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Protein

Small nuclear ribonucleoprotein G

Gene

SNRPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing.2 Publications

GO - Molecular functioni

GO - Biological processi

  • histone mRNA metabolic process Source: Reactome
  • import into nucleus Source: Reactome
  • mRNA splicing, via spliceosome Source: Reactome
  • RNA splicing Source: UniProtKB
  • spliceosomal complex assembly Source: UniProtKB
  • spliceosomal snRNP assembly Source: UniProtKB
  • termination of RNA polymerase II transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-191859 snRNP Assembly
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein G
Short name:
snRNP-G
Alternative name(s):
Sm protein G
Short name:
Sm-G
Short name:
SmG
Gene namesi
Name:SNRPG
Synonyms:PBSCG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143977.13
HGNCiHGNC:11163 SNRPG
MIMi603542 gene
neXtProtiNX_P62308

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143977
PharmGKBiPA36004

Polymorphism and mutation databases

BioMutaiSNRPG
DMDMi59800216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255451 – 76Small nuclear ribonucleoprotein GAdd BLAST76

Proteomic databases

EPDiP62308
MaxQBiP62308
PaxDbiP62308
PeptideAtlasiP62308
PRIDEiP62308
ProteomicsDBi57388
TopDownProteomicsiP62308

PTM databases

iPTMnetiP62308
PhosphoSitePlusiP62308
SwissPalmiP62308

Expressioni

Gene expression databases

BgeeiENSG00000143977 Expressed in 91 organ(s), highest expression level in female gonad
CleanExiHS_SNRPG
ExpressionAtlasiP62308 baseline and differential
GenevisibleiP62308 HS

Organism-specific databases

HPAiHPA064152
HPA067814

Interactioni

Subunit structurei

U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1.6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi112521, 120 interactors
CORUMiP62308
DIPiDIP-34627N
IntActiP62308, 33 interactors
MINTiP62308
STRINGi9606.ENSP00000272348

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62308
SMRiP62308
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62308

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1780 Eukaryota
ENOG41122Q1 LUCA
GeneTreeiENSGT00510000046985
HOVERGENiHBG000513
InParanoidiP62308
KOiK11099
OMAiMDKEMDL
TreeFamiTF315099

Family and domain databases

CDDicd01719 Sm_G, 1 hit
InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR034098 Sm_G
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P62308-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT
60 70
SGQQNNIGMV VIRGNSIIML EALERV
Length:76
Mass (Da):8,496
Last modified:July 5, 2004 - v1
Checksum:i623302BF6BE758FE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVQ0C9JVQ0_HUMAN
Small nuclear ribonucleoprotein G
SNRPG
96Annotation score:
F5H013F5H013_HUMAN
Small nuclear ribonucleoprotein G
SNRPG
68Annotation score:
Q49AN9Q49AN9_HUMAN
Small nuclear ribonucleoprotein G
SNRPG
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85373 mRNA Translation: CAA59689.1
CR456918 mRNA Translation: CAG33199.1
AC079338 Genomic DNA Translation: AAX81996.1
CH471053 Genomic DNA Translation: EAW99817.1
CH471053 Genomic DNA Translation: EAW99818.1
BC000070 mRNA Translation: AAH00070.1
BC022432 mRNA Translation: AAH22432.1
BC066302 mRNA Translation: AAH66302.1
BC070166 mRNA Translation: AAH70166.1
BC071880 mRNA Translation: AAH71880.1
BC106055 mRNA Translation: AAI06056.1
CCDSiCCDS1903.1
PIRiS55054
RefSeqiNP_003087.1, NM_003096.3
UniGeneiHs.465167
Hs.516076
Hs.631639
Hs.654528

Genome annotation databases

EnsembliENST00000272348; ENSP00000272348; ENSG00000143977
GeneIDi6637
KEGGihsa:6637
UCSCiuc002sgp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85373 mRNA Translation: CAA59689.1
CR456918 mRNA Translation: CAG33199.1
AC079338 Genomic DNA Translation: AAX81996.1
CH471053 Genomic DNA Translation: EAW99817.1
CH471053 Genomic DNA Translation: EAW99818.1
BC000070 mRNA Translation: AAH00070.1
BC022432 mRNA Translation: AAH22432.1
BC066302 mRNA Translation: AAH66302.1
BC070166 mRNA Translation: AAH70166.1
BC071880 mRNA Translation: AAH71880.1
BC106055 mRNA Translation: AAI06056.1
CCDSiCCDS1903.1
PIRiS55054
RefSeqiNP_003087.1, NM_003096.3
UniGeneiHs.465167
Hs.516076
Hs.631639
Hs.654528

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CW1X-ray5.493/4/5/G1-76[»]
3JCRelectron microscopy7.00U/u1-76[»]
3PGWX-ray4.40G/J1-76[»]
4F7UX-ray1.90G/J1-76[»]
4PJOX-ray3.30G/U/g/u1-76[»]
4V98X-ray3.10A4/AH/AP/AX/Af/An/Av/B4/BH/BP/BX/Bf/Bn/Bv/CH/CP/CX/Cf/Cn/Cv1-76[»]
4WZJX-ray3.60AG/AN/AU/BG/BN/BU/CG/CN/CU/DG/DN/DU1-76[»]
5MQFelectron microscopy5.90d/k1-76[»]
5O9Zelectron microscopy4.50V/d/k1-76[»]
5XJCelectron microscopy3.60g/n1-76[»]
5XJLX-ray2.50G1-76[»]
5XJQX-ray3.28G1-76[»]
5XJRX-ray3.12G1-76[»]
5XJTX-ray2.92G1-76[»]
5XJUX-ray2.58G1-76[»]
5YZGelectron microscopy4.10g/n1-76[»]
ProteinModelPortaliP62308
SMRiP62308
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112521, 120 interactors
CORUMiP62308
DIPiDIP-34627N
IntActiP62308, 33 interactors
MINTiP62308
STRINGi9606.ENSP00000272348

PTM databases

iPTMnetiP62308
PhosphoSitePlusiP62308
SwissPalmiP62308

Polymorphism and mutation databases

BioMutaiSNRPG
DMDMi59800216

Proteomic databases

EPDiP62308
MaxQBiP62308
PaxDbiP62308
PeptideAtlasiP62308
PRIDEiP62308
ProteomicsDBi57388
TopDownProteomicsiP62308

Protocols and materials databases

DNASUi6637
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272348; ENSP00000272348; ENSG00000143977
GeneIDi6637
KEGGihsa:6637
UCSCiuc002sgp.4 human

Organism-specific databases

CTDi6637
EuPathDBiHostDB:ENSG00000143977.13
GeneCardsiSNRPG
HGNCiHGNC:11163 SNRPG
HPAiHPA064152
HPA067814
MIMi603542 gene
neXtProtiNX_P62308
OpenTargetsiENSG00000143977
PharmGKBiPA36004
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1780 Eukaryota
ENOG41122Q1 LUCA
GeneTreeiENSGT00510000046985
HOVERGENiHBG000513
InParanoidiP62308
KOiK11099
OMAiMDKEMDL
TreeFamiTF315099

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-191859 snRNP Assembly
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

ChiTaRSiSNRPG human
EvolutionaryTraceiP62308
GeneWikiiSNRPG
GenomeRNAii6637
PROiPR:P62308
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143977 Expressed in 91 organ(s), highest expression level in female gonad
CleanExiHS_SNRPG
ExpressionAtlasiP62308 baseline and differential
GenevisibleiP62308 HS

Family and domain databases

CDDicd01719 Sm_G, 1 hit
InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR034098 Sm_G
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRUXG_HUMAN
AccessioniPrimary (citable) accession number: P62308
Secondary accession number(s): D6W5G6, Q15357, Q6IB86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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