UniProtKB - P62320 (SMD3_MOUSE)
Small nuclear ribonucleoprotein Sm D3
Snrpd3
Functioni
GO - Molecular functioni
- enzyme binding Source: MGI
- histone pre-mRNA DCP binding Source: UniProtKB
- RNA binding Source: MGI
- telomerase RNA binding Source: MGI
- U1 snRNP binding Source: MGI
- U7 snRNA binding Source: MGI
GO - Biological processi
- mRNA splicing, via spliceosome Source: UniProtKB
- protein methylation Source: MGI
- spliceosomal snRNP assembly Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-MMU-111367, SLBP independent Processing of Histone Pre-mRNAs R-MMU-191859, snRNP Assembly R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72165, mRNA Splicing - Minor Pathway R-MMU-73856, RNA Polymerase II Transcription Termination R-MMU-77588, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
Names & Taxonomyi
Protein namesi | Recommended name: Small nuclear ribonucleoprotein Sm D3Short name: Sm-D3 Alternative name(s): snRNP core protein D3 |
Gene namesi | Name:Snrpd3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914582, Snrpd3 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- catalytic step 2 spliceosome Source: MGI
- commitment complex Source: GO_Central
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
- precatalytic spliceosome Source: GO_Central
- spliceosomal tri-snRNP complex Source: GO_Central
- telomerase holoenzyme complex Source: MGI
- U1 snRNP Source: UniProtKB
- U12-type spliceosomal complex Source: MGI
- U2 snRNP Source: GO_Central
- U2-type catalytic step 2 spliceosome Source: UniProtKB
- U2-type precatalytic spliceosome Source: UniProtKB
- U4 snRNP Source: UniProtKB
- U4/U6 x U5 tri-snRNP complex Source: UniProtKB
- U5 snRNP Source: GO_Central
- U7 snRNP Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- methylosome Source: UniProtKB
- pICln-Sm protein complex Source: UniProtKB
- SMN-Sm protein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000122215 | 2 – 126 | Small nuclear ribonucleoprotein Sm D3Add BLAST | 125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, MethylationProteomic databases
CPTACi | non-CPTAC-4012 |
EPDi | P62320 |
jPOSTi | P62320 |
MaxQBi | P62320 |
PaxDbi | P62320 |
PeptideAtlasi | P62320 |
PRIDEi | P62320 |
PTM databases
iPTMneti | P62320 |
PhosphoSitePlusi | P62320 |
SwissPalmi | P62320 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020180, Expressed in floor plate of midbrain and 301 other tissues |
Genevisiblei | P62320, MM |
Interactioni
Subunit structurei
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C.
Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity).
Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:19470752).
Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly.
Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity).
By similarity1 PublicationGO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 212112, 69 interactors |
IntActi | P62320, 7 interactors |
MINTi | P62320 |
STRINGi | 10090.ENSMUSP00000020397 |
Miscellaneous databases
RNActi | P62320, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 110 – 111 | 1 | 2 | |
Repeati | 112 – 113 | 2 | 2 | |
Repeati | 114 – 115 | 3 | 2 | |
Repeati | 116 – 117 | 4 | 2 | |
Repeati | 118 – 119 | 5 | 2 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 119 | 5 X 2 AA tandem repeats of [RM]-G | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 84 – 126 | Arg/Lys-rich (basic)Add BLAST | 43 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3172, Eukaryota |
GeneTreei | ENSGT00610000086153 |
HOGENOMi | CLU_099537_1_0_1 |
InParanoidi | P62320 |
OMAi | HESLGHV |
OrthoDBi | 1584810at2759 |
PhylomeDBi | P62320 |
TreeFami | TF354302 |
Family and domain databases
CDDi | cd01721, Sm_D3, 1 hit |
DisProti | DP01706 |
InterProi | View protein in InterPro IPR027141, LSm4/Sm_D1/D3 IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR034099, SmD3 |
PANTHERi | PTHR23338, PTHR23338, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY
60 70 80 90 100
RDGRVAQLEQ VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA
110 120
AILKAQVAAR GRGRGMGRGN IFQKRR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7K5 | A0A1W2P7K5_MOUSE | Small nuclear ribonucleoprotein Sm ... | Snrpd3 SNRPD3 | 84 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005341 mRNA Translation: BAB23963.1 AK006692 mRNA Translation: BAB24705.1 AK019453 mRNA Translation: BAB31729.1 AK160321 mRNA Translation: BAE35738.1 |
CCDSi | CCDS23926.1 |
RefSeqi | NP_080371.1, NM_026095.4 |
Genome annotation databases
Ensembli | ENSMUST00000020397; ENSMUSP00000020397; ENSMUSG00000020180 |
GeneIDi | 67332 |
KEGGi | mmu:67332 |
UCSCi | uc007fqm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005341 mRNA Translation: BAB23963.1 AK006692 mRNA Translation: BAB24705.1 AK019453 mRNA Translation: BAB31729.1 AK160321 mRNA Translation: BAE35738.1 |
CCDSi | CCDS23926.1 |
RefSeqi | NP_080371.1, NM_026095.4 |
3D structure databases
SMRi | P62320 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212112, 69 interactors |
IntActi | P62320, 7 interactors |
MINTi | P62320 |
STRINGi | 10090.ENSMUSP00000020397 |
PTM databases
iPTMneti | P62320 |
PhosphoSitePlusi | P62320 |
SwissPalmi | P62320 |
Proteomic databases
CPTACi | non-CPTAC-4012 |
EPDi | P62320 |
jPOSTi | P62320 |
MaxQBi | P62320 |
PaxDbi | P62320 |
PeptideAtlasi | P62320 |
PRIDEi | P62320 |
Protocols and materials databases
Antibodypediai | 216, 204 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000020397; ENSMUSP00000020397; ENSMUSG00000020180 |
GeneIDi | 67332 |
KEGGi | mmu:67332 |
UCSCi | uc007fqm.1, mouse |
Organism-specific databases
CTDi | 6634 |
MGIi | MGI:1914582, Snrpd3 |
Phylogenomic databases
eggNOGi | KOG3172, Eukaryota |
GeneTreei | ENSGT00610000086153 |
HOGENOMi | CLU_099537_1_0_1 |
InParanoidi | P62320 |
OMAi | HESLGHV |
OrthoDBi | 1584810at2759 |
PhylomeDBi | P62320 |
TreeFami | TF354302 |
Enzyme and pathway databases
Reactomei | R-MMU-111367, SLBP independent Processing of Histone Pre-mRNAs R-MMU-191859, snRNP Assembly R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72165, mRNA Splicing - Minor Pathway R-MMU-73856, RNA Polymerase II Transcription Termination R-MMU-77588, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
Miscellaneous databases
BioGRID-ORCSi | 67332, 10 hits in 17 CRISPR screens |
ChiTaRSi | Snrpd3, mouse |
PROi | PR:P62320 |
RNActi | P62320, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020180, Expressed in floor plate of midbrain and 301 other tissues |
Genevisiblei | P62320, MM |
Family and domain databases
CDDi | cd01721, Sm_D3, 1 hit |
DisProti | DP01706 |
InterProi | View protein in InterPro IPR027141, LSm4/Sm_D1/D3 IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR034099, SmD3 |
PANTHERi | PTHR23338, PTHR23338, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMD3_MOUSE | |
Accessioni | P62320Primary (citable) accession number: P62320 Secondary accession number(s): P43331, Q3TV81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families