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Protein

TATA box-binding protein-like protein 1

Gene

Tbpl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes (By similarity). Seems to also mediate the transcription of NF1. Does not bind the TATA box.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • acrosome assembly Source: MGI
  • DNA-templated transcription, initiation Source: InterPro
  • dTTP biosynthetic process Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • spermatid nucleus differentiation Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-like protein 1
Short name:
TBP-like protein 1
Alternative name(s):
21 kDa TBP-like protein
TATA box-binding protein-related factor 2
Short name:
TBP-related factor 2
TBP-like factor
TBP-related protein
Gene namesi
Name:Tbpl1
Synonyms:Tlf, Tlp, Tlp21, Trf2, Trp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1339946 Tbpl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Significantly reduced NF1 levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539931 – 186TATA box-binding protein-like protein 1Add BLAST186

Proteomic databases

EPDiP62340
MaxQBiP62340
PaxDbiP62340
PeptideAtlasiP62340
PRIDEiP62340

PTM databases

PhosphoSitePlusiP62340

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000071359 Expressed in 292 organ(s), highest expression level in testis
CleanExiMM_TBPL1
GenevisibleiP62340 MM

Interactioni

Subunit structurei

Binds TFIIA and TFIIB.By similarity

Protein-protein interaction databases

BioGridi231864, 3 interactors
IntActiP62340, 1 interactor
MINTiP62340
STRINGi10090.ENSMUSP00000093470

Structurei

3D structure databases

ProteinModelPortaliP62340
SMRiP62340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBP family.Curated

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105162
HOVERGENiHBG044997
InParanoidiP62340
KOiK03120
OMAiQAFEMIY
OrthoDBiEOG091G0K64
TreeFamiTF300102

Family and domain databases

CDDicd04517 TLF, 1 hit
Gene3Di3.30.310.10, 3 hits
InterProiView protein in InterPro
IPR000814 TBP
IPR015445 TBP-like
IPR012295 TBP_dom_sf
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID

Sequencei

Sequence statusi: Complete.

P62340-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK
60 70 80 90 100
LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF
110 120 130 140 150
KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ
160 170 180
IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL
Length:186
Mass (Da):20,887
Last modified:July 5, 2004 - v1
Checksum:i2CDD9F5E7BDDE63F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017697 mRNA Translation: BAA74578.1
AK049975 mRNA Translation: BAC34014.1
AK078547 mRNA Translation: BAC37330.1
CCDSiCCDS23730.1
RefSeqiNP_035733.1, NM_011603.5
XP_006512793.1, XM_006512730.3
UniGeneiMm.86670

Genome annotation databases

EnsembliENSMUST00000095794; ENSMUSP00000093470; ENSMUSG00000071359
ENSMUST00000127698; ENSMUSP00000114223; ENSMUSG00000071359
GeneIDi237336
KEGGimmu:237336
UCSCiuc007epp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017697 mRNA Translation: BAA74578.1
AK049975 mRNA Translation: BAC34014.1
AK078547 mRNA Translation: BAC37330.1
CCDSiCCDS23730.1
RefSeqiNP_035733.1, NM_011603.5
XP_006512793.1, XM_006512730.3
UniGeneiMm.86670

3D structure databases

ProteinModelPortaliP62340
SMRiP62340
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231864, 3 interactors
IntActiP62340, 1 interactor
MINTiP62340
STRINGi10090.ENSMUSP00000093470

PTM databases

PhosphoSitePlusiP62340

Proteomic databases

EPDiP62340
MaxQBiP62340
PaxDbiP62340
PeptideAtlasiP62340
PRIDEiP62340

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095794; ENSMUSP00000093470; ENSMUSG00000071359
ENSMUST00000127698; ENSMUSP00000114223; ENSMUSG00000071359
GeneIDi237336
KEGGimmu:237336
UCSCiuc007epp.2 mouse

Organism-specific databases

CTDi9519
MGIiMGI:1339946 Tbpl1

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105162
HOVERGENiHBG044997
InParanoidiP62340
KOiK03120
OMAiQAFEMIY
OrthoDBiEOG091G0K64
TreeFamiTF300102

Miscellaneous databases

PROiPR:P62340
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071359 Expressed in 292 organ(s), highest expression level in testis
CleanExiMM_TBPL1
GenevisibleiP62340 MM

Family and domain databases

CDDicd04517 TLF, 1 hit
Gene3Di3.30.310.10, 3 hits
InterProiView protein in InterPro
IPR000814 TBP
IPR015445 TBP-like
IPR012295 TBP_dom_sf
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
ProtoNetiSearch...

Entry informationi

Entry nameiTBPL1_MOUSE
AccessioniPrimary (citable) accession number: P62340
Secondary accession number(s): O95753, Q9Z2Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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