insulin secretion involved in cellular response to glucose stimulus Source: MGI
- pancreas development Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of growth hormone secretion Source: UniProtKB
- response to glucose Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Thioredoxin reductase-like selenoprotein TCurated (EC:1.8.1.9By similarity)Short name: SelTBy similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916477, Selenot |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 85 – 103 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Knockout embryos die before E8 (PubMed:26866473). Male conditional pancreatic beta-cell knockout mice display impaired glucose tolerance with an increased number of smaller islets compared to wild-type littermates (PubMed:23913443). Brain conditional knockout mice treated with Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rapidly show tremor and absence of movement to die within 2h after treatment (PubMed:26866473).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000032291 | 20 – 195 | Thioredoxin reductase-like selenoprotein TAdd BLAST | 176 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 46 ↔ 49 | Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis |
Post-translational modificationi
May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).By similarity
Proteomic databases
EPDi | P62342 |
jPOSTi | P62342 |
MaxQBi | P62342 |
PaxDbi | P62342 |
PeptideAtlasi | P62342 |
PRIDEi | P62342 |
PTM databases
iPTMneti | P62342 |
PhosphoSitePlusi | P62342 |
Expressioni
Tissue specificityi
Ubiquitous. Highly expressed in the endocrine pancreas (PubMed:23913443). Expressed at low levels in the adult brain (PubMed:26866473).2 Publications
Inductioni
Rapidly induced by ADCYAP1/PACAP neuropeptide (PubMed:23913443). In striatum neurons and astrocytes, induced by Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or rotenone (PubMed:26866473).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000075700, Expressed in olfactory epithelium and 298 other tissues |
Genevisiblei | P62342, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103557 |
Miscellaneous databases
RNActi | P62342, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Redox-active center, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3286, Eukaryota |
GeneTreei | ENSGT00390000011725 |
HOGENOMi | CLU_113870_1_0_1 |
InParanoidi | P62342 |
OMAi | PQIQVHG |
OrthoDBi | 1542197at2759 |
PhylomeDBi | P62342 |
TreeFami | TF321235 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR011893, Selenoprotein_Rdx-typ IPR019389, Selenoprotein_T IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR13544, PTHR13544, 1 hit |
Pfami | View protein in Pfam PF10262, Rdx, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02174, CXXU_selWTH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P62342-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLLLLLVA ASAVVRSEAS ANLGGVPSKR LKMQYATGPL LKFQICVSUG
60 70 80 90 100
YRRVFEEYMR VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI
110 120 130 140 150
IVGKDPFAFF GMQAPSIWQW GQENKVYACM MVFFLSNMIE NQCMSTGAFE
160 170 180 190
ITLNDVPVWS KLESGHLPSM QQLVQILDNE MKLNVHMDSI PHHRS
Sequence cautioni
The sequence AAH19970 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH38867 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC55254 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC55259 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC55261 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Non-standard residue
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-standard residuei | 49 | SelenocysteineBy similarity | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013022 mRNA Translation: BAC55254.1 Different initiation. AK032838 mRNA Translation: BAC55259.1 Different initiation. AK047958 mRNA Translation: BAC55261.1 Different initiation. BC019970 mRNA Translation: AAH19970.1 Different initiation. BC038867 mRNA Translation: AAH38867.2 Different initiation. BC132453 mRNA Translation: AAI32454.2 BC138424 mRNA Translation: AAI38425.1 |
CCDSi | CCDS38437.1 |
RefSeqi | NP_001035486.2, NM_001040396.2 |
Genome annotation databases
Ensembli | ENSMUST00000107924; ENSMUSP00000103557; ENSMUSG00000075700 |
GeneIDi | 69227 |
KEGGi | mmu:69227 |
UCSCi | uc008phx.2, mouse |
Keywords - Coding sequence diversityi
SelenocysteineSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK013022 mRNA Translation: BAC55254.1 Different initiation. AK032838 mRNA Translation: BAC55259.1 Different initiation. AK047958 mRNA Translation: BAC55261.1 Different initiation. BC019970 mRNA Translation: AAH19970.1 Different initiation. BC038867 mRNA Translation: AAH38867.2 Different initiation. BC132453 mRNA Translation: AAI32454.2 BC138424 mRNA Translation: AAI38425.1 |
CCDSi | CCDS38437.1 |
RefSeqi | NP_001035486.2, NM_001040396.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103557 |
PTM databases
iPTMneti | P62342 |
PhosphoSitePlusi | P62342 |
Proteomic databases
EPDi | P62342 |
jPOSTi | P62342 |
MaxQBi | P62342 |
PaxDbi | P62342 |
PeptideAtlasi | P62342 |
PRIDEi | P62342 |
Protocols and materials databases
Antibodypediai | 48150, 62 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000107924; ENSMUSP00000103557; ENSMUSG00000075700 |
GeneIDi | 69227 |
KEGGi | mmu:69227 |
UCSCi | uc008phx.2, mouse |
Organism-specific databases
CTDi | 51714 |
MGIi | MGI:1916477, Selenot |
Phylogenomic databases
eggNOGi | KOG3286, Eukaryota |
GeneTreei | ENSGT00390000011725 |
HOGENOMi | CLU_113870_1_0_1 |
InParanoidi | P62342 |
OMAi | PQIQVHG |
OrthoDBi | 1542197at2759 |
PhylomeDBi | P62342 |
TreeFami | TF321235 |
Miscellaneous databases
BioGRID-ORCSi | 69227, 0 hits in 17 CRISPR screens |
ChiTaRSi | Selt, mouse |
PROi | PR:P62342 |
RNActi | P62342, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075700, Expressed in olfactory epithelium and 298 other tissues |
Genevisiblei | P62342, MM |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR011893, Selenoprotein_Rdx-typ IPR019389, Selenoprotein_T IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR13544, PTHR13544, 1 hit |
Pfami | View protein in Pfam PF10262, Rdx, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02174, CXXU_selWTH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SELT_MOUSE | |
Accessioni | P62342Primary (citable) accession number: P62342 Secondary accession number(s): A2RTC6 Q9NZJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families