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Protein

U6 snRNA-associated Sm-like protein LSm3

Gene

LSM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).2 Publications

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic mRNA processing body assembly Source: GO_Central
  • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Source: Reactome
  • mRNA processing Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Protein family/group databases

MoonDBiP62310 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm3
Gene namesi
Name:LSM3
ORF Names:MDS017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000170860.3
HGNCiHGNC:17874 LSM3
MIMi607283 gene
neXtProtiNX_P62310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170860
PharmGKBiPA134881991

Polymorphism and mutation databases

BioMutaiLSM3
DMDMi61227725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001255602 – 102U6 snRNA-associated Sm-like protein LSm3Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62310
MaxQBiP62310
PaxDbiP62310
PeptideAtlasiP62310
PRIDEiP62310
ProteomicsDBi57389
TopDownProteomicsiP62310

PTM databases

iPTMnetiP62310
PhosphoSitePlusiP62310

Expressioni

Gene expression databases

BgeeiENSG00000170860 Expressed in 246 organ(s), highest expression level in biceps brachii
CleanExiHS_LSM3
GenevisibleiP62310 HS

Organism-specific databases

HPAiHPA044966

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:11991638, PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166).4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi118105, 82 interactors
CORUMiP62310
DIPiDIP-31218N
IntActiP62310, 40 interactors
MINTiP62310
STRINGi9606.ENSP00000302160

Structurei

3D structure databases

ProteinModelPortaliP62310
SMRiP62310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3460 Eukaryota
ENOG4111PB8 LUCA
GeneTreeiENSGT00390000013951
HOGENOMiHOG000223550
HOVERGENiHBG052368
InParanoidiP62310
KOiK12622
OMAiGHMNLIL
OrthoDBiEOG091G0KWQ
PhylomeDBiP62310
TreeFamiTF312907

Family and domain databases

CDDicd01730 LSm3, 1 hit
InterProiView protein in InterPro
IPR034105 Lsm3
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR040002 Sm-like_LSM3
PANTHERiPTHR13110 PTHR13110, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62310-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL
60 70 80 90 100
NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR

VG
Length:102
Mass (Da):11,845
Last modified:January 23, 2007 - v2
Checksum:i206B0DF0D95CD4D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238095 mRNA Translation: CAB45866.1
AF182289 mRNA Translation: AAD56227.1
AF182418 mRNA Translation: AAG14954.1
CR457185 mRNA Translation: CAG33466.1
CH471055 Genomic DNA Translation: EAW64190.1
BC007055 mRNA Translation: AAH07055.1
CCDSiCCDS2619.1
RefSeqiNP_055278.1, NM_014463.2
UniGeneiHs.111632

Genome annotation databases

EnsembliENST00000306024; ENSP00000302160; ENSG00000170860
GeneIDi27258
KEGGihsa:27258
UCSCiuc003byo.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238095 mRNA Translation: CAB45866.1
AF182289 mRNA Translation: AAD56227.1
AF182418 mRNA Translation: AAG14954.1
CR457185 mRNA Translation: CAG33466.1
CH471055 Genomic DNA Translation: EAW64190.1
BC007055 mRNA Translation: AAH07055.1
CCDSiCCDS2619.1
RefSeqiNP_055278.1, NM_014463.2
UniGeneiHs.111632

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0031-102[»]
5O9Zelectron microscopy4.50p1-102[»]
ProteinModelPortaliP62310
SMRiP62310
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118105, 82 interactors
CORUMiP62310
DIPiDIP-31218N
IntActiP62310, 40 interactors
MINTiP62310
STRINGi9606.ENSP00000302160

Protein family/group databases

MoonDBiP62310 Predicted

PTM databases

iPTMnetiP62310
PhosphoSitePlusiP62310

Polymorphism and mutation databases

BioMutaiLSM3
DMDMi61227725

Proteomic databases

EPDiP62310
MaxQBiP62310
PaxDbiP62310
PeptideAtlasiP62310
PRIDEiP62310
ProteomicsDBi57389
TopDownProteomicsiP62310

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306024; ENSP00000302160; ENSG00000170860
GeneIDi27258
KEGGihsa:27258
UCSCiuc003byo.2 human

Organism-specific databases

CTDi27258
EuPathDBiHostDB:ENSG00000170860.3
GeneCardsiLSM3
HGNCiHGNC:17874 LSM3
HPAiHPA044966
MIMi607283 gene
neXtProtiNX_P62310
OpenTargetsiENSG00000170860
PharmGKBiPA134881991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3460 Eukaryota
ENOG4111PB8 LUCA
GeneTreeiENSGT00390000013951
HOGENOMiHOG000223550
HOVERGENiHBG052368
InParanoidiP62310
KOiK12622
OMAiGHMNLIL
OrthoDBiEOG091G0KWQ
PhylomeDBiP62310
TreeFamiTF312907

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiLSM3 human
GeneWikiiLSM3
GenomeRNAii27258
PROiPR:P62310
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170860 Expressed in 246 organ(s), highest expression level in biceps brachii
CleanExiHS_LSM3
GenevisibleiP62310 HS

Family and domain databases

CDDicd01730 LSm3, 1 hit
InterProiView protein in InterPro
IPR034105 Lsm3
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR040002 Sm-like_LSM3
PANTHERiPTHR13110 PTHR13110, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM3_HUMAN
AccessioniPrimary (citable) accession number: P62310
Secondary accession number(s): Q6IAH0, Q9Y4Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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