Snrpd3

Functionⁱ

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:19470752).By similarity1 Publication

GO - Molecular functionⁱ

enzyme binding Source: MGI
histone pre-mRNA DCP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19470752
RNA binding Source: MGI
telomerase RNA binding Source: MGI
U1 snRNP binding Source: MGI
U2 snRNA binding Source: MGI
U7 snRNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome Source: UniProtKB
protein methylation
Source: MGI
Inferred from sequence orthologyⁱ
- 18495660
spliceosomal snRNP assembly Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-109688 Cleavage of Growing Transcript in the Termination Region R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs R-MMU-191859 snRNP Assembly R-MMU-72163 mRNA Splicing - Major Pathway R-MMU-72165 mRNA Splicing - Minor Pathway R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Reactomeⁱ

R-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-191859 snRNP Assembly
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Small nuclear ribonucleoprotein Sm D3 Short name: Sm-D3 Alternative name(s): snRNP core protein D3
Gene namesⁱ	Name:Snrpd3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1914582 Snrpd3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Spliceosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000122215	2 – 126	Small nuclear ribonucleoprotein Sm D3Add BLAST		125

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineBy similarity		1

Post-translational modificationⁱ

Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.By similarity

Keywords - PTMⁱ

Acetylation, Methylation

Proteomic databases

EPDⁱ	P62320
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62320
PaxDbⁱ	P62320
PeptideAtlas More...PeptideAtlasⁱ	P62320
PRIDEⁱ	P62320

PTM databases

iPTMnetⁱ	P62320
PhosphoSitePlusⁱ	P62320
SwissPalmⁱ	P62320

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020180 Expressed in 287 organ(s), highest expression level in floor plate of midbrain
CleanExⁱ	MM_SNRPD3
ExpressionAtlasⁱ	P62320 baseline and differential
Genevisibleⁱ	P62320 MM

Interactionⁱ

Subunit structureⁱ

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:19470752). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

enzyme binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	212112, 3 interactors
IntActⁱ	P62320, 7 interactors
Molecular INTeraction database More...MINTⁱ	P62320
STRINGⁱ	10090.ENSMUSP00000020397

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P62320
SMRⁱ	P62320
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	110 – 111	1	2
Repeatⁱ	112 – 113	2	2
Repeatⁱ	114 – 115	3	2
Repeatⁱ	116 – 117	4	2
Repeatⁱ	118 – 119	5	2

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	110 – 119	5 X 2 AA tandem repeats of [RM]-G		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	84 – 126	Arg/Lys-rich (basic)Add BLAST		43

Sequence similaritiesⁱ

Belongs to the snRNP core protein family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3172 Eukaryota COG1958 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00610000086153
HOGENOMⁱ	HOG000182712
HOVERGENⁱ	HBG105305
InParanoidⁱ	P62320
KEGG Orthology (KO) More...KOⁱ	K11088
OMAⁱ	IMRANAR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZWE
PhylomeDBⁱ	P62320
TreeFamⁱ	TF354302

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01721 Sm_D3, 1 hit
InterProⁱ	View protein in InterPro IPR027141 LSm4/Sm_D1/D3 IPR001163 LSM_dom_euk/arc IPR010920 LSM_dom_sf IPR034099 SmD3
PANTHERⁱ	PTHR23338 PTHR23338, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01423 LSM, 1 hit
SMARTⁱ	View protein in SMART SM00651 Sm, 1 hit
SUPFAMⁱ	SSF50182 SSF50182, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P62320-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY 
        60         70         80         90        100
RDGRVAQLEQ VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA 
       110        120 
AILKAQVAAR GRGRGMGRGN IFQKRR

Length:126

Mass (Da):13,916

Last modified:July 5, 2004 - v1

Checksum:ⁱ59A6E78E860AA3E0

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1W2P7K5	A0A1W2P7K5_MOUSE		Small nuclear ribonucleoprotein Sm ... Small nuclear ribonucleoprotein Sm D3, Sm-D3 (snRNP core protein D3)	Snrpd3 SNRPD3, mCG_5988	84	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK005341 mRNA Translation: BAB23963.1 AK006692 mRNA Translation: BAB24705.1 AK019453 mRNA Translation: BAB31729.1 AK160321 mRNA Translation: BAE35738.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23926.1
NCBI Reference Sequences More...RefSeqⁱ	NP_080371.1, NM_026095.4
UniGeneⁱ	Mm.392843 Mm.45151

Genome annotation databases

Ensemblⁱ	ENSMUST00000020397; ENSMUSP00000020397; ENSMUSG00000020180
GeneIDⁱ	67332
KEGGⁱ	mmu:67332
UCSC genome browser More...UCSCⁱ	uc007fqm.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62320	Small nuclear ribonucleoprotein Sm D3	)	HUMAN		126	UniRef100_P62318
Small nuclear ribonucleoprotein Sm D3		XENLA		126
Small nuclear ribonucleoprotein Sm D3		FUKDA		236
Small nuclear ribonucleoprotein Sm D3 (Fragment)		Nothobranchius kadleci		112
Small nuclear ribonucleoprotein Sm D3 (Fragment)		AILME		106
+105

Protein	Similar proteins		Species	Score	Length	Source
P62320	Small nuclear ribonucleoprotein Sm D3	)	HUMAN		126	UniRef90_P62318
Small nuclear ribonucleoprotein Sm D3		XENLA		126
Small nuclear ribonucleoprotein Sm D3		FUKDA		236
Small nuclear ribonucleoprotein Sm D3 (Fragment)		Nothobranchius kadleci		112
Small nuclear ribonucleoprotein Sm D3 (Fragment)		AILME		106
+105

Protein	Similar proteins		Species	Score	Length	Source
P62320	Small nuclear ribonucleoprotein Sm D3	)	HUMAN		126	UniRef50_P62318
Small nuclear ribonucleoprotein Sm D3		XENLA		126
Small nuclear ribonucleoprotein Sm D3		FUKDA		236
Small nuclear ribonucleoprotein Sm D3 (Fragment)		Nothobranchius kadleci		112
Small nuclear ribonucleoprotein Sm D3 (Fragment)		AILME		106
+128

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK005341 mRNA Translation: BAB23963.1 AK006692 mRNA Translation: BAB24705.1 AK019453 mRNA Translation: BAB31729.1 AK160321 mRNA Translation: BAE35738.1
CCDSⁱ	CCDS23926.1
RefSeqⁱ	NP_080371.1, NM_026095.4
UniGeneⁱ	Mm.392843 Mm.45151

3D structure databases

ProteinModelPortalⁱ	P62320
SMRⁱ	P62320
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	212112, 3 interactors
IntActⁱ	P62320, 7 interactors
MINTⁱ	P62320
STRINGⁱ	10090.ENSMUSP00000020397

PTM databases

iPTMnetⁱ	P62320
PhosphoSitePlusⁱ	P62320
SwissPalmⁱ	P62320

Proteomic databases

EPDⁱ	P62320
MaxQBⁱ	P62320
PaxDbⁱ	P62320
PeptideAtlasⁱ	P62320
PRIDEⁱ	P62320

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020397; ENSMUSP00000020397; ENSMUSG00000020180
GeneIDⁱ	67332
KEGGⁱ	mmu:67332
UCSCⁱ	uc007fqm.1 mouse

Organism-specific databases

CTDⁱ	6634
MGIⁱ	MGI:1914582 Snrpd3

Phylogenomic databases

eggNOGⁱ	KOG3172 Eukaryota COG1958 LUCA
GeneTreeⁱ	ENSGT00610000086153
HOGENOMⁱ	HOG000182712
HOVERGENⁱ	HBG105305
InParanoidⁱ	P62320
KOⁱ	K11088
OMAⁱ	IMRANAR
OrthoDBⁱ	EOG091G0ZWE
PhylomeDBⁱ	P62320
TreeFamⁱ	TF354302

Enzyme and pathway databases

Reactomeⁱ	R-MMU-109688 Cleavage of Growing Transcript in the Termination Region R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs R-MMU-191859 snRNP Assembly R-MMU-72163 mRNA Splicing - Major Pathway R-MMU-72165 mRNA Splicing - Minor Pathway R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Reactomeⁱ

R-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-191859 snRNP Assembly
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P62320
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020180 Expressed in 287 organ(s), highest expression level in floor plate of midbrain
CleanExⁱ	MM_SNRPD3
ExpressionAtlasⁱ	P62320 baseline and differential
Genevisibleⁱ	P62320 MM

Family and domain databases

CDDⁱ	cd01721 Sm_D3, 1 hit
InterProⁱ	View protein in InterPro IPR027141 LSm4/Sm_D1/D3 IPR001163 LSM_dom_euk/arc IPR010920 LSM_dom_sf IPR034099 SmD3
PANTHERⁱ	PTHR23338 PTHR23338, 1 hit
Pfamⁱ	View protein in Pfam PF01423 LSM, 1 hit
SMARTⁱ	View protein in SMART SM00651 Sm, 1 hit
SUPFAMⁱ	SSF50182 SSF50182, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMD3_MOUSE
Accessionⁱ	P62320Primary (citable) accession number: P62320 Secondary accession number(s): P43331, Q3TV81
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62320 (SMD3_MOUSE)

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Small nuclear ribonucleoprotein Sm D3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ