UniProtKB - P62310 (LSM3_HUMAN)
U6 snRNA-associated Sm-like protein LSm3
LSM3
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- U6 snRNA 3'-end binding Source: MGI
GO - Biological processi
- exonucleolytic catabolism of deadenylated mRNA Source: Reactome
- mRNA processing Source: UniProtKB
- mRNA splicing, via spliceosome Source: UniProtKB
- P-body assembly Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | P62310 |
Reactomei | R-HSA-430039, mRNA decay by 5' to 3' exoribonuclease R-HSA-72163, mRNA Splicing - Major Pathway |
Protein family/group databases
MoonDBi | P62310, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: U6 snRNA-associated Sm-like protein LSm3 |
Gene namesi | Name:LSM3 ORF Names:MDS017 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17874, LSM3 |
MIMi | 607283, gene |
neXtProti | NX_P62310 |
VEuPathDBi | HostDB:ENSG00000170860.3 |
Subcellular locationi
Nucleus
- Nucleus 4 Publications
Cytosol
- cytosol Source: Reactome
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- precatalytic spliceosome Source: GO_Central
- U2-type precatalytic spliceosome Source: UniProtKB
- U4/U6 x U5 tri-snRNP complex Source: UniProtKB
- U6 snRNP Source: GO_Central
Other locations
- Lsm1-7-Pat1 complex Source: GO_Central
- Lsm2-8 complex Source: UniProtKB
- P-body Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 27258 |
OpenTargetsi | ENSG00000170860 |
PharmGKBi | PA134881991 |
Miscellaneous databases
Pharosi | P62310, Tbio |
Genetic variation databases
BioMutai | LSM3 |
DMDMi | 61227725 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000125560 | 2 – 102 | U6 snRNA-associated Sm-like protein LSm3Add BLAST | 101 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P62310 |
jPOSTi | P62310 |
MassIVEi | P62310 |
MaxQBi | P62310 |
PaxDbi | P62310 |
PeptideAtlasi | P62310 |
PRIDEi | P62310 |
ProteomicsDBi | 57389 |
TopDownProteomicsi | P62310 |
PTM databases
iPTMneti | P62310 |
PhosphoSitePlusi | P62310 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170860, Expressed in biceps brachii and 258 other tissues |
Genevisiblei | P62310, HS |
Organism-specific databases
HPAi | ENSG00000170860, Low tissue specificity |
Interactioni
Subunit structurei
Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:11991638, PubMed:28781166).
Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166).
4 PublicationsBinary interactionsi
Hide detailsP62310
Protein-protein interaction databases
BioGRIDi | 118105, 109 interactors |
CORUMi | P62310 |
DIPi | DIP-31218N |
IntActi | P62310, 48 interactors |
MINTi | P62310 |
STRINGi | 9606.ENSP00000302160 |
Miscellaneous databases
RNActi | P62310, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3460, Eukaryota |
GeneTreei | ENSGT00390000013951 |
HOGENOMi | CLU_076902_5_1_1 |
InParanoidi | P62310 |
OMAi | KIYVKMR |
OrthoDBi | 1633672at2759 |
PhylomeDBi | P62310 |
TreeFami | TF312907 |
Family and domain databases
CDDi | cd01730, LSm3, 1 hit |
InterProi | View protein in InterPro IPR034105, Lsm3 IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR040002, Sm-like_LSM3 |
PANTHERi | PTHR13110, PTHR13110, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL
60 70 80 90 100
NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR
VG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238095 mRNA Translation: CAB45866.1 AF182289 mRNA Translation: AAD56227.1 AF182418 mRNA Translation: AAG14954.1 CR457185 mRNA Translation: CAG33466.1 CH471055 Genomic DNA Translation: EAW64190.1 BC007055 mRNA Translation: AAH07055.1 |
CCDSi | CCDS2619.1 |
RefSeqi | NP_055278.1, NM_014463.2 |
Genome annotation databases
Ensembli | ENST00000306024; ENSP00000302160; ENSG00000170860 |
GeneIDi | 27258 |
KEGGi | hsa:27258 |
UCSCi | uc003byo.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238095 mRNA Translation: CAB45866.1 AF182289 mRNA Translation: AAD56227.1 AF182418 mRNA Translation: AAG14954.1 CR457185 mRNA Translation: CAG33466.1 CH471055 Genomic DNA Translation: EAW64190.1 BC007055 mRNA Translation: AAH07055.1 |
CCDSi | CCDS2619.1 |
RefSeqi | NP_055278.1, NM_014463.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JCR | electron microscopy | 7.00 | 3 | 1-102 | [»] | |
5O9Z | electron microscopy | 4.50 | p | 1-102 | [»] | |
6AH0 | electron microscopy | 5.70 | r | 1-102 | [»] | |
6AHD | electron microscopy | 3.80 | r | 1-102 | [»] | |
6QW6 | electron microscopy | 2.92 | 63 | 1-102 | [»] | |
6QX9 | electron microscopy | 3.28 | 63 | 1-102 | [»] | |
SMRi | P62310 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118105, 109 interactors |
CORUMi | P62310 |
DIPi | DIP-31218N |
IntActi | P62310, 48 interactors |
MINTi | P62310 |
STRINGi | 9606.ENSP00000302160 |
Protein family/group databases
MoonDBi | P62310, Predicted |
PTM databases
iPTMneti | P62310 |
PhosphoSitePlusi | P62310 |
Genetic variation databases
BioMutai | LSM3 |
DMDMi | 61227725 |
Proteomic databases
EPDi | P62310 |
jPOSTi | P62310 |
MassIVEi | P62310 |
MaxQBi | P62310 |
PaxDbi | P62310 |
PeptideAtlasi | P62310 |
PRIDEi | P62310 |
ProteomicsDBi | 57389 |
TopDownProteomicsi | P62310 |
Protocols and materials databases
Antibodypediai | 26522, 92 antibodies |
Genome annotation databases
Ensembli | ENST00000306024; ENSP00000302160; ENSG00000170860 |
GeneIDi | 27258 |
KEGGi | hsa:27258 |
UCSCi | uc003byo.2, human |
Organism-specific databases
CTDi | 27258 |
DisGeNETi | 27258 |
GeneCardsi | LSM3 |
HGNCi | HGNC:17874, LSM3 |
HPAi | ENSG00000170860, Low tissue specificity |
MIMi | 607283, gene |
neXtProti | NX_P62310 |
OpenTargetsi | ENSG00000170860 |
PharmGKBi | PA134881991 |
VEuPathDBi | HostDB:ENSG00000170860.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3460, Eukaryota |
GeneTreei | ENSGT00390000013951 |
HOGENOMi | CLU_076902_5_1_1 |
InParanoidi | P62310 |
OMAi | KIYVKMR |
OrthoDBi | 1633672at2759 |
PhylomeDBi | P62310 |
TreeFami | TF312907 |
Enzyme and pathway databases
PathwayCommonsi | P62310 |
Reactomei | R-HSA-430039, mRNA decay by 5' to 3' exoribonuclease R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 27258, 731 hits in 860 CRISPR screens |
ChiTaRSi | LSM3, human |
GeneWikii | LSM3 |
GenomeRNAii | 27258 |
Pharosi | P62310, Tbio |
PROi | PR:P62310 |
RNActi | P62310, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170860, Expressed in biceps brachii and 258 other tissues |
Genevisiblei | P62310, HS |
Family and domain databases
CDDi | cd01730, LSm3, 1 hit |
InterProi | View protein in InterPro IPR034105, Lsm3 IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR040002, Sm-like_LSM3 |
PANTHERi | PTHR13110, PTHR13110, 1 hit |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LSM3_HUMAN | |
Accessioni | P62310Primary (citable) accession number: P62310 Secondary accession number(s): Q6IAH0, Q9Y4Z1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM