UniProtKB - P62327 (TYB4_HORSE)
Protein
Thymosin beta-4
Gene
TMSB4
Organism
Equus caballus (Horse)
Status
Functioni
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.By similarity
GO - Molecular functioni
- actin monomer binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: InterPro
- regulation of cell migration Source: GO_Central
- sequestering of actin monomers Source: GO_Central
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Thymosin beta-4Short name: T beta-4 Cleaved into the following chain: Alternative name(s): Seraspenide |
Gene namesi | Name:TMSB4 Synonyms:THYB4 |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity1 Publication | |||
ChainiPRO_0000045919 | 2 – 44 | Thymosin beta-4Add BLAST | 43 | |
PeptideiPRO_0000034294 | 2 – 5 | Hematopoietic system regulatory peptideBy similarity | 4 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 4 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 12 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 23 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 26 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 32 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 34 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 39 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P62327 |
PeptideAtlasi | P62327 |
PRIDEi | P62327 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000009190, Expressed in blood and 22 other tissues |
Interactioni
Subunit structurei
Interacts with SERPINB1.
Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity).
By similarityGO - Molecular functioni
- actin monomer binding Source: GO_Central
Family & Domainsi
Sequence similaritiesi
Belongs to the thymosin beta family.Curated
Phylogenomic databases
HOGENOMi | CLU_208046_0_0_1 |
InParanoidi | P62327 |
OrthoDBi | 1632292at2759 |
Family and domain databases
Gene3Di | 1.20.5.520, 1 hit |
InterProi | View protein in InterPro IPR001152, Beta-thymosin IPR038386, Beta-thymosin_sf |
PANTHERi | PTHR12021, PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290, Thymosin, 1 hit |
PIRSFi | PIRSF001828, Thymosin_beta, 1 hit |
SMARTi | View protein in SMART SM00152, THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500, THYMOSIN_B4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY246744 mRNA Translation: AAP78720.1 |
RefSeqi | NP_001157420.1, NM_001163948.1 |
Genome annotation databases
GeneIDi | 100034015 |
KEGGi | ecb:100034015 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY246744 mRNA Translation: AAP78720.1 |
RefSeqi | NP_001157420.1, NM_001163948.1 |
3D structure databases
BMRBi | P62327 |
SMRi | P62327 |
ModBasei | Search... |
Proteomic databases
PaxDbi | P62327 |
PeptideAtlasi | P62327 |
PRIDEi | P62327 |
Genome annotation databases
GeneIDi | 100034015 |
KEGGi | ecb:100034015 |
Organism-specific databases
CTDi | 7114 |
Phylogenomic databases
HOGENOMi | CLU_208046_0_0_1 |
InParanoidi | P62327 |
OrthoDBi | 1632292at2759 |
Gene expression databases
Bgeei | ENSECAG00000009190, Expressed in blood and 22 other tissues |
Family and domain databases
Gene3Di | 1.20.5.520, 1 hit |
InterProi | View protein in InterPro IPR001152, Beta-thymosin IPR038386, Beta-thymosin_sf |
PANTHERi | PTHR12021, PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290, Thymosin, 1 hit |
PIRSFi | PIRSF001828, Thymosin_beta, 1 hit |
SMARTi | View protein in SMART SM00152, THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500, THYMOSIN_B4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TYB4_HORSE | |
Accessioni | P62327Primary (citable) accession number: P62327 Secondary accession number(s): P01253 Q6X9X4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families