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Protein

U6 snRNA-associated Sm-like protein LSm5

Gene

Lsm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

GO - Biological processi

  • mRNA catabolic process Source: MGI
  • mRNA splicing, via spliceosome Source: UniProtKB
  • response to bacterium Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm5
Gene namesi
Name:Lsm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913623 Lsm5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001255732 – 91U6 snRNA-associated Sm-like protein LSm5Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62322
PaxDbiP62322
PeptideAtlasiP62322
PRIDEiP62322
TopDownProteomicsiP62322

PTM databases

iPTMnetiP62322
PhosphoSitePlusiP62322

Expressioni

Gene expression databases

BgeeiENSMUSG00000091625 Expressed in 26 organ(s), highest expression level in thymus
ExpressionAtlasiP62322 baseline and differential
GenevisibleiP62322 MM

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211422, 1 interactor
IntActiP62322, 1 interactor
MINTiP62322
STRINGi10090.ENSMUSP00000126565

Structurei

3D structure databases

ProteinModelPortaliP62322
SMRiP62322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1775 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00390000001455
HOVERGENiHBG107310
InParanoidiP62322
KOiK12624
OMAiGSKIWVV
OrthoDBiEOG091G10CG
PhylomeDBiP62322
TreeFamiTF313575

Family and domain databases

CDDicd01732 LSm5, 1 hit
InterProiView protein in InterPro
IPR033871 LSm5
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR20971 PTHR20971, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P62322-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAANATTNPS QLLPLELVDK CIGSRIHIVM KSDKEIVGTL LGFDDFVNMV
60 70 80 90
LEDVTEFEIT PEGRRITKLD QILLNGNNIT MLVPGGEGPE V
Length:91
Mass (Da):9,937
Last modified:January 23, 2007 - v2
Checksum:i82B5C8830E64C992
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BKC5H3BKC5_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm5
42Annotation score:
A0A0N4SVK3A0A0N4SVK3_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm5
59Annotation score:
A0A0N4SUT0A0A0N4SUT0_MOUSE
MCG13108, isoform CRA_b
Lsm5 mCG_13108
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009617 mRNA Translation: BAB26394.1
AK011218 mRNA Translation: BAB27475.1
BC048459 mRNA Translation: AAH48459.1
BC061085 mRNA Translation: AAH61085.1
BC132626 mRNA Translation: AAI32627.1
BC132628 mRNA Translation: AAI32629.1
CCDSiCCDS51788.1
RefSeqiNP_079796.1, NM_025520.3
UniGeneiMm.25642

Genome annotation databases

EnsembliENSMUST00000170382; ENSMUSP00000126565; ENSMUSG00000091625
GeneIDi66373
KEGGimmu:66373
UCSCiuc009cbj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009617 mRNA Translation: BAB26394.1
AK011218 mRNA Translation: BAB27475.1
BC048459 mRNA Translation: AAH48459.1
BC061085 mRNA Translation: AAH61085.1
BC132626 mRNA Translation: AAI32627.1
BC132628 mRNA Translation: AAI32629.1
CCDSiCCDS51788.1
RefSeqiNP_079796.1, NM_025520.3
UniGeneiMm.25642

3D structure databases

ProteinModelPortaliP62322
SMRiP62322
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211422, 1 interactor
IntActiP62322, 1 interactor
MINTiP62322
STRINGi10090.ENSMUSP00000126565

PTM databases

iPTMnetiP62322
PhosphoSitePlusiP62322

Proteomic databases

MaxQBiP62322
PaxDbiP62322
PeptideAtlasiP62322
PRIDEiP62322
TopDownProteomicsiP62322

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170382; ENSMUSP00000126565; ENSMUSG00000091625
GeneIDi66373
KEGGimmu:66373
UCSCiuc009cbj.2 mouse

Organism-specific databases

CTDi23658
MGIiMGI:1913623 Lsm5

Phylogenomic databases

eggNOGiKOG1775 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00390000001455
HOVERGENiHBG107310
InParanoidiP62322
KOiK12624
OMAiGSKIWVV
OrthoDBiEOG091G10CG
PhylomeDBiP62322
TreeFamiTF313575

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:P62322
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091625 Expressed in 26 organ(s), highest expression level in thymus
ExpressionAtlasiP62322 baseline and differential
GenevisibleiP62322 MM

Family and domain databases

CDDicd01732 LSm5, 1 hit
InterProiView protein in InterPro
IPR033871 LSm5
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR20971 PTHR20971, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM5_MOUSE
AccessioniPrimary (citable) accession number: P62322
Secondary accession number(s): A2RTT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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