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Protein

Thioredoxin reductase-like selenoprotein T

Gene

SELENOT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).By similarity1 Publication

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.By similarity

GO - Molecular functioni

  • selenium binding Source: UniProtKB
  • thioredoxin-disulfide reductase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase-like selenoprotein TCurated (EC:1.8.1.9By similarity)
Short name:
SelT1 Publication
Gene namesi
Name:SELENOT1 PublicationImported
Synonyms:SELT1 Publication
ORF Names:UNQ150/PRO176Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18136 SELENOT
MIMi607912 gene
neXtProtiNX_P62341

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 103HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

mRNA levels are increased more than 200-folds in the caudate putamen from Parkinson disease (PD) patients compared to control subjects. In conditional brain knockout mice, treatment with PD-inducing neurotoxins provoke rapid and severe parkinsonian-like motor defects.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49U → S: Increases ROS levels induced by neurotoxins. 1 Publication1

Organism-specific databases

DisGeNETi51714
OpenTargetsiENSG00000198843

Polymorphism and mutation databases

BioMutaiSELT
DMDMi190358765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003229020 – 195Thioredoxin reductase-like selenoprotein TAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki46 ↔ 49Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Post-translational modificationi

May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).By similarity

Proteomic databases

EPDiP62341
MaxQBiP62341
PaxDbiP62341
PeptideAtlasiP62341
PRIDEiP62341
ProteomicsDBi57398

PTM databases

iPTMnetiP62341
PhosphoSitePlusiP62341
SwissPalmiP62341

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in the endocrine pancreas.1 Publication

Inductioni

Induced by Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).1 Publication

Gene expression databases

ExpressionAtlasiP62341 baseline and differential

Organism-specific databases

HPAiHPA039780

Interactioni

Protein-protein interaction databases

BioGridi119693, 16 interactors
IntActiP62341, 1 interactor
STRINGi9606.ENSP00000418910

Structurei

3D structure databases

ProteinModelPortaliP62341
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3286 Eukaryota
ENOG4111J49 LUCA
GeneTreeiENSGT00390000011725
HOGENOMiHOG000045222
HOVERGENiHBG056808
InParanoidiP62341
KOiK22366
PhylomeDBiP62341

Family and domain databases

InterProiView protein in InterPro
IPR011893 Selenoprotein_Rdx-typ
IPR019389 Selenoprotein_T
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR13544 PTHR13544, 1 hit
PfamiView protein in Pfam
PF10262 Rdx, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02174 CXXU_selWTH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P62341-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLLLLLVA ASAMVRSEAS ANLGGVPSKR LKMQYATGPL LKFQICVSUG
60 70 80 90 100
YRRVFEEYMR VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI
110 120 130 140 150
IVGKDPFAFF GMQAPSIWQW GQENKVYACM MVFFLSNMIE NQCMSTGAFE
160 170 180 190
ITLNDVPVWS KLESGHLPSM QQLVQILDNE MKLNVHMDSI PHHRS
Length:195
Mass (Da):22,324
Last modified:February 26, 2008 - v2
Checksum:i5B7949FA7711AE9D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6IAK0Q6IAK0_HUMAN
Selenoprotein T
SELENOT SELT, hCG_20913
137Annotation score:
A0A087WVA1A0A087WVA1_HUMAN
Selenoprotein T
SELENOT
195Annotation score:
F8WBD0F8WBD0_HUMAN
Thioredoxin reductase-like selenopr...
SELENOT
45Annotation score:

Sequence cautioni

The sequence AAD20063 differs from that shown. Reason: Erroneous termination at position 49. Translated as Sec.Curated
The sequence AAF13696 differs from that shown. Reason: Frameshift at position 27.Curated
The sequence AAQ88462 differs from that shown. Reason: Erroneous termination at position 49. Translated as Sec.Curated
The sequence AAQ88463 differs from that shown. Reason: Erroneous termination at position 49. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 18RSE → WSD in AAH09611 (PubMed:15489334).Curated3
Sequence conflicti26V → M in AAH09611 (PubMed:15489334).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei49Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195141 mRNA Translation: AAF13696.1 Frameshift.
AF131856 mRNA Translation: AAD20063.1 Sequence problems.
AY358095 mRNA Translation: AAQ88462.1 Sequence problems.
AY358096 mRNA Translation: AAQ88463.1 Sequence problems.
BC006012 mRNA Translation: AAH06012.2
BC008411 mRNA Translation: AAH08411.2
BC009556 mRNA Translation: AAH09556.2
BC009611 mRNA Translation: AAH09611.2
BC026350 mRNA Translation: AAH26350.2
BC036738 mRNA Translation: AAH36738.3
BC071699 mRNA Translation: AAH71699.1
CCDSiCCDS46936.1
RefSeqiNP_057359.2, NM_016275.3
UniGeneiHs.369052

Genome annotation databases

EnsembliENST00000471696; ENSP00000418910; ENSG00000198843
GeneIDi51714
KEGGihsa:51714

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195141 mRNA Translation: AAF13696.1 Frameshift.
AF131856 mRNA Translation: AAD20063.1 Sequence problems.
AY358095 mRNA Translation: AAQ88462.1 Sequence problems.
AY358096 mRNA Translation: AAQ88463.1 Sequence problems.
BC006012 mRNA Translation: AAH06012.2
BC008411 mRNA Translation: AAH08411.2
BC009556 mRNA Translation: AAH09556.2
BC009611 mRNA Translation: AAH09611.2
BC026350 mRNA Translation: AAH26350.2
BC036738 mRNA Translation: AAH36738.3
BC071699 mRNA Translation: AAH71699.1
CCDSiCCDS46936.1
RefSeqiNP_057359.2, NM_016275.3
UniGeneiHs.369052

3D structure databases

ProteinModelPortaliP62341
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119693, 16 interactors
IntActiP62341, 1 interactor
STRINGi9606.ENSP00000418910

PTM databases

iPTMnetiP62341
PhosphoSitePlusiP62341
SwissPalmiP62341

Polymorphism and mutation databases

BioMutaiSELT
DMDMi190358765

Proteomic databases

EPDiP62341
MaxQBiP62341
PaxDbiP62341
PeptideAtlasiP62341
PRIDEiP62341
ProteomicsDBi57398

Protocols and materials databases

DNASUi51714
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000471696; ENSP00000418910; ENSG00000198843
GeneIDi51714
KEGGihsa:51714

Organism-specific databases

CTDi51714
DisGeNETi51714
GeneCardsiSELENOT
HGNCiHGNC:18136 SELENOT
HPAiHPA039780
MIMi607912 gene
neXtProtiNX_P62341
OpenTargetsiENSG00000198843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3286 Eukaryota
ENOG4111J49 LUCA
GeneTreeiENSGT00390000011725
HOGENOMiHOG000045222
HOVERGENiHBG056808
InParanoidiP62341
KOiK22366
PhylomeDBiP62341

Miscellaneous databases

ChiTaRSiSELENOT human
GeneWikiiSELT
GenomeRNAii51714
PROiPR:P62341
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP62341 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011893 Selenoprotein_Rdx-typ
IPR019389 Selenoprotein_T
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR13544 PTHR13544, 1 hit
PfamiView protein in Pfam
PF10262 Rdx, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02174 CXXU_selWTH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSELT_HUMAN
AccessioniPrimary (citable) accession number: P62341
Secondary accession number(s): O95904
, Q8IY80, Q9CZ45, Q9NZJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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