UniProtKB - P62333 (PRS10_HUMAN)
Protein
26S proteasome regulatory subunit 10B
Gene
PSMC6
Organism
Homo sapiens (Human)
Status
Functioni
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.1 Publication
Caution
Alternative initiation from an upstream conserved methionine cannot be fully excluded but is not experimentally supported while initiation from the displayed methionine is supported by PubMed:17323924.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 174 – 181 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- protein-macromolecule adaptor activity Source: UniProtKB
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: GO_Central
- post-translational protein modification Source: Reactome
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: Reactome
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- ubiquitin-dependent ERAD pathway Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P62333 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit 10BAlternative name(s): 26S proteasome AAA-ATPase subunit RPT4 Proteasome 26S subunit ATPase 6 Proteasome subunit p42 |
Gene namesi | Name:PSMC6 Synonyms:SUG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100519.11 |
HGNCi | HGNC:9553, PSMC6 |
MIMi | 602708, gene |
neXtProti | NX_P62333 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic proteasome complex Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: UniProtKB
- proteasome regulatory particle, base subcomplex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5706 |
OpenTargetsi | ENSG00000100519 |
PharmGKBi | PA33898 |
Miscellaneous databases
Pharosi | P62333, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Polymorphism and mutation databases
BioMutai | PSMC6 |
DMDMi | 51702772 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084732 | 1 – 389 | 26S proteasome regulatory subunit 10BAdd BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 72 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 206 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 244 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P62333 |
jPOSTi | P62333 |
MassIVEi | P62333 |
MaxQBi | P62333 |
PaxDbi | P62333 |
PeptideAtlasi | P62333 |
PRIDEi | P62333 |
ProteomicsDBi | 57397 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00021926 |
PTM databases
iPTMneti | P62333 |
MetOSitei | P62333 |
PhosphoSitePlusi | P62333 |
SwissPalmi | P62333 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100519, Expressed in endometrium and 116 other tissues |
ExpressionAtlasi | P62333, baseline and differential |
Genevisiblei | P62333, HS |
Organism-specific databases
HPAi | ENSG00000100519, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components (PubMed:27428775, PubMed:27342858).
Interacts with PAAF1 (PubMed:15831487).
3 PublicationsBinary interactionsi
Hide detailsP62333
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 111679, 187 interactors |
CORUMi | P62333 |
DIPi | DIP-38150N |
IntActi | P62333, 98 interactors |
MINTi | P62333 |
STRINGi | 9606.ENSP00000401802 |
Miscellaneous databases
RNActi | P62333, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the AAA ATPase family.Curated
Phylogenomic databases
eggNOGi | KOG0651, Eukaryota |
GeneTreei | ENSGT00990000203571 |
HOGENOMi | CLU_000688_2_2_1 |
InParanoidi | P62333 |
OrthoDBi | 571919at2759 |
PhylomeDBi | P62333 |
TreeFami | TF106229 |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB IPR035263, PSMC6 |
PANTHERi | PTHR23073:SF76, PTHR23073:SF76, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
P62333-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADPRDKALQ DYRKKLLEHK EIDGRLKELR EQLKELTKQY EKSENDLKAL
60 70 80 90 100
QSVGQIVGEV LKQLTEEKFI VKATNGPRYV VGCRRQLDKS KLKPGTRVAL
110 120 130 140 150
DMTTLTIMRY LPREVDPLVY NMSHEDPGNV SYSEIGGLSE QIRELREVIE
160 170 180 190 200
LPLTNPELFQ RVGIIPPKGC LLYGPPGTGK TLLARAVASQ LDCNFLKVVS
210 220 230 240 250
SSIVDKYIGE SARLIREMFN YARDHQPCII FMDEIDAIGG RRFSEGTSAD
260 270 280 290 300
REIQRTLMEL LNQMDGFDTL HRVKMIMATN RPDTLDPALL RPGRLDRKIH
310 320 330 340 350
IDLPNEQARL DILKIHAGPI TKHGEIDYEA IVKLSDGFNG ADLRNVCTEA
360 370 380
GMFAIRADHD FVVQEDFMKA VRKVADSKKL ESKLDYKPV
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2I1 | A0A087X2I1_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 403 | Annotation score: | ||
H0YJC0 | H0YJC0_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 262 | Annotation score: | ||
H0YJE9 | H0YJE9_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 70 | Annotation score: | ||
H0YJS8 | H0YJS8_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 194 | Annotation score: | ||
H0YJX2 | H0YJX2_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 67 | Annotation score: | ||
H0YJT1 | H0YJT1_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 97 | Annotation score: | ||
H0YJY8 | H0YJY8_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 36 | Annotation score: | ||
H0YJD2 | H0YJD2_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 33 | Annotation score: | ||
H0YJW2 | H0YJW2_HUMAN | 26S proteasome regulatory subunit 1... | PSMC6 | 14 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 276 | I → T in BAA11338 (PubMed:8674546).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78275 mRNA Translation: BAA11338.1 AF006305 mRNA Translation: AAB61616.1 BT006843 mRNA Translation: AAP35489.1 CR456709 mRNA Translation: CAG32990.1 AK313670 mRNA Translation: BAG36422.1 CH471078 Genomic DNA Translation: EAW65645.1 BC005390 mRNA Translation: AAH05390.1 |
CCDSi | CCDS9710.2 |
PIRi | S71316 |
RefSeqi | NP_002797.3, NM_002806.3 |
Genome annotation databases
Ensembli | ENST00000445930; ENSP00000401802; ENSG00000100519 |
GeneIDi | 5706 |
KEGGi | hsa:5706 |
UCSCi | uc059bor.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78275 mRNA Translation: BAA11338.1 AF006305 mRNA Translation: AAB61616.1 BT006843 mRNA Translation: AAP35489.1 CR456709 mRNA Translation: CAG32990.1 AK313670 mRNA Translation: BAG36422.1 CH471078 Genomic DNA Translation: EAW65645.1 BC005390 mRNA Translation: AAH05390.1 |
CCDSi | CCDS9710.2 |
PIRi | S71316 |
RefSeqi | NP_002797.3, NM_002806.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GJQ | electron microscopy | 4.50 | L | 1-389 | [»] | |
5GJR | electron microscopy | 3.50 | L/z | 1-389 | [»] | |
5L4G | electron microscopy | 4.02 | L | 1-389 | [»] | |
5LN3 | electron microscopy | 6.80 | L | 1-389 | [»] | |
5M32 | electron microscopy | 3.80 | f | 1-379 | [»] | |
5T0C | electron microscopy | 3.80 | AE/BE | 1-389 | [»] | |
5T0G | electron microscopy | 4.40 | E | 1-389 | [»] | |
5T0H | electron microscopy | 6.80 | E | 1-389 | [»] | |
5T0I | electron microscopy | 8.00 | E | 1-389 | [»] | |
5T0J | electron microscopy | 8.00 | E | 1-389 | [»] | |
5VFP | electron microscopy | 4.20 | E | 15-389 | [»] | |
5VFQ | electron microscopy | 4.20 | E | 15-389 | [»] | |
5VFR | electron microscopy | 4.90 | E | 15-389 | [»] | |
5VFS | electron microscopy | 3.60 | E | 1-389 | [»] | |
5VFT | electron microscopy | 7.00 | E | 37-389 | [»] | |
5VFU | electron microscopy | 5.80 | E | 37-389 | [»] | |
5VGZ | electron microscopy | 3.70 | E | 11-114 | [»] | |
5VHF | electron microscopy | 5.70 | E | 11-389 | [»] | |
5VHH | electron microscopy | 6.10 | E | 11-389 | [»] | |
5VHI | electron microscopy | 6.80 | E | 11-389 | [»] | |
5VHJ | electron microscopy | 8.50 | E | 128-389 | [»] | |
5VHM | electron microscopy | 8.30 | E | 128-389 | [»] | |
5VHN | electron microscopy | 7.30 | E | 115-389 | [»] | |
5VHO | electron microscopy | 8.30 | E | 128-389 | [»] | |
5VHP | electron microscopy | 7.90 | E | 128-389 | [»] | |
5VHQ | electron microscopy | 8.90 | E | 128-389 | [»] | |
5VHR | electron microscopy | 7.70 | E | 128-389 | [»] | |
5VHS | electron microscopy | 8.80 | E | 11-389 | [»] | |
6MSB | electron microscopy | 3.00 | E | 1-389 | [»] | |
6MSD | electron microscopy | 3.20 | E | 1-389 | [»] | |
6MSE | electron microscopy | 3.30 | E | 1-389 | [»] | |
6MSG | electron microscopy | 3.50 | E | 1-389 | [»] | |
6MSH | electron microscopy | 3.60 | E | 1-389 | [»] | |
6MSJ | electron microscopy | 3.30 | E | 1-389 | [»] | |
6MSK | electron microscopy | 3.20 | E | 1-389 | [»] | |
6WJN | electron microscopy | 5.70 | E | 15-389 | [»] | |
SMRi | P62333 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111679, 187 interactors |
CORUMi | P62333 |
DIPi | DIP-38150N |
IntActi | P62333, 98 interactors |
MINTi | P62333 |
STRINGi | 9606.ENSP00000401802 |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
PTM databases
iPTMneti | P62333 |
MetOSitei | P62333 |
PhosphoSitePlusi | P62333 |
SwissPalmi | P62333 |
Polymorphism and mutation databases
BioMutai | PSMC6 |
DMDMi | 51702772 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00021926 |
Proteomic databases
EPDi | P62333 |
jPOSTi | P62333 |
MassIVEi | P62333 |
MaxQBi | P62333 |
PaxDbi | P62333 |
PeptideAtlasi | P62333 |
PRIDEi | P62333 |
ProteomicsDBi | 57397 |
Protocols and materials databases
Antibodypediai | 23885, 283 antibodies |
DNASUi | 5706 |
Genome annotation databases
Ensembli | ENST00000445930; ENSP00000401802; ENSG00000100519 |
GeneIDi | 5706 |
KEGGi | hsa:5706 |
UCSCi | uc059bor.1, human |
Organism-specific databases
CTDi | 5706 |
DisGeNETi | 5706 |
EuPathDBi | HostDB:ENSG00000100519.11 |
GeneCardsi | PSMC6 |
HGNCi | HGNC:9553, PSMC6 |
HPAi | ENSG00000100519, Low tissue specificity |
MIMi | 602708, gene |
neXtProti | NX_P62333 |
OpenTargetsi | ENSG00000100519 |
PharmGKBi | PA33898 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0651, Eukaryota |
GeneTreei | ENSGT00990000203571 |
HOGENOMi | CLU_000688_2_2_1 |
InParanoidi | P62333 |
OrthoDBi | 571919at2759 |
PhylomeDBi | P62333 |
TreeFami | TF106229 |
Enzyme and pathway databases
PathwayCommonsi | P62333 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 5706, 753 hits in 850 CRISPR screens |
ChiTaRSi | PSMC6, human |
GeneWikii | PSMC6 |
GenomeRNAii | 5706 |
Pharosi | P62333, Tbio |
PROi | PR:P62333 |
RNActi | P62333, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100519, Expressed in endometrium and 116 other tissues |
ExpressionAtlasi | P62333, baseline and differential |
Genevisiblei | P62333, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB IPR035263, PSMC6 |
PANTHERi | PTHR23073:SF76, PTHR23073:SF76, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRS10_HUMAN | |
Accessioni | P62333Primary (citable) accession number: P62333 Secondary accession number(s): B2R975 Q92524 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM