LSM3

Functionⁱ

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).2 Publications

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic mRNA processing body assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Source: Reactome
mRNA processing
Source: UniProtKB
Traceable author statementⁱ
- 10369684
mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 28781166

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Protein family/group databases

MoonDBⁱ	P62310 Predicted

MoonDBⁱ

P62310 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U6 snRNA-associated Sm-like protein LSm3
Gene namesⁱ	Name:LSM3 ORF Names:MDS017
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170860.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17874 LSM3
MIMⁱ	607283 gene
neXtProtⁱ	NX_P62310

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170860
PharmGKBⁱ	PA134881991

Polymorphism and mutation databases

BioMutaⁱ	LSM3
DMDMⁱ	61227725

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000125560	2 – 102	U6 snRNA-associated Sm-like protein LSm3Add BLAST		101

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P62310
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62310
PaxDbⁱ	P62310
PeptideAtlas More...PeptideAtlasⁱ	P62310
PRIDEⁱ	P62310
ProteomicsDBⁱ	57389
TopDownProteomicsⁱ	P62310

PTM databases

iPTMnetⁱ	P62310
PhosphoSitePlusⁱ	P62310

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170860 Expressed in 246 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_LSM3
Genevisibleⁱ	P62310 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044966

HPAⁱ

HPA044966

Interactionⁱ

Subunit structureⁱ

Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:11991638, PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CLNS1A	P54105	6	EBI-348239,EBI-724693
KEAP1	Q14145	5	EBI-348239,EBI-751001
LSM1	O15116	15	EBI-348239,EBI-347619
LSM10	Q969L4	4	EBI-348239,EBI-373268
LSM2	Q9Y333	28	EBI-348239,EBI-347416
LSM5	Q9Y4Y9	5	EBI-348239,EBI-373007
LSM6	P62312	10	EBI-348239,EBI-373310
LSM7	Q9UK45	6	EBI-348239,EBI-348372
LSM8	O95777	6	EBI-348239,EBI-347779
TCL1A	P56279	5	EBI-348239,EBI-749995
YBX1	P67809	2	EBI-348239,EBI-354065

Protein-protein interaction databases

BioGridⁱ	118105, 82 interactors
CORUMⁱ	P62310
Database of interacting proteins More...DIPⁱ	DIP-31218N
IntActⁱ	P62310, 40 interactors
Molecular INTeraction database More...MINTⁱ	P62310
STRINGⁱ	9606.ENSP00000302160

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P62310
SMRⁱ	P62310
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3460 Eukaryota ENOG4111PB8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013951
HOGENOMⁱ	HOG000223550
HOVERGENⁱ	HBG052368
InParanoidⁱ	P62310
KEGG Orthology (KO) More...KOⁱ	K12622
OMAⁱ	GHMNLIL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KWQ
PhylomeDBⁱ	P62310
TreeFamⁱ	TF312907

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01730 LSm3, 1 hit
InterProⁱ	View protein in InterPro IPR034105 Lsm3 IPR001163 LSM_dom_euk/arc IPR010920 LSM_dom_sf IPR040002 Sm-like_LSM3
PANTHERⁱ	PTHR13110 PTHR13110, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01423 LSM, 1 hit
SMARTⁱ	View protein in SMART SM00651 Sm, 1 hit
SUPFAMⁱ	SSF50182 SSF50182, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P62310-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL 
        60         70         80         90        100
NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR 

VG

Length:102

Mass (Da):11,845

Last modified:January 23, 2007 - v2

Checksum:ⁱ206B0DF0D95CD4D2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ238095 mRNA Translation: CAB45866.1 AF182289 mRNA Translation: AAD56227.1 AF182418 mRNA Translation: AAG14954.1 CR457185 mRNA Translation: CAG33466.1 CH471055 Genomic DNA Translation: EAW64190.1 BC007055 mRNA Translation: AAH07055.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2619.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055278.1, NM_014463.2
UniGeneⁱ	Hs.111632

Genome annotation databases

Ensemblⁱ	ENST00000306024; ENSP00000302160; ENSG00000170860
GeneIDⁱ	27258
KEGGⁱ	hsa:27258
UCSC genome browser More...UCSCⁱ	uc003byo.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62310	U6 snRNA-associated Sm-like protein LSm3		BOVIN		102	UniRef100_P62310
U6 snRNA-associated Sm-like protein LSm3		MOUSE		102
U6 snRNA-associated Sm-like protein LSm3		MACMU		102
U6 snRNA-associated Sm-like protein LSm3		CALJA		102
U6 snRNA-associated Sm-like protein LSm3		PANTR		102
+45

Protein	Similar proteins		Species	Score	Length	Source
P62310	U6 snRNA-associated Sm-like protein LSm3		BOVIN		102	UniRef90_P62310
U6 snRNA-associated Sm-like protein LSm3		MOUSE		102
U6 snRNA-associated Sm-like protein LSm3		MACMU		102
U6 snRNA-associated Sm-like protein LSm3		CALJA		102
U6 snRNA-associated Sm-like protein LSm3		PANTR		102
+92

Protein	Similar proteins		Species	Score	Length	Source
P62310	U6 snRNA-associated Sm-like protein LSm3		BOVIN		102	UniRef50_P62310
U6 snRNA-associated Sm-like protein LSm3		MOUSE		102
U6 snRNA-associated Sm-like protein LSm3		MACMU		102
U6 snRNA-associated Sm-like protein LSm3		CALJA		102
U6 snRNA-associated Sm-like protein LSm3		PANTR		102
+221

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ238095 mRNA Translation: CAB45866.1 AF182289 mRNA Translation: AAD56227.1 AF182418 mRNA Translation: AAG14954.1 CR457185 mRNA Translation: CAG33466.1 CH471055 Genomic DNA Translation: EAW64190.1 BC007055 mRNA Translation: AAH07055.1
CCDSⁱ	CCDS2619.1
RefSeqⁱ	NP_055278.1, NM_014463.2
UniGeneⁱ	Hs.111632

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3JCR	electron microscopy	7.00	3	1-102	[»]
	5O9Z	electron microscopy	4.50	p	1-102	[»]
ProteinModelPortalⁱ	P62310
SMRⁱ	P62310
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118105, 82 interactors
CORUMⁱ	P62310
DIPⁱ	DIP-31218N
IntActⁱ	P62310, 40 interactors
MINTⁱ	P62310
STRINGⁱ	9606.ENSP00000302160

Protein family/group databases

MoonDBⁱ	P62310 Predicted

MoonDBⁱ

P62310 Predicted

PTM databases

iPTMnetⁱ	P62310
PhosphoSitePlusⁱ	P62310

Polymorphism and mutation databases

BioMutaⁱ	LSM3
DMDMⁱ	61227725

Proteomic databases

EPDⁱ	P62310
MaxQBⁱ	P62310
PaxDbⁱ	P62310
PeptideAtlasⁱ	P62310
PRIDEⁱ	P62310
ProteomicsDBⁱ	57389
TopDownProteomicsⁱ	P62310

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000306024; ENSP00000302160; ENSG00000170860
GeneIDⁱ	27258
KEGGⁱ	hsa:27258
UCSCⁱ	uc003byo.2 human

Organism-specific databases

CTDⁱ	27258
EuPathDBⁱ	HostDB:ENSG00000170860.3
GeneCardsⁱ	LSM3
HGNCⁱ	HGNC:17874 LSM3
HPAⁱ	HPA044966
MIMⁱ	607283 gene
neXtProtⁱ	NX_P62310
OpenTargetsⁱ	ENSG00000170860
PharmGKBⁱ	PA134881991
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3460 Eukaryota ENOG4111PB8 LUCA
GeneTreeⁱ	ENSGT00390000013951
HOGENOMⁱ	HOG000223550
HOVERGENⁱ	HBG052368
InParanoidⁱ	P62310
KOⁱ	K12622
OMAⁱ	GHMNLIL
OrthoDBⁱ	EOG091G0KWQ
PhylomeDBⁱ	P62310
TreeFamⁱ	TF312907

Enzyme and pathway databases

Reactomeⁱ	R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	LSM3 human
GeneWikiⁱ	LSM3
GenomeRNAiⁱ	27258
Protein Ontology More...PROⁱ	PR:P62310
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170860 Expressed in 246 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_LSM3
Genevisibleⁱ	P62310 HS

Family and domain databases

CDDⁱ	cd01730 LSm3, 1 hit
InterProⁱ	View protein in InterPro IPR034105 Lsm3 IPR001163 LSM_dom_euk/arc IPR010920 LSM_dom_sf IPR040002 Sm-like_LSM3
PANTHERⁱ	PTHR13110 PTHR13110, 1 hit
Pfamⁱ	View protein in Pfam PF01423 LSM, 1 hit
SMARTⁱ	View protein in SMART SM00651 Sm, 1 hit
SUPFAMⁱ	SSF50182 SSF50182, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LSM3_HUMAN
Accessionⁱ	P62310Primary (citable) accession number: P62310 Secondary accession number(s): Q6IAH0, Q9Y4Z1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P62310 (LSM3_HUMAN)

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U6 snRNA-associated Sm-like protein LSm3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ