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Protein

U6 snRNA-associated Sm-like protein LSm6

Gene

Lsm6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing, rRNA processing, tRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm6
Gene namesi
Name:Lsm6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1925901 Lsm6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255761 – 80U6 snRNA-associated Sm-like protein LSm6Add BLAST80

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62313
PaxDbiP62313
PeptideAtlasiP62313
PRIDEiP62313
TopDownProteomicsiP62313

PTM databases

iPTMnetiP62313
PhosphoSitePlusiP62313

Expressioni

Gene expression databases

BgeeiENSMUSG00000031683 Expressed in 242 organ(s), highest expression level in pes
ExpressionAtlasiP62313 baseline and differential
GenevisibleiP62313 MM

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP62313, 1 interactor
MINTiP62313
STRINGi10090.ENSMUSP00000049722

Structurei

3D structure databases

ProteinModelPortaliP62313
SMRiP62313
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1783 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00730000110856
HOVERGENiHBG052369
InParanoidiP62313
KOiK12625
OMAiVMYISAD
OrthoDBiEOG091G13K2
PhylomeDBiP62313
TreeFamiTF313751

Family and domain databases

InterProiView protein in InterPro
IPR016487 Lsm6/sSmF
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR11021 PTHR11021, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF006609 snRNP_SmF, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

P62313-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRKQTPSD FLKQIIGRPV VVKLNSGVDY RGVLACLDGY MNIALEQTEE
60 70 80
YVNGQLKNKY GDAFIRGNNV LYISTQKRRM
Length:80
Mass (Da):9,128
Last modified:July 5, 2004 - v1
Checksum:i21167891FDE804F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019126 mRNA Translation: BAB31555.1
BC030427 mRNA Translation: AAH30427.1
CCDSiCCDS40396.1
RefSeqiNP_001177933.1, NM_001191004.1
NP_084421.1, NM_030145.3
UniGeneiMm.28694

Genome annotation databases

EnsembliENSMUST00000051867; ENSMUSP00000049722; ENSMUSG00000031683
ENSMUST00000130325; ENSMUSP00000119841; ENSMUSG00000031683
ENSMUST00000146824; ENSMUSP00000148221; ENSMUSG00000031683
GeneIDi78651
KEGGimmu:78651
UCSCiuc009mie.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019126 mRNA Translation: BAB31555.1
BC030427 mRNA Translation: AAH30427.1
CCDSiCCDS40396.1
RefSeqiNP_001177933.1, NM_001191004.1
NP_084421.1, NM_030145.3
UniGeneiMm.28694

3D structure databases

ProteinModelPortaliP62313
SMRiP62313
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62313, 1 interactor
MINTiP62313
STRINGi10090.ENSMUSP00000049722

PTM databases

iPTMnetiP62313
PhosphoSitePlusiP62313

Proteomic databases

EPDiP62313
PaxDbiP62313
PeptideAtlasiP62313
PRIDEiP62313
TopDownProteomicsiP62313

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051867; ENSMUSP00000049722; ENSMUSG00000031683
ENSMUST00000130325; ENSMUSP00000119841; ENSMUSG00000031683
ENSMUST00000146824; ENSMUSP00000148221; ENSMUSG00000031683
GeneIDi78651
KEGGimmu:78651
UCSCiuc009mie.2 mouse

Organism-specific databases

CTDi11157
MGIiMGI:1925901 Lsm6

Phylogenomic databases

eggNOGiKOG1783 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00730000110856
HOVERGENiHBG052369
InParanoidiP62313
KOiK12625
OMAiVMYISAD
OrthoDBiEOG091G13K2
PhylomeDBiP62313
TreeFamiTF313751

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:P62313
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031683 Expressed in 242 organ(s), highest expression level in pes
ExpressionAtlasiP62313 baseline and differential
GenevisibleiP62313 MM

Family and domain databases

InterProiView protein in InterPro
IPR016487 Lsm6/sSmF
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR11021 PTHR11021, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF006609 snRNP_SmF, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM6_MOUSE
AccessioniPrimary (citable) accession number: P62313
Secondary accession number(s): Q9Y4Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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